Laura Stone, PhD

Professor, Department of Anesthesiology

Laura Stone

Contact Info

Mobile Phone 612-422-9880

Mailing Address:
Anesthesiology Administration
420 Delaware Street SEMMC 294
Minneapolis, MN 44544

Lab Address:
Jackson Hall 4-145
321 Church St SE,
Minneapolis, MN 55455

Administrative Assistant Name
Gabi Poor

Administrative Email

Postdoctoral Research Fellow, Vollum Institute, Oregon Health Sciences University, 2000

PhD, Neuroscience, University of Minnesota-Twin Cities, 1999

BS, Biochemistry, University of California-San Diego , 1993


Dr. Stone is a professor in the Department of Anesthesiology at the University of Minnesota Medical School. She received a Bachelor of Science in biochemistry from the University of California-San Diego and PhD in neuroscience from the University of Minnesota-Twin Cities.


Mechanisms of Pain, Epigenetic regulation of chronic pain, Pharmacological and non-pharmacological methods of treatment

Awards & Recognition

2014: International Society for the Study of Lumbar Spine - Best Paper Award (Basic Science Category) – Awarded for the manuscript entitled: “ISSLS Prize Winner: Increased Innervation and Sensory Nervous System Plasticity in a Mouse Model of Low Back Pain due to Intervertebral Disc Degeneration” by M. Miyagi, M. Millecamps, A.T. Danco, S. Ohtori, K. Takahashi and L.S. Stone; Spine 39:1345-1354.

2011:  Quebec Science Top 10 – Selected by Quebec Science Magazine as one of the top 10 scientific discoveries in the province for “Effective treatment of chronic low back pain reverses structural and functional brain changes” by D.A. Seminowicz, T.H. Wideman, L. Naso, Z. Hatami-Khoroushahi, S. Fallatah, M. Ware, P. Jarzem, M.C. Bushnell, Y. Shir, J.A. Ouellet, and L.S. Stone,Journal of Neuroscience, 31(20):7540-7550.

2006:  American Pain Society John C. Liebeskind Early Career Scholar Award - This award recognizes early career achievements that have or show exceptional promise of making an outstanding contribution to pain scholarship. One award per year.

2000:  Association of Neuroscience Departments and Programs Training Fellowship - Awarded to individuals showing outstanding leadership potential.

1999:  John J. Bonica Post-Doctoral Training Fellowship - This training fellowship is awarded annually to one individual by the International Association for the Study of Pain. The 1999 fellowship represented the inaugural award.

1999:  Bacaner Research Award – This award is given annually to recognize excellence in creative research by graduating students in the Medical Sciences.

1998:  Patrick J. Manning Research Award - This award is given annually at the University of Minnesota “In recognition of significant contributions to biomedical research and to the enhancement of the welfare of animals used in research”.

Professional Associations

  • US Association for the Study of Pain (USASP)
  • Orthopedic Research Society & Spine Section
  • Sigma Xi, Scientific Research Society
  • AO Spine Foundation
  • Canadian Neuroscience Association
  • McGill Association of University Teachers
  • Canadian Pain Society
  • American Pain Society
  • International Association for the Study of Pain
  • Society for Neuroscience


Research Summary/Interests

Current research in progress: On-Going, "ACTTION: Pre-Clinical Reproducibility Study". Lead Investigator of a multi-site pre-clinical study to examine the reproducibility of pre- clinical pain studies. Funded by">">"></a>.

 October 2018 - Present


  1. Grégoire, S., Cheishvili, D., Salmon-Divon, M., Dymov, S., Topham, L., Calderon, V., Shir, Y., Szyf, M., & Stone, L. S. (2021). Epigenetic signature of chronic low back pain in human T cells. Pain reports, 6(4), e960. PMID: 34746619 PMCID: PMC8568391 doi: 10.1097/PR9.0000000000000960
  2.  Kawarai, Y., Jang, S. H., Lee, S., Millecamps, M., Kang, H., Gregoire, S., Suzuki-Narita, M., Ohtori, S., & Stone, L. S. (2021). Exercise attenuates low back pain and alters epigenetic regulation in intervertebral discs in a mouse model. The spine journal : official journal of the North American Spine Society, 21(11), 1938-1949. PMID: 34116218 doi: 10.1016/j.spinee.2021.06.002
  3.  Lee, S., Jang, S. H., Suzuki-Narita, M., Gregoire, S., Millecamps, M., & Stone, L. S. (2021). Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice. Osteoarthritis and cartilage. PMID: 34534663 doi: 10.1016/j.joca.2021.06.014
  4. Millecamps, M., Lee, S., Foster, D. Z., & Stone, L. S. (2021). Disc degeneration spreads: long-term behavioural, histologic and radiologic consequences of a single-level disc injury in active and sedentary mice. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the
    Cervical Spine Research Society. PMID: 34216236 doi: 10.1007/s00586-021-06893-2
  5. Kawarai, Y., Jang, S. H., Lee, S., Millecamps, M., Kang, H., Gregoire, S., Suzuki-Narita, M., Ohtori, S., & Stone, L. S. (2021). Exercise attenuates low back pain and alters epigenetic regulation in intervertebral discs in a mouse model. The spine journal : official journal of the North American Spine Society. PMID: 34116218 doi: 10.1016/j.spinee.2021.06.002
  6. James, G., Millecamps, M., Stone, L. S., & Hodges, P. W. (2021). Multifidus Muscle Fibre Type Distribution is Changed in Mouse Models of Chronic Intervertebral Disc Degeneration, but is not Attenuated by Whole Body Physical Activity. Spine. PMID: 33973565 doi: 10.1097/BRS.0000000000004105
  7. Kerr, G. J., To, B., White, I., Millecamps, M., Beier, F., Grol, M. W., Stone, L. S., & Séguin, C. A. (2021). Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice. Arthritis research & therapy, 23(1), 93. PMID: 33752736 PMCID: PMC7983381 doi: 10.1186/s13075-021-02463-5
  8. Buck, E., Lee, S., Stone, L. S., & Cerruti, M. (2021). Protein Adsorption on Surfaces Functionalized with COOH Groups Promotes Anti-inflammatory Macrophage Responses. ACS applied materials & interfaces, 13(6), 7021-7036. PMID: 33539069 doi: 10.1021/acsami.0c16509
  9. Whittal, M. C., Molladavoodi, S., Zwambag, D. P., Millecamps, M., Stone, L. S., & Gregory, D. E. (2021). Mechanical Consequence of Induced Intervertebral Disc Degeneration in the SPARC-Null Mouse. Journal of biomechanical engineering, 143(2). PMID: 32734296 doi: 10.1115/1.4047995