Anna Zilverstand

Biography

I am a psychologist and neuroimaging expert, a faculty member in the Department of Psychiatry and Behavioral Science, and a member of the Medical Discovery Team on Addiction. I received my PhD from Maastricht University in the Netherlands, where I developed fMRI-based neurofeedback training protocols for three different clinical populations. During my postdoctoral training at Mount Sinai, New York, I focused on the potential for personalized medical treatments in human drug addiction, investigating novel approaches for individualized treatments in cocaine-addicted individuals.

My current work focuses on establishing the existence of neurobiological subtypes in different addicted human populations, with the goal of developing individualized brain-based and technology-supported treatments for human drug addiction. My research group combines the analysis of existing large-scale multimodal data sets with the acquisition of new data through a variety of techniques such as interviewing, neurocognitive testing, questionnaires, and multi-modal neuroimaging. Novel computational methods are employed for linking social, demographic, neurocognitive, personality, and clinical measures to the neuroimaging data, to explore the existence of neurobiological subtypes within the addicted population. The goal of this research is to develop a neuroscience-derived individualized treatment for individuals who are at risk for either escalation of drug use or relapse. Within the department, I am a member of the Grand Rounds Committee.

Expertise

Large-scale multimodal data sets
MRI
Human drug addiction treatment

Administrative Assistant

(for academic support only)
Shelly Slominski
slomi001@umn.edu

In the Media

2023: Dr. Zilverstand and her research team are featured in this article titled, “NIH grant enabling U of M team to identify factors involved in alcohol use disorder relapse following treatment.”
2023: Quoted in this Mpls Star Tribune article titled, “As Minnesota considers legalizing marijuana, what does research say about the risks?
2021: Dr. Zilverstand’s work with a national study is highlighted in this KSTP story titled, “U of M team leading 'largest study of early childhood brain development”. Her testimony before the Minnesota legislature earlier this year helped make the state’s portion of the study possible.
2021: Helped change a law to get some important research started in this article titled, “Lobbying Efforts Lead to Research Opportunities on the Effects of Substance Use on Families”.

Languages

Dutch

French

German

Spanish

Education

Publications

Selected Publications

Konova, A.B., Zilverstand, A., 2023. Deriving generalizable and interpretable brain-behavior phenotypes of cannabis use. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 8 (3): 238-240.
doi: https://doi.org/10.1016/j.bpsc.2023.01.003
PubMed ID: 36889869

Manea, A., Zilverstand, A., Ugurbil, K., Heilbronner, S., Zimmerman, J., 2022. Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain. eLife, 11 (e75540)
doi: https://doi.org/10.7554/elife.75540
PubMed ID: 35234612

Song*, S., Zilverstand*, A., Gui, W., Pan, X., Zhou, X, 2022. Reducing craving and consumption in individuals with drug addiction, obesity, or overeating through neuromodulation intervention: A systemic review and meta-analysis of its follow-up effects. Addiction, 117 (5): 1242-1255.
doi: https://doi.org/10.1111/add.15686
PubMed ID: 34514666

Niklason, G., Rawls, E., Ma, S., Kummerfeld, E., Maxwell, A.M., Brucar, L.R., Drossel, G., Zilverstand, A., 2022. Explainable Machine Learning Analysis Reveals Gender Differences in the Phenotypic and Neurobiological Markers of Cannabis Use Disorder. Scientific Reports, 12 (1): 15624.
doi: https://doi.org/10.1038/s41598-022-19804-2
PubMed ID: 36115920

Maxwell, A.M., Harrison, K., Rawls, E., Zilverstand, A. , 2022. Gender differences in the psychosocial determinants underlying the onset and maintenance of Alcohol Use Disorder. Frontiers in Neuroscience, 16: 808776.
doi: https://doi.org/10.3389/fnins.2022.808776
PubMed ID: 35360152

Parvaz, M., Malaker, P., Zilverstand, A., Moeller, S., Alia-Klein, N., Goldstein, R., 2021. Attention bias modification in drug addiction: Enhancing control of subsequent habits. Proceedings of the National Academy of Sciences, 118 (23): e2012941118.
doi: https://doi.org/10.1073/pnas.2012941118
PubMed ID: 34074751

