Most eucaryotic genes are controlled by developmental, hormonal, tissue-specific, and/or nutritional cues. Insight into these complex regulatory events is fundamental to our understanding of the processes controlling cellular proliferation and oncogenesis, differentiation, and development. The long-term goal of the research in my laboratory focuses on investigating how estrogen and testosterone regulate gene expression, both physiologically and pathologically. To address this, we are investigating the structure and function of the estrogen- and testosterone-responsive ZEB-1 (delta EF1) transcription factor.
