Benjamin Clarke
,
Credentials
PhD

Professor
Faculty, PhD Program in Biochemistry, Molecular Biology and Biophysics
Biography

Research Summary

1) Endocrinology: Investigating the role of pituitary hormones as immunomodulators and regulators of development.

2) Lyme disease: Characterizing the entrance of Borrelia burgdorferi into macrophage by non-opsonic mechanisms.

3) Development of active learn tools to teach biomedical concepts

Research Interests
endocrinology
lyme disease

Teaching Summary

Membrane Biology 
Receptor Biology
Immunology

Mentoring/Advising: undergraduate & graduate students

Courses Taught

Biochemistry Laboratory, Chem 5361
Immunobiology, MicB 5545
Immunopathology, MicB 5546
Molecular Pathogenesis, MicB 5555
Advanced Immunology and Immunobiology, MicB 8554
Evolution of Host Defenses, IBS 8980
Cell, Molecular and Developmental Biology, IBS 8102
The Biological Practitioner, IBS 8099
Medical School Immunology, MED 6541, MED 6520, MED 6724
Problem Based Learning Facilitator, Neuromedicine and IHO, MED 6566/6728

Service Summary

Lyme Disease Support; St. Luke’s Hospital
National Alliance for the Mentally Ill (NAMI)
Toastmasters International

Education

PhD, University of Texas Medical Branch
Major: Biochemistry
BS, University of South Florida
Major: Clinical Chemistry
BA, University of South Florida
Major: Biology
AA, Miami-Dade College
Major: Liberal Arts

Fellowships, Residencies, and Visiting Engagements

Fellow, Fellowship
American Association for the Advancement of Science and Society for the Advancement of Chicanos/Hispanics and Native Americans
Senior Postdoctoral Fellow, Fellowship
University of Minnesota
Postdoctoral Fellow, Fellowship
University of Texas System Cancer Center

Honors and Recognition

Mentor Training, University of Minnesota NIH Proposal Preparation Program
2014
Scholarship: Facilitation Role for Entering Mentoring Workshop, Institute for Clinical and Translational Research, University of Wisconsin-Madison
2013
Awarded Scholarship, SACNAS 2010 Summer Leadership Institute
2010
Travel Scholarship, Washington University School of Medicine
2006
Travel Scholarship, Washington University School of Medicine
2002
Awarded Scholarship, Workshop: Write Winning Grants, The Federation of American Societies for Experimental Biology and The Minority Access to Research Careers
1999
Minnesota Nominee for the 1996 Camille and Henry Dreyfus Teacher-Scholar Award (National)
1996
Travel Award, Minorities Affairs Committee of the ASCB
1992
Awarded Scholarship, Monoclonal Antibodies and Immunocytochemistry, Minorities Affairs Committee, ASCB
1990
Graduate Research Assistantship
1986
Gip A. Hudson Memorial Award, 1986 National Student Research Forum
1986
Shirley Patricia Parker Memorial Award
1985

Professional Memberships

ASCB Minority Affairs Committee
2015-2021
American Chemistry Society
American Society for Cell Biology
American Indian Science and Engineering Society
Society for the Advancement of Chicanos/Hispanics and Native Americans in Science
American Society for Biochemistry and Molecular Biology
Endocrine Society
The Association of American Indian and Alaska Native Professors
The American Association for Immunology
American Association for the Advancement of Science
Selected Presentations

