Charles Lewis
,
Credentials
MD

Assistant Professor
Biography

Bio

I obtained a Bachelor of Arts with a major in Psychology from Rice University in 2005, followed by my Doctor of Medicine from the University of Texas Medical School at Houston in 2010. I completed clinical training in Psychiatry (2014) and Child and Adolescent Psychiatry (2016) at the Mayo Clinic School of Graduate Medical Education, where I twice served as Chief Resident. I then undertook a two-year clinical research fellowship, the Clinician-Investigator Training Program, with a focus on neuromodulation in adolescent mood disorders and suicidal behavior.

I joined the University of Minnesota Medical School faculty in 2019. My research focuses on the neurobiological correlates of suicidal behavior in adolescents with mood disorders, with the aim of improving risk assessment and identifying novel treatment approaches. I am also involved in ongoing projects utilizing noninvasive brain stimulation, including repetitive TMS, theta burst stimulation, and transcranial direct current stimulation (tDCS), as treatment interventions for children and adolescents with depression.

I am also the recipient of a 2018 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation, which will support my work in studying state-dependent impairment in cortical inhibition and network connectivity in adolescents with suicidal behavior. I have also presented both nationally and internationally at over 35 conferences.

Expertise

  • Mood disorders

Administrative Assistant

(for academic support only)
Molly Jokimaki
jokim004@umn.edu

Research Summary

Dr. Lewis' research focuses on the neurobiological correlates of suicidal behavior in adolescents with mood disorders, with the aims of improving risk assessment and identifying novel treatment approaches. His previous work has found impaired cortical inhibition, measured by transcranial magnetic stimulation (TMS), and alterations in excitatory neurotransmitter levels, measured by magnetic resonance spectroscopy, in youth with suicidal behavior. Dr. Lewis is also involved in ongoing projects utilizing noninvasive brain stimulation, including repetitive TMS, theta burst stimulation, and transcranial direct current stimulation (tDCS), as treatment interventions for children and adolescents with depression. 

Education

MD, University of Texas Medical School at Houston
BA, Rice University
Major: Psychology

Fellowships, Residencies, and Visiting Engagements

Fellowship,
Mayo School of Graduate Medical Education, Minnesota Child & Adolescent Psychiatry
Clinician-Investigator,
Mayo School of Graduate Education
Residency,
Mayo School of Graduate Medical Education

Licensures and Certifications

American Board of Psychiatry and Neurology Diplomate
Minnesota Board of Medical Practice
American Board of Psychiatry and Neurology Diplomate, Child and Adolescent Psychiatry

Honors and Recognition

Clinical Excellence Honor, University of Minnesota Physicians (multiple)
Young Investigator Grant, American Foundation for Suicide Prevention
Fellow in Depression, Klingenstein Third Generation Foundation
Howard P. Rome Academic Writing Award, Mayo Clinic Department of Psychiatry and Psychology
NARSAD Young Investigator Award, Alan G. Ross Memorial Investigator, Brain & Behavior Research Foundation
Howard P. Rome Resident Grand Rounds Award, Mayo Clinic Department of Psychiatry and Psychology
Chief Resident Award, Child and Adolescent Psychiatry, Mayo Clinic Department of Psychiatry and Psychology
Chief Resident Award, Psychiatry, Mayo Clinic Department of Psychiatry and Psychology
Outstanding Resident in Psychiatry, Dr. Henry P. and M. Page Durkee Laughlin Foundation
Helen and William Guynn Award for Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston
Outstanding Medical Student in Neuroscience, University of Texas Medical School at Houston
Organization of Parents and Friends Scholarship, University of Texas Medical School at Houston
Psi Chi (Psychology Honor Roll), Rice University
President's Honor Roll, Rice University

Professional Memberships

American Academy of Child and Adolescent Psychiatry
Minnesota Society of Child and Adolescent Psychiatry
Minnesota Psychiatry Society
American Psychiatric Association
American Medical Association
Selected Publications

