Xavier Revelo, PhD

Assistant Professor, Department of Integrative Biology and Physiology (IBP)

Xavier Revelo

Contact Info

xrevelo@umn.edu

Office Phone 612-301-7688

Office Address:
3-145 CCRB
2231 6th St. SE
Minneapolis, MN 55455

Mailing Address:
Cancer & Cardiovascular Research Building
2231 6th St. SE
Minneapolis, MN 55455

Postdoctoral Fellowship, University of Toronto, 2018

Ph.D., University of Missouri, 2012

M.S., University of Vermont, 2008

B.S., Zamorano University, 2005

Summary

Dr. Revelo is an Assistant Professor in the Department of Integrative Biology & Physiology with expertise in inflammation and cardio-metabolic disease. His research explores the molecular and integrative biology of inflammation and metabolism with emphasis on the immune mechanisms that drive obesity, insulin resistance, fatty liver disease and cardiac dysfunction.

Awards & Recognition

  • 2020    American Association of Immunologists Careers in Immunology Fellowship
  • 2018    Maurice Visscher Biomedical Scholar, University of Minnesota
  • 2015    Canadian Diabetes Association Postdoctoral Fellowship
  • 2013    Banting and Best Diabetes Centre Postdoctoral Fellowship, University of Toronto
  • 2011    Graduate Student Award, Experimental Biology Meeting
  • 2011    Graduate Student Award, American Association Veterinary Immunologists
  • 2011    Douglas Randall Young Scientists Development Scholarship, University of Missouri
  • 2010   Turner Graduate Scholarship, University of Missouri

Research

Research Summary/Interests

Our NIH-funded laboratory investigates the role of the immune system and inflammation in the pathophysiology of cardio-metabolic diseases such as diabetes, non-alcoholic fatty liver disease, and heart failure. As the outcome of inflammation largely depends on the balance between the pro- and anti-inflammatory functions, strategies that modulate these pathways will provide avenues to manage these diseases.

Our research program focuses on the following areas:

  1. Mechanisms of hepatic and intestinal inflammation in non-alcoholic fatty liver disease, steatohepatitis, and liver cancer
  2. Immune mechanisms of cardiac remodeling
  3. Mechanisms of obesity-related inflammation and food allergy
  4. Anti-inflammatory mechanisms of exercise training

Research Funding Grants

  1. R01DK122056 (NIH NIDDK). PI. Mechanisms of B Cell Pathogenicity in Non-Alcoholic Fatty Liver Disease. 2019-2024
  2. R01HL155993 (NIH NHLBI). MPI. Immune Mechanisms Regulating Cardiac Remodeling . 2020-2024
  3. Careers in Immunology Fellowship (American Association of Immunologists). Gut microbial factors promote B cell inflammatory responses in NAFLD. 2020-2021

Publications

Selected Publications


  • Khan S., Chan Y.T., Revelo X.S.*, and Winer D.A.* The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging. Frontiers in Endocrinology 2020. DOI: 10.3389/fendo.2020.00267.*Coresponding authors
  • Parthasarathy G., Revelo X., and Malhi H. Pathogenesis of Nonalcoholic Steatohepatitis: An Overview. Hepatology Communications 2020 4(4):478.
  • Revelo X. S.*, M. Ghazarian*,M. K. Nøhr,H. Luck, J. Kim, K. Zeng, S. Tsai, H. Lei, P. Ohashi, N. Hirano, O. Adeyi, T. Jin, S. Winer and D. A. Winer. Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome. Science Immunology 2017; 2 eaai7616 (Pub April 21 2017). *Equally contributed to this work
  • Revelo X. S*., M. Ghazarian, M. H. Y. Chng, H. Luck, J. Kim, K. Zeng, S. Y. Shi, S. Tsai, H. Lei, J. Kenkel, C. L. Liu, S. Tangsombatvisit, H. Tsui, C. Sima, C. Xiao, L. Shen, X. Li, T. Jin, G. F. Lewis, M. Woo, P. J. Utz, M. Glogauer, S. Winer and D. A. Winer*. Nucleic acid targeting pathways promote inflammation in obesity related insulin resistance. Cell Reports 2016;16(3):717-730. *Corresponding authors
  • Revelo X. S., S. Winer and D. A. Winer. Starving Intestinal Inflammation with the Amino Acid Sensor GCN2. Cell Metabolism 2016;23(5):763-5.
  • Revelo X. S., S. Tsai, H. Lei, H. Luck, H. Tsui, S. Schroer, C. Luck, M. Woo, S. Winer, and D. A. Winer. Perforin is a Novel Immune Regulator of Obesity Related Insulin Resistance. Diabetes 2015. 64(1):90-103.
  • Revelo X. S., S. Winer, and D. A. Winer. Morphological and inflammatory changes in visceral adipose tissue during obesity. Endocrine Pathology 2014. 25(1):93-101.