Stephen Huddleston
,
Credentials
MD, PhD

Associate Professor, Division of Cardiothoracic Surgery
Biography

Research Summary

Surgical outcomes in lung transplantation. Use of ex vivo lung perfusion in standard of care as well as expanded criteria lung donors. The tracking and characterization of graft antigen-specific CD4+ T cells responses with respect to antibody mediated rejection and chronic lung allograft disease in the lung transplant recipients.

Clinical Summary

Lung transplantation for end-stage lung disease, valve repair and replacement, complex and redo cardiac surgery, aortic dissection repair, coronary artery bypass grafting, and surgical treatment of atrial fibrillation.

Education

PhD, University of Minnesota
MD, Columbia University, College of Physicians and Surgeons
BA, University of Kansas

Fellowships, Residencies, and Visiting Engagements

Fellow in Thoracic Surgery, Fellowship
John Hopkins Hospital
Postdoctoral Research Fellow , Other
University of Minnesota
Residency in General Surgery, Residency
University of Minnesota
Internship in General Surgery, Internship
University of Minnesota

Licensures and Certifications

DEA,
Maryland Medical License,
Licensure/Certification Number: #D71652
Minnesota Medical License,
Licensure/Certification Number: #46209
Minnesota Medical License,
Licensure/Certification Number: #46209
American Board of Surgery,
American Board of Thoracic Surgery ,

Honors and Recognition

Recognized as 2023 Top Doctor by Mpls.St.Paul Magazine
2023
2021 Top Doctors (Cardiothoracic Surgery) Minneapolis/St. Paul Magazine, Minnesota Monthly
2021
2020 Top Doctors (Cardiothoracic Surgery) Minneapolis/St. Paul Magazine, Minnesota Monthly
2020
Cassius Ellis Award, University of Minnesota
2009
The Doctor David Gaviser Mount Sinai Surgical Research Award, University of Minnesota
2008
Resident Award for Basic Research, Minnesota Surgical Society
2004
Richard C. Lillehei, MD/Earl Bakken Prize, University of Minnesota
2004
Naomie Berrie Diabetes Summer Research Fellowship, Columbia University, Department of Cell Biology
1997
National Science Foundation Undergraduate Research Award, University of Kansas, Department of Pharmacology and Toxicology
1996
National Science Foundation Undergraduate Research Award, University of Kansas, Department of Pharmacology and Toxicology
1995
National Science Foundation Undergraduate Research Award, University of Kansas, Department of Pharmacology and Toxicology
1994

Professional Memberships

Society of American College of Surgeons, Resident and Associate Society
2001-2012
American Society of Transplant Surgeons, Thoracic Organ Transplantation Committee
American College of Surgeons, Fellow (FACS)
International Society for Heart & Lung Transplantation
Society of Thoracic Surgeons
Selected Publications

Selected Publications

Loor, G., Hartwig, M., Bottiger, B., Daoud, D., Wei, Q., Zhang, Q., I, F., Warnecke, G., Villaviencio, M., Tirabassi, B., Van Raemdonck, D., Frick, A., Neyrinck, A., Toyoda, Y., Kashem, M., Landeweer, M., Chandrashekaran, S., 2022. Effect of mode of intraoperative support on primary graft dysfunction after lung transplant. Journal of Thoracic and Cardiovascular Surgery, 4 (S0022-5223):
Aggarwal, R., Jackson, S., Lemke, N., Shumway, S., Kelly, R., Hertz, M., Huddleston, S. J., 2021. Lung transplant recipients with prior coronary artery bypass grafting are at increased risk of death and early perioperative hemorrhage. Seminars in thoracic and cardiovascular surgery, 21 (00244-6): S1043-0679.
Huddleston, S. J., Shumway, S., 2021. Minimally Invasive Left Atrial Appendage Excision and Atrial Fibrillation Ablation as Secondary Prevention of Thromboembolic Stroke-Weighing the Risk Versus the Benefit. Seminars in thoracic and cardiovascular surgery, 33 (1): 68-69.
Kelly, R., 2021. Commentary: Coronary revascularization in patients with left ventricular systolic dysfunction. Journal of Thoracic and Cardiovascular Surgery, 161 (3): 1033-1034.
Jackson, S., Kane, K., Lemke, N., Shaffer, A., Soule, M., Hertz, M., Shumway, S., Qi, S., Perry, T., Kelly, R., 2020. Separate Effect of Perioperative Recombinant Human Factor VIIa Administration and Packed Red Blood Cell Transfusions on Midterm Survival in Lung Transplantation Recipients. Journal of Cardiothoracic and Vascular Anesthesiology, 34 (11): 3013-3020.
doi: https://doi.org/10.1053/j.jvca.2020.05.038 PubMed ID: 32718888.
Brown, R., Rudser, K., Goswami, U., Tomic, R., Lemke, N. T., Shaffer, A. W., Soule, M. R., Hertz, M., Shumway, S., Kelly, R., Loor, G., 2019. Need for Tracheostomy after Lung TransplantPredicts Decreased Mid- and Long-Term Survival. Clin Transplantation, 1 (e13766): 34.
doi: https://doi.org/10.1111/ctr.13766 PubMed ID: 31815320.
Warnecke, G., Villavicencio, M. A., Smith, M. A., Ardehali, A., Hartwig, M., Daneshmand, M. A., Hertz, M. I., Huddleston, S. J., Haverich, A., Madsen, J. C., Van Raemdonck, D., 2019. Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors. Lancet Respir Med, 7 (11): 975-984.
Selected Presentations

