Carl McGary, PhD, MD

Assistant Professor, Medical School, Duluth Campus

Carl McGary

Contact Info

cmcgary@d.umn.edu

Office Phone 218-726-8003

Office Address:
Department of Biomedical Sciences
SMed 227
1035 University Drive
Duluth, MN 55812

Assistant Professor, Medical School, Duluth Campus

Department of Biomedical Sciences


College of American Pathologists

Member, American Society for Clinical Pathology

Member, United States and Canadian Academy of Pathology


MD, Pennsylvania State University, The Milton S. Hershey Medical Center, 1988-1990

Resident Physician in Anatomic Pathology, The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Department of Pathology, Hershey, PA 17033, 1990-1994

Fellow in Anatomic Pathology (Surgical Pathology and Cytopathology), The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, 1995-1995

M.D.- Ph.D. Combined Degree Program, The University of Texas Medical Branch, School of Medicine and Graduate School of Biomedical Sciences, 1983-1988

Doctor of Philosophy, Chemistry and Genetics, Galveston, Texas 77550, August 1988

BS in Biology, Slippery Rock University of Pennsylvania, 1979-1983

Postdoctoral Research in metastasis, Danny R. Welch, Ph.D., Division of Experimental Pathology, The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 1703, 1993-1994

Summary

Awards & Recognition

2009-Minnesota Monthly Top Doctor for Women

1998-Eric A. Schenk Award for Excellence in Teaching, In Recognition of Exceptional Contributions for Pathology Education. University of Rochester Medical Center Department of Pathology and Laboratory Medicine, $500.00.

1997-1998 Buswell Research Fellowship, University of Rochester, $8,000

1993-1994 Listed in American Men and Women of Science

1989-Rose and Harry Walk Research Award Graduate School of Biomedical Sciences, UTMB, Galveston, Texas 77550

1983-Slippery Rock University Alumni Association Outstanding Senior Man Award

1983-Award by the Association of Pennsylvania State College and University Biologists for Outstanding Senior Biology Major at Slippery Rock University

1982-Who's Who Among Students in American Universities and Colleges

Professional Associations

  • 2016-17 Health East Provider Informatics Council
  • 2013-15 EPIC- Anatomic Pathology Information Systems Working Group. Health East
  • 2002-17 Health East Cancer Care Clinical Council
  • 1994-95 Surgical Case Review Committee, M.S. Hershey Medical Center
  • 2000-01 Dissertation Advisory Committee, Amy Wagner, University of Rochester Dept of Pathology.
  • 2000 Dissertation Advisory Committee for Javelle Symons, University of Rochester Dept of Pathology, M.S. awarded Fall 2000
  • 1998-00 Dissertation Advisory Committee for Heidi Collins, Ph.D. Candidate, University of Rochester Dept of Pathology. Ph.D. awarded Fall 2000.
  • 1998-01 University of Rochester Dept of Pathology Executive Committee
  • 1997-98 University of Rochester Dept of Pathology Program and Faculty Development
  • 1996 Chair, Subcommittee of the Residency Review Committee for Graduated Resident Responsibility in Anatomic Pathology, University of Rochester.
  • Research

    Research Summary/Interests

    My current clinical interests are general surgical pathology with subspecialty interest in breast, gynecologic, and Head and Neck Pathology. FNA cytopathology and GYN cytology are also areas of expertise. I have performed FNA's (several hundred in my career) mostly of head and neck lesions. I have presented pathology monthly at the head and neck tumor board for Midwest Otolaryngology and MHOPA at the Maplewood MHOPA office. I recently supervised the HealthEast cytology lab and Histology lab as medical director, and oversaw immunohistochemistry in that role.

    My training in gynecologic pathology was during residency with Richard J. Zaino, M.D. who helped foster my interest in this area. I was involved in the gynecologic oncology tumor board at The University of Rochester, and had been the University of Rochester pathology representative to the Gynecologic Oncology Group pathology committee. I have also presented a workshop for head and neck fine needle aspiration cytopathology for the Upper New York State Society for Cytopathology in September 1998, and I had been providing pathology review and instruction for the otolaryngology residents at Strong Memorial Hospital. Currently at St. Joe's I review most all of the ER/PR/Her-2 stains, all the MMR stains, and see a good spectrum of general surgical pathology and cytopathology material.

