Ricardo Battaglino
,
Credentials
PhD
MSc
Credentials
PhD
MSc
Professor
Vice Chair of Research
Diversity Officer
Faculty
Office of Diversity, Equity, and Inclusion Member
Biography
Bio
Expertise
- Gait-training and evaluation
- osteoclast biology
Professional Associations
- American Society for Bone and Mineral Research
- Association of Academic Physiatrists
Research Summary
Research Funding Grants
- R01 AR064793-01A1 (Battaglino)
04/01/2015 – 03/31/2020
NIH/NIAMS
"Regulation of gastric and osteoclast acidification by Snx10"
The specific aims to be addressed in this project are: 1) Determine the cellular mechanisms by which Snx10 regulates osteoclast function. 2) Determine the role of osteoclastic expression of Snx10 on bone homeostasis in vivo. 3) Determine the role of gastric expression of Snx10 on bone homeostasis in vivo.
Role: PI - W81XWH-14-SCIRP-CTA (Morse)
09/01/2015-08/31/19
Department of Defense
"Effects of Ekso-assisted gait training on Bone Health and Quality of Life: A Randomized Clinical Trial"
The goals of this project are to 1) determine whether exoskeleton-assisted gait training increases bone strength in the paralyzed lower extremity and 2) determine whether exoskeleton-assisted gait training improves quality of life after SCI. Secondarily, to determine whether gait training improves the following related outcomes and mediators of quality of life: mood, pain, and cortical activity of related emotional networks in the brain.
Role: Site PI
Publications
2019
- Morse L, Troy K, Fang Y, Nguyen N, Battaglino R, Goldstein, Richard, Gupta R, Taylor J. Combination Therapy with Zoledronic Acid and FES-row Training Mitigates Bone Loss in the Paralyzed Legs: Results of a Randomized Comparative Clinical Trial. Submitted to JBMR PLUS.
- Battaglino R, NguyenN, MorseLR. Bisphosphonate use is associated with lower levels of the bone-derived hormone osteocalcin in men with spinal cord injury. Ricardo A., Nguyen,Leslie R. Submitted to Osteoporosis International.
2018
- Morse LR, Coker J, Battaglino R. Statins and Bone Health: A Mini Review. Actual. Osteol 14(1) :31:35, 2018
- Battaglino R, Jha P, Liu W, Morse LR. FKBP12: a partner of Snx10 required for vesicular trafficking in osteoclasts. Submitted, Journal Cellular Biochemistry.
- Liu W, Morse LR, Picotto G, Sultana F, Odgren P, Battaglino R. Snx10 and PIKfyve are Required for Lysosome Formation in Osteoclasts, Submitted, Journal of Bone and Mineral Research.
- Park AJ, Battaglino RA, Nguyen N, Morse LR. Associations between lean mass and leptin in men with chronic spinal cord injury: results from the FRASCI-muscle study. Accepted, PLOS One. 2018.
- Hirai K, FurushoH, KawashimaN, XuS, de BeerMC, Battaglino R, Van DykeT, StashenkoP, SasakiH. SAA contributes to the chronicity of periapical lesions via TLR2 and TLR4. Accepted, Journal of Dental Research. 2018.
