Damien Fair, PA-C, PhD

Professor, Department of Pediatrics

Professor, Department of Pediatrics

Professor, Institute of Child Development

Faculty Member, Division of Clinical Behavioral Neuroscience

Co-Director, Masonic Institute for the Developing Brain (MIDB)


PhD, Neuroscience, Washington University School of Medicine, St. Louis, MO

MMSc, Yale University School of Medicine Physician Associate Program, New Haven, CT

Summary

Awards & Recognition

  • MacArthur Fellowship, John D. & Catherine T. MacArthur Foundation (2020)

Research

Research Summary/Interests

The Fair laboratory focuses on mechanisms and principles that underlie the developing brain. The majority of this work uses functional MRI and resting state functional connectivity MRI to assess typical and atypical populations. Dr. Fair is the co-director of the new Masonic Institute for the Developing Brain.

Publications

Dr. Fair is the author of many manuscripts, which have appeared in premier peer-reviewed publications. Following are selected peer-reviewed papers, 2018 - present:

Morin EL, Howell BR, Feczko E, Earl E, Pincus M, Reding K, Kovacs-Balint ZA, Meyer JS, Styner M, Fair DA, Sanchez MM. (2020). Developmental Outcomes of Early Adverse Care on Amygdala Functional Connectivity in Nonhuman Primates. Dev and Psychopathology. [Epub ahead of print].

Gratton C, Dworetsky A, Coalson RS, Adeyemo B, Laumann TO, Wig GS, Kong TS, Gratton G, Fabiani M, Barch DM, Tranel D, Dominguez OM, Fair DA, Dosenbach NUF, Snyder AZ, Perlmutter JS, Petersen SE, Campbell MC. (2020). Removal of high frequency contamination from motion estimates in single-band fMRI saves data without biasing functional connectivity. Neuroimage. [Epub ahead of print].

Godfrey JR, Pincus M, Kovacs-Balint Z, Feczko E, Earl E, Miranda-Dominguez O, Fair DA, Jones SR, Locke J, Sanchez MM, Wilson ME, Michopoulos V. (2020). Obesogenic diet-associated C-reactive protein predicts reduced central dopamine and corticostriatal functional connectivity in female rhesus monkeys. Brain Behav Immun. [Epub ahead of print].

Cordova M, Shada K, Demeter DV, Doyle O, Miranda-Dominguez O, Perrone A, Schifsky E, Graham A, Fombonne E, Langhorst B, Nigg J, Fair DA, Feczko E. (2020). Heterogeneity of executive function revealed by a functional random forest approach across ADHD and ASD. Neuroimage Clin. 26:102245.

Cui Z, Li H, Xia CH, Larsen B, Adebimpe A, Baum GL, Cieslak M, Gur RE, Gur RC, Moore TM, Oathes DJ, Alexander-Bloch AF, Raznahan A, Roalf DR, Shinohara RT, Wolf DH, Davatzikos C, Bassett DS, Fair DA, Fan Y, Satterthwaite TD. (2020). Individual Variation in Functional Topography of Association Networks in Youth. Neuron. 106(2):340-353.

Reding KM, Grayson DS, Miranda-Dominguez O, Ray S, Wilson ME, Roufexis D, Fair DA, Sanchez MM. (2020). Effects of social subordination and oestradiol on resting-state amygdala functional connectivity in adult female rhesus monkeys. J Neuroendocrinol. 32(2): 312822.

Mooney MA, Bhatt P, Hermosillo RJM, Ryabinin P, Nikolas M, Faraone SV, Fair DA, Wilmot B, Nigg JT. (2020). Smaller total brain volume but not subcortical structure volume related to common genetic risk for ADHD. Psychol Med. 1-10.

Hermosillo RJM, Mooney MA, Fezcko E, Earl E, Marr M, Sturgeon D, Perrone A, Miranda-Dominguez O, Faraone SV, Wilmot B, Nigg JT, Fair DA. (2019). Polygenic risk score-derived subcortical connectivity mediates attention-deficit/hyperactivity disorder diagnosis. Biol Psychiatry Cogn Neurosci Neuroimaging. 5(3):330-341.

Fair DA, Miranda-Dominguez O,… Dosenbach NUF. (2020). Correction of respiratory artifacts in MRI head motion estimates. Neuroimage. 208: 116400.

Postema MC, van Rooij D,… Fair DA,… Francks C. (2019). Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets. Nat Commun. 10(1): 4958.

Ramirez JSB, Graham AM,… Fair DA. (2019). Maternal interleukin-6 is associated with macaque offspring amygdala development and behavior. Cereb Cortex. 30(3): 1573-1585.