Selected Presentations

Redbrook, S., Little, C., Clarke, B. L. "Borrelia burgdorferi entry into an internal compartment in various vertebrate cell types", 2018 American Society for Cell Biology, January 01, 2018.
Clarke, B. L., Boyce, M. "Hitting the ground running: Early success in graduate medical school", Career Development Session, American Society for Cell Biology and the European Molecular Biology Organization, San Diego, California, January 01, 2018.
Clarke, B. L. "Penetration of Borrelia burgdorferi into vertebrate cells", SACNAS 2017, Society for the Advancement of Chicanos/Hispanics and Native Americans in Science, Salt Lake City, Utah, January 01, 2017.
Clarke, B. L. "Voyage from community college to STEM professional and transitions along the way panel", SACNAS 2017, Society for the Advancement of Chicanos/Hispanics and Native Americans in Science, Salt Lake City, Utah, January 01, 2017.
Finlon, J., Clarke, B. L. "Borrelia burgdorferi entering into RAW macrophage establish a refuge compartment", American Society for Cell Biology, Molecular Biology of the Cell , January 01, 2016.
Clarke, B. L. "Native American reception panel", SACNAS 2016, Society for the Advancement of Chicanos/Hispanics and Native Americans in Science, Long Beach, California, January 01, 2016.
Walker, M., Ragan, R., Regal, R., Boyd, C., Clarke, B. L., Prunuske, A. "Factors supporting undergraduate biology degree completion at a regional public university", Society for the Advancement of Biology Education Research (SABER), University of Minnesota-Twin Cities, Minneapolis, Minnesota, January 01, 2016.
Clarke, B. L. "Developing professional skill and critical reasoning to improve American Indian participation in biomedical research", 2013 American Society for Cell Biology Annual Meeting, New Orleans, Louisiana, January 01, 2013.
Clarke, B. L. "Herd immunity: Does not mean take your chances", Minnesota State Science Teachers Association, March 01, 2012.
Prunuske, A. J., Wilson, J., Walls, M., Regal, R., Trachte, G., Clarke, B. L. "Investigation of benefits and challenges of mentoring undergraduates from underrepresented groups", Molecular Biology of the Cell, January 01, 2012.
Mayasich, S. A., Clarke, B. L. "Characterization of vasotocin hormone and two receptors in the sea lamprey (Petromyzon marinus)", ENDO 2012, January 01, 2012.
Clarke, B. L., Gillespie, M., Peterson, S., Williams, P. "Co-culture of splenic lymphocytes with bone marrow derived dendritic cells boost mitogen activation of T cells in vitro", 2006 AAI National meeting, January 01, 2006.
Clarke, B. L. "Effects of acute stress on inflammation", UMD Biology Department Seminar, Duluth, Minnesota, November 01, 2005.
Clarke, B. L., Wittmers, L. E. "Using problem-based learning in graduate school curriculum to teach current concepts in immunology", International Association of Medical Science Educators, January 01, 2005.
Kane, T. M., Moen, S. T., Clarke, B. L. "Functional melanocortin 5 receptors (MC5-R) are expressed on dendritic cells", ASCB Meetings, January 01, 2003.
Clarke, B. L. "Adrenocorticotropic hormone modulation of Interleukin 2 production by rat lymphocytes: A nexus between stress and inflammation", MARC/RISE Seminar Series , San Francisco State University, January 01, 2003.
Clarke, B. L. "American Indians entering into the sciences: My 12 years experiences about a 510 year story", Sigma Xi Symposia, Sigma Xi Duluth Chapter, Duluth, Minnesota, January 01, 2002.
Clarke, B. L. "Global perspectives on international terrorism", University of Minnesota Duluth, Duluth, Minnesota, January 01, 2002.
Clarke, B. L. "Science careers for Native Americans", American Indian Science and Engineering Society Regional Conference, Fond du Lac Tribal and Community College, Cloquet, Minnesota, January 01, 2002.
Clarke, B. L. "Native Americans in biomedical research", Minority International Research Training Program Annual Network Meeting, Tucson, Arizona, January 01, 2002.
Zimmer, S. L., Dominguez, F. X., LaTocha, D. H., Clarke, B. L. "Adrenocorticotropic hormone regulates IL-2 production in rat splenic lymphocytes by controlling calcium influx", FASEB Journal, January 01, 2002.