    Publications

    See full list of publications at: PubMed

    JOURNAL ARTICLES

    1. Fuller, G. M., Otto, J. M., Woloski, B. M., McGary, C. T., and Adams, M. A. The Effects of Hepatocyte Stimulating Factor on Fibrinogen Biosynthesis in Hepatocyte Monolayers. J. Cell Biol. (1985) 101:1481-1486.

    2. Raja,R. H., McGary, C. T., and Weigel, P. H. Affinity and Distribution of Surface and Intracellular Hyaluronic Acid Receptors in Isolated Rat Liver Endothelial Cells. J. Biol. Chem. (1988) 263:1666116668.

    3. Frost, S. J., McGary, C. T., and Weigel, P. H. Specific Intracellular Hyaluronic Acid Binding to Isolated Rat Hepatocytes is Membrane Associated. Biochim. Biophys. Acta (1988) 946:6674.

    4. McGary, C. T., Raja, R. H., and Weigel, P. H. Endocytosis of Hyaluronic Acid by Rat Liver Endothelial Cells: Evidence for Receptor Recycling. Biochem. J. (1989) 257:875884.

    5. Weigel, P. H., Frost, S. J., McGary, C. T., and LeBoeuf, R. D. The Role of Hyaluronic Acid in Inflammation and Wound Healing. Int. J. Tissue React. (1988) X:355365.

    6. Weigel, P. H., Frost, S. J., LeBoeuf, R. D., and McGary, C. T. The Specific Interaction Between Fibrin(ogen) and Hyaluronan: Possible Consequences in Hemostasis, Inflammation and Wound Healing. Ciba Foundation Symposium "The Biology of Hyaluronan". (1989) 143:248264.

    7. Wasserstrom, R., Mamourian, A. C., McGary, C. T., and Miller, G. Bulbar Poliomyelitis: MR Findings with Pathologic Correlation. AJNR (1992) 13:371-373.

    8. Yannariello-Brown, J.,McGary, C. T., and Weigel, P. H. The Endocytic Hyaluronan Receptor in Rat Liver Sinusoidal Endothelial Cells is Ca+2-Independent and Distinct from a Ca+2-Dependant Hyaluronan Binding Activity. J.Cell. Biochem. (1992) 48:73-80.

    9. McGary, C.T., Yannariello-Brown, J., Kim,D., Stinson, T.C., and Weigel, P.H. Degradation and Intracellular Accumulation of a Residualizing Hyaluronan Derivative by Liver Endothelial Cells. Hepatology (1993) 18:1465-1476.

    10. Welch, D.R., Chen, P., Miele, M.E., McGary, C.T., Bower, J.M., Stanbridge, E.J., and Weissman, B.E. Microcell-Mediated Transfer of Chromosome 6 into Metastatic Human C8161 Melanoma Cells Suppresses Metastasis but does not Inhibit Tumorigenicity. Oncogene (1994) 9:255-262.

    11. McGary, C.T., Miele, M.E., and Welch, D.R. Highly Metastatic 13762NF Rat Mammary Carcinoma Cell Clones Stimulate Bone Marrow by Secretion of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)/ Interleukin-3 (IL-3) Activity. Am. J. Path. (1995) 147:1668-1681.

    12. Miele, M.E., McGary, C.T., and Welch, D.R. SOD2 (MnSOD) Does Not Suppress Tumorigenicity or Metastasis of Human Melanoma C8161 Cells. Anticancer Research (1996) 15:2065-2070.

    13. Miele, M.E., Robertson, G., Lee, J-H., Coleman, A., McGary, C.T., Fisher, P.B., Lugo, T.G., and Welch, D.R. Metastasis Supressed, But Tumorigenicity and Local Invasiveness are Unaffected, in the Human Melanoma Cell Line Meljuso After Introduction of Human Chromosomes 1 or 6. Molecular Carcinogenesis (1996) 15:284-299.

