Walter Low, PhD
Administrative Contact
Claire Olesen
Administrative Email: [email protected]
Address
LRB/MTRF
2001 6th St SE, Rm 4-216
Minneapolis, MN 55455
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Biography
Dr. Walter Low is a Professor in the Department of Neurosurgery and serves as the Associate Head for Research. He earned his PhD in Bioengineering from the University of Michigan, and was a National Science Foundation/NATO Fellow in Neurophysiology/Neuroscience at the University of Cambridge in England. He is currently Director of the Research Laboratories in the Department of Neurosurgery.
Dr. Low was formerly on the faculty at Indiana University School of Medicine where he was the Director of the Graduate Program in Physiology and Biophysics. He has served as a member of numerous grant review study sections for the National Institutes of Health, the National Science Foundation, and the Veterans Administration Medical Centers.
The h-index for the scientific impact of Dr. Low's research publications is ranked above the 95th percentile among faculty in neurosurgery departments in the United States.
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Education
PhD, University of Michigan
MS, University of Michigan
BS, University of California Santa Barbara
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Publications
2022. Strell, P, Shetty A, Steer CJ and Low WC, Interspecies chimeric barriers for generating exogenic organs and cells for transplantation, Cell Transp 2022, Jan-Dec;31:9636897221110525. doi: 10.1177/09636897221110525. Interspecies chimeric barriers for generating exogenic organs and cells for transplantation.
2022. Cell Reprogramming for Regeneration and Repair of the Nervous System.Clark IH, Roman A, Fellows E, Radha S, Var SR, Roushdy Z, Borer SM, Johnson S, Chen O, Borgida JS, Steevens A, Shetty A, Strell P, Low WC, Grande AW.Biomedicines. 2022 Oct 17;10(10):2598. doi: 10.3390/biomedicines10102598.. Cell Reprogramming for Regeneration and Repair of the Nervous System.
2022. Wu L, Canna A, Narvaez O, Ma J, Sang S, Lehto LJ, Sierra A, Tanila H, Zhang Y, Gröhn O, Low WC, Filip P, Mangia S, Michaeli S. Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition. Sci Rep. 2022 May 20;12(1):8565. doi: 10.1038/s41598-022-12383-2.. Orientation selective DBS of entorhinal cortex and medial septal nucleus modulates activity of rat brain areas involved in memory and cognition.
2022. Saha R, Faramarzi S, Bloom RP, Benally OJ, Wu K, di Girolamo A, Tonini D, Keirstead SA, Low WC, Netoff TI, Wang JP. Strength-frequency curve for micromagnetic neurostimulation through excitatory postsynaptic potentials (EPSPs) on rat hippocampal neurons and numerical modeling of magnetic microcoil (μcoil). J Neural Eng. 2022 Feb 4;19(1). doi: 10.1088/1741-2552/ac4baf.. Strength-frequency curve for micromagnetic neurostimulation through excitatory postsynaptic potentials (EPSPs) on rat hippocampal neurons and numerical modeling of magnetic microcoil (μcoil).
2021. Var SR, Shetty AV, Grande AW, Low WC, Cheeran MC. Microglia and Macrophages in Neuroprotection, Neurogenesis, and Emerging Therapies for Stroke. Cells. 2021 Dec 16;10(12):3555. doi: 10.3390/cells10123555.. Microglia and Macrophages in Neuroprotection, Neurogenesis, and Emerging Therapies for Stroke.
2021. Harris MA, Kuang H, Schneiderman Z, Shiao ML, Crane AT, Chrostek MR, Tăbăran AF, Pengo T, Liaw K, Xu B, Lin L, Chen CC, O'Sullivan MG, Kannan RM, Low WC, Kokkoli E. ssDNA nanotubes for selective targeting of glioblastoma and delivery of doxorubicin for enhanced survival. Sci Adv. 2021 Dec 3;7(49):eabl5872. doi: 10.1126/sciadv.abl5872.. SSDNA nanotubes for selective targeting of glioblastoma and delivery of doxorubicin for enhanced survival.
Li Y, Yi B, Rong G, Wang, Zhang, Chrostek M, Low WC, Zhu X, and Chen W, Machine Learning-Enabled High-Resolution Dynamic Deuterium MR Spectroscopic Imaging, IEEE Transactions in Medical Imaging, 40(12):3879-3890 (2021).. Machine Learning-Enabled High-Resolution Dynamic Deuterium MR Spectroscopic Imaging, IEEE Transactions in Medical Imaging.
Ruiz-Estevez M, Crane AT, Rodriguez-Villamil P, Ongaratto FL, Steevens A, Hill C, Goldsmith T, Webster D, Sherry L, Denman N, Lim S, Low WC, Carlson DF, Dutton JR, Steer CJ, Gafni O, Liver development in restored by blastocyst complementation of HHEX knockout in mice and pigs, Stem Cell Research and Therapy, doi:10.1186/s13287-02348-z (2021).. Liver development in restored by blastocyst complementation of HHEX knockout in mice and pigs.
Belur, LR, Romera M Lee J, Poetz-Pedersen KM, Nan Z, Riedl MS, Vulshanova L, Kitto KF, Fairbanks, CA, Kozarsky KF, Orchard PJ, Frey WH 2nd, Low WC, and McIvor RS, Comparative effectiveness of intracerebroventricular, intrathecal, and intranasal routes of AAV9 vector administration for genetic therapy of neurologic disease in murine muscopolysaccharidosis Type I, Frontiers in Molecular Neuroscience, doi:10.3389/fnmol.2021618360. eCollection (2021). . Comparative effectiveness of intracerebroventricular, intrathecal, and intranasal routes of AAV9 vector administration for genetic therapy of neurologic disease in murine muscopolysaccharidosis Type I.
Zhu XH, Lee BY, Tuite P, Coles L, Sathe AG, Cloyd J, Low WC, Steer CJ, Chen C, and Chen W, Quantitative assessment of occipital metabolic and energetic changes in Parkinson’s patients using in vivo 31P MRS-based metabolic imaging at 7T, Metabolites 11(3):145. doi: 10.3390/metabo11030145 (2021).. Quantitative assessment of occipital metabolic and energetic changes in Parkinson’s patients using in vivo 31P MRS-based metabolic imaging at 7T.
Zhan L. Guo S, Kangas, J, Shao Q, Shiao M, Khosla K, Low WC, McAlpine M, and Bischof J. Conduction cooling and plasmonic heating dramatically increase droplet vitrificaiton volumes for cell cryopreservation, Advanced Sciences, 8: 2004605 (1-14), DOI: 10.1002/advs.202004605 (2021).. Conduction cooling and plasmonic heating dramatically increase droplet vitrificaiton volumes for cell cryopreservation.
Crane AT, Shen FX, Low WC, Continuing the dialog on human-animal chimerism, Stem Cell Reports, 16:227 (2021).. Continuing the dialog on human-animal chimerism.
Steevens AR, Griesbach MW, You Y, Dutton JR, Low WC, and Santi PA, Generation of inner ear sensory neurons using blastocyst complementation in a Neurog1-deficient mouse. Stem Cells & Developmental Biology, 12(1):122. doi: 10.1186/s13287-021-02184-1. (2021).. Generation of inner ear sensory neurons using blastocyst complementation in a Neurog1-deficient mouse.
Crane AT, Chrostek MR, Krishna VD, Shiao M, Toman NG, Pearce C, Tran SK, Sipe CJ, Buo W, Voth JP, Vaid S, Xie H, Lu WC, Swanson W, Grande AW, Schleiss MR, Bierle CJ, Cheeran MCJ, Low WC, Zika virus-based immunotherapy enhances long-term survial of rodents with brain tumors through upregulation of memory T-cells, PLoS ONE 15(10):e0232858. doi: 10.1371 (2020).. Zika virus-based immunotherapy enhances long-term survival of rodents with brain tumors through up regulation of memory T-cells
Crane AT, Shen FX, Brown JL, Carmack W, Ruiz-Estevez M, Voth JP, Sawai T, Hatta T, Fujita M, and Low WC, The American public is ready to accept human-animal chimera research, Stem Cell Reports, 15:804-810 (2020).. The American public is ready to accept human-animal chimera research.
Walsh P, Troung V, Saldia Montivero M, Nayak S, Low WC, Parr AM, Dutton J, Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population, Stem Cells 38:1400-1408 (2020).. Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population.
Lehto LJ, Canna A, Wu L, Sierra A, Pearce C, Shiao M, Johnson MD, Low WC, Grohn O, Tanila H, Mangia S, and Michaeli S, Orientation selective deep brain stimulation of the subthalamic nucleus in rats, Neuroimaging, 213:116750, doi:10.1016/j.neuroimage.2020.116750. (2020).. Orientation selective deep brain stimulation of the subthalamic nucleus in rats.
Chrostek MR, Fellows EG, Crane AT, Grande AW, and Low WC, Efficacy of Stem Cell-Based Therapies for Stroke, Brain Research. doi: 10.1016/j.brainres.2019.146362. (2020).. Efficacy of Stem Cell-Based Therapies for Stroke.
Sathe AG, Tuite P, Chen C, Ma YW, Chen W, Cloyd J, Low WC, Steer CJ, Lee BY, Zhu XH, and Coles LD, Pharmacokinetics, safety and tolerability of orally administered ursodeoxycholic acid in patients with Parkinson’s disease – A pilot study, Journal of Clinical Pharmacology, 11(3):145. doi: 10.3390/metabo11030145. (2020).. Pharmacokinetics, safety and tolerability of orally administered ursodeoxycholic acid in patients with Parkinson’s disease – A pilot study.
Crane AT, Aravalli RN, Asakura A, Grande AW, Krishnan VD, Carlson DF,Cheeran MCJ, Danczyk G, Durron JR, Hackett PB, Hu WS, Li L, Lu WC, Miller ZD, O’Brien T, Panoskaltsis-Mortari A, Parr AM, Pearce C, Ruiz M, Shiao M, Sipe C, Toman NG, Voth J, Xie H, Steer, CJ, and Low WC, Interspecies organogenesis for human transplantation, Cell Transplantation. doi: 10.1177/0963689719845351. (2019).. Interspecies organogenesis for human transplantation.
Crane AT, Voth JP, Shen FX, and Low WC, Human-animal neurological chimeras: humanized animals or human cells in an animal, Stem Cells. doi: 10.1002/stem.2971. (2019). Human-animal neurological chimeras: humanized animals or human cells in an animal.
Chrostek MR, Fellows EG, Guo WL, Swnson WJ, Crane AT, Cheeran MC, Low WC, and Grande, AW, Efficacy of cell-based therapies for traumatic brain injuries, Brain Sciences (in press, 2019).. Efficacy of cell-based therapies for traumatic brain injuries.
Shiao ML, Yuan C, Crane AT, Voth JP, Juliano M, Hocum-Stone LL, Nan Z, Zhang Y, Kuzman-Nichols N, Sanberg PR, Grande AW, and Low WC, Immunomodulation with human umbilical cord blood stem cells ameliorates ischemic brain injury – A brain transcriptome profiling analysis, Cell Transplantation. doi: 10.1177/0963689719836763. (2019).. Immunomodulation with human umbilical cord blood stem cells ameliorates ischemic brain injury – A brain transcriptome profiling analysis.
