Riley McIvor
,
Credentials
PhD
Credentials
PhD
Professor
Biography
Research Summary
Gene therapy The general research interest of Dr. McIvor's laboratory is gene therapy for genetic diseases and cancer. Specific research activities include: (i) Use of recombinant retroviral and lentiviral vectors for gene transfer into hematopoietic stem cells in the treatment of cancer and inherited disorders such as immunodeficiency diseases and lysosomal storage diseases; (ii) Introduction of drug-resistance genes into normal hematopoietic cells to protect against the toxic side effects of cancer chemotherapy; (iii) Use of adeno-associated virus for treatment of storage diseases and as a vector for gene transfer into the central nervous system in the treatment of neurological disorders; (iv) Adaptation of a novel vertebrate transposon ("Sleeping Beauty") to viral and non-viral delivery systems for gene therapy.
Selected Publications
Selected Publications
Romero, M., Lee, J., Podetz-Pedersen, K. M., Nan, Z., Reidl, M. S., Vulchanova, L., Kitto, K. F., Fairbanks, C. A., Kozarsky, K. F., Orchard, P. J., Frey II, W. H., Low, W. C., McIvor, R. S.,
2021.
Comparative Effectiveness of Intracerebroventricular, Intrathecal, and Intranasal Routes of AAV9 Vector Administration for Genetic Therapy of Neurologic Disease in Murine Mucopolysaccharidosis Type I.
Front Mol Neurosci,
14
St. Louis Park,
United States:
doi: https://doi.org/10.3389/fnmol.2021.618360
PubMed ID: 34040503.
Selected Presentations
Selected Presentations
McIvor, R. S., (Author & Presenter)
"AAV and Lentivirus Vectors for Treatment of Primary Immune Deficiency and Metabolic Disease",
9th Annual ‘ Wisc - e- sota ’ T32 Symposium,
Institute for Molecular Virology, University of Minnesota,
Minneapolis,
Minnesota,
United States.
October 15, 2022.
Grants and Patents
Grants and Patents
Patents
Adeno-associated Virus for Therapeutic Delivery to the Central Nervous System.
Issued: 2021
Modified Cells and Methods of Therapy.
Issued: 2021
Modified Cells and Methods of Therapy.
Issued: 2021
Methods and Compositions for the Treatment of Neurologic Disease.
Issued: 2021
Adeno-associated Virus for Therapeutic Delivery to the Central Nervous System.
Issued: 2021
Adeno-associated Virus Mediated Gene Transfer to the Central Nervous System.
Issued: 2021
Methods and Compositions for the Treatment of Neurologic Disease.
Issued: 2021
Methods and Compositions for the Treatment of Neurologic Disease.
Issued: 2021
Methods and Compositions for the Treatment of Neurologic Disease.
Issued: 2021
Methods and Compositions for the Treatment of Neurologic Disease.
Issued: 2021
Methods and Compositions for the Treatment of Neurologic Disease.
Issued: 2021
Adeno-associated Virus for Therapeutic Delivery to the Central Nervous System.
Issued: 2021
METHOD FOR IMPROVING NEUROLOGICAL FUNCTION IN MPSI ANDMPSII AND OTHER NEUROLOGICAL DISORDERS, Hong Kong.
Issued: 2020
Adeno-associated Virus for Therapeutic Delivery to the Central Nervous System.
Method for Improving Neurological Function in Mpsi and Mpsii and Other Neurological Disorders.
Methods for Preventing Cardiac or Skeletal Defects in Diseases Including Mucopolysaccharidoses.
Contact
Contact
Address
5-102 MolCellBio420 Washington Ave SE
Minneapolis, MN 55455