Selected Presentations

Huddleston, S. J. "Detection of Directly Alloreactive Graft Antigen-Specific CD4+ T Cells in Peripheral Blood", ISHLT 42nd Annual Meeting & Scientific Sessions, Boston, Massachusetts, April 28, 2022.
Ius, F., Van Raemdonck, D., Hartwig, M., Bottiger, B., Loor, G., Daoud, D., Wei, Q., Villavicencio, M., Osho, A., Chandrashekaran, S., Machuca, T., Neyrinck, A., Toyoda, Y., Kashem, M., Huddleston, S. J., Myers, M., Sanchez, P., Ryssel, N., Warnecke, G. "Effect of Surgical Exposure on Outcomes in Lung Transplantation: Insight from the International Multicenter Extracorporeal Life Support (ECLS) in Lung Transplantation Registry", ISHLT 41st Annual Meeting & Scientific Sessions – Virtual Experience, Minneapolis, Minnesota, April 28, 2021.
Villavicencio, M., Kashem, M., Loor, G., Hartwig, M., Bottiger, B., Ius, F., Daoud, D., Warnecke, G., Wei, Q., Chandrashekaran, S., Machuca, T., Van Raemdonck, D., Neyrinck, A., Huddleston, S. J., Myers, M., Moonsamy, P., Toyoda, Y. "Impact of Cold Ischemic Time on Morbidity and Mortality after Lung Transplantation. An Updated Analysis of the International Multicenter Extracorporeal Life Support in Lung Transplantation Registry", ISHLT 41st Annual Meeting & Scientific Sessions – Virtual Experience, Minneapolis, Minnesota, April 25, 2021.
Richardson, S., Olejniczack, M., Jackson, S., Siers, D., Huddleston, S. J. "Predictors of Primary Graft Dysfunction Following Bilateral Lung Transplantation", ISHLT 41st Annual Meeting & Scientific Sessions – Virtual Experience, Minneapolis, Minnesota, April 25, 2021.
Aggarwal, R., Jackson, S., Lemke, N., Huddleston, S. J. "Time from Start of Agonal Phase to Pulmonary Artery Cross Clamp in Donor Cardiac Death Donors Does Not Correlate with Diminished Recipient Lung Function or Survival", ISHLT 41st Annual Meeting & Scientific Sessions – Virtual Experience, Minneapolis, Minnesota, April 25, 2021.
Kashem, M., Loor, G., Hartwig, M., Villavicencio, M., Axtell, A., Sanchez, P., Ryssel, N., Bottiger, B., Daoud, D., Zhao, H., Wei, Q., Bussetty, A., Ius, F., Warnecke, G., Machuca, T., Van Raemdonck, D., Frick, A., Neyrinck, A., Chandrashekaran, S., Toyoda, Y., Huddleston, S. J. "Interim Results - The Effect of Donor Type (Donor after Cardiac Death vs Donor after Brain Death) and Use of Intraoperative Extracorporeal Lung Support on Survival after Lung Transplantation", ISHLT 41st Annual Meeting & Scientific Sessions – Virtual Experience, Minneapolis, Minnesota, April 25, 2021.
Huddlestson, S. J. "When to Use Nitric Oxide of Flolan or both?", Symposium of perioperative right heart failure in the cardiac surgical patient, Department of Anesthesiology, Minneapolis, Minnesota, United States. March 13, 2021.
Huddlestson, S. J. "Mitral Regurgitation: Curing the Disease", Lillehei Symposium, MHealth Fairview, Minneapolis, Minnesota, United States. September 20, 2020.
Huddlestson, S. J. "Current status of Ex vivo lung perfusion in lung transplantation", 21st Annual Cutting Edge Conference (Virtual), MHealth Fairview, Minneapolis, Minnesota, United States. March 09, 2020.
