Kenneth Dornfeld, MD, PhD

Adjunct Professor, Department of Biomedical Sciences

Kenneth Dornfeld

Contact Info

Adjunct Professor, Department of Biomedical Sciences


Radiation Oncologist


MD, University of Minnesota, 1993

PhD, Biochemistry, University of Minnesota, 1991

Summary

Awards & Recognition

Teacher of the Year Award, Department of Radiation Oncology, University of Michigan, Ann Arbor MI, 2000-2001 Invited Participant, Radiation Research Program, Young Investigators Workshop, sponsored by the National Cancer Institute, 2000 Cyrus P. Barnum, Jr. Memorial Teaching Fellowship, Department of Biochemistry, 1989

Professional Associations

Member, American Society for Therapeutic and Radiologic Oncology (ASTRO), 1994-present American College of Radiology, 2003 - present American Association of Cancer Research, 2002-present Genetics Society of America, 2003 - present

Research

Publications

Ahn BY, Dornfeld KJ, Fagrelius TJ, Livingston DM. Effect of Limited Homology on Gene Conversion in a Saccharomyces cerevisiae Plasmid Recombination System. Mol Cell Biol. 1988;8:2442-2448.

Dornfeld KJ, Livingston DM. Effects of Controlled RAD52 Expression on Repair and Recombination in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11:2013-2017.

Dornfeld, KJ, Livingston, DM. Plasmid Recombination in a rad52 Mutant of Saccharomyces cerevisiae. Genetics. 1992;131:261-76.

Barkan AL, Halasz I, Dornfeld KJ, Jaffe CA, Friberg RD, Chandler WF, Sandler, HM. Pituitary Irradiation is Ineffective in Normalizing Plasma Insulin-Like Growth Factor I in Patients with Acromegaly. J Clin Endocrinol Metab. 1997;82:3187-3191.

Radany EH, Dornfeld KJ, Sanderson RJ, Savage MK, Majundar A, Seidman MM, Mosbaugh DW. Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase. Mutat Res. 2000;461:41-58.

Dornfeld KJ, Lawrence TS. A Predisposition Supposition for Glioma. J Natl Cancer Inst. 2001;93:1512-1513.

Editorial Nyati MK, Symon Z, Kievit E, Dornfeld KJ, Rynkiewicz SD, Ross BD, Rehemtulla A, Lawrence TS. The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model. Gene Ther. 2002;9:844-849.

Nussembaum B, Rutherford RB, Teknos TN, Dornfeld KJ, and Krebsbach PH. Ex Vivo Gene Therapy for Skeletal Regeneration in Cranial Defects Compromised by Radiotherapy. Hum Gene Ther. 2003;14:1107-1115.

Yao M, Graham MM, Hoffman HT, Smith RB, Funk GF, Graham SM, Dornfeld KJ, Skwarchuk M, Menda Y, Buatti JM. The role of post-radiation therapy FDG PET in prediction of necessity for post-radiation therapy neck dissection in locally advanced head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2004;59:1001-1010.

Rehemtulla A, Hamstra DA, Kievit E, Davis MA, Ng EY, Dornfeld K, Lawrence TS. Extracellular expression of cytosine deaminase results in increased 5-FU production for enhanced enzyme/prodrug therapy. Anticancer Res. 2004;24:1393-1399.

Hamstra DA, Lee KC, Tychewicz JM, Schepkin VD, Moffat BA, Chen M, Dornfeld KJ, Lawrence TS, Chenevert TL, Ross BD, Gelovani JT, Rehemtulla A. The use of (19)F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies. Mol. Ther. 2004;10:916-928.

Yao M, Buatti JM, Dornfeld KJ, Graham MM, Smith RB, Funk GF, Hoffman HT. Can post-RT FDG PET accurately predict the pathologic status in neck dissection after radiation for locally advanced head and neck cancer? Int J Radiat Oncol Biol Phys. 2005; 58: 694-697.

El-Deiry M, Funk GF, Nalwa S, Karnell LH, Smith RB, Buatti JM, Hoffman HT, Clamon GH, Graham SM, Trask DK, Dornfeld KJ, Yao M. Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer. Arch Otolaryngol Head Neck Surg. 2005 131(10):879-85.

Lee KC, Hamstra D, Bullarayasamudram S, Bhojani MS, Moffat BA, Dornfeld KJ, Ross BD, Rehemtulla A, Fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit. Gene Therapy 2006 Jan;13(2):127-37.

Dornfeld, K and Johnson, M., AP Endonuclease deficiency results in extreme sensitivity to thymidine deprivation, 2005 Nucleic Acids Research 33(20):6644-53.

Allen BG, Johnson M, Marsh AM and Dornfeld K. Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation induced radiosensitization. Int Journal of Radiation Oncology Biology and Physics 2006 65:1544-52.

Yao M, Nguyen T, Buatti JM, Dornfeld KJ, Tan H, Wacha J, Bayouth JE, Clamon GH, Funk GF, Smith RB, Chang K, Hoffman HT. Changing failure patterns in oropharyngeal squamous cell carcinoma treated with intensity modulated radiotherapy and implications for future research. Am J Clin Oncol. 2006 Dec;29(6):606-12.

Yao M, Chang K, Funk GF, Lu H, Tan H, Wacha J, Dornfeld KJ, Buatti JM. The failure patterns of oral cavity squamous cell carcinoma after intensity-modulated radiotherapy-the university of iowa experience. Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1332-41.

Yao M, Hoffman HT, Chang K, Funk GF, Smith RB, Tan H, Clamon GH, Dornfeld K, Buatti JM. Is planned neck dissection necessary for head and neck cancer after intensity-modulated radiotherapy? Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):707-13.

Dornfeld K, Simmons JR, Karnell L, Karnell M, Funk G, Yao M, Wacha J, Zimmerman B, Buatti JM. Radiation doses to structures within and adjacent to the larynx are correlated with long-term diet- and speech-related quality of life. Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):750-7.

Simons AL, Fath MA, Mattson DM, Smith BJ, Walsh SA, Graham MM, Hichwa RD, Buatti JM, Dornfeld K, Spitz DR. Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging. Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1222-30.

Yao M, Karnell LH, Funk GF, Lu H, Dornfeld K, Buatti JM. Health-related quality-of-life outcomes following IMRT versus conventional radiotherapy for oropharyngeal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1354-60.

Simons AL, Ahmad IM, Mattson DM, Dornfeld KJ, Spitz DR. 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res. 2007 Apr 1;67(7):3364-70.

Dornfeld K, Hopkins S, Simmons J, Spitz DR, Menda Y, Graham M, Smith R, Funk G, Karnell L, Karnell M, Dornfeld M, Yao M, Buatti J. Posttreatment FDG-PET Uptake in the Supraglottic and Glottic Larynx Correlates with Decreased Quality of Life After Chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2007 Dec 28 [Epub ahead of print].