Melanie Graham
,
Credentials
MPH, PhD
Credentials
MPH, PhD
Robert and Katherine Goodale Chair in Minimally Invasive Surgery Professor of Surgery, Medical School
Biography
Bio
Teaching: AnSci/CMB/VMed 8134 – Ethical Conduct of Animal Research
Research Summary
Application of the 3Rs to guard the cumulative experience of animal subjects and improve model validity and translation Diabetic animal models Nonhuman primate disease models Animal behavior Development of cell-based therapies for treatment of diabetes Extrahepatic delivery of islets, both free and encapsulated
Education
PhD,
Utrecht University
Major: Animal modeling, welfare, refinement
MPH,
University of Minnesota, School of Public Health
Major: Epidemiology
BA,
University of Saint Thomas
Major: Quantitative Methods and Computer Science
Honors and Recognition
The Patrick J. Manning Award
2004
Professional Memberships
The Transplantation Society, Member
2013-2023
The North American 3Rs Collaborative, Emeritus Board Member
2021-2023
International Xenotransplantation Association, Member
2013-2023
American Association for Laboratory Animal Science, Member
2013-2023
The American Society of Primatologists and the International Primatological Society, Member
2013-2023
Academy of Surgical Research, Director at Large, Board Member
2015-2023
The North American 3Rs Collaborative, Board Member
2017-2020
Scientific Advisory Committee for the Primate Circadian Research Lab, Boston University, Chair
2015-2017
Grant Review Panel, Member
2016-2016
Grant Review Panel, Member
2016-2016
Academy of Surgical Research, Member
International Pancreas & Islet Transplant Association, Member
Cell Transplant Society, Member
Selected Presentations
Selected Presentations
Graham, M. L., Oppler, Jr., S. H.
"The impact of experimental design in stress-dependent perturbations of the primate immune system on rigor, reproducibility, and clinical translation",
2022 NC3Rs Primate Welfare Meeting,
London,
England.
November 08, 2022.
Graham, M. L.
"The pivotal role of Refinement for ensuring translational relevance in NHP modeling.",
Invited Scientist Lecture, Biomedical Primate Research Centre,
Netherlands.
May 03, 2022.
Graham, M. L.
"Targeting Inflammation to Drive Translational Success in Metabolic Disease",
Diabetes Plenary Lecture Series, UAB Diabetes Research Center, Held Virtually,
April 21, 2022.
Graham, M. L.
"Using the 3Rs to impact the animal experience, their caregivers, and successful clinical translation",
APBI 317 - Welfare and Ethics of Using Animals in Science, University of British Columbia, *Lecture held virtually due to COVID-19,
Canada.
February 17, 2022.
Graham, M. L.
"Experimental Design Strategies in Primate Trials That Strengthen the Translational Bridge to Clinical Success in Cell And Gene Therapy",
American Society of Gene + Cell Therapy Annual Meeting, *Meeting held virtually due to COVID-19,
United States.
May 13, 2021.
Graham, M. L.
"A bioengineered pancreas supports high density islet cell transplantation without immunosuppression in nonhuman primates",
Academy of Surgical Research Virtual Meeting., *Meeting held virtually due to COVID-19,
October 13, 2020.
Nugent, J., Graham, M. L.
"Laparoscopic Vertical Sleeve Gastrectomy in Nonhuman Primates Shifts the Microbiome and Drives Changes in Microbial Metabolites",
Scientific Forum at the American College of Surgeons Clinical Congress 2020, Held Virtually Due to COVID-19,
United States.
October 03, 2020.
Graham, M. L., Lech, P.J., Tesfay, M., Gnanadurai, C., Carey, T.
"Safety and Immunogenicity of VSV-SARS2 as a Potential COVID19 Vaccine: Preliminary Findings in Cynomolgus Macaques",
ASGCT 2020 COVID-19 Symposium, Held virtually due to COVID-19,
United States.
September 15, 2020.
Graham, M. L.
"Using the 3Rs as a tool for rigorous study design to strengthen NHP translation to clinical success",
Queens U Symposium, *Lecture given via Zoom due to COVID-19 travel restrictions,
Canada.
March 11, 2020.
Graham, M. L.
"The role of behavioral management in research and the animal experience.",
Queens U Symposium., *Lecture given via Zoom due to COVID-19 travel restrictions,
Canada.