Toman, N, Grande AW, and Low WC, Neural repair in stroke, Cell Transplantationdoi: 10.1177/0963689719863784. (2019).. Neural repair in stroke.
Lehto LJ, Filip P, Laakso H, Sierra A, Slopsema J, Johnson MD, Eberly LE, Utecht L, Low WC, Grohn O, Tanila H, Mangia S, and Michaeli S, Tuning neuromodulation effects by orientation selective deep brain stimulation in the rat medial frontal cortex. Frontiers in Neuroscience, doi: 10.3389/fnins.00899. (2019).. Tuning neuromodulation effects by orientation selective deep brain stimulation in the rat medial frontal cortex.
Do TH, Miller C, Low WC, Haines SJ, The Radicchi Index (hf) for Comparing Academic Productivity of Medical Specialties, Neurosurgery, doi: 10.1093/neuros/nyz207.(in press, 2019).. The Radicchi Index (hf) for Comparing Academic Productivity of Medical Specialties.
Steevens AR, Glatzer JC, Kellogg CC, Low WC, Santi P, and Kiernam AE, SOX2 is required for inner ear growth and nonsensory formation prior to sensory development, Development.doi: 10.1242/dev.170522. (2019). . SOX2 is required for inner ear growth and nonsensory formation prior to sensory development.
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Research
Dr. Low's research is focused on translating neuroscience developments from the laboratory to the clinic. He has been involved in a number of technologies that include neural progenitor/stem cell therapies, gene therapies, neuroprotective therapies, and medical devices for treating a variety of neurological conditions. Neural disorders of interest include ischemic and hemorrhagic stroke, Parkinson's disease, brain tumors, Alzheimer's disease, lysosomal storage disorders of the brain, Huntington's disease, spinal cord injury, and traumatic brain injury.
Dr. Low's group was the first to: Demonstrate that the transplantation of cholinergic neurons into the hippocampal formation could restore learning and memory function in a rat model of Alzheimer's disease Demonstrate the efficacy of immunotherapy for eradicating intracranial tumors in rodents Receive FDA approval for clinical trials in the United States to study the efficacy of deep brain stimulation for the treatment of Parkinson's disease. Read more.
Brain and tumor immunology and development of cancer vaccines
Dr. Low's laboratory is focused on the study of brain tumors. Primary tumors that originate in the brain represent some of the most malignant types of cancers. Patients diagnosed with grade IV glioblastoma multiforme have a mean survival time of 11 months after diagnosis. Our studies of brain tumors have emphasized the development of immunotherapeutic approaches for the treatment of these tumors. Cancer vaccines consisting of cytokines and tumor antigens are used to stimulate cells of the immune system to recognize and destroy tumors within the brain.
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Awards, Honors and Recognitions
Agan Award, American Heart Association, 1981
National Science Foundation NATO Fellow, 1980
National Research Service Award, National Institute of Neurological and Communicative Disorders, and Stroke, 1979
NIGMS, Predoctoral Fellow, National Institutes of Health, 1978
California State Scholar Award, 1972
Rotarian Scholar Award, 1969
University of California Honors at Entrance, 1968
Bank of America Laboratory Sciences Award, 1968
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Presentations
Low, W. C. "Generating Exogenic Cells for Transplantation in Gene Edited Animals via Blastocyst Complementation", Association for Research in Otolaryngology, San Jose, California. January 01, 2020.
Low, W. C. "Human-Animal Chimeras Generated via Blastocyst Complementation", American Society for Neural Therapy and Repair, Clearwa, Florida. January 01, 2019.
Low, W. C. "Generating Exogenic Organs for Transplantation", Departments of Surgery and Research Day, University of Minnesota, Minneapolis, Minnesota. January 01, 2019.
Low, W. C. "Harnessing the Zika Virus for Brain Tumor Immunotherapy", 2019 East Asia Neurosurgery Summit, Shenyang, China. January 01, 2019.
Low, W. C. "Towards the Generation of Nigral Dopamine Neurons in Gene Edited Animals via Stem Cell Complementation for Treating Parkinson’s Disease", 13th International Conference on Alzheimer’s and Parkinson’s, Vienna, Austria. January 01, 2017.
Low, W. C. "Zika virus targeting of human DAOY medulloblastoma", Peyton Society 80th Anniversary Meeting, Minneapolis, Minnesota, United States. January 01, 2017.
Low, W. C. "Assessing the ability of the Zika virus to infect human GBM6 and U87 gliomas", Peyton Society 80th Anniversary Meeting, Minneapolis, Minnesota. January 01, 2017.
Low, W. C., Parr, A. M. "Porcine to porcine blastocyst complementation to generate oligodendrocytes", Peyton Society 80th Anniversary Meeting, Minneapolis, Minnesota. January 01, 2017.
Low, W. C. "Characterization of the Zika virus as an oncolytic virus in murine GL261 gliomas", Peyton Society 80th Anniversary Meeting, Minneapolis, Minnesota, United States. January 01, 2017.
Low, W. C. "Gene Editing for Generating Exogenic Organs and Cells", Cambridge HealthTech Institute, Boston, Massachusetts. January 01, 2016.
Low, W. C. "Generating Authentic Neural Cells for Cellular Replacement and Repair", American Society for Neural Therapy and Repair, Workshop on Techniques for NeuroRepair, Clearwater, Florida. January 01, 2016.
Low, W. C. "Use of blastocyst complementation in identifying novel source of tissue for craniofacial and neural regenerative therapies", Federation of European Neuroscience Society Annual Meeting, Copehagen, Denmark. January 01, 2016.
Low, W. C. "The Genesis Project – Generating Organs and Cells for Transplantation", Department of Medicine Research Conference, University of Minnesota, Minneapolis, Minnesota. January 01, 2016.
Low, W. C. "The Genesis Project: Generating Exogenic Organs and Cells for Regenerative Medicine", 4th Engineering and Stem Cell Institute Symposium, University of Minnesota, Minneapolis, Minnesota. January 01, 2016.
Low, W. C. "Creating Human Organs/Cells via Gene Editing and Blastocyst Complementation", Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota. January 01, 2015.
Low, W. C. "Interrogation of PITX# for blastocyst complementationin generating lens", Institute for Engineering in Medicine Annual Meeting, Minneapolis, Minnesota. January 01, 2015.
Low, W. C. "Stem Cells for Ischemic Brain Injury", Lillihei Heart Institute, University of Minnesota, Minneapolis, Minnesota. January 01, 2015.
Low, W. C. "Characterization of Human-Porcine Blastocysts and Fetuses", National Institutes of Health, Workshop on Animals Containing Human Cells, Bethesda, Maryland. January 01, 2015.
Low, W. C., Grande, A. W. "Amelioration of ischemic brain injury with non-hematopoietic umbilical cord blood stem cells (nh-UCBSCs): Mechanisms of action, Cell Transplantation". January 01, 2014.
Low, W. C. "Optimzation of an immunohistochemical fluorescent antibody staining protocol for use on chimeric tissues", Proceedings of the Summer Undergraduate Research Symposium, University of Minnesota, Minneapolis, Minnesota. January 01, 2014.
Low, W. C. "Translational Neuroscience in Neurodegenerative Diseases", St. Thomas University, St. Paul, Minnesota. January 01, 2013.
Low, W. C. " Spatial navigation and working memory tests demonstrate neurological deficits in a murine model of mucopolysaccharidosis Tye II (Hunter syndrome)", Proceedings for the WORLD Conference. January 01, 2012.
Low, W. C. "Cancer Vaccines for Treating Brain Tumors", Minnesota Mini Medical School, University of Minnesota Medical School, Minneapolis, Minnesota, United States. January 01, 2011.
Low, W. C. "Stem Cells for the Protection of the Brain and Heart", Institute for Engineering in Medicine Symposium on The Heart-Brain Connection, Minneapolis, Minnesota. January 01, 2011.
Low, W. C. "New Novel Model of Blast Traumatic Brain Injury", The 1st International Congress of Interventional Neurology, Minneapolis, Minnesota. January 01, 2011.
Low, W. C. "Central nervous system biodistribution of AAV5-GFP following intraventricular administration in neonatal and adult mice", Proceedings of the American Society for Neural Therapy and Repair. January 01, 2010.
Low, W. C. "Stem Cells for Neural Repair", Frontiers in Biomedical Research Symposium, Karolinska Institute, Stockholm, Sweden. January 01, 2010.
Low, W. C. "State of the Art in Neural Stem Cell Biology", International Meeting of the Society for NeuroImmune Pharmacology, Wuhan, China. January 01, 2009.
Low, W. C. "Long-term effects of human umbilical cord stem cells on myocardial function in post-infarct rat heart", Proceedings of the American Heart Association Annual Meeting. January 01, 2009.
Low, W. C. "Mathematical analyses of in vivo Proton Nuclear Magnetic Resonance Spectroscopy (1H NMRS) in the diagnosis, assessment of clinical change, and metabolomics investigation of the underlying causes of the neuropathology of Huntington’s disease in R6/2 transgenic mice", Proceedings of the American Society for Neural Therapy and Repair. January 01, 2008.
Low, W. C. "Orr HT and McIvor RS, Antisense RNA Sequences Modulating the Ataxin-1 Message: Molecular Model of Gene Therapy for Spinocerebellar Ataxia Type 1, a Dominant-Acting Unstable Trinucleotide Repeat Disease", Proceedings of the American Society for Neural Therapy and Repair. January 01, 2007.
Low, W. C. "Heparan sulfate mediates neuroprotection from degeneration in experimental glutaric aciduria", American Society for Neural Therapy and Repair Abstracts, Experimental Neurology 198:582-583. January 01, 2006.
Low, W. C. "Decreased proliferation of endogenous neural stem cells in transgenic tau Alzheimer's mice", American Society for Neural Therapy and Repair Abstracts, Experimental Neurology 198:595. January 01, 2006.
Low, W. C. "Non-viral gene transfer using Sleeping Beauty transposition for long-term gene expression in the CNS of neonatal mice", American Society for Neural Therapy and Repair Abstracts, Experimental Neurology 198:565-566. January 01, 2006.
Low, W. C. "Stem Cells for the Treatment of Ischemic Brain Injury", University of Minnesota Duluth, Duluth, Minnesota, United States. January 01, 2006.
Low, W. C. "Stem Cells and Neuroscience", New Horizons in Minnesota Medicine Symposium, University of Minnesota Medical School Alumni Association, Minneapolis, Minnesota, United States. January 01, 2006.
Low, W. C. "Stem Cells and the Brain", Minnesota Science Teachers Association, 12th Annual Meeting of Life Science and Biology Teachers, St. Paul, Minnesota. January 01, 2005.
Low, W. C. "The Future of Stem Cells and Regenerative Medicine", Minnesota Biotechnology Symposium, Bloomington, Minnesota, United States. January 01, 2004.
