Anna D. Tischler, PhD

Associate Professor, Department of Microbiology and Immunology

Anna D. Tischler

Contact Info

Office Phone 612-624-9685

Fax 612-626-0623

Lab Phone 612-624-9686

Office Address:
4-113 MRF
689 23rd Ave SE
Minneapolis, MN 55455

Mailing Address:
Department of Microbiology and Immunology
4-113 Microbiology Research Facility (MRF)
CDC: 2821A
689 23rd Ave SE
Minneapolis, MN 55455-1507

PhD, Tufts University, 2005


Research Summary/Interests

Mycobacterium tuberculosis Counter-immune Mechanisms

The bacterial pathogen Mycobacterium tuberculosis (Mtb) is unusual in its ability to persist in the lungs of infected humans for many years, despite triggering a robust immune response. My laboratory seeks to identify and characterize factors that Mtb requires for evasion of host adaptive immunity and persistence. We use a combination of bacterial genetics and the mouse infection model to identify these “counter-immune” factors.

The laboratory is currently focused on characterization of an Mtb signal transduction system, Pst/SenX3-RegX3, which regulates gene expression in response to phosphate availability. Mtb mutants that lack components of this system are specifically sensitive to host adaptive immunity and fail to persist in the lungs of mice. We aim to identify the genes controlled by this system that directly contribute to avoidance of host immune responses. Knowledge of these interactions between host and pathogen may contribute to vaccine design, as well as provide novel targets for therapeutic intervention.


  • Tischler AD, Leistikow, RL, Kirksey MA, Voskuil MI, McKinney JD. 2013. Mycobacterium tuberculosis requires phosphate-responsive gene regulation to resist host immunity. Infect. Immun. 81: 317-328.
  • Kirksey MA, Tischler AD, Siméone R, Hisert KB, Uplekar S, Guilhot C, McKinney JD. 2011. Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity. Infect Immun. 79:2829-2838.
  • Tischler AD, McKinney JD. 2010. Contrasting persistence strategies in Salmonella and Mycobacterium. Curr. Opin. Microbiol. 13:93-99.
  • Tischler AD, Camilli A. 2005. Cyclic diguanylate regulates Vibrio cholerae virulence gene expression. Infect. Immun. 73:5873-5882.
  • Tamayo R, Tischler AD, Camilli A. 2005. The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase. J. Biol. Chem. 280: 33324-33330.
  • Tischler AD, Camilli A. 2004. Cyclic diguanylate (c-di-GMP) regulates Vibrio cholerae biofilm formation. Mol. Microbiol. 53:857-869.