2017
- Rivoira M, RodrĂguez V, Picotto G, Battaglino R, Tolosa de Talamoni N. Naringin prevents bone loss in a rat model of type 1 Diabetes mellitus. Arch Biochem Biophys. 2018 Jan 1;637:56-63. doi: 10.1016/j.abb.2017.12.001. Epub 2017 Dec 5. PMID: 29208404
- Silva LAB, Azevedo LU, Consolaro A, Barnett F, Xu Y, Battaglino RA, Cañadas PS, de Oliveira KMH, Silva RAB. Novel endodontic sealers induce cell cytotoxicity and apoptosis in a dose-dependent behavior and favorable response in mice subcutaneous tissue. Clin Oral Investig. 2017 Dec 21(9):2851-2861. doi: 10.1007/s00784-017-2087-1. Epub 2017 Mar 9. PMID: 28281012
2016
- Morse LR, Nguyen N, Battaglino RA, Guarino AJ, Gagnon D, Zafonte R, Garshick E. Wheelchair use and Lipophilic Statin Medications May Influence Bone Loss in Chronic Spinal Cord Injury: Findings from the FRASCI Study. Osteoporos Int. 2016 Jul 13. [Epub ahead of print]. PMID: 27412619
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:27412619 - Sasaki H, Hirai K, Men Martins C, Furusho H, Battaglino R, Hashimoto K. Interrelationship between Periapical Lesion and Systemic Metabolic Disorders. Curr Pharm Des. 2016 Feb [Epub ahead of print]. PMID: 26881444
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:26881444
2015
- Guo F, He H, Fu ZC, Huang S, Chen T, Papasian CJ, Morse LR, Xu Y, Battaglino RA, Yang XF, Jiang Z, Xin HB, Fu M. Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling. Biochem J. 2015 Dec 15;472(3):309-18. doi: 10.1042/BJ20150019. Epub 2015 Oct 5. PMID: 26438880
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:26438880 - Xu Y; Morse LR; Bezerra da Silva R; Wang D, Battaglino RA. A Short Report: PAMM, a Novel Antioxidant Protein, Induced by Oxidative Stress. Redox Biol. 2015 Dec;6:446-453. PMID: 26402163.
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:26402163 - Ye L, Morse LR, Zhang L, Sasaki H, Mills J, Odgren P, Sibbel G, Zamarioli A, Battaglino RA. Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genet. 2015 Mar 26;11(3):e1005057.
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:25811986
2014
- Tan C, Battaglino R, Doherty A, Gupta R, Lazzari A, Garshick E, Zafonte R, Morse LR. (2014) Adiponectin is Associated with Bone Strength and Fracture History in Paralyzed Men with Spinal Cord Injury. Osteoporos Int. 2014 Nov;25(11):2599-607.
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:24980185
2013
- Liang Ye, Leslie R Morse, Ricardo A Battaglino. Snx10: a newly identified locus associated with human osteopetrosis. IBMS BoneKEy (2013) 10, Article number: 421
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:25419438 - Saltzman JW, Battaglino R, Stott H, Morse LR. Neurotoxic or Neuroprotective? Current Controversies in SCI-Induced Autoimmunity. Curr Phys Med Rehabil Reports. 2013 Sep;1(3). PMID: 24416711
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:24416711 - Choi E, Carruthers K, Zhang L, Thomas N, Battaglino RA, Morse LR, Widrick JJ. Concurrent muscle and bone deterioration in a murine model of cancer cachexia. Physiol Rep. 2013 Nov;1(6): PMID: 24400146
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:24400146 - Doherty AL, Battaglino RA, Donovan J, Gagnon D, Lazzari AA, Garshick E, Zafonte R, Morse LR. Adiponectin is a candidate biomarker of lower extremity bone density in men with chronic spinal cord injury. J Bone Miner Res. 2013 Jun 20. PMID: 23787489
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:23787489 - Tan CO, Battaglino RA, Morse LR. Spinal Cord Injury and Osteoporosis: Causes, Mechanisms, and Rehabilitation Strategies. Int J Phys Med Rehabil. 2013;1. pii: 127. PMID: 25419534
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:25419534 - Zamarioli A, Battaglino RA, Morse LR, Sudhakar S, Maranho DA, Okubo R, Volpon JB, Shimano AC. Standing frame and electrical stimulation therapies partially preserve bone strength in a rodent model of acute spinal cord injury. Am J Phys Med Rehabil. 2013 May;92(5):402-10 PMID: 23478455
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:23478455 - Lucisano MP, Nelson-Filho P, Morse L, Battaglino R, Watanabe PC, da Silva RA, da Silva LA. Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy. Braz Oral Res. 2013 May-Jun;27(3):252-7. PMID: 23739782
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:23739782 - Saltzman JW, Battaglino R, Salles L, Jha P, Sudhakar S, Garshick E, Stott HL, Zafonte R, Morse LR. (2013). B-cell maturation antigen, a proliferation-inducing ligand, and B-cell activation factor are candidate mediators of spinal cord injury-induced autoimmunity. J. Neurotruama 30(6): 434-440.
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:23088438 - Morse LR, Sudhakar S, Tun C, Lazzari A, Garshick E, Zafonte R, Battaglino RA. (2013) Sclerostin: A candidate biomarker of SCI-induced osteoporosis. Osteoporos Int. 24(3): 961-968.