Low, W. C. "Characterization and transplantation of a novel population of umbilical cord blood stem cells in experimental ischemic brain injury", Iowa State University Stem Cell Meeting Abstracts, Iowa State University, Iowa, United States. January 01, 2004.
Low, W. C. "Neural Induction of Multipotent Adult Progenitor Cells (MAPCs) from Bone Marrow", University of South Florida, Tampa, Florida. January 01, 2003.
Low, W. C. "Neurogenesis and axonal fiber sprouting following human multipotent adult progenitor cells (MAPC) transplantation in acutely ischemic rats", Society for Neuroscience Abstracts. January 01, 2003.
Low, W. C. "Pluripotency and Neural Induction of Mesenchymal Stem Cells Derived from Adult Bone Marrow", International Symposium on Stem Cells and Transplantation, Nantes, France. January 01, 2003.
Low, W. C. "Survival and distribution of adult-derived stem cells transplanted into the adult mouse inner ear", Society for Neuroscience Abstracts. January 01, 2003.
Low, W. C. "Characterization and Neural Induction of Bone Marrow Derived Stem Cells", University of Louisville, Louisville, Kentucky. January 01, 2003.
Low, W. C. "Neural Induction of Bone Marrow-Derived Stem Cells", Iowa State University, Ames, Iowa. January 01, 2003.
Low, W. C. "TUDCA, a common bile acid, amerliorates neuropathology and associated behavioral deficits in a transgenic mouse model of Huntington’s disease", Society for Neuroscience Abstracts, Program Number 195.13. January 01, 2002.
Low, W. C. "Neural Induction of Bone Marrow-Derived Adult Stem Cells", Medical College of Georgia, Agusta, Georgia. January 01, 2002.
Low, W. C. "Stem Cells and the Brain", Veterans Administration Hospital, Minneapolis, Minnesota, United States. January 01, 2002.
Low, W. C. "Human and rat derived multipotent adult progenitor cells (MAPC) survive and express neural markers when transplanted into neonatal rats", Society for Neuroscience Abstracts, Program Number 237.19. January 01, 2002.
Low, W. C. "The Promise of Stem Cells for Parkinson’s Disease", Minnesota Medical Foundation, Minneapolis, Minnesota. January 01, 2002.
Low, W. C. "Neuroprotective effects of TUDCA, a hydrophilic bile acid, in experimental Huntington’s disease", Society for Neuroscience Abstracts, Program Number 968.10. January 01, 2001.
Low, W. C. "Evidence that transduction of cerebellar purkinje cells by adeno-associated virus type 2 is mediated by bFGF receptor type 1", Society for Neuroscience Abstracts, Program Number 294.6. January 01, 2001.
Low, W. C. "Neural Transplantation of Marrow-Derived Stem Cells", Central Michigan University, Mt. Pleasant, Michigan. January 01, 2001.
Low, W. C. "Tauro-ursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson’s disease", Society for Neuroscience Abstracts, abstract 328.6. January 01, 2000.
Low, W. C. "Development of Cancer Vaccines for the Treatment of Brain Tumors", Fairview-University Medical Center, Brain Tumor Symposium, Bloomington, Minnesota. January 01, 2000.
Low, W. C. "Parkinson’s Disease: Current Clinical Trials and Future Therapies", Brain Awareness Week Symposium, Minneapolis, Minnesota. January 01, 2000.
Low, W. C. "Ex vivo differentiation of mesenchymal stem cells into oligodendrocytes, astrocytes, and/or dopaminergic, gamma amino butyric acid-ergic, or serotonergic neurons", Society for Neuroscience Abstracts, abstract 415.15. January 01, 2000.
Low, W. C. "Creatine supplemented diet extends Purkinje cell survival in SCA-1 transgenic mice", Society for Neuroscience Abstracts, abstract 203.12. January 01, 2000.
Low, W. C. "Transplantation of bone marrow derived multipotent adult stem cells into the rat CNS: Phenotypic expression", Society for Neuroscience Abstracts, abstract 327.6. January 01, 2000.
Low, W. C. "Human bone marrow stem cells exhibit neural phenotypes after transplantation and ameliorate neurologic deficits with ischemic brain injury", Society for Neuroscience Abstracts, abstract 860.1. January 01, 2000.
Low, W. C. "Xenotransplantation Workshop", Minneapolis, Minnesota. January 01, 1999.
Low, W. C. "Tauroursodeoxycholic acid prevents apoptosis induced by the neurotoxin 3-nitropropionic acid in rat neuronal cells: evidence for a mitochondrial-dependent pathway that does not involve the permeability transition", European Association for the Study of Liver Diseases. January 01, 1999.
Low, W. C. "Transplantation of Cerebellar Purkinje Cells in Experimental Ataxia", Ataxia-Telangietasia Children's Project, Washington DC, District of Columbia. January 01, 1998.
Low, W. C. "Immunotherpay with B16 melanoma cells transfected with the B7-1 co-stimulatory molecule increases the survival of mice with melanoma", Congress of Neurological Surgeons. January 01, 1998.
Low, W. C. "Dendritic cells pulsed with tumor extract is a potent treatment for C57Bl/6 mice bearing intracranial GL261 gliomas", 5th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology. January 01, 1998.
Low, W. C. "Reperfusion injury after focal cerebral ischemia: the role of inflammation and treatment strategies", Congress of Neurological Surgeons. January 01, 1998.
Low, W. C. "Neural Xenotransplantation", 25th Lehman Swine Conference, Symposium on Swine in Biomedical Research, Minneapolis, Minnesota, United States. January 01, 1998.
Low, W. C. "Immunization with dendritic cells pulsed with tumor extract increases survival of C57BL/6 mice bearing intracranial GL261 glioma", Congress of Neurological Surgeons. January 01, 1998.
Low, W. C. "Proton magnetic resonance spectroscopic identification of alterations in the neurochemical profile of the rat striatum following quinolinic acid lesions", Society for Neuroscience. January 01, 1998.
Low, W. C. "Intrastriatal grafting of ventral mesencephalic tissue from MHC knockout mice to adult rats", Society for Neuroscience. January 01, 1998.
Low, W. C. "Dendritic cells pulsed with tumor extract is a potent treatment for C57BL/6 mice bearing intracranial GL261 gliomas", Society for Neuroscience. January 01, 1998.
Low, W. C. "Xenotransplantation of fetal dopamine neurons from MHC I and MHC II knockout mice to adult rats: enhancement of cell survival", Annual Meeting of the American Society for Neural Transplantation. January 01, 1998.
Low, W. C. "Effects of combined GM-CSF and IL-2 in the treatment of rat 9L glioma", Annual Meeting of the American Association of Neurological Surgeons . January 01, 1998.
Low, W. C. "Paradoxical effects of antisense oligonucleotides in the treatment of brain tumors: an illustration using the mdm-2 gene", Society for Neuroscience, 23:2447. January 01, 1997.
Low, W. C. "Effects of combined GM-CSF and IL-2 in the treatment of rat 9L glioma", Annual Meeting of the American Association of Neurological Surgeons. January 01, 1997.
Low, W. C. "Cerebellar transplants into spinocerebellar ataxia type-1 (SCA1) transgenic mice improve motor behavior", Proceedings of the 19th Annual Meeting of Midwest Neurobiologists. January 01, 1997.
Low, W. C. "Increased survival of fetal ventral mesencephalon cells following treatment with an L-cysteine prodrug: in vitro studies", Proceedings of the 19th Annual Meeting of Midwest Neurobiologists. January 01, 1997.
Low, W. C. "Antisense oligonucleotides to the mdm-2 gene yield paradoxical effects in the treatment of brain tumors", Annual Meeting of the Congress of Neurological Surgeons. January 01, 1997.
Low, W. C. "Antisense oligonucleotide vaccine for intracerebral metastatic breast cancer", Annual Meeting of the Congress of Neurological Surgeons. January 01, 1997.
Low, W. C. "Neurosurgical Advances for Treating Parkinson’s Disease", Minnesota Medical Foundation - New Horizons in Minnesota Medicine Symposium, Minneapolis, Minnesota, United States. January 01, 1997.
Low, W. C. "Effects of intraventricular injection of antisense oligodeoxynucleotides on NR1 protein production in neonatal rat brain", Society for Neuroscience, 23:2434. January 01, 1997.
Low, W. C. "Spontaneous regression of C6 glioma tumors in BD-IX rats". January 01, 1997.
Low, W. C. "Liposomes as vectors for the delivery of antisense oligonucleotides targeting the mRNA of the p53 tumor-suppressor gene", Proceedings of the American Association of Pharmaceutical Scientists Annual Meeting. January 01, 1997.
Low, W. C. "Organotypic organization of human fetal cerebellar tissue following transplantation into the cerebellum of nude mice", Proceedings of the 6th International Neural Transplantation Meeting, pg. 50. January 01, 1997.
Low, W. C. "c-myb antisense oligonucleotide uptake and diffusion in the brain", Proceedings of the Congress of Neurological Surgeons Poster Program. January 01, 1997.
Low, W. C. "IL-12 based tumor cell vaccine for the treatment of gliomas", Annual Meeting of the Congress of Neurological Surgeons. January 01, 1997.
Low, W. C. "Pretreatment with antisense oligonucleotides against mRNA to the NMDA receptor is neuroprotective in a rat model of neonatal ischemic-hypoxia", Society for Neuroscience, 23:2434. January 01, 1997.
Low, W. C. "GPi stimulator efficacy in PD patient with prior contralateral pallidotomy", Proceedings of the American Neurological Association Symsosium on the Etiology, Pathogenesis, and Treatment of Parkinson’s Disease & Hyperkinetic Move. January 01, 1997.
Low, W. C. "Increased survival of fetal ventral mesencephalon cells following treatment with an L-cysteine prodrug: in vitro studies", Proceedings of the 6th International Neural Transplantation Meeting. January 01, 1997.
Low, W. C. "IL-2 treatment of 9L glioma provides additional long-term immunity to alternate glioma cell line", Annual Meeting of the American Association of Neurological Surgeons. January 01, 1997.
Low, W. C. "Peripheral vaccines for the treatment and prevention of 9L glioblastoma also provide long-term immunity to an alternate glioma cell line of syngeneic origin", Proceedings of the Congress of Neurological Surgeons. Poster Program, pg. 278. January 01, 1997.
Low, W. C. "Localization of dopamine receptors and associated mRNA in human fetal striatal transplants in an animal model of Huntington’s disease", Proceedings of the 19th Annual Meeting of Midwest Neurobiologists, P14. January 01, 1997.
Low, W. C. "Pallidal stimulation for the treatment of Parkinson’s disease", Society for Neuroscience Abstracts. January 01, 1997.
Low, W. C. "Deep Brain Stimulation for the Treatment of Parkinson's Disease", National Institutes of Health Workshop on Neuroprosthetics, Washington DC, District of Columbia. January 01, 1997.