Clarke, B. L., Gillespie, M. A. "Identification of an internal and cell-surface pool of melanocortin 5 receptors on rat lymphocytes: Evidence for receptor recycling", ASCB Meetings, January 01, 2002.
Dominguez, F. X., Clarke, B. L. "Verapamil R(+) blocks lymphocyte activation by a mechanism not related to calcium influx", ABRCMS Conference, January 01, 2001.
Clarke, B. L., Gillespie, M. A., Dominguez, F. X., LaTocha, D. H. "ACTH activates lymphocytes by a Verapamil sensitive signal transduction pathway", FASEB Journal, January 01, 2001.
Zimmer, S. L., Clarke, B. L. "Adrenocorticotropic hormone modulates IL-2 production by rat lymphocytes by a Nickel and Verapamil sensitive pathway", Molecular Biology of the Cell, January 01, 2001.
Drewett, J. G., Zimmer, S. L., Clarke, B. L. "Expression of melanocortin-5 receptor reveals agonist-stimulated human aldosteronogenesis", FASEB Journal, January 01, 2000.
Zimmer, S. L., LaTocha, D. A., Clarke, B. L. "Adrenocorticotropic hormone modulation of lymphocyte activation is mediated by a Verapamil (+) isomer sensitive mechanism", FASEB Journal, January 01, 2000.
Akbulut, S., Zimmer, S. L., Clarke, B. L. "Adrenocorticotropic hormone stimulates the JAK/STAT pathway in isolated rat splenic lymphocytes", FASEB Journal, January 01, 2000.
Cannedy-Clarke, M. M., Smith, R. J., Clarke, B. L. "Development of a Bridges Program targeted to a small population", NIH-Bridges Directors Meeting, January 01, 1999.
Clarke, B. L. "American Indians in science", Lac Courte Oreilles Ojibwa Community College, Hayward, Wisconsin, January 01, 1998.
Clarke, B. L. "Recruitment of students from small pools", Minorities Opportunities in Research and Education Meetings, National Institutes of Health, Bethesda, Maryland, January 01, 1998.
Gillespie, M. A., Clarke, B. L. "Adrenocorticotropic hormone inhibits concanavalin A induced apoptosis in rat splenic lymphocytes: A cell cycle analysis", Molecular Biology of the Cell, January 01, 1998.
Zimmer, S. L., Clarke, B. L. "Expression of the melanocortin MC5 receptor (MCR5) in HeLa cells: The role of the C-tail vicinal cystinyl groups in signal transduction", Molecular Biology of the Cell, January 01, 1998.
Clarke, B. L. "Can Native Americans develop an industry using natural medicine?", Holistic Approaches to Healing: A Cross-Cultural Symposium, Lac Courte Oreilles Ojibwa Community College, Hayward, Wisconsin, January 01, 1997.
Gillespie, M. A., Freed, A., Clarke, B. L. "Adrenocorticotropic hormone rescues concanavalin A treated lymphocytes from apoptosis", Molecular Biology of the Cell, January 01, 1997.
Byersdorfer, C. A., Clarke, B. L. "Identification of the MC5 receptor on rat splenocytes", Molecular Biology of the Cell, January 01, 1996.
LaTocha, D. H., Clarke, B. L. "The effects of verapamil stereoisomers on concanavalin A stimulated calcium uptake in isolated rat splenocytes", SACNAS Conference, January 01, 1996.
Clarke, B. L. "Adrenocorticotropin hormone as a mediator of stress and immunity: A rational hypothesis for the mind-body problem", SACNAS 1996, Society for the Advancement of Chicanos/Hispanics and Native Americans in Science , Los Angeles, California, January 01, 1996.
Clarke, B. L. "Welcome speech", American Indian and Alaskan Native Student Awards Banquet, University of Minnesota Duluth, Duluth, Minnesota, January 01, 1995.
Clarke, B. L. "Signal transduction in lymphocytes due to ACTH stimulation", Psychoneuroimmunology and Addiction Seminar, University of Minnesota, Minnea, Minnesota, January 01, 1995.
Clarke, B. L. "Immunoendocrinology: The role of adreno-corticotropic hormone as a cytokine and a hormone", Chemistry Seminar, Department of Chemistry, University of Minnesota Duluth, Duluth, Minnesota, January 01, 1995.
Clarke, B. L. "The paracrine properties of immune derived corticotropin", Division of Endocrinology, Brown University School of Medicine, Providence, Rhode Island, January 01, 1994.
