Tanya Freedman, PhD

Assistant Professor, Department of Pharmacology

Tanya Freedman

Contact Info


Office Phone 612-301-8313

Lab Phone 612-306-6713

Office Address:
3-190 Wallin Medical Biosciences Building
2101 6th St SE
Minneapolis, MN 55414

2-106 Nils Hasselmo Hall
312 Church St SE
Minneapolis, MN 55455

Lab Address:
2-200 Wallin Medical Biosciences Building
2101 6th St SE
Minneapolis, MN 55414

Postdoctoral Fellowship, University of California, San Francisco

PhD, University of California, Berkeley, Molecular and Cell Biology

AB, Bowdoin College, Brunswick, ME, Biochemistry


Dr. Freedman is an Assistant Professor of Pharmacology with a research laboratory in the Center for Immunology. She is also a member of the Masonic Cancer Center's Cancer Immunology Program and the Center for Autoimmune Diseases Research. She received her AB degree with honors in Biochemistry from Bowdoin College in Brunswick, ME. She earned her PhD in Molecular and Cell Biology with a focus on Biochemistry and Molecular Biology from the University of California, Berkeley, studying allosteric regulation of Ras-activating proteins under the mentorship of Drs. John Kuriyan and Susan Marqusee. She completed her postdoctoral fellowship in immune-cell signaling in the laboratory of Dr. Arthur Weiss at the University of California, San Francisco. Dr. Freedman's current research is focused on postive- and negative-regulatory signaling pathways in immune cells with a special emphasis on protein tyrosine kinases.



Innate-immune signaling

Cancer immune microenvironment

Autoimmune disease


Awards & Recognition

NIH R01 Grant AR073966 (2018)

Travel Award, FASEB Science Research Conferences (2018)

Travel Award, FASEB Science Research Conferences (2017)

NIH R03 Grant AI130978 (2017)

NIH T32 Training Award (Predoctoral Student Ben Brian) DA007097 (2016)

NIH F32 NRSA Individual Postdoctoral Fellowship F32 AI082926 (2011)

Outstanding Graduate Student Instructor Award, University of California, Berkeley (2004)

Copeland-Gross Biology Prize, Bowdoin College, Brunswick, ME (1999)

Howard Hughes Medical Institute REU Fellowship (1998)

NIH T32 Training Award (Postdoctoral Fellow J.T. Greene) CA009138 (2020)

Dr. Marvin and Hadassah Bacaner Research Award in Pharmacology (Predoctoral Student Ben Brian), UMN Medical School (2020)

Frederick E. Shideman Research Proposal Award (Predoctoral Student Ben Brian), Department of Pharmacology (2019)

J. Jacob Kaplan Award in Clinical or Basic Medical Research (Predoctoral Student Ben Brian), UMN Medical School (2020)

Veneziale-Steer Award for Research in Cellular Growth Regulation (Predoctoral Student Ben Brian), UMN Medical School (2020)

Professional Associations

American College of Rheumatology (ACR)

The American Association of Immunologists (AAI)

American Association for Cancer Research (AACR)


Research Summary/Interests

Immune cells are tuned exquisitely to identify pathogens and avoid hypersensitivity. In macrophages Src-family tyrosine kinases (LynA, LynB, Hck, and Fgr) regulate a size sensing mechanism based on their ability to nucleate clustering of ITAM-coupled receptors. Under normal circumstances small debris cannot trigger macrophage activation, but this regulatory process can be subverted in inflamed tissues. We are studying how the Src-family kinases, especially LynA, tune the sensitivity of macrophages and other immune cells to triggering and the regulation or dysregulation of these processes in autoimmune disease, infection, and breast cancer.


View list of publications

Selected publications:

  • Freedman TS*, Headley MB*, Serwas N, Ruhland M, Castellanos CA, Combes AJ, Krummel MF*. (2020) Viewpoint: "Lessons of COVID-19: A roadmap for post-pandemic science" J Exp Med. 217(9):e20201276 (*Corresponding)
  • Brian BF, Jolicoeur AS, Guerrero CR, Nunez MG, Sychev ZE, Hegre SA, Sætrom P, Habib N, Drake JM, Schwertfeger KL, Freedman TS. (2019) "Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells" eLife 8:e46043
  • Freedman TS*, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A*. (2015) "LynA regulates an inflammation-sensitive signaling checkpoint in macrophages" eLife 4:e09183 (*Corresponding)
  • Tan YX, Manz BN, Freedman TS, Killeen N, Zhang C, Shokat K, Weiss A. (2014) "Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling" Nat Immunol 15(2):186-194.
  • Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. (2011) "STIM1, PKC-? and RasGRP set a threshold for proapoptotic Erk signaling during B cell development" Nat Immunol 12(5):425-33.
  • Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A.(2010) "ZAP-70: an essential kinase in T-cell signaling" Cold Spring Harb Perspect Biol. 2(5):a002279.
  • Freedman TS, Sondermann H, Kuchment O, Friedland GD, Kortemme T, Kuriyan J. (2009) "Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1" Structure 17(1): 41-53.
  • Freedman TS, Sondermann H, Friedland GD, Kortemme T, Bar-Sagi D, Marqusee S, Kuriyan J. (2006) "A Ras-induced conformational switch in the Ras activator Son of sevenless" Proc Natl Acad Sci USA 103(45): 16692-16697.