March 10, 2020.
Janecek, J. L., Pheil, N., Dalton, J., Graham, M. L.
"A Bioengineered Artificial Interstitium Supports High Density Islet Cell Transplantation Without Immunosuppression In Nonhuman Primates",
TERMIS-AM,
Orlando,
Florida,
United States.
December 02, 2019.
Graham, M. L.
"Why the Animal Experience Matters for Tomorrows Cures",
Keynote/Plenary Address: The Animal-Human Relationship University of Saskatchewan,
Saskatoon,
Canada.
November 19, 2019.
Graham, M. L.
"Using PRT to evaluate welfare in macaques undergoing medical procedures",
2019 Primate Welfare Meeting: Harmonising Welfare Indicators,
London,
England.
November 08, 2019.
Graham, M. L.
"Application of the Three Rs to Achieve a More Clinical Trial-Like Model Strengthens Translation and Improves Animal Well-Being",
CACC National Workshop Lecture,
Richmond,
Canada.
May 25, 2019.
Graham, M. L.
"Creating a 3Rs culture that supports science, innovation, and animal welfare",
OVC Welfare Forum,
University of Guelph,
Guelph, ON,
Canada.
October 13, 2018.
Graham, M. L.
"Creating a 3Rs culture that supports science, innovation, and animal welfare",
Keynote/Plenary Address: OVC Welfare Forum, University of Guelph,
Guelph,
Canada.
October 13, 2018.
Graham, M. L.
"Responsible Conduct of Research: A focus on animal subject protection",
Grand Rounds, Department of Surgery,
University of Minnesota,
Minneapolis,
Minnesota,
United States.
July 17, 2018.
Graham, M. L.
"Nonhuman primate modeling for gene therapy applications in T1D",
JDRF Gene Therapy Applications for T1D Workshop,
New York City,
New York,
United States.
May 22, 2018.
Graham, M. L.
"A novel macroencapsulation device designed for nutrient and oxygen delivery",
IPITA-JDRF-HSCI Key Opinion Leaders Meeting,
Boston,
Massachusetts,
United States.
May 07, 2018.
Graham, M. L.
"A novel macroencapsulation device designed for nutrient and oxygen delivery",
IPITA-JDRF-HSCI Key Opinion Leaders Meeting,
Boston,
Massachusetts,
United States.
May 07, 2018.
Graham, M. L., Prescott, M.
"Supporting Active 3Rs Culture Within Academic Organizations: New Strategies and Tools from the United Kingdom (Animal Well-Being and the 3Rs Track)",
Public Responsibility in Medicine and Research 2018 IACUC Conference,
Columbus,
Ohio,
United States.
March 20, 2018.
Graham, M. L., Prescott, M.
"Supporting Active 3Rs Culture Within Academic Organizations: New Strategies and Tools from the United Kingdom (Animal Well-Being and the 3Rs Track)",
Public Responsibility in Medicine and Research 2018 IACUC Conference,
Columbus,
Ohio,
United States.
March 20, 2018.
Graham, M. L.
"Refinement",
NWABR Annual Institutional Animal Care and Use Conference, “All the R’s”,
Lynwood,
Washington,
United States.
February 27, 2018.
Graham, M. L.
"Positive reinforcement training and research",
Primate Behavioral Management Conference,
Bastrop,
Texas,
United States.
February 27, 2018.
Graham, M. L.
"Can you create a 3Rs culture? Bring on the revolution",
University of Washington "Bridging the Gap",
Seattle,
Washington,
United States.
February 26, 2018.
Graham, M. L., Pate Metclaf, K.
"A Tale of Two Researchers: How Refinement Improves Our Research And Why You May Want to Refine Your Animal Work Too",
Progress in Refinement: Enhancement of Scientific Integrity and Animal Well-Being,
Johns Hopkins University Center for Alternatives to Animal Testing’s Refinement Symposium,
Baltimore,
Maryland,
United States.
November 30, 2017.
Graham, M. L.
"Practical application of harm-benefit in research using animals: protecting animal wellbeing and advancing science",
3Rs Sharing Conference,
Boston,
Massachusetts,
United States.
November 09, 2017.
Graham, M. L.
"High impact outcomes: Accelerating the adoption of refinement as a transformative technology in nonhuman primate disease models",
NC3Rs 2017 Primate Welfare Meeting,
London,
United Kingdom.
