Bryon Mueller

Associate Professor


I received my BS in physics here at the University of Minnesota and my MS and PhD in nuclear physics at the California Institute of Technology in Pasadena, California. I completed a postdoctoral fellowship in the Medium Energy Physics group at Argonne National Laboratory in Lemont, IL, and then completed my medical physics residency at the Mayo Clinic in Rochester, MN.

I am a medical physicist with a research interest in applying novel magnetic resonance imaging methods to help understand the structural and functional differences in the brains of clinical populations. I am a member of the International Society for Magnetic Resonance in Medicine. 

Within the University of Minnesota, I am a member of the 3T operations committee, which sets policy for the use of the 3-Tesla systems at the U’s Center for Magnetic Resonance Research (CMRR). I am also responsible for quality assurance monitoring of the 3T systems at CMRR and am available as a consultant to members of the 3T community. I am a Co-Investigator or collaborator on more than 140 unique ongoing or completed imaging studies involving more than three dozen principal investigators within the Department, two dozen principal investigators from other departments in the Medical School and University, and a dozen multicenter studies involving dozens of Universities from across the country. 


  • Design, implementation, acquisition, and analysis of research MRI protocols in the study of brain structure and function

Administrative Assistant

(for academic support only)
Natasha Hampton-Anderson

In the Media

Research Summary

Applying advanced MRI methods to better understanding structural and functional differences of the brains of clinical populations relative to controls. Developing MRI scanner quality assurance methods to quantify MRI scanner performance. Developing improved methods for performing Multi-center MRI experiments.


MS, California Institute of Technology
Major: Physics
PhD, California Institute of Technology
Major: Physics
BS, University of Minnesota
Major: Physics

Fellowships, Residencies, and Visiting Engagements

Postdoctoral Fellowship,
Argonne National Laboratory
Diagnostic Clinical Medical Physics Resident,
Mayo Clinic

Honors and Recognition

Peter T. Demos Outstanding PhD Thesis Award, Bates Linear Accelerator Facility
Selected Publications

Selected Publications

Gimbel, B., Anthony, M., Ernst, A., Roediger, D., de Water, E., Eckerle, J., Boys, C., Radke, J., Mueller, B., Fuglestad, A., Zeisel, S., Georgieff, M., Wozniak, J., 2022. Long-term follow- up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes. J Neurodev Discord, 14 (1): 59.
doi: PubMed ID: 36526961.
Motlaghian, S., Belger, A., Bustillo, J., Ford, J., Iraji, A., Lim, K., Mathalon, D., Mueller, B., O'Leary, D., Pearlson, G., Potkin, S., Preda, A., van Erp, T., Calhoun, V., 2022. Nonlinear functional network connectivity in resting functional magnetic resonance imaging data. Hum Brain Mapp., 43 (15): 4556-4566.
doi: PubMed ID: 35762454.
Meng, X., Iraji, A., Fu, Z., Kochunov, P., Belger, A., Ford, J., McEwen, S., Mathalon, D., Mueller, B., Pearlson, G., Potkin, S., Preda, A., Turner, J., Erp, T., Sui, J., Calhoun, V., 2022. Multimodel Order Independent Component Analysis: A Data-Driven Method for Evaluating Brain Functional Network Connectivity Within and Between Multiple Spatial Scales. Brain Connect, 12 (7): 617-628.
doi: PubMed ID: 34541879.
Ellinwood, N., Valentine, B., Hess, A., Jens, J., Snella, E., Jamil, M., Hostetter, S., Jeffery, N., Smith, J., Millman, S., Parsons, R., Butt, M., Chandra, S., Egeland, M., Assis, A., Nelvagal, H., Cooper, J., Nestrasil, I., Mueller, B., et al., 2022. Tralesinidase alfa enzyme replacement therapy prevents disease manifestations in a canine model of mucopolysaccharidosis type IIIB. J Pharmacol Exp Ther, 382 (3): 277-286.
doi: PubMed ID: 35717448.
Ramsay, I., Mueller, B., Ma, Y., Shen, C., Sponheim, S., 2022. Thalamocortical connectivity and its relationship with symptoms and cognition across the psychosis continuum.. Psychol Med, 1-10.
doi: PubMed ID: 36047043.
Rawls, E., Kummerfeld, E., Mueller, B., Ma, S., Zilverstand, A., 2022. The resting-state causal human connectome is characterized by hub connectivity of executive and attentional networks. Neuroimage, 255 119211.
Falakshahi, H., Rokham, H., Fu, Z., Iraji, A., Mathalon, D., Ford, J., Mueller, B., Preda, A., van Erp, T., Turner, J., Pils, S., Calhoun, V., 2022. Path analysis: A method to estimate altered pathways in time-varying graphs of neuroimaging data. Netw Neurosci, 6 (3): 634-664.
doi: PubMed ID: 36204419.
Iraji, A., Faghiri, A., Fu, Z., Rachakonda, S., Kochunov, P., Belger, A., Ford, J., McEwen, S., Mathalon, D., Mueller, B., Pearlson, G., Potkin, S., Preda, A., Turner, J., van Erp, T., Calhoun, V., 2022. Multi-spatial-scale dynamic interactions between functional sources reveal sex-specific changes in schizophrenia. Newt Neurosci, 6 (2): 357-381.
doi: PubMed ID: 35733435.
Tseng, A., Camchong, J., Francis, S. M., Mueller, B. A., Lim, K. O., Conelea, C. A., Jacob, S., 2022. Differential extrinsic brain network connectivity and social cognitive task-specific demands in Autism Spectrum Disorder (ASD). Journal of psychiatric research, 148 230-239.
Klimes-Dougan, B., Başgöze, Z., Mueller, B., Wiglesworth, A., Carosella, K., Schreiner Westlund, M., Bortnova, A., Reigstad, K., Cullen, K., Gunlicks-Stoessel, M., 2022. Structural and Functional Neural Correlates of Treatment Response for Interpersonal Psychotherapy for Depressed Adolescents. J Clin Med, 11 (7): 1878.
doi: PubMed ID: 35407493.
Selected Presentations