    14. McGary, C.T., Pan, Y-C. E., Hanspeter,M. Guntrum, W.D., Neri, A., and Welch, D.R. Elevated Expression of the Neutrophil Calcium-Binding Protein, MRP-14, in Metastasis-Enhancing Neutrophils. Anti-Cancer Res. (1997) 17:1-6.

    15. LeVea, C.M., McGary, C.T., Delano, J.R., and Mooney, R.A. PTP LAR Expression Compared to Prognostic Indicies in Matastatic and Non-Metastatic Breast Cancer. Breast Cancer Research and Treatment (2000) 64:221-228.

    16. Duff, B., Weigel, J.A., Bourne,P., Weigel,P.H.,McGary, C.T. Endothelium in Hepatic Cavernous Hemangiomas Does Not Express the Hyaluronan Receptor for Endocytosis. Human Pathology (2001) 33:265-269.

    17. Wiseman, S.M., Popat, S.R., Rigual, N.R., Hicks, W.L., Orner, J.B., Wein, R.O., McGary, C.T., Loree, T.R. Adenoid Cystic Carcinoma of the Paranasal Sinuses or Nasal Cavity: A 40 Year Review of 35 cases. Ear Nose Throat J. (2002) 81:510-4.

    18. Weigel, P.H., Zhou, B. McGary, C.T. and Oka, J.A. Purification and Characterization of the Hyaluronan Receptor for Endocytosis (HARE). Hyaluronan 2000 Meeting. Book Chapter.

    19. Zhou, B., McGary, C.T., Weigel, J.A., Saxena, A., and Weigel, P.H. Purification and Molecular Identification of the Human Hyaluronan Receptor for Endocytosis. Glycobiology (2003) 13:339-49.

    20. Weigel, J.A., Raymond, R.C., McGary, C.T., Singh, A., and Weigel, P.H. A Blocking Antibody to the Hyalluronan Receptor for Endocytosis (HARE) Inhibits Hyaluronan Clearance by Perfused Liver. J. Biol. Chem. (2003) 278:9808-12.

    21. Weigel, P.H., McGary, C.T., and Weigel, J.A. Use of Iodinated-Hyaluronan Derivatives to Study Hyaluronan Binding, Endocytosis, and Metabolism by Cultured Cells. Methods in Enzymology (2003), 363:382-91.

    22. McGary, C.T., Weigel, J.A., and Weigel, P.H. Study of Hyaluronan Binding Proteins and Receptors Using Iodinated Hyaluronan Derivatives. Methods in Enzymology (2003) 363:354-65.

    23. Wein, R.O., McGary, C.T., Doerr, T.D., Popat, S.R., Howard, J.L., Weigel, J.A., and Weigel, P.H. Hyaluronan and its Receptors in Mucoepidermoid Carcinoma. Head and Neck (2006) 28:176-81.

    24. Gurram, M.K., Pulivarthi, S., McGary, C.T. Fatal Hypersensitivity Pneumonitis Associated with Docetaxal. Tumori (2013) 99(3):e100-3.

    25. Gurram, M.K., Pulivarthi, S, McGary, C.T., Defillo, A. Brain and Multi Organ Metastasis from Uterine Leiomyosarcoma. Tumori (2014) 100(1):e8-13

    26. Pulivarthi,S, Reshi,R.A., McGary,C.T, Gurram, M. K. Cerebral Toxoplasmosis in a Patient on Methotraxate for Rheumatoid Arthritis. Intern. Med. (2015) 54(11):1433-6.

    27. Pulivarthi,S., Haglind,E., McGary,C.T., Gurram,M.K. Glioblastoma Multiforme and Papillarty Thyroid Carcinoma - A Rare Combination of Multiple Primary Malignancies. J. Neurosci. Rural Pract. (2015) 6(2):241-244.

    ABSTRACTS

    1. McGary, C. T., Raja, R. H., and Weigel, P. H. The Rat Liver Endothelial Cell Hyaluronic Acid Receptor Recycles During Continuous Endocytosis. J. Cell Biol. (1987) 105:313a.

