Dr. Hirsch has two major areas of research focus: chromosome instability and the cytogenomic landscape of myeloid and lymphoid neoplasms. The University of Minnesota has a comprehensive Fanconi anemia center, and her laboratory has been involved in the development of methods and algorithms for diagnosis of FA, for differentiating subtypes of FA, and for monitoring for emergence of clinically significant clones that may herald the development of myelodyspalstic syndrome, leukemia., and/or solid tumors. As a member of the Children's Oncology Group cytogenetic and myeloid disease committees, she reviews all cytogenetic analyses performed on patients enrolled on myeloid studies, in addition to developing biology studies aimed at improving risk stratification for pediatric AML, and elucidating factors involved in disease progression. Additionally, as the Director of a research Cytogenomics Core resource of a Cancer Genomics Center, her laboratory has facilitated the research of investigators at the University of Minnesota's Masonic Cancer Center and other Cancer Centers that require seamless integration of techniques to pursue studies of tumorgenesis.
