Germaine Cornelissen-Guillaume, PhD

Professor, Department of Integrative Biology and Physiology (IBP)

Germaine Cornelissen-Guillaume

Contact Info

Office Phone 612-624-6976

Office Address:
Halberg Chronobiology Center
University of Minnesota
Rm. 715 Mayo (Mayo Mail Code 8609)
420 Delaware St. S.E.
Minneapolis, MN 55455

PhD, University of Brussels (Physics), 1976

MS, University of Brussels (Physics, MS, and Science, MEd), 1971

BS, University of Brussels (Physics), 1969


Awards & Recognition

  • Elected Member of the Presidium (2019-2022), International Academy of Science
  • Member, Leibniz Society, 2009
  • Foreign member: Problem Commission on Chronobiology and Chronomedicine, Russian Academy of Medical Sciences, 2006
  • Honorary member, Cardiff Scientific Society, 2002
  • Profiled in “The Achievements of Chronobiology and Chronomedicine” by NI Aslanyan & SKh Madoyan, 2002
  • Member, Book Committee, National Chapters of Phi Beta Kappa, 2000-present
  • Member of Sigma Xi Society, 1988
  • Hoechst Foundation Chronobiology Award, 1983


Research Summary/Interests

Our team studies how blood pressure and heart rate vary in response to stimuli in everyday life, for health surveillance and maintenance.

We use timing according to rhythms (chronobiologic principles) for assessing cardiovascular health, and to detect pre-disease early, so that treatment administration schedules can be optimized to reduce the number of people dying of preventable heart attacks and strokes.

We also explore how solar cycles and changes in the Earth’s radiation environment affect human physiology as their impact has implications for long-term missions in space.

Our extensive archives support research and education in chronobiology as it applies to various fields of medicine.


Selected Publications

Saka F, Cornelissen G. Chronobiologic assessment of the effect of the DASH diet on blood pressure. Journal of Human Hypertension 2020. DOI: 10.1038/s41371-020-00408-0

Lusczek ER, Parsons LS, Elder J, Harvey SB, Skube M, Muratore S, Beilman G, Cornelissen-Guillaume G. Metabolomics pilot study identifies desynchronization of 24-hour rhythms and distinct intra-patient variability patterns in critical illness: A preliminary report. Front. Neurol. - Sleep Disorders 2020. DOI: 10.3389/fneur.2020.533915

Cornelissen G, Watanabe Y, Siegelova J, Beaty LA, Singh RK, Singh R, Singh RB, Delcourt A, Gumarova L, Gubin D, Chen CH, Otsuka K, for Investigators of the Project on the BIOsphere and the COSmos (BIOCOS) and Members of the Phoenix Study Group. Chronobiologically interpreted ambulatory blood pressure monitoring: past, present, and future. Biological Rhythm Research 2019; 50 (1): 46-62.

Cornelissen G. Metabolic syndrome, adiponectin, sleep, and the circadian system. EBioMedicine 2018; 33: 20-21. doi: 10.1016/j.ebiom.2018.06.013

Otsuka K, Cornelissen G, Kubo Y, Shibata K, Hayashi M, Mizuno K, Ohshima H, Furukawa S, Mukai C. Circadian challenge of astronauts’ unconscious mind adapting to microgravity in space, estimated by heart rate variability. Scientific Reports 2018; DOI:10.1038/s41598-018-28740-z

Sletten J, Cornelissen G, Assmus J, Kiserud T, Albrechtsen S, Kessler J. Maternal exercise, season and sex modify the daily fetal heart rate rhythm. Acta Physiologica 2018; 224 (2): e13093. doi: 10.1111/apha.13093

Cornelissen G, Otsuka K. Chronobiology of aging: a mini-review. Gerontology 2017; 63 (2): 118-128. DOI: 10.1159/000450945

Otsuka K, Cornelissen G, Halberg F. Chronomics and Continuous Ambulatory Blood Pressure Monitoring – Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring. Tokyo: Springer Japan, 2016, 870 + lxxv pp. 10.1007/978-4-431-54631-3.

Lee Gierke C, Cornelissen G. Chronomics analysis toolkit (CATkit). Biological Rhythm Research 2016; 47: 163-181. doi: 10.1080/09291016.2015.1094965

Cornelissen G, Watanabe Y, Otsuka K, Halberg F. Influences of space and terrestrial weather on human physiology and pathology. In: Rosch PJ (Ed.) Bioelectromagnetic and Subtle Energy Medicine, 2nd ed. Boca Raton: CRC Press; 2015. pp. 389-400.

Otsuka K, Cornelissen G, Kubo Y, Hayashi M, Yamamoto N, Shibata K, Aiba T, Furukawa S, Ohshima H, Mukai C. Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study. npj Microgravity 2015; 1: 15018. doi:10.1038/npjmgrav.2015.18.

Cornelissen G. Cosinor-based rhythmometry. Theoretical Biology and Medical Modelling 2014; 11: 16. doi:10.1186/1742-4682-11-16. 24 pp.