Lucy Vulchanova, PhD

Associate Professor, Department of Neuroscience

Lucy Vulchanova

Contact Info

vulch001@umn.edu

Office Phone 612-626-5726

Lab Address:
4-115 Jackson Hall

Research

Research Summary/Interests

Research in the Vulchanova lab is focused on mechanisms underlying persistent pain. Our long-term goal is to contribute to the development of novel non-addictive chronic pain treatments. We are interested in elucidating the spinal circuits that mediate pain signaling, and in the discovery of novel signaling pathways involved in the development and maintenance of chronic pain. We are employing cutting-edge circuit-tracing, functional imaging, and transcriptomic approaches to investigate the organization of spinal pain circuits, and to quantify the contribution of novel signaling mediators (VGF-derived peptides) to chronic pain.

Publications

Osborn JW, Tyshynsky R, Vulchanova L. Function of Renal Nerves in Kidney Physiology and Pathophysiology. Annu Rev Physiol. 2021 Feb 10;83:429-450. doi: 10.1146/annurev-physiol-031620-091656.

Pflepsen KR, Peterson CD, Kitto KF, Riedl MS, McIvor RS, Wilcox GL, Vulchanova L, Fairbanks CA. Biodistribution of Adeno-Associated Virus Serotype 5 Viral Vectors Following Intrathecal Injection. Mol Pharm. 2021 Oct 4;18(10):3741-3749. doi: 10.1021/acs.molpharmaceut.1c00252.

Lyons CE, Razzoli M, Larson E, Svedberg D, Frontini A, Cinti S, Vulchanova L, Sanders M, Thomas M, Bartolomucci A. Optogenetic-induced sympathetic neuromodulation of brown adipose tissue thermogenesis. FASEB J. 2020 Feb;34(2):2765-2773. doi: 10.1096/fj.201901361RR.

Khasabov SG, Rogness VM, Beeson MB, Vulchanova L, Yuan LL, Simone DA, Tran PV. The nAChR Chaperone TMEM35a (NACHO) Contributes to the Development of Hyperalgesia in Mice. Neuroscience. 2021 Mar 1;457:74-87. doi: 10.1016/j.neuroscience.2020.12.027.

Belur LR, Romero M, Lee J, Podetz-Pedersen KM, Nan Z, Riedl MS, Vulchanova L, Kitto KF, Fairbanks CA, Kozarsky KF, Orchard PJ, Frey WH 2nd, Low WC, McIvor RS. Comparative Effectiveness of Intracerebroventricular, Intrathecal, and Intranasal Routes of AAV9 Vector Administration for Genetic Therapy of Neurologic Disease in Murine Mucopolysaccharidosis Type I. Front Mol Neurosci. 2021 May 10;14:618360. doi: 10.3389/fnmol.2021.618360.

Joukal M, Vulchanova L, Huffman C, Dubový P, Honda CN. Peripheral Deltorphin II Inhibits Nociceptors Following Nerve Injury. Front Pharmacol. 2020 Jul 31;11:1151. doi: 10.3389/fphar.2020.01151. 

Belur LR, Podetz-Pedersen KM, Tran TA, Mesick JA, Singh NM, Riedl M, Vulchanova L, Kozarsky KF, McIvor RS. Intravenous delivery for treatment of mucopolysaccharidosis type I: A comparison of AAV serotypes 9 and rh10. Mol Genet Metab Rep. 2020 May 20;24:100604. doi: 10.1016/j.ymgmr.2020.100604.

Lyons, CE, Razzoli, M, Larson, E, Svedberg, D, Frontini, A, Cinti, S, Vulchanova, L, Sanders, M, Thomas, M & Bartolomucci, A 2020, ‘Optogenetic-induced sympathetic neuromodulation of brown adipose tissue thermogenesis’ FASEB J, vol. 34, no. 2, pp. 2765-2773. https://doi.org/10.1096/fj.201901361RR

Gore, R, Riedl, MS, Kitto, KF, Fairbanks, CA & Vulchanova, L 2019, ‘AAV-Mediated Gene Delivery to the Enteric Nervous System by Intracolonic Injection’ Methods Mol Biol, vol. 1950, pp. 407-415. https://doi.org/10.1007/978-1-4939-9139-6_24

Peterson, CD, Skorput, AGJ, Kitto, KF, Wilcox, GL, Vulchanova, L & Fairbanks, CA 2019, ‘AAV-Mediated Gene Delivery to the Spinal Cord by Intrathecal Injection’ Methods Mol Biol, vol. 1950, pp. 199-207. https://doi.org/10.1007/978-1-4939-9139-6_11

Pflepsen, KR, Peterson, CD, Kitto, KF, Vulchanova, L, Wilcox, GL & Fairbanks, CA 2019, ‘Detailed Method for Intrathecal Delivery of Gene Therapeutics by Direct Lumbar Puncture in Mice’ Methods Mol Biol, vol. 1937, pp. 305-312. https://doi.org/10.1007/978-1-4939-9065-8_20

Skorput, AGJ, Zhang, X, Waataja, JJ, Peterson, CD, Riedl, MS, Kitto, KF, Truong, H, Huffman, C, Salton, SR, Fairbanks, CA, Honda, CN & Vulchanova, L 2018, 'Involvement of the VGF-derived peptide TLQP-62 in nerve injury-induced hypersensitivity and spinal neuroplasticity' Pain, vol. 159, no. 9, pp. 1802-1813. https://doi.org/10.1097/j.pain.0000000000001277

Borges Da Silva, H, Beura, LK, Wang, H, Hanse, EA, Gore, R, Scott, MC, Walsh, DA, Block, KE, Fonseca, R, Yan, Y, Hippen, KL, Blazar, BR, Masopust, D, Kelekar, A, Vulchanova, L, Hogquist, KA & Jameson, SC 2018, ' The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8 + T cells ' Nature, vol. 559, no. 7713, pp. 264-268. https://doi.org/10.1038/s41586-018-0282-0

Doolen, S, Cook, J, Riedl, MS, Kitto, KF, Kohsaka, S, Honda, CN, Fairbanks, CA, Taylor, BK & Vulchanova, L 2017, 'Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling' GLIA, vol. 65, no. 12, pp. 1976-1989. https://doi.org/10.1002/glia.23208

Belur, LR, Temme, A, Podetz-Pedersen, KM, Riedl, M, Vulchanova, L, Robinson, N, Hanson, LR, Kozarsky, KF, Orchard, PJ, Frey, WH, Low, WC & Scott McIvor, R 2017, 'Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System: A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type i' Human Gene Therapy, vol. 28, no. 7, pp. 576-587. https://doi.org/10.1089/hum.2017.187

Peterson, CD, Kitto, KF, Akgun, E, Lunzer, MM, Riedl, MS, Vulchanova, L, Wilcox, GL, Portoghese, PS & Fairbanks, CA 2017, 'Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice' Pain, vol. 158, no. 12, pp. 2431-2441. https://doi.org/10.1097/j.pain.0000000000001050

Kashem, SW, Riedl, MS, Yao, C, Honda, CN, Vulchanova, L & Kaplan, DH 2015, 'Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity' Immunity, vol. 43, no. 3, 3159, pp. 515-526. https://doi.org/10.1016/j.immuni.2015.08.016