November 03, 2017.
Metcalf Pate, K., Buckmaster, C., Graham, M. L., Clifford, P.
"The Laboratory Animal Professional's Guide to the Art and Science Behind Effectively Communicating Animal Research",
68th AALAS National Meeting,
Austin,
Texas,
United States.
October 16, 2017.
Gresch, S., Mutch, L., Janecek, J., Hegstad-Davies, R., Graham, M. L.
"Evaluation and comparison of commercial radio and enzyme-linked immunoassays for porcine C-peptide measurements in nonhuman primate serum",
14th Congress of the International Xenotransplantation Association,
Baltimore,
Maryland,
United States.
September 20, 2017.
Janecek, J., Mutch, L., Pheil, N., Brekke, J., Dalton, M., O'Brien, T., Graham, M. L.
"Development of a novel ultra filtrate perfusion device bioengineered for high density islet cell transplantation without immunosuppression",
14th Congress of the International Xenotransplantation Association ,
Baltimore,
United States.
September 20, 2017.
Mutch, L., Janecek, J., Lee, R., Niewinski, M., Yang, L., Navarro, T., Graham, M. L.
"Training nonhuman primates for cooperation with medical device management to enhance human factor prediction and usability evaluations",
The 14th Congress of the International Xenotransplantation Association,
Baltimore,
Maryland,
United States.
September 20, 2017.
Graham, M. L.
"Best practices to improve validity and enhance wellbeing in nonhuman primate disease models",
Johns Hopkins School of Medicine Special Seminar,
Baltimore,
Maryland,
United States.
September 19, 2017.
Graham, M. L.
"Bringing Behavioral Management Together with Instrumentation: a Transformative Technology for Animal-Centric Care",
Keynote/Plenary Address: 10th Congress on Alternatives and Animal Use in the Life Sciences,
Seattle,
United States.
August 23, 2017.
Graham, M. L.
"Bringing Behavioral Management Together with Instrumentation: a Transformative Technology for Animal-Centric Care",
10th Congress on Alternatives and Animal Use in the Life Sciences,
Seattle,
Washington,
United States.
August 23, 2017.
Graham, M. L.
"Positive reinforcement training and research",
Research Animal Resources Enrichment Seminar Series,
Minneapolis,
Minnesota,
United States.
July 14, 2017.
Graham, M. L.
"Practical application of harm-benefit analysis in research using animals: protecting animal wellbeing and advancing science",
Veterinary Summer Scholars,
Saint Paul,
Minnesota,
United States.
May 23, 2017.
Graham, M. L.
"Advancing the leading edge of science through comprehensive and responsible care of lab animals",
Biomedical Research Awareness Day,
Saint Paul,
Minnesota,
United States.
April 19, 2017.
Graham, M. L.
"Utilization of enrichment and behavioral management to enhance validity in nonhuman primate models",
Science of Enrichment Symposium,
Michigan Society for Medical Research,
Ann Arbor,
Michigan,
United States.
April 12, 2017.
Graham, M. L.
"Practical application of harm-benefit analysis in research using animals: protecting animal wellbeing and advancing science",
District 6 AALAS Meeting,
Bloomington,
Minnesota,
United States.
March 30, 2017.
Graham, M. L.
"Positive reinforcement training and research",
Primate Behavioral Management Conference,
Bastrop,
Texas,
United States.
February 28, 2017.
Graham, M. L.
"Nonhuman primate husbandry, enrichment, and behavioral management",
Minnesota Association of Veterinary Technicians,
Minneapolis,
Minnesota,
United States.
February 24, 2017.
Graham, M. L.
"Ethical use of animals in research, protecting animal well-being and advancing science",
Minnesota Association of Veterinary Technicians,
Minneapolis,
Minnesota,
United States.
February 24, 2017.
Graham, M. L.
"Designing enrichment and husbandry to enhance translation",
Laboratory Animal Sciences, A virtual event produced by Labroots,
Labroots,
February 08, 2017.
Graham, M. L.
"Utilization of holistic reduction and refinement to make preclinical research more effective in complex nonhuman primate disease models",
3Rs Sharing Conference V,
Raleigh,
North Carolina,
United States.
November 18, 2016.
Graham, M. L.