Low, W. C. "Organization and phenotypic expression of human fetal cerebellar cells following transplantation into normal cerebellum of nude mice", Proceedings of the 19th Annual Meeting of Midwest Neurobiologists. January 01, 1997.
Low, W. C. "Localization of striatal markers in human ganglionic eminence transplants in quinolinic acid-lesioned rats", Society for Neuroscience, 23:84. January 01, 1997.
Low, W. C. "Characterization of the cholinergic system in transgenic mice overexpressing human APP695 containing a double mutation", Proceedings of the 19th Annual Meeting of Midwest Neurobiologists. January 01, 1997.
Low, W. C. "Cytokine dependent lymphocyte infiltration of 9L gliosarcoma peripheral tumors in Fischer 344 rats", Annual Meeting of the American Association of Neurological Surgeons. January 01, 1997.
Low, W. C. "Effects of antisense oligonucleotides to the IGF-1 receptor on the growth of F98 gliomas in Fischer 344 rats", Proceedings of the 19th Annual Meeting of Midwest Neurobiologists, P13. January 01, 1997.
Low, W. C. "Development of granulocyte-macrophage colony stimulating factor (GM-CSF) vaccines for the treatment of brain tumors in syngeneic Fischer 344 rats", Proceedings of the 19th Annual Meeting of Midwest Neurobiologists, P7. January 01, 1997.
Low, W. C. "Histochemistry of neocortical grafts in rats following neonatal ischemic-hypoxia", Experimental Neurology, 143:329. January 01, 1997.
Low, W. C. "Brain tumor regression in Fischer 344 rats vaccinated with F98 glioma cells treated with antisense oligonucleotides for the IGF1 receptor", Society for Neuroscience, 23:2448. January 01, 1997.
Low, W. C. "Neuroprotection with antisense to the NR1 subunit of the NMDA receptor in a rodent model of neonatal ischemic-hypoxia", Proceedings of the 19th Annual Meeting of Midwest Neurobiologists, P6. January 01, 1997.
Low, W. C. "GM-CSF Based Vaccines for the Treatment of Brain Tumors", Hennepin County Medical Center, Department of Surgery, Minneapolis, Minnesota. January 01, 1997.
Low, W. C. "Wildtype cerebellar grafts into spinocerebellar ataxia Type-1 transgenic mice survive and improve motor behavior", Society for Neuroscience, 23:347. January 01, 1997.
Low, W. C. "Cell Transplantation Therapies for Experimental Neurodegenerative Diseases", Microbiology, Immunology, and Molecular Pathology Program, University of Minnesota, Minneapolis, Minnesota, United States. January 01, 1996.
Low, W. C. "Recovery of Motor Function Following Transplantation of Human Fetal Striatum in Rodents with Experimental Huntington’s Disease", Huntington’s Disease Society of America Annual Meeting, Symposium on Recent Advances in Huntington’s Research, Minnea, Minnesota. January 01, 1996.
Low, W. C. "Assessment of cholinergic neurons in transgenic mice overexpressing Alzheimer amyloid precursor proteins", Society for Neuroscience Abstracts 22:206. January 01, 1996.
Low, W. C. "Development of granulocyte/macrophage-colony stimulating factor (gm-csf)-based peripheral vaccines for the treatment and prevention of 9l glioblastoma in syngeneic Fischer 344 rats", Proceedings of the Congress of Neurological Surgeons. January 01, 1996.
Low, W. C. "Effects of IGF-1R antisense and nonsense oligonucleotide administration on 9L glioblastoma and MAT B3 breast tumor growth in Fischer 344 rats", Proceedings of the American Association for Cancer Research. January 01, 1996.
Low, W. C. "Phenotypic expression of human fetal cerebellar cells following transplantation into nude mouse cerebellum", Society for Neuroscience Abstracts 22:579. January 01, 1996.
Low, W. C. "IGF-1R antisense and nonsense oligonucleotide therapy for 9L glioblastoma results in immune response against an unrelated syngeneic tumor in Fischer 344 rats", Society for Neuroscience Abstracts 22:948. January 01, 1996.
Low, W. C. "Antisense oligonucleotides to insulin-like growth factor 1 receptor (IGF-1R) mediate a systemic defense against C6 rat glioma tumors", Proceedings of the American Association for Neurological Surgeons. January 01, 1996.
Low, W. C. "Pretreatment with antisense oligonucleotides against mRNA to the NMDA glutamate receptor is neuroprotective in rodent model of neonatal ischemic-hypoxia: behavioral and morphometric analyses", Society for Neuroscience Abstracts, 22:937. January 01, 1996.
Low, W. C. "Pallidotomy for the treatment of dystonia", Proceedings of the American Association of Neurological Surgeons. January 01, 1996.
Low, W. C. "Suitability and availability of human fetal neural tissue from spontaneous abortions for transplantation in Parkinson’s disease", Experimental Neurology, 143:332. January 01, 1996.
Low, W. C. "Development of Antisense Oligonucleotides for the Treatment of Brain Tumors", Clinical Neuroscience Conference, University of Minnesota, Minneapolis, Minnesota, United States. January 01, 1995.
Low, W. C. "Incorporation of human glial cells into host rodent striatum following transplantation of fetal striatum, thalamus and ventral mesencephalon", Experimental Neurology 135:168. January 01, 1995.
Low, W. C. "Transplantation of fetal neocortical tissue in a rodent model of neonatal ischemic-hypoxia: behavioral analysis", Experimental Neurology 135:166. January 01, 1995.
Low, W. C. "Secondary changes in substantia nigra after intracerebral hemorrhage in rat striatum", Society for Neuroscience Abstracts 21:497. January 01, 1995.
Low, W. C. "Suppression of human U87 glioblastoma tumor growth in the flank of nude mice with antisense oligonucleotides to the c-myb oncogene", Society for Neuroscience Abstracts 21:2136. January 01, 1995.
Low, W. C. "Isoflurane is neuroprotective in a rodent model of neonatal ischemic hypoxia: behavioral and morphological analyses", Society for Neuroscience Abstracts 21:227. January 01, 1995.
Low, W. C. "Prospective analysis of human fetal tissue from spontaneous abortuses as potential sources of donor tissue for cell transplantation therapies", Proceedings of the 2nd International Congress of the Cell Transplant Society. January 01, 1994.
Low, W. C. "Hematopoietic progenitor content of liver and bone marrow from spontaneously aborted fetuses", Proceedings of the 2nd International Congress of the Cell Transplant Society. January 01, 1994.
Low, W. C. "Transplantation of human fetal striatal tissue in experimental Huntington’s disease: host-to-graft fiber innervation and development of NADPH diaphorase immunoreactive neurons", Proceedings of the 5th International Symposium on Neural Transplantation. January 01, 1994.
Low, W. C. "Transplanted human fetal dopaminergic neurons obtained from a spontaneous abortion can survive and result in behavior recovery in a rat model of Parkinson’s disease", Proceedings of the 5th International Symposium on Neural Transplantation. January 01, 1994.
Low, W. C. "Retrospective and prospective studies of human fetal pancreatic tissue from spontaneous and elective abortions as potential sources of islet cells for transplantation", Proceedings of the 2nd International Congress of the Cell Transplant Society. January 01, 1994.
Low, W. C. "Isolation and culture of human fetal calvarium", Proceedings of the 2nd International Congress of the Cell Transplant Society. January 01, 1994.
Low, W. C. "Transplantation of cholinergic-rich nervous system tissue from spontaneously aborted human fetuses into a rodent model of Alzheimer's disease", Proceedings of the 2nd International Congress of the Cell Transplant Society. January 01, 1994.
Low, W. C. "Transplantation of human fetal striatal brain tissue from spontaneous abortuses into a rodent model of Huntington's disease", Proceedings of the 2nd International Congress of the Cell Transplant Society. January 01, 1994.
Low, W. C. "Transplantation of dopamine rich human fetal ventral mesencephalic brain tissue from spontaneous abortuses into a rodent model of Parkinson's disease", Proceedings of the 2nd International Congress of the Cell Transplant Society. January 01, 1994.
Low, W. C. "Functional regulation of cholinergic neurons transplanted into the hippocampal formation of rats: evidence for host-to-graft modulation of cholinergic activity by behavioral activation", Proceedings of the 1st Annual Meeting of the American Society for Neural Transplantation. January 01, 1994.
Low, W. C. "Suppression of glioblastoma (U87) tumor growth in the flank of nude mice with antisense oligonucleotides to c ymb oncogene (codons 2-7)", American Association of Neurological Surgeons. January 01, 1994.
Low, W. C. "A paradigm for the objective quantification of immune response to intrastriatal xenografts", Proceedings of the 5th International Symposium on Neural Transplantation. January 01, 1994.
Low, W. C. "Growth suppression of glioma and medulloblastoma cells by IGF-1 receptor antisense oligonucleotides", Proceedings of the Annual Meeting of the Congress of Neurological Surgeons. January 01, 1994.
Low, W. C. "Growth inhibition of glioma and medulloblastoma cells and down regulation of PDGF receptors with antisense oligonucleotides to c-myb oncogene", Proceedings of the Annual Meeting of the Congress of Neurological Surgeons. January 01, 1994.
Low, W. C. "Posteroventral pallidotomy for the treatment of dystonia", Society for Neuroscience Abstracts, 20:1257. January 01, 1994.
Low, W. C. "Host brain modulation of intra-retrosplenial transplants of cholinergic septal neurons", Society for Neuroscience Abstracts, 20:1708. January 01, 1994.
Low, W. C. "Suppression of human medulloblastoma cell proliferation with antisense oligonucleotides to the c-myb oncogene", Society for Neuroscience Abstracts, 20:835. January 01, 1994.
Low, W. C. "Human fetal striatum exhibits viable tissue and cells for transplantation from donors 7-18 weeks in gestation", Society for Neuroscience Abstracts, 20:473. January 01, 1994.
Low, W. C. "Quantitative analysis of hypertrophy in brains of adult animals following ischemic-hypoxia", Society for Neuroscience Abstracts, 20:178. January 01, 1994.
Low, W. C. "Amelioration of locomotor deficits in a rodent model of experimental Huntington’s Disease with transplants of human fetal striatal tissue", Proceedings of the 1st Annual Meeting of the American Society for Neural Transplantation. January 01, 1994.
Low, W. C. "Isolation and culture of osteoblast progenitors from human fetal calvarium", Proceedings of the 3rd European Conference on Tissue Banking and Clinical Application of Grafts. January 01, 1994.
Low, W. C. "Down regulation of EGF receptor expression in glioblastoma cells with c-myb antisense oligonucleotides", Proceedings of the Annual Meeting of the Congress of Neurological Surgeons, Tumor Satellite Conference. January 01, 1994.
Low, W. C. "A Retrospective Study of Human Fetal Tissue from Spontaneous Abortions: Potential Application for Cell Transplantation Therapies", Annual Meeting, American Association of Tissue Banks, Boston, Massachusetts. January 01, 1993.
Low, W. C. "Reconstructive Neurosurgery in Experimental Cerebral Palsy", United Cerebral Palsy Teleconference, Washington DC, District of Columbia. January 01, 1993.
