Suma Jacob, MD, PhD

Professor, Department of Psychiatry and Behavioral Sciences

Suma Jacob

Contact Info

sjacob@umn.edu

Office Phone 612-626-6824

Fax 612-273-9774

Office Address:
Suma Jacob, M.D., Ph.D.
Child & Adolescent Psychiatry
University of Minnesota
717 Delaware St SE, Ste 516
Minneapolis, MN 55414

Administrative Assistant Name
Natasha Hampton-Anderson

Administrative Email
nhampton@umn.edu

Medical School, University of Chicago

Residency, UCLA, UChicago, UIC

Fellowship, UChicago and UIC

PhD, University of Chicago, Committee on Neurobiology

MD, University of Chicago, Pritzker School of Medicine

AB, The University of Chicago College, Chicago, Illinois

Summary

I graduated from the University of Chicago with honors in psychology before completing an MD/PhD program in Neurobiology. I went to UCLA for general psychiatry training and completed an extended clinical-research child fellowship at UIC. I am board certified in general adult as well as child & adolescent psychiatry.

My research interests include: social neuroscience; neuroendocrinology, and genetics. My current research focuses on biomarkers, neurochemical/genetic risk and treatments related to hormonal systems like oxytocin. My research lab conducts studies that examine effects of novel interventions on social functioning and repetitive behaviors for both children and adults. I have published over 70 peer-reviewed articles, have 3536 citations, and an h-index of 27. I have also given 10 grand rounds presentations nationwide, and presented nationally and internationally at more than 150 conferences.

My clinical specialties include: developmental disorders that affect rigid, inflexible behaviors and social functioning including autism; obsessive compulsive disorder; social anxiety and selective mutism. Treatment modalities include group, family and individual cognitive behavioral therapy along with medication management.

Within the University, I am the Director of Autism Research and a member of the University of Minnesota Autism Initiative (UMAI) steering committee that hosts the annual UMAI Autism day event which explores research, and treatment of individuals with autism and related developmental disabilities.

Expertise

Autism Spectrum Disorder, neuroendocrinology, genetics

Awards & Recognition

  • Mentor Award for AACAP Summer Medical Student Fellowships 2013, 2016, 2018
  • Nominated as Full Member, Sigma Xi Scientific Research Society 2017
  • Kavli Fellow, sponsored by U.S. National Academy of Science, Germany-U.S. Frontiers 2016
  • Fraser Appreciation for Service, Community Mental Health Partnership 2015 

Professional Associations

  • Director, Autism Research Program
  • American Academy of Child and Adolescent Psychiatry
  • A.K. Rice Institute for the Study of Social Systems

Research

Research Summary/Interests

Research interests include social neuroscience, neuroendrocinology and genetics. Current research focuses on biomarkers, neurochemical/genetic risk and treatments related to hormonal systems like oxytocin.

Publications

Peer-Reviewed Publications

1. Jiang M, Francis SM, Srishyla D, Conelea C, Zhao Q*, Jacob S*. Classifying individuals with ASD through facial emotion recognition and eye-tracking. Conf Proc IEEE Eng Med Biol Soc. July 2019, full conference paper in press.

Impact Factor = NA; Scopus # of Citations = 0; Role = *authors contributed equally, dual-lab collaboration, SJ designed the study and led study including recruitment and data collection, QZ led computational analyses, both supervised students and post doc on project and manuscript writing and submission.

2. Feliciano P, Zhou X, Astrovskaya I, Turner TN, Want T, Brueggeman, Barndard R, Hseih A, Snyder LG, Muzny DM, Sabo A, The SPARK Consortium*. Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes. Genomic Medicine, In press.

Impact Factor = 4.422; Scopus # of Citations = 0; Role = site PI contributed to implementatioin of project in four-five state region, led site data collection team and outreach efforts, reviewed drafts and revision of paper for publication.

3. Jacob S, Wolff JJ, Steinbach MS, Doyle CB, Kumar V, Elison JT. Neurodevelopmental heterogeneity and computational approaches for understanding autism. Translational Psychiatry. 2019;9(1):63. doi: 10.1038/s41398-019-0390-0. PubMed PMID: 30718453; PMCID: PMC6362076.

Impact Factor = 4.691; Scopus # of Citations = 0; Role = lead role in reviewing computational data in autism and generating example data seections, the writing of the first draft, and revising for publication.

