Sophia Yohe



Dr. Yohe is a hematopathologist and molecular genetic pathologist, director of the Molecular Diagnostics Laboratory, and a member of the Division of Molecular Pathology and Genomics. In her molecular pathology role, Dr. Yohe works with her colleagues in the Molecular Diagnostics Laboratory and the bioinformatics group at the Minnesota Supercomputing Institute to implement genomic testing into clinical practice. In addition to offering next generation sequencing (NGS) testing for many inherited conditions, the team performs NGS for a number of genes commonly mutated in leukemias, lymphomas, and solid tumors. She is Vice Chair of the College of American Pathologists' (CAP) Personalized Health Care Committee, which makes recommendations for setting standards in rapidly emerging fields like clinical genomics. She is active in education and is the Molecular Genetic Pathology Fellowship Program Director.

Research Summary

Dr. Yohe's research interests include understanding genetic changes and improving detection of minimal residual disease (MRD) in hematopoietic malignancies, like acute myeloid leukemia and myelodysplastic syndrome, using genomic and flow cytometric technologies. One of the challenges in the field is the heterogeneity of the immunophenotype and genetics of these diseases. She has collaborated with her clinical colleagues to show the importance of MRD detection pre-transplant and is pursuing novel methods to detect MRD in acute myeloid leukemia and myelodysplastic syndrome.





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