I study the interaction of DNA and chemicals to investigate how lifestyle and environment exposures cause disease. My work focuses on the development of mass spectrometry-based methods for the identification and quantification of DNA addition products (called adducts) in animals and humans.
My work focuses on studying mechanisms of chemical carcinogenesis, in particular those related to alcohol and tobacco exposures. I am working to develop more accurate methods to quantify the genotoxic effects deriving from these exposures and thus to measure the corresponding DNA damage. I draw upon my expertise in organic synthesis, analytical chemistry, cell culture, and molecular epidemiology to develop integrated approaches aiming at quantifying DNA samples collected in clinical trials and molecular epidemiology studies.
In addition to teaching toxicology courses, I teach and train in my laboratory, where I supervise students and post-doctoral fellows.