Hageman, G. R., Simor, T., Jarpe, M., Clarke, B. L., Blalock, J. E. "Effects of a peptide mimetic of calcium upon the neural regulation of sinus rate and atrial contractile force", 32nd International Congress of Physiological Sciences, Glasgow, Scotland. January 01, 1993.
Clarke, B. L., Moore, D. R., Blalock, J. E. "Calcium uptake by adrenocorticotropin-stimulated rat lymphocytes requires channel activity and membrane fluidity", Molecular Biology of the Cell, January 01, 1993.
Clarke, B. L. "Paracrine properties of immune-derived corticotropin", Seminar Series, Dept. of Microbiology & Immunology, Louisiana State University Medical Center, New Orleans, Louisiana, January 01, 1993.
Clarke, B. L., Blalock, J. E. "Corticotropin stimulates a calcium influx that regulates rat lymphocyte cAMP and cGMP levels", Molecular Biology of the Cell, January 01, 1992.
Clarke, B. L. "The differential modulation of lymphocyte activity by corticotropin", Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine, School of Medicine, Tufts University, Boston, Massachusetts, January 01, 1991.
Clarke, B. L., Lyons, P. D., Carr, D. J., Blalock, J. E. "Corticotropin-induced nucleotide cyclase activity in isolated rat lymphocytes", Journal of Cell Biology, January 01, 1991.
Clarke, B. L., Blalock, J. E., Gebhardt, B. M. "Mitogen-stimulated lymphocytes secrete biologically active corticotropin in a co-culture system", FASEB Journal, January 01, 1991.
Clarke, B. L., Swords, B. H., Blalock, J. E., Leboeuf, R. D. "Antisense oligonucleotides block expression of arginine vasopressin and adrenocorticotropic hormone receptors", Journal of Cell Biology, January 01, 1990.
McAbee, D. D., Oka, J. A., Clarke, B. L., Lear, M., Weigel, P. H. "Redistribution and inactivation/reactivation of a subset of rat hepatic galactosyl receptors are uncoupled and differentially affected by various inhibitors", Journal of Cell Biology, January 01, 1989.
Clarke, B. L., Bost, K. L. "Adrenocorticotropic hormone stimulates protein phosphorylation in isolated rat lymphocytes", Journal of Cell Biology, January 01, 1989.
Burkart, M. F., Clarke, B. L., Shur, B. D., Shaw, D. R., Marchase, R. B. "Beta phosphorothioate analogues of nucleotide sugars are resistant to hydrolytic degradation but utilized efficiently by glycosyltransferases", Journal of Cell Biology, January 01, 1989.
Clarke, B. L., Bost, K. L. "A monoclonal anti-peptide antibody recognizes the ACTH receptor on rat adrenal cells", FASEB Journal, January 01, 1989.
Clarke, B. L. "Keynote speaker", Summer Student Awards Banquet, Center for American Indian and Minority Health, University of Minnesota Duluth, Duluth, Minnesota, January 01, 1989.
Gottlieb, R. A., Knowles, R. D., Clarke, B. L., Lachman, L. B., Dinarello, C. A., Lennarz, W. J., Kleinerman, E. S. "A heptadecapeptide homologous to retroviral envelope proteins blocks the action of interleukin-1", American Association of Cancer Research, January 01, 1988.
Clarke, B. L., Lennarz, W. J. "Topology of mannosyl- and glucosyl-phosphoryl-dolichol synthases in sealed microsomes from chicken oviduct", Journal of Cell Biology, January 01, 1987.
Weigel, P. H., Clarke, B. L., Oka, J. A. "Endocytosis and ligand dissociation and degradation mediated by the hepatic galactosyl receptor occur via two different pathways", Federation Proceedings, January 01, 1986.
Clarke, B. L., Weigel, P. H. "Asialoglycoprotein receptors can mediate protein degradation by two different pathways in isolated rat hepatocytes", Journal of Cell Biology, January 01, 1985.
Weigel, P. H., Clarke, B. L., Oka, J. A. "Surface and intracellular galactosyl receptor activity is reversibly decreased by metabolic energy poisons", Journal of Cell Biology, January 01, 1984.
Oka, J. A., Clarke, B. L., Weigel, P. H. "The internal pool of slowly dissociating receptor asialoglycoprotein complexes return to the cell surface prior to dissociating", Journal of Cell Biology, January 01, 1983.
Clarke, B. L., Weigel, P. H. "Effects of metabolic energy poisons on endocytosis mediated by the asialoglycoprotein receptor", Journal of Cell Biology, January 01, 1982.