Nigg JT, Karalunas SL, Gustafsson HC, Bhatt P, Ryabinin P, Mooney MA, Faraone SV, Fair DA, Wilmot B. (2020). Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD. J Child Psychol Psychiatry. 61(2): 205-214.

Marek S, Tervo-Clemmens B,… Fair DA, Luna B, Dosenbach NUF. (2019). Identifying reproducible individual differences in childhood functional brain networks: An ABCD study. Dev Cogn Neurosci. 40: 100706.

Hagler DJ Jr, Hatton S,… Fair DA, …Dale AM. 2019. Image processing and analysis methods for the Adolescent Brain Cognitive Development Study. Neuroimage. 202: 116091.

Karstens L, Asquith M, Davin S, Fair DA, Gregory WT, Wolfe AJ, Braun J, McWeeney S. (2019). Controlling for contaminants in low-biomass 16S rRNA gene sequencing experiments. mSystems. 4(4).

Hoogman M,…Fair, DA,… Franke B. (2019). Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples. Am J Psychiatry. 176(7): 531-42.

Colon E, Ludwick A, Wilcox SL, Youssef AM, Danehy A, Fair DA, Lebel AA, Burstein R, Becerra L, Borsook D. (2019). Migraine in the Young Brain: Adolescents vs Young Adults. Front Hum Neurosc. 13: 87.

Xu T, Sturgeon D, Ramirez JSB, Froudist-Walsh S, Margulies DS, Schroeder CE, Fair DA, Milham MP. (2019). Interindividual Variability of Functional Connectivity in Awake and Anesthetized Rhesus Macaque Monkeys. Biol Psychiatry Cogn Neurosci Neuroimaging. 4(6): 543-553.

Henry TR, Feczko E, Cordova M, Earl E, Williams S, Nigg JT, Fair DA, Gates KM. (2019) Comparing directed functional connectivity between groups with confirmatory subgrouping GIMME. Neuroimage. 188: 642-653.

Thomas E, Buss C, Rasmussen JM, Entringer S, Ramirez JSB, Marr M, Rudolph MD, Gilmore JH, Styner M, Wadhwa PD, Fair DA, Graham AM. (2019). Newborn Amygdala Connectivity and Emerging Fear. Dev Cogn Neurosci. 37: 100604.

Kovacs-Balint Z, Feczko E, Pincus M, Earl E, Miranda-Dominguez O, Howell B, Morin E, Maltbie E, Li L, Steele J, Styner M, Bachevalier J, Fair D, Sanchez M. (2019). Early Developmental Trajectories of Functional Connectivity Along the Visual Pathways in Rhesus Monkeys. Cerebral Cortex. 29(8): 3514-3526.

Milham MP, Ai L,… Fair DA,… Schroeder CE. (2018) An Open Resource for Non-human Primate Imaging. Neuron. 100(1):61-74.e2.

Graham AM, Rasmussen JM, Entringer S, Ben Ward E, Rudolph MD, Gilmore JH, Styner M, Wadhwa PD, Fair DA, Buss C. (2019). Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors. Biol Psychiatry. 85(2): 172-181.

Rasmussen JM, Graham AM, Entringer S, Gilmore JH, Styner M, Fair DA, Wadhwa PD, Buss C. (2019). Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life. Neuroimage. 185: 825-835.

Anandakumar J, Mills KL, Earl EA, Irwin L, Miranda-Dominguez O, Demeter DV, Walton-Weston A, Karalunas S, Nigg J, Fair DA. (2018). Individual differences in functional brain connectivity predict temporal discounting preference in the transition to adolescence. Dev Cogn Neurosci. 34: 101-113.

Kong XZ, Mathias SR, Guadalupe T, Fair DA, ENIGMA Laterality Working Group, Glahn DC, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher SE, Thompson PM, Francks C. (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci. 115(22): E5154-63.

Alarcón G, Pfeifer JH, Fair DA, Nagel BJ. (2018) Adolescent Gender Differences in Cognitive Control Performance and Functional Connectivity Between Default Mode and Fronto-Parietal Networks Within a Self-Referential Context. Front Behav Neurosci. 12:73.

van Rooij D, Anagnostou E,… Fair DA,…Buitelaar JK. (2018). Cortical and Subcortical Brain Morphometry Differences Between Patients With Autism Spectrum Disorder and Healthy Individuals Across the Lifespan: Results From the ENIGMA ASD Working Group. Am J Psychiatry. 175(4): 359-369.

Mavigner M, Raper J, Kovacs-Balint Z, Gumber S, O'Neal JT, Bhaumik SK, Zhang X, Habib J, Mattingly C, McDonald CE, Avanzato V, Burke MW, Magnani DM, Bailey VK, Watkins DI, Vanderford TH, Fair D, Earl E, Feczko E, Styner M, Jean SM, Cohen JK, Silvestri G, Johnson RP, O'Connor DH, Wrammert J, Suthar MS, Sanchez MM, Alvarado MC, Chahroudi A. (2018) Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques. Sci Transl Med. 10: 435.

