Hubert Lim



Professor in the Department of Biomedical Engineering and Otolaryngology as well as an Institute for Translational Neuroscience Scholar. Graduated with a BSE in Bioengineering from University of California-San Diego in 2000. Completed a dual MSE in Biomedical Engineering and Electrical Engineering & Computer Science from University of Michigan where he also completed his PhD in Biomedical Engineering in 2005. His graduate work at the University of Michigan was advised by Dr. David Anderson, who established and served as Director of the Center for Neural Communication Technology. Completed postdoctoral research in the Otorlaryngology Department at Hannover Medical School in Germany from 2006 to 2009 under Dr. Thomas Lenarz, who is the Chair of the Department of Otolaryngology and Director of the German Hearing Center in Hannover.

Research Summary

Neural Prostheses, Auditory Neuroscience, Neural Plasticity The goal of my lab is to push the development and translation of brain-machine interfaces from scientific concept into clinical application with close collaboration with clinicians and industry. Brain-machine interfaces span a broad array of applications and consist of either direct connection of a device to neurons within the brain or neural communication through noninvasive techniques, such as EEG recordings and transcranial magnetic stimulation. The initial focus of my lab is to develop and improve implantable neural prostheses for restoring auditory function in deaf or hearing-impaired patients as well as those experiencing severe tinnitus (i.e., a phantom auditory percept that persists without any actual sound input). There are several auditory implants currently used in humans. This includes the cochlear implant (stimulates auditory nerve fibers), the auditory brainstem implant (stimulates the cochlear nucleus), and the auditory midbrain implant (stimulates the inferior colliculus), which my colleagues and I recently developed and translated into a clinical device. Some of these implants, as well as a few recent cortical devices, have also been used to suppress tinnitus. Although the outcomes have been encouraging, there are still many limitations with these devices, such as poor hearing in noisy environments and substantial variability in performance across patients. One fundamental limitation in improving these devices has been the lack of understanding of how the central auditory system in humans processes and represents sound information.My lab employs various experimental and engineering techniques in animals (e.g., guinea pig, cat) and humans to understand the human brain and how to successfully implement a neural device. This includes acute and chronic implantation of electrode arrays into the animal brain to investigate how the auditory system codes for different sound features as well as the effects of electrical activation of multiple auditory and nonauditory pathways on sound coding and perception. Various electrophysiological and modeling techniques are also used to investigate the descending and plasticity circuitry of the auditory system, which is important for understanding how to improve and optimize stimulation strategies for restoring hearing as well as suppressing tinnitus. By performing EEG and psychophysical studies in humans in response to acoustic and electrical stimulation and linking these results to those obtained in animals, we then obtain a better understanding of sound processing within the human brain that can guide the development of the next generation of auditory implants. Although the initial focus of my lab is to develop improved auditory implants, we will expand our techniques and technologies to develop improved neural prostheses for other clinical applications, especially those investigated by other leading research groups at University of Minnesota (e.g., epilepsy, pain, motor control).




6-132 NHH

Minneapolis, MN 55455