Low, W. C. "Restoration of Spatial Memory Function with Transplanted Cholinergic Neurons", Learning Center, University of Minnesota, Minneapolis, Minnesota, United States. January 01, 1993.
Low, W. C. "Decade of the Brain", Rotary Club, Minneapolis, Minnesota, United States. January 01, 1993.
Low, W. C. "Recovery of spatial memory function in fornix-lesioned rats with intra retrosplenial and/or intrahippocampal transplants", Society for Neuroscience Abstracts 19:1741. January 01, 1993.
Low, W. C. "Persistence of choline acetyltransferase-immunopositive nerve fibers in the ischemic rat hippocampus", Society for Neuroscience Abstracts 19:1652. January 01, 1993.
Low, W. C. "Locomotor deficits in rats with a collagenase-induced intrastriatal hemorrhage", Society for Neuroscience Abstracts 19:1653. January 01, 1993.
Low, W. C. "Effects of selective D1 and D2 receptor agonists on locomotor function in a rodent model of Huntington's disease", Society for Neuroscience Abstracts 19:409 . January 01, 1993.
Low, W. C. "Locomotor deficits in adult animals following neonatal ischemic hypoxia", Society for Neuroscience Abstracts 19:1653. January 01, 1993.
Low, W. C. "Changes in extracellular striatal dopamine (DA) in the rat during graded cerebral ischemia: response to potassium stimulation and DA reuptake blockade", Society for Neuroscience Abstracts 19:1663. January 01, 1993.
Low, W. C. "Neural Transplantation and Pallidotomy for Parkinson's Disease", Beijing, China. January 01, 1993.
Low, W. C. "Temporal course of acute immune rejection of intrastriatal xenografts in a rodent model of Parkinson's disease", Society for Neuroscience Abstracts 19:684. January 01, 1993.
Low, W. C. "Assessment of human fetal tissue from spontaneous abortions for potential cell transplantation therapies", Proceedings of American Association of Tissue Banks. January 01, 1993.
Low, W. C. "Isolation and culture of human osteoblast progenitors from human fetal calvarium", Proceedings of American Association of Tissue Banks. January 01, 1993.
Low, W. C. "Glutamate uptake blockade induces striatal dopamine release in normal rats and 6-OHDA rats with intrastriatal grafts: an intracerebral microdialysis study", Restorative Neurology and Neuroscience. January 01, 1992.
Low, W. C. "Neuronal Transplantation in Experimental Models of Neurodegenerative Disorders", M.D./Ph.D. Program, University of Minnesota Medical School, Minneapolis, Minnesota. January 01, 1992.
Low, W. C. "Behavioral Tests for Learning and Memory, and Locomotor Function in Rodents", Research Animal Resources, University of Minnesota Medical School, Minneapolis, Minnesota, United States. January 01, 1992.
Low, W. C. " GAP-43, MAP2 and βAPP gene expression in the nigrostriatal system of normal and weaver mutant mice and in intrastriatal mesencephalic grafts", Journal of Neuropathology and Experimental Neurology, 51:35. January 01, 1992.
Low, W. C. "Comparison of transplant-derived cholinergic parameters in experimental Alzheimer's disease", Proceedings of the Minnesota Society of Neurological Sciences. January 01, 1992.
Low, W. C. "Locomotor heterogeneity of the striatum in a rodent model of Huntington's disease", Proceedings of the Minnesota Society of Neurological Sciences. January 01, 1992.
Low, W. C. "Intra-retrosplenial cortical transplantation of cholinergic neurons derived from the septal nucleus of fetal rats: pattern of innervation", Journal of Neural Transplantation and Plasticity, 3:190-191. January 01, 1992.
Low, W. C. "Glutamatergic control of striatal dopamine release in normal rats and 6-OHDA rats with intrastriatal grafts", Journal of Neural Transplantation and Plasticity. January 01, 1992.
Low, W. C. "Functional heterogeneity of the striatum in a rodent model of Huntington's disease: considerations for neurological transplantation", Journal of Neural Transplantation and Plasticity, 3:185-186. January 01, 1992.
Low, W. C. "Behavioral model of cerebral palsy: considerations for transplantation", Proceedings of the Minnesota Society of Neurological Sciences. January 01, 1992.
Low, W. C. "Host brain modulation of striatal dopamine release in 6-OHDA rats with intrastriatal grafts", Proceedings of the Minnesota Society of Neurological Sciences. January 01, 1992.
Low, W. C. "Neuropathology and motor behavior in immature rat hypoxia-ischemia", Journal of Neural Transplantation and Plasticity, 3:309-310. January 01, 1992.
Low, W. C. "Pathways mediating the cholinergic innervation of the retrosplenial cortex as revealed by ChAT immuno-cytochemistry", Society for Neuroscience Abstracts, 18:324. January 01, 1992.
Low, W. C. "Evaluation of the extracellular concentrations of dopamine and serotonin in rat striatum during graded cerebral ischemia", Proceedings of the Congress of Neurological Surgeons. January 01, 1992.
Low, W. C. "Functional locomotor heterogeneity of the striatum in a rodent model of Huntington's disease", Society for Neuroscience Abstracts, 18:168. January 01, 1992.
Low, W. C. "Can alternate sources of cholinergic nerve cells transplanted into the hippocampal formation have functional effects?", Restorative Neurology and Neuroscience, 4:144. January 01, 1992.
Low, W. C. "Structural protein and receptor gene expression in mesencephalic cell suspensions transplanted to the weaver mouse neostriatum", 7th International Catecholamine Symposium. January 01, 1992.
Low, W. C. "Development of cerebellar cell suspensions intraparenchymally transplanted to the deep cerebellar nuclei of pcd mutant mice", Journal of Neuropathology and Experimental Neurology, 51:349. January 01, 1992.
Low, W. C. "Structural protein and receptor gene expression in ventral mesencephalic grafts transplanted to the striatum of weaver mutant mice", Restorative Neurology and Neuroscience, 4:160. January 01, 1992.
Low, W. C. "Functional analysis of intrahippocampal septal grafts: comparison of neurochemical cholinergic parameters", Restorative Neurology and Neuroscience, 4:176. January 01, 1992.
Low, W. C. "Evidence for host-derived glutamate afferent modulation of intrastriatally transplanted dopamine neurons", Society for Neuroscience Abstracts, 18:59. January 01, 1992.
Low, W. C. "Morphological comparison of grafted cholinergic neurons into the posterior retrosplenial cortex with intrinsic cholinergic nerve cells", Proceedings of the Minnesota Society for Neurological Sciences. January 01, 1992.
Low, W. C. "Effect of ischemia on the extracellular dopamine level in rat striatum by intracerebral microdialysis", Proceedings of the Minnesota Society for Neurological Science. January 01, 1991.
Low, W. C. "Persistence of serotonin and cholecystokinin immunoreactive nerve fibers in the gerbil hippocampal formation following cerebral ischemia", Society for Neuroscience Abstracts, 17:1262. January 01, 1991.
Low, W. C. "Repair and restoration of hippocampal function using nerve cell transplants in a rodent model of cerebral ischemia", Proceedings of the 59th Annual Meeting of the American Association of Neurological Surgeons, pp.146-148. January 01, 1991.
Low, W. C. "Brain Cell Transplants: Repair of Dopaminergic and Cholinergic Pathways and Restoration of Neurologic Function", Clinical Neuroscience Conference, University of Minnesota Medical School, Minneapolis, Minnesota, United States. January 01, 1991.
Low, W. C. "Neural Grafting in Experimental Models of Neurodegenerative Disorders", Neuroscience Seminar Series, University of Minnesota Medical School, Minneapolis, Minnesota. January 01, 1991.
Low, W. C. "The Hippocampal Formation: Remembrance of Places Past, Present and Future", Department of Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States. January 01, 1991.
Low, W. C. "BAPP and GAP-43 gene expression in normal and weaver mice and in intrastriatal dopamine neuron grafts", Society for Neuroscience Abstracts, 17:770. January 01, 1991.
Low, W. C. "Physiologically inspired neural networks", Proceedings of the National Conference on Undergraduate Research. January 01, 1991.
Low, W. C. "Repair of Neural Connections with Nerve Cell Transplants: Restoration of Neurologic Function", Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota. January 01, 1991.
Low, W. C. " Dopaminergic-cholinergic interactions following transplantation of ventral mesencephalic grafts to the weaver mouse striatum", Neurology, 41:398. January 01, 1991.
Low, W. C. "Intrahippocampal grafts from fetal striatum ameliorate spatial memory deficits in rats with fimbria-fornix lesions", Society for Neuroscience Abstracts, 17:1139. January 01, 1991.
Low, W. C. "Fetal hippocampal transplants into ischemically-damaged hippocampi of adult mongolian gerbils ameliorate a spatial memory deficit", Proceedings of the 7th Regional Meeting, Society for Neuroscience,Indianapolis Chapter, pg. 2. January 01, 1990.
Low, W. C. "Denervated retrosplenial cortex is diffusely reinnervated by transplanted fetal cholinergic cells", Proceedings of the 7th Regional Meeting, Society for Neuroscience, Indianapolis Chapter, pg. 10. January 01, 1990.
Low, W. C. "The fornix mediates an acetylcholinesterase (AChE) positive pathway from the basal forebrain to the retrosplenial cortex", Proceedings of the 7th Regional Meeting, Society for Neuroscience, Indianapolis Chapter, pg. 8. January 01, 1990.
Low, W. C. "Rat basal nuclei project to the retrosplenial cortex via the fornix", Society for Neuroscience Abstracts, 16:124. January 01, 1990.
Low, W. C. "Cerebellar sereotonin fiber innervation in normal and pcd mutant mice and host afferents into intraparenchymal cerebellar grafts", Proceedings of the 7th Regional Meeting, Society for Neuroscience, Indianapolis Chapter, pg. 19. January 01, 1990.
Low, W. C. "Cerebellar serotonin fiber innervation in normal and pcd mutant mice and host afferents into intraparenchymal cerebellar grafts", Society for Neuroscience Abstracts 16:834. January 01, 1990.
Low, W. C. "Cholinergic grafts innervate the retrosplenial cortex in a diffuse pattern", Society for Neuroscience Abstracts, 16:1286. January 01, 1990.
Low, W. C. "Neural Grafting and the Restoration of Function", Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, Minnesota, United States. January 01, 1990.
Low, W. C. "Intraparenchymal grafting of cerebellar cell suspensions to the deep cerebellar nuclei of pcd mutant mice: Rationale and histochemical organization", Proceedings of the 7th Regional Meeting, Society for Neuroscience, Indianapolis Chapter, pg. 4. January 01, 1990.
Low, W. C. "Adaptive Neural Networks in the Hippocampal Formation", 7th Annual Meeting, Society for Neuroscience, Indianapolis Chapter, Indianapolis, IN, Symposium on Neural Networks, Indianapolis, Indiana. January 01, 1990.
Low, W. C. "Neural grafting and functional restoration in animal models of neuronal degeneration", Medical Science Program, Indiana University, Bloomington, Minnesota. January 01, 1989.