"Developing a clinically relevant macrodevice for the treatment of diabetes",
FDA Symposium Session,
Silver Spring,
Maryland,
United States.
November 15, 2016.
Graham, M. L.
"Novel sites for islet implantation: an overview of approaches",
4th NHP Transplantation Techniques Workshop,
Boston,
Massachusetts,
United States.
November 07, 2016.
Graham, M. L.
"Evaluation of islet xenograft survival and function using a novel bioengineered serum ultrafiltrate perfusion device innonhuman primates",
JDRF Encapsulation Consortium,
Boston,
Massachusetts,
United States.
September 21, 2016.
Graham, M. L.
"Best practices in nonhuman primate transplant models",
IPITA-JDRF/Helmsley-HSCI Key Opinion Leaders Meeting on Stem Cell Derived Beta Cells,
Boston,
Massachusetts,
United States.
September 19, 2016.
Graham, M. L.
"Responsible Conduct of Research: A focus on animal subject protection",
Grand Rounds, Department of Surgery,
University of Minnesota,
Minneapolis,
Minnesota,
United States.
July 19, 2016.
Graham, M. L.
"Fostering the implementation of the 3Rs at the University of Minnesota",
The North American 3Rs Collaborative Summer Conference,
Providence,
Rhode Island,
United States.
June 26, 2016.
Zhao, H., Woodward, K., Yolcu, E., Graham, M. L., Hering, B. J., Shirwan, H.
"Porcine Islets Engineered to Display SA-FasL Protein on Their Surface Induce Tolerance in Mice Following Transplantation into the Liver or Under the Kidney Capsule",
2016 American Transplant Congress,
Boston,
Massachusetts,
United States.
June 13, 2016.
Woodward, K., Zhao, H., Yolcu, E., Wang, F., Graham, M. L., Hering, B. J., Shirwan, H.
"Porcine Islets Engineered with SA-FasL Protein Induces Robust Tolerance in Mice through CD4+ CD25+ FoxP3+ Treg Cells",
2016 American Transplant Congress,
Boston,
Massachusetts,
United States.
June 11, 2016.
Graham, M. L.
"The role of enrichment and positive reinforcement training in research",
Clinical Conference,
Research Animal Resources University of Minnesota,
Minneapolis,
Minnesota,
United States.
May 26, 2016.
Graham, M. L.
"Training for cooperative handling in a macaque model of chronic disease",
Veterinary Summer Scholars,
University of Minnesota,
Minneapolis,
Minnesota,
United States.
May 20, 2016.
Graham, M. L.
"The Role of Enrichment, Handling, and Husbandry in Animal Model Validity and Research Quality: Enhancing Welfare and Scientific Outcomes Using Refinement",
AHC Duluth Research Seminar Series,
Duluth,
Minnesota,
United States.
May 11, 2016.
Graham, M. L.
"The role of enrichment, handling, and husbandry in nonhuman primate model validity and research quality: enhancing welfare and scientific outcomes using refinement",
Boston University-Pfizer,
Boston,
Massachusetts,
United States.
April 19, 2016.
Graham, M. L.
"Evaluation of islet xenograft survival and function using a novel bioengineered serum utrafiltrate perfusion device in nonhuman primates",
JDRF Encapsulation Consortium,
New York ,
New York,
United States.
April 12, 2016.
Graham, M. L.
"Positive reinforcement training and research, the social impact",
Symposium on Social Housing or Laboratory Animals,
Sacramento,
California,
United States.
March 17, 2016.
Graham, M. L.
"Positive reinforcement training and research",
Primate Behavioral Management Conference,
Bastrop,
Texas,
United States.
March 01, 2016.
Kim, J., Furrow, E., M., Eckert, A., Steubner, K., Graham, M. L., Fife, B., O'Brien, T., Yu, L., Utz, P., Robinson, W., Steinman, L., Modiano, J.
"Tolerization of antigen-specific immune responses in diabetic dogs",
Keystone (Systems Immunology: From Molecular Networks to Human Biology) ,
Big Sky,
Montana,
United States.
January 10, 2016.
Graham, M. L.
"Holistic Care: incorporating behavioral management to lower stress and partner with our animals to enable exceptional medical treatment",
Research Animal Medicine Club Seminar Series,
Minneapolis,
Minnesota,
United States.
December 02, 2015.
