Anna Prizment

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Credentials

PhD, MPH

Bio

Dr. Prizment is a chronic disease epidemiologist who studies blood, tissue, and genetic biomarkers in cancer, dementia and other age-related diseases. Two main areas of Dr. Prizment’s research are: (1) inflammation and immune responses associated with cancer, with a main focus on gastrointestinal cancers in large observational studies and clinical trials; and (2) the role of biomarkers of aging in predicting chronic disease, particularly cancer risk and outcomes after cancer diagnosis. Dr. Prizment is a Principal Investigator of the NIH/NCI fNCI-fundedunded study on functional mutations in the CFTR (Cystic fibrosis transmembrane conductance regulator) gene in colorectal cancer. Recently, she has expanded her research into studying biological aging in cancer and other chronic diseases. Her NCI R01 and NIA R21 projects utilized a novel aging construct — a proteomic aging clock based on the SomaScan proteomic data of 5000 proteins in ARIC and validated its performance in Multi-Ethnic Study of Atherosclerosis (MESA). R01 examines proteomic aging clock as a predictor of cancer risk and mortality and frailty after cancer diagnosis, while R21 studies proteomic aging clock in relation to dementia risk and cognitive changes.  Dr. Prizment is a member of the “Measures” core in the NIH-funded Cancer and Aging Research Group.

Research Summary

• The immune response and survival of colorectal patients
• Role of germline mutations in colorectal and pancreatic cancers
• Clinical trials on anti-inflammatory agents and gut microbiome
• Quality of life and cardiovascular health of cancer patients
• Role of obesity, diabetes and other comorbidities in cancer development and survival 
• Role of androgen in prostate cancer

Publications

PubMed article list

Polter EJ, Blaes A, Wolfson J, Lutsey PL, Florido R, Joshu CE, Guha A, Platz EA, Prizment A. Performance of the pooled cohort equations in cancer survivors: the Atherosclerosis Risk in Communities study. J Cancer Surviv. 2024;18(1):124-134. PMID: 37140677.

Prakash A, Rubin N, Staley C, Onyeaghala G, Wen J, Shaukat A, Ginger Milne G, Straka R, Church TR, Prizment A. Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma. Sci Rep. 2024;14(1):2988. PMID: 38316805

Casanova R, Walker KA, Justice JN, Anderson A, Duggan MR, Cordon J, Barnard RT, Lu L, Hsu FC, Sedaghat S, Prizment A, Kritchevsky SB, Wagenknecht LE, Hughes TM. Associations of plasma proteomics and age-related outcomes with brain age in a diverse cohort. GeroScience. 2024; Online ahead of print. PMID: 38438772

Wang S, Rao Z, Cao R, Blaes AH, Coresh J, Joshu CE, Lehallier B, Lutsey PL, Pankow JS, Sedaghat S, Tang W, Thyagarajan B, Walker KA, Ganz P, Platz EA, Guan W, Prizment A. Development and Characterization of Proteomic Aging Clocks in the Atherosclerosis Risk in Communities (ARIC) Study. 2023. medRxiv [Preprint]. 2023:2023.09.06.23295174.

Seshadri G, Vivek S, Prizment A, Crimmins EM, Klopack ET, Faul J, Guan W,Meier HCS, Thyagarajan B. Immune cells are associated with mortality: the Health and Retirement Study. Front Immunol. 2023;14:1280144. PMID: 37928548

Vivek S, Crimmins EM, Prizment AE, Meier HCS, Ramasubramanian R, Barcelo H, Faul J, Thyagarajan B. Age-related Differences in T-cell Subsets and Markers of Subclinical Inflammation in Aging Are Independently Associated With Type 2 Diabetes in the Health and Retirement Study. Can J Diabetes. 2023;47(7):594-602.e6PMID: 37269981

Wang S, Onyeaghala GC, Pankratz N, Nelson HH, Thyagarajan B, Tang W, Norby FL, Ugoji C, Joshu CE, Gomez CR, Couper DJ, Coresh J, Platz EA, Prizment AE. Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC). Cancer Epidemiol Biomarkers Prev. 2023;32(6):784-794. PMID: 36958849

Teaching Summary

Courses

• PUBH 6355
  Pathophysiology of Human Disease (Cancer Unit)