Low, W. C. "Bilateral nigral grafts to the striatum of weaver mutant mice enhance locomotor coordination", Society for Neuroscience Abstracts, 15:1355. January 01, 1989.
Low, W. C. "Evidence for innervation of grafted cholinergic neurons by GABAergic afferents", Third International Symposium on Neural Transplantation, Cambridge, United Kingdom. January 01, 1989.
Low, W. C. "Amelioration of spatial memory deficits with hippocampal transplants in Mongolian gerbils with ischemia-induced damage to the hippocampus", Proceedings of the 3rd International Symposium on Neural Transplantation, pg. 42. January 01, 1989.
Low, W. C. "Evidence for innervation of grafted cholinergic neurons by GABAergic afferents", Proceedings of the 3rd International Symposium on Neural Transplantation, pg. 46. January 01, 1989.
Low, W. C. "Cerebellar transplants in pcd mutant mice: Expression of Purkinje cell specific proteins in the graft and chronology of implantation relative to transsynaptic changes of the host", Proceedings of the 3rd International Symposium on Neural Transplantation, pg. 42. January 01, 1989.
Low, W. C. "Intraparenchymal grafting of cerebellar cell suspensions to the deep cerebellar nuclei of pcd mutant mice: Rationale and histochemical organization", Society for Neuroscience Abstracts, 15:10. January 01, 1989.
Low, W. C. "Effects of insulin-like growth factor II (IGF-II) on transplanted cholinergic neurons from the fetal septal nucleus", Proceedings of the 3rd International Symposium on Neural Transplantation. January 01, 1989.
Low, W. C. "Spatial memory deficits in Mongolian gerbils with ischemia-induced damage to CA1 pyramidal neurons in the dorsal hippocampus", Proceedings of the Indiana University School of Medicine First Annual Scientific Session, p. P-56. January 01, 1989.
Low, W. C. "Fetal hippocampal transplants ameliorate spatial-memory deficits in Mongolian gerbils with ischemia-induced damage to the hippocampus", Society for Neuroscience Abstracts, 15:1094. January 01, 1989.
Low, W. C. "Insulin-like growth factor II (IGF- II) has a trophic effect on fetal cholinergic neurons grafted into the adult hippocampus", Proceedings of the Indiana University School of Medicine First Annual Scientific Session. January 01, 1989.
Low, W. C. "Fetal hippocampal transplants into ischemically-damaged hippocampus of Mongolian gerbils survive and are innervated by host hippocampal afferents", Proceedings of the 6th Annual Regional Meeting of the Society for Neuroscience, Indianapolis Chapter. January 01, 1989.
Low, W. C. "Lesions of the perforant path and not of the fimbria fornix block the seizure-induced increase of thyrotropin-releasing hormone (TRH) in the rat hippocampus", Proceedings 71st Annual Meeting of the Endocrine Society, pg. 396. January 01, 1989.
Low, W. C. "Dopamine neuron grafts in the weaver mouse neostriatum: histochemical phaenotypy, specificity of the striatal innervation, and behavioral improvement following bilateral transplantation", Proceedings of the 3rd International Symposium on Neural Transplantation, pg. 53. January 01, 1989.
Low, W. C. "Nerve Cell Transplantation and the Restoration of Function", Department of Biology, Indiana University Purdue University, Indianapolis, Indiana. January 01, 1988.
Low, W. C. "Transplantation of Cholinergic Neurons and Functional Restoration in the Mammalian Central Nervous System: An Overview", International Symposium on Molecular Neurobiology, the Aging Process and Neurodegenerative Disease, Indianapolis, Indiana, United States. January 01, 1988.
Low, W. C. "Restoration of Function with Intrahippocampal Grafts of Cholinergic Neurons from the Medial Septal Nucleus", Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana. January 01, 1988.
Low, W. C. "Dissociation of 5-HT from thyrotropin releasing hormone (TRH) in rat forebrain regions", Society for Neuroscience Abstracts, 14:672. January 01, 1988.
Low, W. C. "Purkinje cell degeneration weaver double mutant mouse", Journal of Neuropathology and Experimental Neurology, 47:384. January 01, 1988.
Low, W. C. "Age-related changes in dopamine D2 receptors in the striatum of weaver mutant mice", Journal of Neuropathology and Experimental Neurology, 47:360. January 01, 1988.
Low, W. C. "Reactive gliosis in the cerebellum of pcd mutant host does not prevent the survival and differentiation of transplanted Purkinje cells", Journal of Neuropathology and Experimental Neurology, 47:384. January 01, 1988.
Low, W. C. "Neuropeptide-dopamine coexistence in ventral mesencephalic grafts transplanted to the striatum of weaver mutant mice", Journal of Neuropathology and Experimental Neurology, 47:383. January 01, 1988.
Low, W. C. "Expression of the developmentally regulated polypeptide PEP-19 by Purkinje cells transplanted to the cerebellum of pcd mutant mice", Anatomical Record, 220:20A-21A. January 01, 1988.
Low, W. C. "Functional innervation of transplanted cholinergic neurons by GABAergic afferents: Determination by high-affinity choline uptake", Proceedings of the 5th Annual International Symposium on Neuronal Control of Bodily Function . January 01, 1988.
Low, W. C. "Comparative analysis of PEP-19 and 28-kDa Ca-binding protein expression in purkinje cells grafted to pcd mutant cerebellum", Society for Neuroscience Abstracts, 14:1144. January 01, 1988.
Low, W. C. "Transplantation of cholinergic neurons and functional restoration in the mammalian central nervous system", Proceedings of the 5th Annual International Symposium on Neuronal Control of Bodily Function. January 01, 1988.
Low, W. C. "Effects of insulin-like growth factor II (IGF-II) on transplanted cholinergic neurons from the fetal septal nucleus", Proceedings of the 5th Annual International Symposium on Neuronal Control of Bodily Function. January 01, 1988.
Low, W. C. "Development of wild-type Purkinje cells grafted to pcd mutant cerebellum during or after the degeneration of host Purkinje cells", European Journal of Neuroscience, Suppl. 1:309. January 01, 1988.
Low, W. C. "The change in hippocampal high-affinity choline uptake after transplantation of fetal septal cell suspensions", Proceedings of the Japanese Society for Neuroscience. January 01, 1988.
Low, W. C. "Analysis of neuronal losses in the cerebellar circuitry of 'Purkinje cell degeneration' mutant mice: Insight into strategies of neural transplantation", Clinical Neuropathology, 7:164. January 01, 1988.
Low, W. C. "Compensation of genetic mesostriatal dopamine deficiency by embryonic nigral transplants in weaver mutant mice", Clinical Neuropathology, 7:215. January 01, 1988.
Low, W. C. "The cerebellum in Purkinje cell degeneration*weaver (pcd/pcd*wv/wv) double mutant mice", Society for Neuroscience Abstracts, 14:472. January 01, 1988.
Low, W. C. "Functional recovery of high-affinity choline uptake in the hippocampus following septal cell suspension transplants in rats with fimbria-fornix lesions", Society for Neuroscience Abstracts,14:1005. January 01, 1988.
Low, W. C. "Differential pattern of CA1pyramidal cell degeneration in the dorsal and ventral hippocampal formation after cerebral ischemia in Mongolian gerbils", Proceedings of the 5th Annual International Symposium on Neuronal Control of Bodily Function . January 01, 1988.
Low, W. C. "Reconstruction of the mesostriatal dopamine pathway in weaver mutant mice by intrastriatal implants of dissociated nigral cell suspensions", Neurology, 38 (Suppl 1.):123. January 01, 1988.
Low, W. C. "Transplantation of Dopaminergic and Cholinergic Neurons and the Restoration of Function", Department of Physiology, Syracuse University, Syracuse, New York. January 01, 1988.
Low, W. C. "Functional Reinnervation of Transplanted Dopamine Neurons in Mutant Mice with Inherited Nigrostriatal Dopamine Deficiency", Schmitt Neurological Sciences Symposium on Transplantation into the Mammalian CNS, Rochester, New York. January 01, 1987.
Low, W. C. "Effects of Insulin like Growth Factor II (IGF II) on Neurite Extension of Hippocampal Neurons in Tissue Culture", Eli Lilly and Co., Indianapolis, Indiana. January 01, 1987.
Low, W. C. "Dopamine neuron grafting in a murine model of genetic parkinsonism: Immunohistochemical, ultrastructural, and behavioral correlates", Proceedings of the International Brain Research Satellite Symposium. January 01, 1987.
Low, W. C. "Thryotropin-releasing hormone (TRH) in subregions of the hippocampal formation", Society for Neuroscience Abstracts, 13:995. January 01, 1987.
Low, W. C. "Synaptology of dopamine afferents in the dorsal striatum of weaver mutant mice following grafting of ventral mesencephalic transplants", Society for Neuroscience Abstracts, 13:286. January 01, 1987.
Low, W. C. "Long-term survival of ventral mesencephalic grafts reinnervating the neostriatum of adult weaver mutant mice", Journal of Neuropathology and Experimental Neurology, 46:352. January 01, 1987.
Low, W. C. "Effects of insulin-like growth factor II (IGF-II) on hippocampal and septal neurons maintained in tissue culture", Society for Neuroscience Abstracts, 13:1615. January 01, 1987.
Low, W. C. "Up-regulation of D2 receptors in the striatum of weaver mutant mice", Journal of Neuropathology and Experimental Neurology, 46:358. January 01, 1987.
Low, W. C. "Reinnervation of the dopamine deficient frontal cortex of weaver mutant mice by grafted mesencephalic dopaminergic neurons", Abstracts of the Second World Congress of Neuroscience. January 01, 1987.
Low, W. C. "Improvement of locomotor coordination with transplants containing dopamine nerve cells in mutant mice with nigrostriatal dopamine deficiency", Federation Proceedings, 46:341. January 01, 1987.
Low, W. C. "Functional innervation of the neostriatum in weaver mutant mice by grafted mesencephalic dopamine neurons", Society for Neuroscience Abstracts, 13:286. January 01, 1987.
Low, W. C. "Purkinje and granule cells survive in cerebellar grafts implanted into hosts with genetically-determined Purkinje or granule cell loss", Annals of Neurology, 20:138. January 01, 1986.
Low, W. C. "Computer simulations to enhance physiology instruction", Proceedings of the IBM College and University Executive Conference. January 01, 1986.
Low, W. C. "Growth and Development of Neural Transplants", Medical Science Program, Indiana University, Bloomington, Indiana. January 01, 1986.
Low, W. C. "Experimental cerebral ischemia, tissue damage and behavior", Proceedings of the 3rd Regional Meeting, Society for Neuroscience, Indianapolis Chapter, 3:1. January 01, 1986.
Low, W. C. "Cerebellar transplants into mutant mice with Purkinje cell degeneration", Abstracts of the New York Academy of Science Conference on Brain Tissue Transplantation in Adult Brain. January 01, 1986.