Godfrey JR, Diaz MP, Pincus M, Kovacs-Balint Z, Feczko E, Earl E, Miranda-Dominguez O, Fair D, Sanchez MM, Wilson ME, Michopoulos V. (2018) Diet matters: Glucocorticoid-related neuroadaptations associated with calorie intake in female rhesus monkeys. Psychoneuroendocrinology. 91: 169-178.

Karalunas SL, Hawkey E, Gustafsson H, Miller M, Langhorst M, Cordova M, Fair DA, Nigg JT. (2018). Overlapping and Distinct Cognitive Impairments in Attention-Deficit/Hyperactivity and Autism Spectrum Disorder without Intellectual Disability. J Abnormal Child Psychol. 46(8): 1705-16.

Thompson JR, Gustafsson HC, DeCapo M, Takahashi DL, Bagley JL, Dean TA, Kievit P, Fair DA, Sullivan EL. (2018). Maternal Diet, Metabolic State, and Inflammatory Response Exert Unique and Long-Lasting Influences on Offspring Behavior in Non-Human Primates. Front Endocrinol. 9:161.

Mills BD, Grayson D, Shunmugavel A, Miranda-Dominguez O, Earl E, Feczko E, Neve K, Fair DA. (2018). Correlated gene expression and anatomical communication support synchronized brain activity in the mouse functional connectome. J. Neurosci. 38(25):5774-5787.

Xu T, Falchier A, Sullivan EL, Linn G, Ramirez JSB, Ross D, Feczko E, Opitz A, Bagley J, Sturgeon D, Earl E, Miranda-Domínguez O, Perrone A, Craddock RC, Schroeder CE, Colcombe S, Fair DA, Milham MP. (2018) Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo. Cell Rep. 23(2):429-441.

Rudolph MD, Graham AM, Feczko E, Miranda-Dominguez O, Rasmussen JM, Nardos R, Entringer S, Wadhwa PD, Buss C, Fair DA. (2018). Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring. Nature Neuroscience. 21(5):765-772.

Casey BJ, Cannonier T,… Fair DA, Dale AM. ABCD Imaging Acquisition Workgroup. (2018). The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites. Dev Cogn Neurosci. 32: 43-54.

Nigg JT, Gustafsson HC, Karalunas SL, Ryabinin P, McWeeney SK, Faraone SV, Mooney MA, Fair DA, Wilmot B. (2018) Working Memory and Vigilance as Multivariate Endophenotypes Related to Common Genetic Risk for Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 57(3):175-182.

Gilat M, Ehgoetz Martens KA, Miranda-Domínguez O, Arpan I, Shine JM, Mancini M, Fair DA, Lewis SJG, Horak FB. (2018). Dysfunctional Limbic Circuitry Underlying Freezing of Gait in Parkinson's Disease. Neuroscience. 374:119-132.

Breiner K, Li A, Cohen AO, Steinberg L, Bonnie RJ, Scott ES, Taylor-Thompson K, Rudolph MD, Chein J, Richeson JA, Dellarco DV, Fair DA, Casey BJ, Galván A. (2018) Combined effects of peer presence, social cues, and rewards on cognitive control in adolescents. Dev Psychobiol. 60(3):292-302.

Greene DJ, Koller JM, Hampton JM, Wesevich V, Van AN, Nguyen AL, Hoyt CR, McIntyre L, Earl EA, Klein RL, Shimony JS, Petersen SE, Schlaggar BL, Fair DA, Dosenbach NUF. (2018) Behavioral interventions for reducing head motion during MRI scans in children. Neuroimage. 171:234-245.

Feczko E, Balba NM, Miranda-Dominguez O, Cordova M, Karalunas SL, Irwin L, Demeter DV, Hill AP, Langhorst BH, Grieser Painter J, Van Santen J, Fombonne EJ, Nigg JT, Fair DA. (2018). Subtyping cognitive profiles in Autism Spectrum Disorder using a Functional Random Forest algorithm. Neuroimage. 172:674-688.

Mills B.D, Miranda-Dominguez, O., Mills, K., Earl, E., Cordova, M., Grieser-Painter,J., Karalunas, S.L., Nigg, J.T., Fair D.A. (2018) ADHD and Attentional Control: Impaired Segregation of Task Positive and Task Negative Brain Networks. Network Neuroscience.

Miranda-Dominguez O, Feczko E, Grayson DS, Wallum H, Nigg JT, Fair DA. (2018). Heritability of the Human Connectome: A connectoyping study. Network Neuroscience. 2(2): 175-199.