4. Aaron E, Montgomery A, Ren X, Guter S, Anderson G, Carneiro A, Jacob S, Mosconi M, Pandey GN, Cook E, Veenstra-VanderWeele J. Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder. Journal of Autism and Developmental Disorders. 2018; 3: 1-9. doi: 10.1007/s10803-019-03989-z. PubMed ID: 30927179

Impact Factor =3.341; Scopus # of Citations = 0; Role = co-author role includes assisting with this ASD study, supervising biomarker data collection, also interactive approval of manuscript content and revisions for publication.

5. Montgomery AK, Shuffrey LC, Guter SJ, Anderson GM, Jacob S, Mosconi MW, Sweeney JA, Turner JB, Sutcliffe JS, Cook EH, Jr., Veenstra-VanderWeele J. Maternal serotonin levels are associated with cognitive ability and coresymptoms in autism spectrum disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2018;57(11):867-75. doi: 10.1016/j.jaac.2018.06.025. PubMed PMID: 30392628.

Impact Factor = 6.250; Scopus # of Citations = 1; Role = co-author role includes assisting with this ASD study, supervising biomarker data collection, also interactive approval of manuscript content and revisions for publication.

6. Francis SM, Camchong J, Brickman L, Goelkel-Garcia L, Mueller BA, Tseng A, Lim KO, Jacob S. Hypoconnectivity of insular resting-state networks in adolescents with autism spectrum disorder. Psychiatry Research: Neuroimaging. 2018;283:104-12. doi: 10.1016/j. pscychresns.2018.12.003. PubMed PMID: 30594068.

Impact Factor = 2.455; Scopus # of Citations = 0; Role = as senior author, led the study and coordinated aspects including recruitment and data management, contributed to manuscript preparation and revisions for publication.

7. Esler AN, Stronach ST, Jacob S. Insistence on sameness and broader autism phenotype in simplex families with autism spectrum disorder. Autism Research. 2018;11(9):1253-63. doi: 10.1002/aur.1975. PubMed PMID: 3028961

Impact Factor = 3.768; Scopus # of Citations = 1; Role =initiated research idea and topic based on previous results, contributed to manuscript preparation and revisions for publication.

8. Fatemi SH, Wong DF, Brasic JR, Kuwabara H, Mathur A, Folsom TD, Jacob S, Realmuto GM, Pardo JV, Lee S. Metabotropic glutamate receptor 5 tracer [(18)F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: A pilot PET study. Cerebellum Ataxias. 2018;5:3. Epub 2018/02/17. doi: 10.1186/s40673-018-0082-1. PubMed PMID: 29449954; PMCID: PMC5810020.

Impact Factor = NA; Scopus # of Citations = NA; Role = co-author role included contributing to the study design and interactive approval of manuscript content and revisions for publication.

9. Pamela Feliciano, Amy M Daniels, LeeAnne Green Snyder, The SPARK Consortium.* SPARK: A US cohort of 50,000 families to accelerate autism research. Neuron. 2018;97(3):. doi: 10.1016/j. neuron.2018.01.015. PubMed PMID: 29420931.488-93, pfeliciano@simonsfoundation.org. doi: 10.1016/j. neuron.2018.01.015. PubMedPMID: 29420931.

Impact Factor = 14.024; Scopus# of Citations= 0; Role =site PI contributed toimplementation of project in four-five state region,led site data collectionteamand outreachefforts, reviewed drafts andrevisions of paperfor publication.

10.Guoynes CD, Simmons TC, Downing GM, Jacob S, Solomon M, BalesKL. Chronic intranasaloxytocin has dose-dependent effects oncentral oxytocin and vasopressin systems in prairievoles (microtus ochrogaster).Neuroscience. 2018;369:292-302. doi:10.1016/j.neuroscience.2017.11.037. PubMed PMID: 29183825; PubMed Central PMCID: PMC5766367.

Impact Factor = 3.277; Scopus# of Citations = 0; Role = co-authorrolein translational studydesign of animal research modeled after Dr. Jacob’s parallel human treatment study, discusseddesign/outcome variables, assisted with interpretation and writing revisions for publication.

Teaching

Teaching Areas

Developmental disorders such as autism, OCD, anxiety, child psychiatry, neuroscience related to behavioral endocrinology & genetics

Clinical

Board Certifications

Child & Adolescent Psychiatry, Adult & General Psychiatry

Clinical Interests

Dr. Jacob's clinical specialties include developmental disorders that affect rigid, inflexible behaviors and social functioning including autism, obsessive compulsive disorder, social anxiety and selective mutism. Treatment modalities include group, family and individual cognitive behavioral therapy along with medication management.