Low, W. C. "Microcomputer Simulations in Physiology", IBM College and University Executive Conference, Palm Springs, California. January 01, 1986.
Low, W. C. "Cerebellar Transplants into Mutant Mice with Purkinje Cell Degeneration", New York Academy of Science Conference on Brain Tissue Transplantation in the Adult Brain, New York, New York. January 01, 1986.
Low, W. C. "Transplants of Cholinergic Nerve Cells", Department of Anatomy, University of Illinois, Chicago, Illinois. January 01, 1986.
Low, W. C. "Cerebellar transplants in mice with inherited Purkinje and granule cell loss", Proceedings of the 10th International Congress of Neuropathology. January 01, 1986.
Low, W. C. "Intracerebral grafting of embryonic substantia nigra into a genetic model of degeneration of the nigrostriatal projection", Proceedings of the IV Congress of the International Society of Greek Neuroscientists. January 01, 1986.
Low, W. C. "Dorsal and ventral hippocampal ChAT activity and maze performance in "old" and young rats", Proceedings of the 3rd Regional Meeting, Society for Neuroscience, Indianapolis Chapter, 3:6. January 01, 1986.
Low, W. C. "Differences in thyrotropin-releasing hormone (TRH) between dorsal and ventral hippocampus", Society for Neuroscience Abstracts, 12:300. January 01, 1986.
Low, W. C. "Hippocampal choline acetyltransferase (ChAT) activity and maze performance in "old" and young rats", Society for Neuroscience Abstracts, 12:1313. January 01, 1986.
Low, W. C. "Experimental cerebral ischemia, tissue damage, and neuronal transplantation", Society for Neuroscience Abstracts, 12:1287. January 01, 1986.
Low, W. C. "Transplantation of cerebellar grafts into adult 'Purkinje cell degeneration' (pcd) and weaver mutant mice", Society for Neuroscience Abstracts, 12:1291. January 01, 1986.
Low, W. C. "Reinnervation of the dopamine depleted striatum of adult weaver mutant mice by grafted mesencephalic dopaminergic neurons", Society for Neuroscience Abstracts, 12:1477. January 01, 1986.
Low, W. C. "Dopaminergic mesencephalic grafts into the striatum of weaver (wv/wv) mutant hosts may compensate for the genetically determined loss of substantial nigra neurons", Journal of Cell Biology, 103:234a. January 01, 1986.
Low, W. C. "Analysis of genetic and epigenetic components in the phenotypic expression of neurological mutations by means of cerebellar transplantation", Proceedings of the IV Congress of the International Society of Greek Neuroscientists, Patras . January 01, 1986.
Low, W. C. "Effects of neurotoxic doses of diphenylhydantoin on the cerebellum and behavior of rats", Proceedings of the 3rd Regional Meeting, Society for Neuroscience, Indianapolis Chapter, 3:3. January 01, 1986.
Low, W. C. "Effect of fimbria-fornix lesions on septal, hippocampal and hypothalamic thyrotropin-releasing hormone (TRH) in the rat", Endocrine Society Abstracts, pp. 130. January 01, 1985.
Low, W. C. "Methods of Neural Transplantation", Vascular Biology Training Program, Indiana University School of Medicine, Indianapolis, Indiana. January 01, 1985.
Low, W. C. "Thyrotropin-releasing hormone projection to the hippocampal formation via the fornix", Society for Neuroscience Abstracts, 11:680. January 01, 1985.
Low, W. C. "Cross Species Transplants of Cholinergic Neurons and the Recovery of Function", Fernstrom International Symposium, Neural Grafting in the Mammalian Central Nervous System, Lund, Sweden. January 01, 1984.
Low, W. C. "Transplantation of Cholinergic Neurons and the Recovery of Function", Evansville Center for Medical Education, Indiana University School of Medicine, Evansville, Indiana. January 01, 1984.
Low, W. C. "Cross-species septal transplants: The relationship between the restoration of ChAT and AChE activity in the host hippocampal formation", Society for Neuroscience Abstracts, 10:982. January 01, 1984.
Low, W. C. "Kinetics of norepinephrine uptake in hippocampal synaptosomes and maze performance in genetically related rats", Federation Proceedings, 43:924. January 01, 1984.
Low, W. C. "Neural Transplantation of Cholinergic Neurons and the Recovery of Function", Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana. January 01, 1984.
Low, W. C. "Transplantation of Cholinergic Neurons", Department of Physiology and Biophysics Retreat, Indiana University School of Medicine, Brown County, Indiana. January 01, 1983.
Low, W. C. "Cross species Transplantation of Cholinergic Neurons", International Symposium on Brain Tissue Transplantation, European Winter Brain Conference, Les Arc, France. January 01, 1983.
Low, W. C. "Methods of Neural Transplantation", Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Washington DC, District of Columbia. January 01, 1983.
Low, W. C. "The Development of Transplanted Nerve Cells and the Recovery of Function", Department of Biology, Rutgers University, Camden, New Jersey. January 01, 1983.
Low, W. C. "Transplantation of Cholinergic Nerve Cells and the Recovery of Function", Department of Physiology, Texas Tech University, Lubbock, Texas. January 01, 1983.
Low, W. C. "Alterations in medial lemniscal field potential responses in spontaneously hypertensive and normotensive Wister-Kyoto rats", Society for Neuroscience Abstracts, 9:545. January 01, 1983.
Low, W. C. "Cross-species septal transplants: Cholinergic enhancement of T-maze performance", Society for Neuroscience Abstracts, 9:859. January 01, 1983.
Low, W. C. "Neural transplants of septal nuclei from fetal mice to the hippocampal formation of adult rats", Anatomical Record, 205:43A . January 01, 1983.
Low, W. C. "Age, sex and strain differences in activity and habituation patterns in SHR and WKY rats", Society for Neuroscience Abstracts, 9:546 . January 01, 1983.
Low, W. C. "Ultrastructural X-ray microanalysis of hippocampal acetylcholinesterase activity derived from septal transplants", Society for Neuroscience Abstracts, 9:860. January 01, 1983.
Low, W. C. "Septal transplants restore spatial memory performance in rats with fornix-fimbria lesions", Proceedings of the International Brain Research Organization, First International Congress. January 01, 1982.
Low, W. C. "Cross-strain transplants of embryonic septum: Survival and specificity of innervation", Society for Neuroscience Abstracts, 8:747. January 01, 1982.
Low, W. C. "Differences in paired pulse potentiation in hippocampal slices from spontaneously hypertensive and Wistar Kyoto rats", Society for Neuroscience Abstracts, 8:328. January 01, 1982.
Low, W. C. " Independence of locomotor activity and blood pressure in adult hypertensive and normotensive rats", Society for Neuroscience Abstracts, 8:433. January 01, 1982.
Low, W. C. "Neural Transplantation", Department of Anatomy, Medical College of Pennsylvania, Philadelphia, Pennsylvania, United States. January 01, 1982.
Low, W. C. "Methods of Transplanting Cholinergic Neurons and the Recovery of Function", Department of Neurosurgery, Tufts University School of Medicine, Boston, Massachusetts. January 01, 1982.
Low, W. C. "Electrophysiological properties of neural transplants reinnervating the denervated rat hippocampus", Neuroscience Letters, Supplement 7:S299. January 01, 1981.
Low, W. C. "Evidence for postsynaptic alterations in paired pulse potentiation of CA1 pyramidal cells in hippocampal slices", Society for Neuroscience Abstracts, 7:887. January 01, 1981.
Low, W. C. "Habituation of motor activity: Genetic and developmental aspects", Society for Neuroscience Abstracts, 7:181. January 01, 1981.
Low, W. C. "Restoration of synaptic and behavioral function with embryonic transplants of cholinergic neurons", Society for Neuroscience Abstracts, 7:259. January 01, 1981.
Low, W. C. "Transplants and drugs", Science 81, 2(3):118. January 01, 1981.
Low, W. C. "Neural Transplantation of Cholinergic Neurons", Department of Physiology and Biophysics, University of Vermont, Burlington, Vermont. January 01, 1981.
Low, W. C. "Behavioral, neural and cardiovascular influences of taurine", Society for Neuroscience Abstracts, 7820. January 01, 1981.
Low, W. C. "Neural Transplantation and the Recovery of Function", Society for Neuroscience, Vermont Chapter, University of Vermont, Burlington, Vermont. January 01, 1980.
Low, W. C. "Electrophysiological Recordings from in vitro Hippocampal Slices", Symposium on State of the Art Techniques in Neuroscience, Society for Neuroscience, 9th Annual Meeting of the Michigan Chapter, East Lansing, Michigan. January 01, 1979.
Low, W. C. "X-ray microanalysis of frozen-hydrated bulk biological specimens: Fundamental considerations", Electron Microscopy 1978, Vol. II, Ed. by J.M. Sturgess, Imp. Press, Ltd. January 01, 1978.
Low, W. C. "A new specimen holder design for X-ray microanalysis of bulk frozen-hydrated biological specimens", Electron Microscopy 1978, Vol. II, Ed. by J.M. Sturgess, Imp. Press Ltd. January 01, 1978.
Low, W. C. "A new procedure for preparing bulk frozen-hydrated biological specimens for X-ray microanalysis", Proceedings of the 13th Annual Conference of the Microbeam Analysis Society, pp. W9A-W9B. January 01, 1978.
Low, W. C. "Synaptic Potentiation of CA1 Pyramidal Cells in Hippocampal Slices", Department of Physiology, Downstate Medical Center, State University of New York, Brooklyn, New York. January 01, 1978.
Low, W. C. "Heterosynaptic potentiation of CA1 neurons in the hippocampal formation: Longitudinal field potential profile analysis of neuronal populations", Society for Neuroscience Abstracts, 3:428. January 01, 1977.
Low, W. C. "Scanning electron microscopy of the hippocampal formation", Proceedings of the Society for Neuroscience, 7th Annual Meeting of the Michigan Chapter. January 01, 1977.
Low, W. C. "Evidence for long-term potentiation in the in vitro hippocampal preparation: Fimbrial-CA1 synaptic activation", Proceedings of the Society for Neuroscience, 7th Annual Meeting of the Michigan Chapter, Abstract 21. January 01, 1977.
Low, W. C. "Heterosynaptic Potentiation of Pyramidal Cells in Hippocampal Slices", Neuroscience Program, University of Michigan, Ann Arbor, Michigan. January 01, 1977.
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Grants & Patents
Selected Grants
Award: "2022-2027 "Generating Exogenic Organs for Transplantation without the Use of Immunosuppression” R01-AI173804, (Co-Principal Investigator)"
Sponsoring Organization: National Institutes of Health
Award: "“Acute and Long-Term Impact of SARS-CoV2 Infection and its Interaction with APOE on Cognitive Function and Neuropathology in Aging and Alzheimer’s Disease”."
Sponsoring Organization: National Institutes of Health
Funded Amount: 3,687,171
Award: "“Gene Therapy for Treating Acute Spinal Cord Injury”"
Sponsoring Organization: State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Program
Funded Amount: 160,000
Award: "“Combined Effects of TBI and Covid19 on Developing Alzheimer’s Disease.”"