Selected Publications

Sonmez, A., Lewis, C. P., Port, J., Athreya, A., Choi, D.-S., Zaccariello, M., Shekunov, J., Blacker, C., Croarkin, P., 2021. A pilot spectroscopy study of adversity in adolescents. Biomarkers in Neuropsychiatry, 5
Shekunov, J., Lewis, C. P., Vande Voort, J. L., Bostwick, J. M., Romanowicz, M., 2021. Clinical Characteristics, Outcomes, Disposition, and Acute Care of Children and Adolescents Treated for Acetaminophen Toxicity. Psychiatric Services (Washington D.C.), 72 (7): 758-765.
doi: https://doi.org/10.1176/appi.ps.202000081 PubMed ID: 33887959.
Sonmez, A. I., Lewis, C. P., Athreya, A. P., Shekunov, J., Croarkin, P. E., 2021. Preliminary Evidence for Anhedonia as a Marker of Sexual Trauma in Female Adolescents. Adolescent health, medicine and therapeutics, 12 67-75.
doi: https://doi.org/10.2147/ahmt.s300150 PubMed ID: 34163277.
Sonmez, A. I., Lewis, C. P., Port, J. D., Cabello-Arreola, A., Blacker, C. J., Seewoo, B. J., McKean, A. J., Leffler, J. M., Frye, M. A., Croarkin, P. E., 2020. Glutamatergic Correlates of Bipolar Symptoms in Adolescents. Journal of Child and Adolescent Psychopharmacology, 30 (10): 599-605.
doi: https://doi.org/10.1089/cap.2020.0082 PubMed ID: 33179961.
Lewis, C. P., Port, J., Blacker, C., Sonmez, A., Seewoo, B., Leffler, J., Frye, M., Croarkin, P., 2020. Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation. Translational Psychiatry, 10 (119):
doi: https://doi.org/10.1038/s41398-020-0792-z PubMed ID: 32327639.
Sonmez, A. I., Kucuker, M. U., Lewis, C. P., Kolla, B. P., Doruk Camsari, D., Vande Voort, J. L., Schak, K. M., Kung, S., Croarkin, P. E., 2020. Improvement in hypersomnia with high frequency repetitive transcranial magnetic stimulation in depressed adolescents: Preliminary evidence from an open-label study. Progress in Neuro-psychopharmacology & Biological Psychiatry, 97 109763.
Doruk Camsari, D., Lewis, C. P., Sonmez, A. I., Nandakumar, A. L., Gresbrink, M. A., Daskalakis, Z. J., Croarkin, P. E., 2019. Transcranial Magnetic Stimulation Markers of Antidepressant Treatment in Adolescents With Major Depressive Disorder. The International Journal of Neuropsychopharmacology, 22 (7): 435-444.
doi: https://doi.org/10.1093%2Fijnp%2Fpyz021 PubMed ID: 31095686.
Sonmez, A. I., Camsari, D. D., Nandakumar, A. L., Voort JLV, Kung, S., Lewis, C. P., Croarkin, P. E., 2019. Accelerated TMS for Depression: A systematic review and meta- analysis. Psychiatry Research, 273 770-781.
Blacker, C. J., Lewis, C. P., Swintak, C. C., Bostwick, J. M., Rackley, S. J., 2019. Medical Student Suicide Rates: A Systematic Review of the Historical and International Literature. Academic medicine : journal of the Association of American Medical Colleges, 94 (2): 274-280.
Lewis, C. P., Camsari, D. D., Sonmez, A. I., Nandakumar, A. L., Gresbrink, M. A., Daskalakis, Z. J., Croarkin, P. E., 2019. Preliminary evidence of an association between increased cortical inhibition and reduced suicidal ideation in adolescents treated for major depression. Journal of Affective Disorders, 244 21-24.
Selected Presentations

Selected Presentations

Lee, J., (Author), Farzan, F., (Author), Moreno, S., (Author), Lewis, C. P., (Author), Croarkin, P., (Author), Blumberger, D., (Author), Daskalakis, Z., (Author) "Differences in motor cortical plasticity between healthy and depressed youth", 65th Annual Meeting, American Academy of Child and Adolescent Psychiatry, Seattle, Washington. October 2018,
Sonmez, A., (Author), Lewis, C. P., (Author), Doruk Camsari, D., Vande Voort, J., (Author), Schak, K., (Author), Croarkin, P., (Author) "Improvement in sleep disturbances with high frequency repetitive transcranial magnetic stimulation in depressed adolescents", 3rd International Brain Stimulation Conference, Vancouver, British Columbia, Canada. February 2019 ,
Croarkin, P., (Author), Lewis, C. P., Sonmez, I., (Author), Doruk Camsari, D., (Author), Daskalakis, Z., (Author) "Monitoring and modulating adolescent depression and suicidality", 3rd International Brain Stimulation Conference, Vancouver, British Columbia, Canada. February 2019,
Sonmez, A., (Author), Lewis, C. P., (Author), Doruk Camsari, D., (Author), Almorsy, A., (Author), Vande Voort, J., (Author), Romanowicz, M., (Author), Port, J., (Author), Croarkin, P., (Author) "Spectroscopic glutamatergic correlates of bipolarity in depressed adolescents", American Academy of Child and Adolescent Psychiatry 66th Annual Meeting, American Academy of Child and Adolescent Psychiatry, Chicago, Illinois. October 2019,
Lewis, C. P., (Author), Nakonezny, P., (Author), Frye, M., (Author), Singh, B., (Author), Croarkin, P., (Author), Port, J., (Author) "Low reliability between in vivo measurements of glutamatergic metabolite concentrations in two proton MR spectroscopy sequences", 27th Annual Meeting & Exhibition, International Society for Magnetic Resonance in Medicine, Montreal, Quebec, Canada. May 2019,
Lewis, C. P., Thai, M., Silamongkol, T., Hill, D., Corkrum, M., Klimes-Dougan, B., Cullen, K. "Stability of motor threshold in adolescents undergoing high-frequency deep transcranial magnetic stimulation for depression", 59th Annual Meeting, American College of Neuropsychopharmacology, December 2020,
Lewis, C. P., (Author & Presenter), Chahine, G., Doumit, M., Schmidt, M., George, M., Nahas, Z. "Altered visual attention and default mode network activity in adults with major depressive disorder", 76th Annual Meeting, Society of Biological Psychiatry, May 2021,
"Excitatory/Inhibitory Neurophysiology and Metabolism in Suicidal Adolescents", Citrus Health Network/Florida International University Herbert Wertheim College of Medicine Department of Psychiatry & Behavioral Health - Psychiatry. August 2021,
"Noninvasive Neuromodulation in Pediatric Mental Health", Child & Adolescent Psychiatry Practical Review for Primary Care Providers and Mental Health Professionals, April 2023, Two Harbors, Minnesota,
"Assessment and Pharmacologic Treatment of Depression in Youth", Child & Adolescent Psychiatry Practical Review for Primary Care Providers and Mental Health Professionals, April 2023, Two Harbors, Minnesota,
Contact

Contact

Address

Masonic Institute for the Developing Brain, 2025 E River Pkwy, Minneapolis, MN 55414