Graham, M. L.
"Clinical care in the immunosuppressed nonhuman primate model",
European Primate Veterinarians 15th Symposium,
Florence,
Italy.
November 19, 2015.
Graham, M. L.
"Clinical care in the immunosuppressed nonhuman primate model",
European Primate Veterinarians 15th Symposium,
Florence,
Italy.
November 19, 2015.
Singh, A., Graham, M. L., Suarez-Pinzon, W., Naqvi, R., Burlak, C., Luo, X., Miller, S., Hering, B. J.
"Cellular Immunity to Porcine Islet Xenografts in Nonhuman Primates Receiving B Cell-Targeted Immunosuppression Without and With Peritransplant Donor Apoptotic Leukocyte Infusions",
The 14th Transplantaton Science Symposium,
Lorne,
Australia.
November 11, 2015.
Graham, M. L.
"Validity of animal models of type 1 diabetes and strategies to enhance their utility",
Michigan ULAM Seminar Series,
October 22, 2015.
Graham, M. L.
"Training for cooperative handling in a macaque chronic disease model",
NC3Rs Primate Welfare Meeting: 10 years of supporting NHP welfare,
London,
United Kingdom.
October 09, 2015.
Graham, M. L.
"Evaluation of islet xenograft survival and function using a novel bioengineered serum ultrafiltrate perfusion device in nonhuman primates",
JDRF Encapsulation Consortium,
Brooklyn,
New York,
United States.
September 28, 2015.
Graham, M. L.
"Applying the 3Rs to make preclinical research more effective in complex nonhuman primate disease models",
NJABR's 3Rs Webinar Series,
Pfizer,
July 29, 2015.
Graham, M. L.
"Validity of animal models of type 1 diabetes and strategies to enhance their utility",
Mass General Harvard Veterinary Service Rounds,
July 28, 2015.
Graham, M. L.
"The Use of Animal Models in Diabetes Research",
28th Annual Charles River Labs Short Course,
Boston,
Massachusetts,
United States.
June 15, 2015.
Graham, M. L.
"Applying the 3Rs to Make Research more Effective in Complex NHP Disease Models",
28th Annual Charles River Labs Short Course,
Boston,
Massachusetts,
United States.
June 15, 2015.
Graham, M. L.
"Validity of animal models of diabetes, and strategies to enhance their utility in translational research",
31st Annual Charles River Labs Short Course,
Mashantucket,
Connecticut,
United States.
June 13, 2015.
Graham, M. L.
"Harm-benefit analysis",
University of Minnesota IACUC,
Minneapolis,
Minnesota,
United States.
June 09, 2015.
Graham, M. L.
"Designing complex animal disease models that enhance translational value to the clinic",
Brown Bag Series, Department of Surgery,
University of Minnesota,
Minneapolis,
Minnesota,
United States.
May 29, 2015.
Weegman, B., Einstein, S., Purvis, W., Steyn, L., Stanton, J., Kitzmann, J., Mueller, K., Limesand, S., Suszynski, T., Firpo, M., Graham, M. L., Janacek, J., Eberly, L., Garwood, M., Papas, K.
"Non-Invasive Monitoring of Hypoxia and Viability Assessment of Implanted High-Cell-Density Tissue-Engineered Grafts",
The 19th Annual Hilton Head Regenerative Medicine Workshop,
Hilton Head,
South Carolina,
United States.
May 01, 2015.
Graham, M. L.
"Improving face, construct, and predictive validity in animal models of diabetes",
SNBL USA,
Everett,
Washington,
United States.
April 02, 2015.
Graham, M. L.
"The use of animal models in the study of diabetes: application of the 3Rs",
SAVMA Symposium,
Minneapolis,
Minnesota,
United States.
March 21, 2015.
Graham, M. L.
"Positive reinforcement training and research",
Primate Behavioral Management Conference,
Bastrop,
Texas,
United States.
March 04, 2015.
Naqvi, R., Suarez-Pinzon, W., Singh, A., Burlak, C., Li, L., Subramanian, S., Graham, M. L., Hering, B. J.
"Plasma microRNA-375 – A single test to quantitate injury to porcine islet grafts and to diagnose accelerated porcine islet graft loss in nonhuman primates",
IPITIA-IXA-CTS,
Melbourne,
Australia.
January 01, 2015.