Sponsoring Organization: State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Program
Funded Amount: 83,333
Award: "“Impact of Traumatic Brain Injury on Opiate Addiction”"
Sponsoring Organization: State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Program
Funded Amount: 125,000
Award: "“Targeting Trem2 on Monocytes to Regulate Neuroinflammation following Traumatic Brain Injury”"
Sponsoring Organization: State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Program
Funded Amount: 125,000
Award: "“Delivery of Synthetic Zika Virus-Based Peptides for Brain Tumor Vaccine Development”"
Sponsoring Organization: Randy Shaver Cancer Research Community Fund
Funded Amount: 43,500
Award: "“Cell Reprogramming for Spinal Cord Regeneration”"
Sponsoring Organization: State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Program
Funded Amount: 243,000
Award: "“Cell Reprogramming for Traumatic Brain Injury”"
Sponsoring Organization: State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Program
Funded Amount: 125,000
Award: "“Unlocking Chimeric Competency for Regenerative Medicine”"
Sponsoring Organization: Regenerative Medicine Minnesota
Funded Amount: 250,000
Award: "“Technology to Realize the Full Potential of UHF MRI – Rotating Frame MRI Biomarkers to Monitor Alzheimer’s Disease”"
Sponsoring Organization: National Institutes of Health
Funded Amount: 377,216
Award: ""Zika Virus-Based Immunotherapy for Treating Breast Cancer Metastasis to the Brain”"
Sponsoring Organization: Randy Shaver Cancer Research and Community Fund
Funded Amount: 25,000
Award: "“Generating Exogenic Hippocampal Neural Cells via Blastocyst Complementation for Transplantation in Alzheimer’s Disease”"
Sponsoring Organization: National Institutes of Health
Funded Amount: 385,000
Award: "“Microbial Synthesis of Therapeutic Bile Acids”"
Sponsoring Organization: National Institutes of Health
Funded Amount: 422,378
Award: "“Zika Virus-Based Immunotherapy for Treating Malignant Brain Tumors: FDA Enabling Studies”"
Sponsoring Organization: Randy Shaver Cancer Research and Community Fund
Funded Amount: 79,176
Award: "“Modeling and Reversing Alzheimer’s Pathology via Human Brain Organoids”"
Sponsoring Organization: UMN AHC Faculty Research Development Program
Funded Amount: 200,000
Award: ""Magnetic Nanodevice Arrays for the Treatment of Neurological Disorders""
Sponsoring Organization: State of Minnesota University of Minnesota–Mayo Clinic Biotechnology Program
Funded Amount: 913,049
Award: "“Brain Connectome as a Novel Biomarker for Krabbe Disease”"
Sponsoring Organization: Legacy of Angels
Funded Amount: 105,000
Award: "“Stem Cells for Treating Acute Stroke”"
Sponsoring Organization: National Institutes of Health
Funded Amount: 4,209,449
Award: "“Novel Highly Regenerative and Scalable Progenitor Cell Exosomes for Treating Stroke”"
Sponsoring Organization: National Institutes of Health
Funded Amount: 385,923
Award: "“High Density Multielectrode Arrays with Spatially Selective Unidirectional and Rotating Fields for Investigation of Neural Networks – in Alzheimer’s Disease”"
Sponsoring Organization: National Institutes of Health
Funded Amount: 334,020
Award: ""Spinal Cord Regeneration by Cell Reprogramming in Chronic Spinal Cord Injury""
Sponsoring Organization: State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Program
Funded Amount: 151,000
Award: "“Orientation Selective Activation of Neural Circuits of the Limbic System""
Sponsoring Organization: Institute for Engineering in Medicine, University of Minnesota
Funded Amount: 60,000
Award: "“Enhancing Zika Virus-Based Therapies for Treating Malignant Brain Tumors”"
Sponsoring Organization: Randy Shaver Cancer Research and Community Fund
Funded Amount: 50,000
Award: "“Analysis of Stem Cell-derived Extracellular Vesicle Targeting to Sites of Tissue Damage and Cancer”"
Sponsoring Organization: Biomedical Research Awards for Interdisciplinary New Science (BRAINS), University of Minnesota
Funded Amount: 75,000
Patents
Precision Blood Brain Barrier Opening using Dual-mode Transcranial Focused Ultrasound “Precision Blood Brain Barrier Opening using Dual-mode Transcranial Focused Ultrasound” UMN Case Number 2019-309 (2019). Issued: 2019.
Composition for the Prevention and Treatment of Parkinson’s Disease“Composition for the Prevention and Treatment of Parkinson’s Disease” US application number 62/649,892, Metselex (2018) . Issued: 2018.
Orientation Selective and Rotating Field Steering of Electrical Stimulation for Treatment of Malignant Tumors“Orientation Selective and Rotating Field Steering of Electrical Stimulation for Treatment of Malignant Tumors” (2018) . Issued: 2018.
Methods to Treat Mucopolysaccharide Type I for deficiency in Alpha-L-Iduronidase using a Recombinant Adeno-Associated Virus Encoding Alpha-L-Iduronidase“Methods to Treat Mucopolysaccharide Type I for deficiency in Alpha-L-Iduronidase using a Recombinant Adeno-Associated Virus Encoding Alpha-L-Iduronidase, University of Minnesota Docket No. 600.915PRV, Serial No. 61/823,757 (2013).
U.S. Patent No. 9,827,295 (2017) . Issued: 2017.
Methods and Compositions for Treating Glioma and Medulloblastoma Brain Tumors using the Zika Virus “Methods and Compositions for Treating Glioma and Medulloblastoma Brain Tumors using the Zika Virus“ (UMN Docket #920171.00171) (2017). Issued: 2017.
Deuterated Bile Acids“Deuterated Bile Acids”, U.S. Patent No. 9,708,362 (2017) . Issued: 2017.
Vaccine Therapeutic Composition and Methods for Treating or Inhibiting Glioblastoma"Vaccine Therapeutic Composition and Methods for Treating or Inhibiting Glioblastoma”, U.S. Patent Application Serial No.: 61/406,429 (2010)’ PCT/US2011/057654 (2011) U.S. Patent No. 9,364,505 B2 (June 14, 2016) . Issued: 2016.
Engineering of Humanized Dopamine Neurons by Genetic Complementation “Engineering of Humanized Dopamine Neurons by Genetic Complementation”, University of Minnesota and Recombinetics (2015) . Issued: 2015.
Magnetic Brain Array for Neuron Modulation and Mapping“Magnetic Brain Array for Neuron Modulation and Mapping”, University of Minnesota Docket # 20150177 (2015). Issued: 2015.
Use of Human Umbilical Cord Stem Cells to Treat Ischemic Event “Use of Human Umbilical Cord Stem Cells to Treat Ischemic Event”, University of Minnesota, Office of Patents and Technology Marketing, UM Docket 600.623PV (2004). U.S. Patent No. 8,309,070 (2012) . Issued: 2012.
Methods for Treating Vision Disorders “Methods for Treating Vision Disorders”, University of Minnesota, Office of Patents and Technology Marketing, M&R Docket No.: 110.02650160 (2005)
European patent EP1871385 (Granted 2010)
U.S. patent 20080194531 (A1) (pending 2010)
Japan patent number JP 2008530100 (pending 2010). Issued: 2010.
Methods for Treating Vision Disorders “Methods for Treating Vision Disorders”, University of Minnesota, Office of Patents and Technology Marketing, M&R Docket No.: 110.02650160 (2005)
European patent EP1871385 (Granted 2010)
U.S. patent 20080194531 (A1) (pending 2010)
Japan patent number JP 2008530100 (pending 2010) . Issued: 2010.
Methods of Promoting Cell Viability. Issued: 2010.
Mathematical Analyses of Magnetic Resonance Spectroscopy in the Diagnosis, Assessment of Clinical Change, and Metabolic Investigation of Disease “Mathematical Analyses of Magnetic Resonance Spectroscopy in the Diagnosis, Assessment of Clinical Change, and Metabolic Investigation of Disease” UM Docket # 1008-055USP1 . Issued: 2009.
Methods of Treating Injuries of the Nervous System Associated with Hemorrhage. Issued: 2009.
CpGs for treating Brain Tumors. Issued: 2007.
Repair of Ischemic Heart Injury with Cord Blood Stem Cells“Repair of Ischemic Heart Injury with Cord Blood Stem Cells”, UM Docket #Z06124 (2006). 13. “CpGs for treating Brain Tumors”, UM Docket # (2007) . Issued: 2007.
Repair of Ischemic Heart Injury with Cord Blood Stem Cells“Repair of Ischemic Heart Injury with Cord Blood Stem Cells”, UM Docket #Z06124 (2006). Issued: 2006.
Umbilical Cord Blood Stem Cells“Umbilical Cord Blood Stem Cells”, Patent License to Saneron CCEL, Tampa Bay, Florida. Issued: 2005.
Protection Against Nervous System Toxins“Protection Against Nervous System Toxins”, Invention Disclosure, University of Minnesota, Office of Patents and Technology Marketing (2003)
. Issued: 2003.
Insulin-like Growth Factor 1 Receptor (IGF-1R) Antisense Oligonucleotide-Based Vaccine for the Treatment of Breast Tumors. Issued: 1996.
Antisense Oligonucleotides and Methods for Treating Central Nervous System Tumors. Issued: 1996.
GM-CSF Administration for the Treatment and Prevention of Recurrence of Brain Tumors. Issued: 1995.
Methods of Use of Beta1-Integrin Inhibitors.
Methods of Use of B1-Integrin Inhibitors.
Ovarian Cancer Prognosis“Ovarian Cancer Prognosis”, U.S. Patent Application Serial No.: 61/481,556 (2011) .
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Professional Memberships
Genome Writers’ Guild, Member, Ethics Committee
Thesis Defense, University of South Florida, External Chair
NIH Study Section, ZHL1 CSR-H, National Heart Lung and Blood Institute Special Emphasis Panel
American Society for Neural Transplantation and Repair, President-elect
Doctoral Thesis Committee, Stem Cells and Cerebral Ischemia, University of South Florid
Education Committee, American Society for Neural Transplantation and Repair
Society for Neuroscience
American Society for Neural Transplantation, Clinical Practice Committee
American Society for Neural Transplantation and Repair
American Society for Neural Transplantation, Secretary Elect
American Society for Neural Transplantation, Scientific Program Committee
Cell Transplantation Society
Workshop on Scientific Literacy in Neuroscience, Society for Neuroscience
Minnesota Academy of Science
Colloquium on Computational Neuroscience, Satellite Conference of the IEEE International Symposium on Systems, Man and Cybernetics, Technical Committee
International Society of Neuropathology
Stroke Council, American Heart Association National Center
American Physiological Society
European Neuroscience Association
International Brain Research Organization
American Heart Association,
National Research Council, Washington, D.C, Advisory Panel
Society for Neuroscience, National Chapters Delegate
American Association for the Advancement of Science
New York Academy of Sciences
Sigma Xi Scientific Honor Society