Laura Stone, PhD
Administrative Contact
Angela Chen
Executive Office & Admin. Specialist
[email protected]
Address
4-145 Jackson Hall,
321 Church Street SE,
Minneapolis, MN 55455
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Angela Chen
Executive Office & Admin. Specialist
[email protected]
4-145 Jackson Hall,
321 Church Street SE,
Minneapolis, MN 55455
Dr. Laura Stone is a professor in the Department of Anesthesiology at the University of Minnesota. She received a Bachelor of Science in biochemistry from the University of California-San Diego and PhD in neuroscience from the University of Minnesota.
Cholewicki J, Hodges PW, Popovich JM Jr, et al. A meta-model of low back pain to examine collective expert knowledge of treatment effects and their mechanisms. Eur Spine J. Published online May 19, 2026. doi:10.1007/s00586-026-09932-y
Ghazizadeh S, Cherif H, Mannarino M, et al. Senolytic therapy as a preventive strategy for spine degeneration and pain. Adv Sci (Weinh). Published online May 25, 2026:e22770. doi:10.1002/advs.202522770
Rought R, Rodrigues R, Sharif-Naeini R, et al. A new and less invasive surgical approach to the mouse spared nerve injury model of peripheral neuropathic pain. J Neurosci Methods. 2026;431:110751. doi:10.1016/j.jneumeth.2026.110751
Venkatachala Babu J, Puvanesarajah V, Mesfin A, et al. TRPC6-mediated Ca2+ influx activates MAPK and NFκB signaling and elicits pro-inflammatory and catabolic responses in human intervertebral disc cells. Cells. 2026;15(6):534. doi:10.3390/cells15060534
Pruinelli L, Mathiason MA, Ma S, et al. Age differences in patients with postoperative pain and their relationships to comorbid conditions: multivariate logistic regression analysis. AANA J. 2025;93(5):331-337. doi:10.70278/AANAJ/.0000001024
Schorn R, Riedl M, Stone LS, Lee AM, Vulchanova L. Chronic alcohol drinking delays recovery from capsaicin- and nerve injury-induced hypersensitivity in mice. Alcohol. 2025;129:123-133. doi:10.1016/j.alcohol.2025.10.001
Osagie RO, Tufa I, Angarita-Fonseca A, et al. Impact of different acute low back pain definitions on the predictors and on the risk of transition to chronic low back pain: a prospective longitudinal cohort study. Pain. 2025;166(11):e577-e589. doi:10.1097/j.pain.0000000000003669
Roberts JB, Rockel JS, Mulders R, et al. From mechanism to medicine: the progress and potential of epigenetics in osteoarthritis. Osteoarthr Cartil Open. 2025;7(3):100621. doi:10.1016/j.ocarto.2025.100621
Mannarino M, Cherif H, Ghazizadeh S, et al. Senolytic treatment for low back pain. Sci Adv. 2025;11(11):eadr1719. doi:10.1126/sciadv.adr1719
Yeater TD, Kawarai Y, Lee S, et al. Investigating the epigenetic landscape of symptomatic disk degeneration: a case study. Pain Rep. 2025;10(2):e1237. doi:10.1097/PR9.0000000000001237
Kaneda G, Huang D, Pham N, et al. Exercise improves load bearing bone structural properties in female secreted protein acidic and rich in cysteine (SPARC) null mice but not in males. J Orthop Res. 2024;42(12):2725-2734. doi:10.1002/jor.25950
Jenkins LC, Chang WJ, Humburg P, et al. Sex differences in the serum proteomic profile during acute low back pain—a preliminary study of the relationship to future low back pain. J Pain. 2024;25(5):104426. doi:10.1016/j.jpain.2023.11.009
Barbe MF, Chen FL, Loomis RH, et al. Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury. Front Pain Res (Lausanne). 2024;5:1394017. doi:10.3389/fpain.2024.1394017
Koroth J, Chitwood C, Kumar R, et al. Identification of a novel, MSC-induced macrophage subtype via single-cell sequencing: implications for intervertebral disc degeneration therapy. Front Cell Dev Biol. 2023;11:1286011. doi:10.3389/fcell.2023.1286011
Bussières A, Hancock MJ, Elklit A, et al. Adverse childhood experience is associated with an increased risk of reporting chronic pain in adulthood: a systematic review and meta-analysis. Eur J Psychotraumatol. 2023;14(2):2284025. doi:10.1080/20008066.2023.2284025