Graham, M. L.
"Improving face, construct, and predictive validity in animal models of diabetes",
Wisconsin National Primate Center,
Madison,
Wisconsin,
United States.
December 12, 2014.
Graham, M. L.
"A holistic approach to refinement improves medical management and safety in nonhuman primate disease models",
9th World Congress on Alternatives and Animal Use in the Life Sciences,
Prague,
Czech Republic.
August 24, 2014.
Graham, M. L.
"The Use of Animal Models in Diabetes Research",
28th Annual Charles River Labs Short Course,
Boston,
Massachusetts,
United States.
June 16, 2014.
Graham, M. L.
"Applying the 3Rs to Make Research more Effective in Complex NHP Disease Models",
28th Annual Charles River Labs Short Course,
Boston,
Massachusetts,
United States.
June 16, 2014.
Stein, S., Weegman, B., Suszynski, T., Firpo, M., Graham, M. L., Papas, K., Garwood, M.
"Monitoring Tissue-Engineered Graft Oxygenation In Vivo by Fluorine-19 Magnetic Resonance Spectroscopy",
Joint Annual Meeting: International Society for Magnetic Resonance in Medicine and the European Society for Magnetic Resonance in Medicine and Biology,
Milan,
Italy.
May 10, 2014.
Graham, M. L.
"Technical and surgical aspects of long term vascular access that eliminates the need for restraint of nonhuman primates in favour of cooperative handling",
European Primate Veterinarians 13th Symposium,
German Primate Center Gottingen,
Gottingen,
Germany.
November 29, 2013.
Graham, M. L.
"Lessons from islet transplant studies in nonhuman primates",
1st International Conference of Clinical Islet Xenotransplantation,
Osaka,
Japan.
November 09, 2013.
Graham, M. L.
"Animal Models of Diabetes",
27th Annual Charles River Labs Short Course,
Boston,
Massachusetts,
United States.
June 17, 2013.
Graham, M. L.
"IACUC approval in the ever changing research environment",
Des Moines University,
Des Moines,
Indiana,
United States.
June 14, 2013.
Graham, M. L.
"The Use of Animal Models in the Study of Diabetes",
Texas Biomedical Research Institute Faculty Seminar Series,
San Antonio,
Texas,
United States.
February 15, 2013.
Graham, M. L.
"The impact of Instrumentation and Behavioral Training in Nonhuman Primate Disease Models: advancing promising research to the clinic",
Data Sciences International,
Saint Paul,
Minnesota,
United States.
December 10, 2012.
Graham, M. L.
"Pragmatic and proven refinement techniques in diabetic nonhuman primates that enhance translational value in islet transplantation",
National AALAS Annual Meeting,
Minneapolis,
Minnesota,
United States.
November 08, 2012.
Graham, M. L.
"Broadening our perspective on refinement: addressing model divergence to target a net-positive animal experience",
The 28th Annual Meeting of the Academy of Surgical Research,
Charlotte,
North Carolina,
United States.
October 04, 2012.
Mutch, L., Graham, M. L.
"Percutaneous fine needle aspiration biopsy of the liver for RNA extraction and gene expression profiling",
The 28th Annual Meeting of the Academy of Surgical Research,
Charlotte,
North Carolina,
United States.
October 04, 2012.
Graham, M. L.
"Development and management of the diabetic nonhuman primate model",
The 28th Annual Meeting of the Academy of Surgical Research,
Charlotte,
North Carolina,
United States.
October 04, 2012.
Graham, M. L.
"Applying refined methods in infusion technology to promote well-being in nonhuman primates",
Infusion Technology Organization, 3rd Annual ITO Meeting,
New Brunswick,
New Jersey,
United States.
September 25, 2012.
Graham, M. L.
"Anterior cruciate ligament reconstruction in the baboon: a nonhuman primate model for evaluation of engineered tissue graft immunocompatibility",
International Medical Device Expo,
Chicago,
Illinois,
United States.
September 19, 2012.
Graham, M. L., Hennessy, E., Wang, S., Martins, K., Suarez-Pinzon, W., Flanagan, B., Murtaugh, M., Azimzadeh, A., Hancock, W., Miller, S., Luo, X., Hering, B.