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22801952
2012
- Battaglino RA, Lazzari AA, Garshick E, Morse LR. Spinal cord injury-induced osteoporosis: pathogenesis and emerging therapies. Curr Osteoporos Rep. 2012 Dec;10(4):278-85. PMID: 22983921
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22983921 - Nelson-Filho P, Lucisano MP, Da Silva RA, Da Silva RS, Serra MC, Gerlach RF, Neto FC, Carneiro ZA, Zamarioli A, Morse L, Battaglino R. Systemically alendronate was incorporated into dental tissues but did not cause morphological or mechanical changes in rats teeth. Microsc Res Tech. 2012 Sep;75(9):1265-71. doi: 10.1002/jemt.22059. PMID: 22508272
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22508272 - Goy DP, Gorosito E, Costa HS, Mortarino P, Pedemonte NA, Toledo J, Mansur HS, Pereira MM, Battaglino R, Feldman S. Hybrid matrix grafts to favor tissue regeneration in rabbit femur bone lesions. Open Biomed Eng J. 2012;6:85-91. Epub 2012 Jul 10. PMID: 22848334
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22848334 - Battaglino RA, Sudhakar S, Lazzari A, Garshick E, Zafonte R, Morse LR. (2012). Circulating sclerostin is elevated in short-term and reduced in long-term SCI. Bone. May 7. [Epub ahead of print]. PMID: 22575440
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22575440
2011
- Morse LR, Xu Y, Solomon B, Boyle L, Yoganathan S, Stashenko P, Battaglino RA. Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction. Transl Stroke Res. 2011 Dec 1;2(4):643-50. doi: 10.1007/s12975-011-0118-9. PMID: 22368723
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22368723 - Morse LR, Sudhakar S, Danilack V, Tun C, Lazzari A, Gagnon DR, Garshick E, Battaglino RA. Association between sclerostin and bone density in chronic SCI. J Bone Miner Res. 2011 Oct 17. doi: 10.1002/jbmr.546. [Epub ahead of print] PMID: 22006831
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22006831 - Zhu Cuihua, Morse LR, Battaglino R. (2011) SNX10 is required for osteoclast formation and resorption activity. SNX10 is required for osteoclast formation and resorption activity. J Cell Biochem. 2011 Dec 15. doi: 10.1002/jcb.24029. [Epub ahead of print]. PMID: 22174188
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22174188
2010
- Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino R. (2010) Mutational analysis of NHAcc/NHA2 in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1800(12): 1241-1247. PMCID: PMC2967667
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:20713131 - Sasaki H, Suzuki N, Alshwaimi E, Xu Y, Morse LR, Battaglino RA, Stashenko P. 18-beta-Glycyrrhetinic Acid Inhibits Periodontitis Via Glucocorticoid-independent NF-kB Inactivation In IL-10 Deficient Mice. J Periodontal Res. 2010 Dec;45(6):757-63. PMID: 20682015
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:20682015 - Xu Y, Morse LR, da Silva R, Odgren PR, Sasaki H, Stashenko P, Battaglino RA. PAMM: A redox regulatory protein that modulates osteoclast differentiation. Antioxid Redox Signal 2010 Jul 1;13(1):27-37. Antioxid Redox Signal. 2010 Jul 1;13(1):27-37. PMID: 19951071
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:19951071
2009
- Xu Y, Young M, Battaglino RA, Morse LR, Fontana CR, Pagonis TC, Kent R, Stashenko P, Soukos NS. Endodontic antiomicrobial photodynamic therapy: Assessment of safety on fibroblasts and osteoblasts in vitro. J Endod. 2009 Nov;35(11):1567-72. PMID: 19840649
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:19840649 - Morse LR, Lazzari A, Battaglino RA, Stolzmann K, Matthess K, Gagnon D, Davis S, Garshick E. Dual energy X-Ray absorptiometry of the distal femur may be more reliable than the proximal tibia in spinal cord injury. Arch Phys Med Rehabil 2009; 90:827-831. PMID: 19406303
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:19406303 - Morse LR, Giangregori L, Battaglino RA, Holland R, Craven BC, Stolzmann K, Lazzari A, Sabharwal S, Garshick E. VA Based Survey of Osteoporosis Management in Spinal Cord Injury. PMR. 2009 Mar:1(3):240-244. PMID: 19627901
