Frank Ondrey



I have been on the University of Minnesota Otolaryngology Faculty and at Masonic Cancer Center  for more than 25 years. I specialize in the multidisciplinary care of Head and neck malignancies and related conditions.  With other  multidisciplinary cancer care teams I  provide comprehensive care and surveillance of head and neck cancers and achieve cutting edge care through innovative clinical trials in oral precancerous lesions and cancers. 


Head and Neck Oncologic Surgery and related diseases


Undergrad: Loyola University
Medical school: Rush-Presbyterian St. Luke Medical Center
Graduate School: Rush University
Residency: University of Minnesota & Hennepin County Medical Center
Fellowship: National Institutes of Health, Bethesda, Maryland

Board Certifications

American Board of Otolaryngology

Awards and Recognitions

  • Director, Molecular Oncology Program
  • Co Leader: Carcinogenesis and Prevention Program, Masonic Cancer Center

Professional Associations

American College of Surgeons

Research Summary

Our bench to bedside research team has  performed several federally funded  cancer prevention trials for oral cancer. I lead a research team whose goal is to find drugs  that reduce head and neck cancer incidence while providing screening services for patients with precancerous conditions.  


  • Elton AC, Cedarstrom V, Quraishi A, Wuertz B, Murray K, Markowski TW, Seabloom D, Ondrey FG. Metabolic and Metabolomic Effects of Metformin in Murine Model of Pulmonary Adenoma Formation. Nutr Cancer. 2023;75(3):1014-1027. doi: 10.1080/01635581.2023.2165692. Epub 2023 Jan 23. PMID: 36688306.
  • Elton AC, Ondrey FG. Commentary on the letter to the editor regarding "reflux symptoms may develop in cases of throat mucosa injury, stress and related-autonomic nerve dysfunction.". Am J Otolaryngol. 2023 Jan-Feb;44(1):103688. doi: 10.1016/j.amjoto.2022.103688. Epub 2022 Oct 31. PMID: 36370652.
  • Archibald H, Kalland K, Kuehne A, Ondrey F, Roby B, Jakubowski L. Oral Premalignant and Malignant Lesions in Fanconi Anemia Patients. Laryngoscope. 2023 Jul;133(7):1745-1748. doi: 10.1002/lary.30370. Epub 2022 Aug 30. PMID: 36054728.



Philips Wangensteen Building
420 Delaware St SE - MMC-396
Minneapolis, MN 55455

Administrative Contact

Shane Gullikson