"The immunobiology of pig-to-nonhuman primate islet xenotransplantation: insights, innovation, and impact",
15th Berlin Symposium Xenotransplantation in association with the 24th International Congress of the Transplantation Society (TTS),
The International Xenotransplantation Association (IXA) and the Robert Koch Institute,
Berline,
Germany.
July 13, 2012.
Graham, M. L.
"Animal modeling in T1D: using refinement to enhance the value of translational research",
Research Animal Medicine Club,
Saint Paul,
Minnesota,
United States.
April 20, 2012.
Graham, M. L.
"The Impact of Instrumentation and Behavioral Training in Nonhuman Primate Disease Models: Coping Mechanisms for Experimental Animals",
Hennepin County Medical Center,
Minneapolis,
Minnesota,
United States.
April 06, 2012.
Graham, M. L.
"Utilization of the 3Rs to enhance the value of translational research",
Minnesota AALAS Annual Meeting,
Minnesota,
United States.
March 05, 2012.
Graham, M. L.
"Refining the T1D NHP model",
Ohio State University,
Columbus,
Minnesota,
United States.
February 20, 2012.
Graham, M. L.
"Working on the 3Rs",
Erasmus MC,
Rotterdam,
Netherlands.
December 14, 2011.
Graham, M. L.
"Working on the 3Rs",
Biomedical Primate Research Center,
Rijswijk,
Netherlands.
December 13, 2011.
Graham, M. L., Schuurman, H.
"Limitations of the model of porcine islet transplantation in diabetic nonhuman primates affecting long-term survival and graft function",
CTS-IXA Joint Congress,
Miami,
Florida,
United States.
October 01, 2011.
Papas, K., Graham, M. L., Avgoustiniatos, E., Mueller, K., Flanagan, B., Schuurman, H., Hering, B. J.
"Quality assessment as a predictor for graft function in the pig-to-nonhuman primate islet transplantation model",
CTS-IXA Joint Congress,
Miami,
Florida,
United States.
October 01, 2011.
Graham, M. L., Rieke, E., Mutch, L., Zolondek, E., Faig, A., Dufour, T., Munson, J., Kittredge, J., Schuurman, H.
"Experience with a training program for cooperative handling in nonhuman primates: reduced stress, improved care, and higher validity of scientific results",
CTS-IXA Joint Congress,
Miami,
Florida,
United States.
October 01, 2011.
Graham, M. L., Mutch, L., Rieke, E., Robinson, N., Kittredge, J., Faig, A., DuFour, T., Munson, J., Zolondek, E., Hering, B. J., Schuurman, H.
"Diabetes induction in nonhuman primates using high-dose streptozotocin: evaluation of risk factors and outcomes relevant for cell- and xeno-transplantation",
CTS-IXA Joint Congress,
Miami,
Florida,
United States.
October 01, 2011.
Mueller, K., Appakalai, B., Cline, G., Pongratz, R., Hooper, R., Weegman, B., Taylor, M., Graham, M. L., Schuurman, H., Papas, K.
"Comparison of glucose-stimulated insulin secretion between isolated human, nonhuman primate and porcine islets",
CTS-IXA Joint Congress,
Miami,
Florida,
United States.
October 01, 2011.
Graham, M. L., Janacek, J., Kittredge, J., Hering, B. J., Schuurman, H.
"The streptozotocin-induced diabetic nude mouse model: differences between source animals relevant for cell- and xeno-transplantation",
CTS-IXA Joint Congress,
Miami,
Florida,
United States.
October 01, 2011.
Graham, M. L., Schuurman, H.
"Limitations of the model of porcine islet transplantation in diabetic nonhuman primates affecting long-term survival and graft function",
The 14th Minisymposium Xenotransplantation of the German Working Group Xenotransplantation (DAX),
DFG-Transregio Research Group Xenotransplantation (FOR 535), Robert Koch Institute,
Berlin,
Germany.
June 09, 2011.
Bansal-Pakala, P., Pahuja, A., Hennessey, E., Graham, M. L., Hering, B. J., Blazar, B. R.
"Ex vivo expanded Treg therapy promotes long-term islet allograft survival in a non-human primate model",
2011 American Transplant Congress,
Philadelphia,
Pennsylvania,
United States.
May 01, 2011.
Bansal-Pakala, P., Graham, M. L., Hennessy, E., Pahuja, A., Schuurman, H., Hering, B. J.