Huddlestson, S. J. "Tracking Graft Antigen-Specific CD4+ T cells in Lung Transplant Recipients Using Peptide:HLA Tetramers", Research-in-Progress Conference, Division of Pulmonary & Critical Care Medicine at Northwestern, Chicago, Illinois, United States. March 09, 2020.
Huddlestson, S. J. "Immune System, Tolerance and Reject", 20th Annual Cutting Edge Conference: Two Decades of Progress in Transplantation, MHealth Fairview, Minneapolis, Minnesota, United States. April 11, 2019.
Huddleston, S. J. "Modified Bypass Strategy for Lung Transplant, The Extracorporeal Life Support in Lung Transplantation Committee", 39th Annual Conference of the International Society for Heart & Lung Transplantation, Orlando, Florida, United States. April 02, 2019.
Huddlestson, S. J. "The Evolving Role of Organ Care Systems in Lung Transplantation", Earl E. Bakken Surgical Device Symposium 2018, MHealth Fairview, Minneapolis, Minnesota, United States. October 12, 2018.
Huddleston, S. J. " ", International Transplant Nurses Society (ITNS) Dinner, Minneapolis, Minnesota, United States. April 01, 2018.
Huddlestson, S. J. "Lung transplant at the University of Minnesota", Sanford Bemidji, MHealth Fairview / Sanford, Minneapolis, Minnesota, United States. November 30, 2017.
Huddleston, S. J. "Tracheostomy after lung transplant predicts mid and long term decreased survival.", 37th Annual Meeting, The International Society for Heart & Lung Transplantation, San Diego, California, United States. April 01, 2017.
Huddleston, S. J., (Author), Shumway, S. J., (Author) "Great Institutions in Cardiothroacic Surgery: The University of Minnesota", Lillehei Surgical Society, University of Minnesota, Houston, Texas, United States. January 01, 2017.
Huddleston, S. J. "The history of cardiac surgery at the University of Minnesota: How do we carry the tradition forward?", 31st Annual Meeting, The C Walton and Richard C Lillehei Surgical Society, Houston, Texas, United States. January 01, 2017.
Huddleston, S. J., Ingulli, E., Jenkins, M. K. "Delayed gratification: a program of intimal hyperplasia progresses even as graft antigen-specific CD4+ T cells subside", ACS Surgical Forum, New Orleans, Louisiana, United States. October 01, 2007.
Huddleston, S. J., Ingulli, E., Jenkins, M. K. "IFN-γ production by graft antigen-specific CD4+ T cells is not required for the development of intimal hyperplasia", 39th Annual Conference of the International Society for Heart and Lung Transplantation, San Francisco, California, United States. April 01, 2007.
Huddleston, S. J., Ingulli, E. "Rosiglitazone prevents intimal hyperplasia in a murine model of chronic rejection", World Transplant Congress, Boston, Massachusetts, United States. July 01, 2006.
Huddleston, S. J., Hays, W. S., Filatenkov, A., Ingulli, E., Jenkins, M. K. "Intragraft antigen-specific CD4+ T cell-mediated smoldering rejection associated with IFN-γ production", American Transplant Congress, Seattle, Washington, United States. May 01, 2005.
Contact

Contact

Address

Division of Cardiothoracic Surgery
420 Delaware St. S.E., MMC 207
Minneapolis, MN 55455

Administrative Contact

Rick Castillo | 612-625-3904 | casti020@umn.edu