Whittal M, Poynter S, Samms K, et al. TAK-242 treatment and its effect on mechanical properties and gene expression associated with IVD degeneration in SPARC-null mice. Eur Spine J. 2022;31(10):2669-2679. doi:10.1007/s00586-022-07310-y
Bolt J, Patel F, Stone LS, Pandian D, Manuel M, Gaines N. Impact of COVID-19 on pediatric mental and behavioral health visits to the emergency department. Pediatr Emerg Care. 2022;38(8):e1473-e1478. doi:10.1097/PEC.0000000000002794
Angarita-Fonseca A, Pagé G, Meloto C, et al. The Canadian version of the NIH minimum dataset for chronic low back pain research: reference values from the Quebec Low Back Pain Study. Pain. 2022;163(12):e1150-e1162. doi:10.1097/j.pain.0000000000002703
Millecamps M, Sotocinal S, Austin JS, Stone LS, Mogil JS. Sex-specific effects of neuropathic pain on long-term pain behavior and mortality in mice. Pain. 2022;163(12):e1163-e1173. doi:10.1097/j.pain.0000000000002742
Lee S, Kawarai Y, Ouellet J, Haglund L, Szyf M, Stone LS. DNA methylation in degenerating human intervertebral discs. J Pain. 2022;23(5):824-839. doi:10.1016/j.jpain.2022.03.148
Millecamps M, Gregoire S, Stone LS. Inter- and trans-generational inheritance of paternal chronic pain to male and female offspring in mice. J Pain. 2022;23(5):824. doi:10.1016/j.jpain.2022.03.102
Buck E, Lee S, Gao Q, et al. The role of surface chemistry in the osseointegration of PEEK implants. ACS Biomater Sci Eng. 2022;8(4):1501-1512. doi:10.1021/acsbiomaterials.1c01434
Massé-Alarie H, Angarita-Fonseca A, Lacasse A, et al. Low back pain definitions: effect on patient inclusion and clinical profiles. Pain Rep. 2022;7(2):e0997. doi:10.1097/PR9.0000000000000997
Grégoire S, Cheishvili D, Salmon-Divon M, et al. Epigenetic signature of chronic low back pain in human T cells. Pain Rep. 2021;6(4):e0960. doi:10.1097/PR9.0000000000000960
Kawarai Y, Jang SH, Lee S, et al. Exercise attenuates low back pain and alters epigenetic regulation in intervertebral discs in a mouse model. Spine J. 2021;21(11):1938-1949. doi:10.1016/j.spinee.2021.06.002
Lee S, Jang SH, Suzuki-Narita M, Gregoire S, Millecamps M, Stone LS. Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice. Osteoarthritis Cartilage. 2021;29(10):1478-1489. doi:10.1016/j.joca.2021.06.014
Millecamps M, Lee S, Foster DZ, Stone LS. Disc degeneration spreads: long-term behavioural, histologic and radiologic consequences of a single-level disc injury in active and sedentary mice. Eur Spine J. 2021;30(8):2184-2195. doi:10.1007/s00586-021-06893-2
James G, Millecamps M, Stone LS, Hodges PW. Multifidus muscle fibre type distribution is changed in mouse models of chronic intervertebral disc degeneration, but is not attenuated by whole body physical activity. Spine (Phila Pa 1976). 2021;46(24):E1300-E1308. doi:10.1097/BRS.0000000000004105
Jang S, Millecamps M, Danco A, et al. Effect of voluntary running activity on mRNA expression of extracellular matrix genes in a mouse model of intervertebral disc degeneration. JOR Spine. 2021;4(3):e1148. doi:10.1002/jsp2.1148
Kerr GJ, To B, White I, et al. Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice. Arthritis Res Ther. 2021;23(1):93. doi:10.1186/s13075-021-02463-5
Buck E, Lee S, Stone LS, Cerruti M. Protein adsorption on surfaces functionalized with COOH groups promotes anti-inflammatory macrophage responses. ACS Appl Mater Interfaces. 2021;13(6):7103-7115. doi:10.1021/acsami.0c16509
Whittal MC, Molladavoodi S, Zwambag DP, Millecamps M, Stone LS, Gregory DE. Mechanical consequence of induced intervertebral disc degeneration in the SPARC-null mouse. J Biomech Eng. 2021;143(2):021008. doi:10.1115/1.4047995
Dr. Stone's research interests include the mechanisms of pain, epigenetic regulation of chronic pain, and pharmacological and non-pharmacological methods of treatment.
US Association for the Study of Pain
Orthopedics Research Society
Canadian Pain Socitey
International Association for the Study of Pain
Society for Neuroscience