"Increased direct and indirect anti-donor CD$ T cell responses and inflammatory serum cytokines early posttransplant leads to rejection of islet xenografts in pig-to-monkey model of islet transplantation",
Joint Meeting of the International Pancreas and Islet Transplant Association (IPITA) and International Xenotransplantation Association (IXA),
Venice,
Italy.
October 01, 2009.
Graham, M. L., Mutch, L., Rieke, E., Zolondek, E., Faig, A., DuFour, T., Munson, J., Schuurman, H., Hering, B. J.
"Improved welfare of nonhuman primates used in xenotransplantation: beneficial effect of peripherally placed central vascular access ports (VAPs) in conjunction with cooperative handling",
Joint Meeting of the International Pancreas and Islet Transplant Association (IPITA) and International Xenotransplantation Association (IXA),
Venice,
Italy.
October 01, 2009.
Graham, M. L., Mutch, L., Munson, J., Rieke, E., Faig, A., Zolondek, E., DuFour, T., Schuurman, H., Hering, B. J.
"Chronic immunosuppression with tacrolimus is associated with an increased risk of drug-induced diarrhea post islet xenotransplant in cynomolgus macaques",
Joint Meeting of the International Pancreas and Islet Transplant Association (IPITA) and International Xenotransplantation Association (IXA),
Venice,
Italy.
October 01, 2009.
Graham, M. L.
"Curing diabetes with cell-based therapies",
Grand Rounds, UMN hematology and oncology,
Minneapolis,
Minnesota,
United States.
September 30, 2009.
Johnson, J., Hennessy, E., Pahuja, A., Graham, M. L., Blazar, B., Hering, B. J., Bansal-Pakala, P.
"Non-human primate regulatory T cells can be successfully expanded ex vivo, express CTLA4 and granzyme B and inhibit allo- and polyclonal effector T cell responses",
2009 American Transplant Congress,
Boston,
Massachusetts,
United States.
June 01, 2009.
Johnson, J., Hennessy, E., Pahuja, A., Graham, M. L., Blazar, B. R., Hering, B. J., Bansal-Pakala, P.
"Contact-dependent suppression pathways in non-human primate Tregs expanded ex vivo in the presence of Rapamycin",
Immunology 2009,
Seattle,
Washington,
United States.
May 01, 2009.
Jie, T., Graham, M. L., Wijkstrom, M., Aasheim, T., Ansite, J., Nakano, M., Guenther, L., Liu, B., Moran, K., Li, W., Kirchhof, N., Schuurman, H., Hering, B. J.
"Pancreatic Islet xenotransplants restore mormoglycemia and insulin independence in immunosuppressed nonhuman primates",
XX International Congress of the Transplantation Society,
Vienna,
Austria.
May 01, 2009.
Graham, M. L.
"A novel alternative placement site and technique for totally implantable vascular access ports in nonhuman primates",
NIH NHP Assays and Techniques Workshop,
Miami,
Florida,
United States.
November 13, 2008.
Graham, M. L.
"A novel alternative placement site and technique for totally implantable vascular access ports in nonhuman primates",
Academy of Surgical Research, 24th Annual Meeting,
Indianapolis,
Indiana,
United States.
November 06, 2008.
Graham, M. L.
"The changing face of nonhuman primates in biomedical research",
Minnesota AALAS Annual Meeting,
Minnesota,
United States.
August 08, 2007.
Graham, M. L.
"Islet Transplantation, Progress and Prospects",
Research Animal Resources,
Minneapolis,
Minnesota,
United States.
June 15, 2007.
Pratima Pakala, P., Shufeski, W., Sullivan, N., Pahuja, A., Graham, M. L., Hering, B. J., Morelli, A.
"Apoptotic donor cell transfusion in nonhuman primates: A strategy for preemptive tolerization",
2007 American Transplant Congress,
San Francisco,
California,
United States.
May 01, 2007.
Graham, M. L.
"Cooperative sirolimus administration in nonhuman primates",
NIH NHP Assays and Techniques Workshop,
Bethesda,
Maryland,
United States.
May 07, 2004.
Contact
Contact
Address
Animal Science/Veterinary Medicine 2951988 Fitch Ave
Saint Paul, MN 55108
Administrative Contact
Jade Wilder | 612-625-5504 |Â addin038@umn.edu