    2. Christensen, M. D., McGary, C. T., and Weigel, P. H. Ultrastructural Localization of Internalized Hyaluronic Acid in Cultured Rat Endothelial Cells Using a Novel Streptavidin Gold Probe. J. Texas Electron Microscopy Society (1988)

    3. McGary, C. T., Medh, J. D., Christensen, M. D., and Weigel, P. H. Degradation and Intracellular Processing of Hyaluronic Acid by Rat Liver Endothelial Cells. J. Cell Biol. (1988) 107:113a.

    4. McGary, C.T. and Welch, D.R. Differential Protein Expression Between Tumor Elicited:tcPMN, Phorbol Ester Activated:PMA-PMN, or Normal Circulating:cPMN Rat Polymorphonuclear Leukocytes. Frontiers in Biomedical Research. Penn State University College of Medicine. (1993)

    5. McGary, C.T. and Welch, D.R. Stimulation of Bone Marrow by Highly Metastatic 13762NF Rat Mammary Carcinoma Cell Clones. Proceedings of the AACR (1994) 35:55.

    6. McGary, C.T. and Welch,D.R. Differential Protein Expression in Tumor-Elicited, Mammary Carcinoma Metastasis-Enhancing Neutrophils. Proceedings of the AACR (1994) 35:55.

    7. McGary, C.T. and Welch, D.R. Highly Metastatic 13762NF Rat Mammary Adenocarcinoma Clones Secrete IL-3 or GM-CSF Like Activity. Proceedings of the AACR (1995) 36:76.

    8. Dabbs, D.J., and McGary, C.T. A Search for the Meaning of Breast Lumpectomy Margins. A. J. C. P. (1995) 104:338.

    9. Miele, M.E., Robertson, G., Lee, J-H., Coleman, A., McGary, C.T., Fisher, P.B., Lugo, T.G., and Welch, D.R. Metastasis is Supressed in Human Melanoma Cell Line MelJuSo Following Introduction of Chromosomes 1 or 6 but Tumorigenicity and Local Invasiveness are Unaffected. Proceedings of the AACR (1996) 37:76.

    10. Wang, A.R., Zotalis, G.Z., Teot, L.A., O’Keefe, R.J., McGary, C.T., Rosier, R.N.,and Hicks, D.G. Dedifferentiated Chondrosarcoma: An Immunohistochemical Study. Mod. Pathol. 11:16A(1998)

    11. Comerci, J.T., Rodriguez-Rodriguez, L., Gibbon, D.G., Miller, L.F., Bourne, P.A., and McGary, C.T. Differential Expression of Retinoic Acid Receptor-Beta in Normal and Neoplastic Cervical Squamous Epithelium. Society of Gynecologic Oncologists, (1998)

    12. LeVea, C.M., Bleyle, L., McGary, C.T., and Mooney, R.A. Breast Cancer Metastasis: A Potential Role for the LAR protein Tyrosine Phosphatase. Mod. Pathol. 12:25A (1999)

    13. Leo, S., McGary, C.T., and Lowe, M.C. The Diagnostic Implication of Histiocytes(HC) in Routine Cervical/Vaginal Cytology. Acta Cytologica 43(5):913A (1999)

    14. Weigel, P.H., Zhou, B. McGary, C.T. and Oka, J.A. Purification and Characterization of the Hyaluronan Receptor for Endocytosis (HARE). Hyaluronan 2000 Meeting.

    15. McGary, C.T., Zhou, B., Duff, B., Oka, J.A. and Weigel, P.H. Localization of HARE - The Hyaluronan Receptor For Endocytosis. Molcular Biology of the Cell 11S:105-6a (2000).

    16. Wiseman, S., Rigual, N., Hicks, W., Orner, J., Loree,T., Popat, S., Wein, R., and McGary, C.T. Adenoid Cystic Carcinoma of The Paranasal Sinuses And Nasal Cavity A 40 Year Review Of The Western New York Experience. American Head and Neck Society, 2001.

    17. Zhou, B., McGary, C.T., Weigel, J.A., Saxena, A., Weigel, P.H. Purification and Characterization of the Human Hyaluronan Receptor for Endocytosis (HARE). Glycobiology 2001.  

    Teaching

    Teaching Areas

    Pathology