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:19627901 - Morse LR, Geller A, Battaglino RA, Stolzmann K, Matthess K, Lazzari A, Garshick E. Barriers to Providing Dual Energy X-ray Absorptiometry Services to Individuals with Spinal Cord Injury. Am J Phys Med Rehabil. 2009 Jan;88(1):57-60. PMID: 18824888
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:18824888 - Morse LR, Battaglino RA, Stolzmann K, Hallett L, Waddimba A, Gagnon D, Lazzari A, Garshick E. Osteoporotic fractures and hospitalization risk in chronic spinal cord injury. Osteoporos Int. 2009 Mar;20(3):385-92. Epub 2008 Jun 26. PMID: 18581033
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:18581033
2008
- Morse LR, Nguyen HP, Jain N, Williams S, Tun CG, Battaglino RA, Stashenko P, Garshick E. (2008) Age and motor score predict osteoprotegerin level in chronic SCI. J. Musculoskelet. Neuronatal Interact. 8(1): 50-57. PMID: 18398265
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:18398265 - Morse L, Teng YD, Pham L, Newton K, Du Y, Liao WL, Kohler T, MĂĽller R, Graves D, Stashenko P, Battaglino R. (2008) Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats. (SCI-induced bone loss in growing rats) Osteoporos Int. 19(3): 645-652. PMID: 17987335
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17987335 - Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P. (2008) NHA-oc/NHA2: A mitochondrial cation-proton antiporter selectively expressed in osteoclasts. Bone 42(1): 180-192. PMID: 17988971
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17988971
2007
- Pham L, Purcell P, Morse LR, Stashenko P, Battaglino RA. (2007) Expression Analysis of nha-oc/NHA2: a Novel Osteoclast-Specific Gene. Gene Expr. Patterns 7(8): 846-851. PMID: 17698421
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17698421 - Schulze-Späte U, Battaglino R, Fu J, Sharma A, Vokes M, Stashenko P. (2007) Brn3 Transcription factors control terminal osteoclastogenesis. J. Cell Biochem. 102(1): 1-12. PMID: 17668438
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17668438
2006
- Battaglino R, Vokes M, Spate U, Sharma A, Graves D, Kohler T, Muller R, Yoganathan S, Stashenko P. (2006) Fluoxetine treatment increases trabecular bone formation in mice. J. Cell. Biochem.100(6): 1387-1394. PMID: 17041947
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17041947
2005
- Gyurko R, Shoji H, Battaglino RA, Boustany G, Gibson FC 3rd, Genco CA, Stashenko P, Van Dyke TE. Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone 2005; Mar; 36(3):472-9. PMID: 15777672
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:15777672
2004
- Battaglino R, Fu J, Späte U, Ersoy U, Joe M, Sedaghat L, Stashenko P. Serotonin regulates osteoclasts differentiation via its transporter. Journal of Bone and Mineral Research 2004; 19(9):1420-1431. PMID: 15312242
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:15312242 - Okamatsu Y, Kim D, Battaglino R, Sasaki H, Späte U, Stashenko P. MIP-1g promotes receptor activator of NF-?B ligand-induced osteoclast formation and survival. Journal of Immunology 2004; 173(3):2084-2090. PMID: 15265944
http://www.jimmunol.org/content/173/3/2084
2002
- Battaglino R, Kim D, Fu J, Vaage B, Fu XY, Stashenko P. c-myc is required for osteoclast differentiation. Journal of Bone and Mineral Research 2002; 17(5):763-773. PMID: 12009006
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:12009006
1998
- Xiong J, Battaglino R, Stuhlmann H. Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Developmental Dynamics 1998; 212(2):181-197. PMID: 9626494
http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:9626494 - Battaglino R. A Genetic Screen for Developmentally Regulated Genes in Mice (Ph.D. dissertation, 1998). University of New York.
1991
- Battaglino RA, Huergo M, Pilosof AMR, Bartholomai GB. (1991) Culture requirements for the production of protease by Aspergilius-oryzae in solid-state fermentation. Appl. Microbiol. Biotechnol. 35(3):292-296.
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500 Boynton420 Delaware St SE
Minneapolis, MN 55455-0341