Selected Presentations

Kowalski, J., Nemanich, S., Chen, C.-Y., Mueller, B. A., Rao, R., Georgieff, M., Menk, J., Rudser, K., Gillic, B. "Understanding Longitudinal Brain Reorganization in Infants After Perinatal Stroke.", Annual Meeting of the American Academy for Cerebral Palsy and Developmental Medicine, Cincinnati, Ohio, October 09, 2018.
Nemanich, S., Opitz, A., Mueller, B. A., Gillick, B. "Multimodal Neurophysiologic and Neuroanatomic Assessment of Brain Connectivity in Pediatric Stroke.", 72nd Annual Meeting of the American Academy for Cerebral Palsy and Developmental Medicine, Cincinnati, Ohio, October 09, 2018.
Cullen, K. R., Roy, A., (Presenter), Westlund Schreiner, M., Lim, K. O., Dougan-Klimes, B., Mueller, B. A. "Increased Resting-State Entropy Correlates with Reduction of Depression Symptoms in Response to Glutamate-Modulating Agents in Adolescents.", Sixth Biennial Conference on Resting State and Brain Connectivity, Montreal, Canada, September 26, 2018.
Nestrasil, I., Mueller, B. A., Nguyen, C., Deelchan, D., Jens, J., Valentine, B., Pinkstaff, J., Mcullagh, R., Ellinwood, N. "Pharmacology of BMN 250: Brain Magnetic Resonance Studies in Treated MPS IIIB Affected Dogs.", 15th International Symposium on MPS and Related Diseases, San Diego, California, August 02, 2018.
Cullen, K. R., Westlund Schreiner, M., Klimes-Dougan, B., Lim, K., Mueller, B. A. "Resting-State Functional Connectivity of Medial Cortical Network Nodes in Depressed Adolescents With versus Without Non-Suicidal Self-Injury.", International Society for the Study of Self-Injury, Brussels, Belgium, June 23, 2018.
Westlund Schreiner, M., Klimes-Dougan, B., Mueller, B. A. "White Matter Disorganization in Non-Suicidal Self-Injury.", International Society for the Study of Self-Injury, Brussels, Belgium, June 22, 2018.
Svatkova, A., Mueller, B. A., Bednarik, P., Vojtisek, L., Mangia, S., Nissi, M., Michaeli, S., Nestrasil, L. "Rotating Frame MRI Contrasts for Assessment of White Matter Alteration in Mucopolysaccharidosis Type I.", Joint Annual Meeting of ISMRM-ESMRMB, Paris, France. June 21, 2018.
Hendrickson, T., Gilmore, C., Mueller, B. A., Kardon, R., Lim, K. O. "Greater Attentional Resources Are Required in Older Veterans with More Severe mTBI: An fMRI Study", 4th Federal Interagency Conference on Traumatic Brain Injury, Washington, District of Columbia, June 11, 2018.
Dengel, D., Evanoff, N., Marlatt, K., Geijer, J., Mueller, B. A. "Microvascular Cerebral Vascular Reactivity and Neurocognition and in Cancer Survivors.", Annual Meeting of the American College of Sports Medicine (ACSM), Minneapolis, Minnesota, May 29, 2018.
Roy, A., Mueller, B. A., Klimes-Dougan, B., Schreiner, M., Thai, M., Lim, K. O., Cullen, K. R. "Increased Resting State FMRI Entropy Associated with Clinical Response to Ketamine for Treatment Resistant Depression in Adolescents.", 73rd Annual Meeting of the Society of Biological Psychiatry, New York, New York, May 12, 2018.



Department of Psychiatry & Behavioral Sciences, F282/2A West Building, 2450 Riverside Avenue South, Minneapolis, MN 55454