Yacoub, E., Grier, M., Auerbach, E., Lagore, R., Harel, N., Adriany, G., Zilverstand, A., Hayden, B., Heilbronner, S., Ugurbil, K., Zimmerman, J, 2020. Ultra-high field (10.5 T) resting state fMRI in the macaque. Neuroimage, 223 (117349)
doi: https://doi.org/10.1016/j.neuroimage.2020.117349
PubMed ID: 32898683

Wang, C., Song, S., d’Oleire Uquillas, F., Zilverstand, A., Song, H., Chen, H., Zou, Z., 2020. Altered brain network organization in romantic love as measured with resting-state fMRI and graph theory.. Brain Imaging and Behavior, 14 (6): 2771-2784.
doi: https://doi.org/10.1007/s11682-019-00226-0
PubMed ID: 31898089

Zilverstand, A., et al., 2019. A roadmap for integrating neuroscience into addiction treatment: A consensus of the neuroscience interest group of the international society of addiction medicine. Frontiers in Psychiatry, 10: 877.
doi: https://doi.org/10.3389/fpsyt.2019.00877
PubMed ID: 31920740

Colicino, E., Hazeltine, D., Schneider, K., Zilverstand, A., Bachi, K., Alia-Klein, N., Goldstein, R., Todd, A., Horton, M., 2019. Cocaine addiction severity exacerbates the negative association of lifetime lead exposure with blood pressure levels: Evidence from a pilot study. Environmental Disease , 4 (3): 75-80.
doi: https://doi.org/10.4103/ed.ed_21_19
PubMed ID: 33490759

Research

Awards, Honors and Recognitions

Presentations

Zilverstand, A. K. "Computational Approaches for Understanding Drug Addiction", Yale University - Division of Addiction, New Haven, Connecticut. May 03, 2023.

Zilverstand, A. K. "Computational Approaches for Understanding Drug Addiction", Bethesda, Maryland. April 21, 2023.

Zilverstand, A. K. "Computational Approaches for Understanding Drug Addiction", International Symposium on Addiction Research, Queretaro, Mexico. March 01, 2023.

Zilverstand, A. K. "Computational Approaches for Understanding Drug Addiction", Healthy Brain and Mind Research Center, Australian Catholic University, Melbourne, Australia. November 02, 2022.

Zilverstand, A. K. "Data-mining of public data sets for understanding the complex factors underlying human drug addiction", New York State Psychiatric Institute at Columbia University, New York, New York. July 28, 2022.

Zilverstand, A. "Subtypes in Addiction and their Neurobehavioral Impairments in Approach Behavior, Negative Emotionality and Executive Function", Research Society on Alcoholism (RSA) Scientific Meeting, Orlando, Florida. June 27, 2022.

Gunner, D., Zilverstand, A. "Subtypes in Individuals with Current Cocaine Use Disorder and their Impairments in Negative Emotionality and Executive Function", Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD), Minneapolis, Minnesota. June 15, 2022.

Niklason, G., Zilverstand, A. "Family, neighborhood and individual factors linked to early sipping as identified by machine learning analysis", Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD), College on Problems of Drug Dependence (CPDD), Minneapolis, Minnesota. June 13, 2022.

Zilverstand, A. "An Empirically Derived Neurobehavioral Three-domain Model Underlying Addiction-general Subtypes: Implications for Personalized Addiction Medicine", Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD), Minneapolis, Minnesota. June 12, 2022.

Zilverstand, A. "Meta-Analytical Evidence for the Short- and Long-Term Efficacy of Neuromodulation of the Dorsolateral Prefrontal Cortex in Drug Addiction and Excessive Eating", Annual Meeting Society of Biological Psychiatry, Society of Biological Psychiatry (SOBP), New Orleans, Louisiana. April 29, 2022.

Anna Zilverstand, PhD

Address

Biography

Expertise

Administrative Assistant

In the Media

Education

Publications

Research

Awards, Honors and Recognitions

Presentations

Professional Memberships

Clinical Summary

Anna Zilverstand, PhD

Address

+ Biography

+ Education

+ Publications

+ Research

+ Awards, Honors and Recognitions

+ Presentations

+ Professional Memberships

+ Clinical Summary

Biography

Education

Publications

Research

Awards, Honors and Recognitions

Presentations

Professional Memberships

Clinical Summary