Xavier Revelo, PhD

Assistant Professor, Department of Integrative Biology and Physiology (IBP)

Xavier Revelo

Contact Info

xrevelo@umn.edu

Office Phone 612-301-7688

Office Address:
3-145 CCRB
2231 6th St. SE
Minneapolis, MN 55455

Mailing Address:
Cancer & Cardiovascular Research Building
2231 6th St. SE
Minneapolis, MN 55455

Postdoctoral Fellowship, University of Toronto (Immunometabolism), 2018

Ph.D., University of Missouri (Animal Science), 2012

M.S., University of Vermont (Animal Science) 2008

B.S, Zamorano University (Animal Science), 2005

Summary

Dr. Revelo is an Assistant Professor in the Department of Integrative Biology & Physiology with expertise in Immunometabolism. His research explores the molecular and integrative biology of inflammation and metabolism with emphasis on the immune mechanisms that drive obesity, insulin resistance and non-alcoholic fatty liver disease.

Awards & Recognition

2015 Canadian Diabetes Association, Postdoctoral Fellowship

2014 Banting and Best Diabetes Centre, University of Toronto; Postdoctoral Fellowship

2013 Banting and Best Diabetes Centre, University of Toronto; Postdoctoral Fellowship

2011 University of Missouri, Douglas D. Randall Young Scientists Development Fund

Research

Research Summary/Interests

The incidence of obesity has advanced rapidly in recent decades and is now considered a major health issue worldwide. Inflammation of metabolic tissues is a dominant factor in the development of obesity-related insulin resistance and nonalcoholic fatty liver disease (NAFLD), though many of the contributing mechanisms remain unclear.

I investigate novel immune mechanisms underlying insulin resistance and NAFLD. As the outcome of inflammation largely depends on the balance between the pro- and anti-inflammatory functions, strategies that modulate these pathways will provide avenues to manage the metabolic syndrome.

My research program focuses on three areas:

1. Mechanisms of hepatic and intestinal inflammation in obesity and NAFLD

2. Anti-inflammatory mechanisms of exercise in obesity and NAFLD

3. Modulation of immune pathways as potential therapeutics for metabolic disease

Publications

Ghazarian M.*, Revelo X.S.* (co- 1st authors), H. Luck, J. Kim, K. Zeng, S. Tsai, H. Lei, P. Ohashi, N. Hirano, O. Adeyi, T. Jin, S. Winer and D.A. Winer Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome.Science Immunology 2017; 2(10). pii:eaai761.

Revelo X.S., M. Ghazarina, M.H.Y, Chng, H. Luck, J. Kim, K. Zeng, S.Y.Shi, S. Tsai, H. Lei, J. Kenkel, C.L. Liu, S. Tangsombatvisit, H. Tsui, C. Sima, C. Xiao, L. Shen, X. Li, T. Jin, G.F. Lewis, M. Woo, P.J. Utz, M. Glogauer, S. Winer and D.A. Winer.Nucleic acid targeting pathways promote inflammation in obesity related insulin resistance.Cell Reports 2016; 16 (3):717-730.

Revelo, X.S., S. Winder and D.A. Winer.Starving Intestinal Inflammation with the Amino Acid Sensor GCN2.Cell Metabolism 2016; 23 (5): 763-5.

Revelo X.S., Luck, H., Winer, S., Winer, D.A., 2016. The Immunology of Adipose Tissue, Encyclopedia of Immunobiology, Vol. 5, pp. 37–45. Oxford: Academic Press.

Revelo, X.S., S. Tsai, H. Lei, H. Luck, H. Tsui, S. Schroer, C. Luck, M. Woo, S. Siner, and D.A. Winer.Perform is a Novel Immune Regulator of Obesity Related Insulin Resistance.Diabetes 2015. 64(1): 90-103.

Revelo X.S., S. Winer, and D.A. Winer. Morphological and inflammatory changes in visceral adipose tissue during obesity. Endocrine Pathology 2014. 25(1):93-101.

Revelo X.S. and M.R. Waldron. In vitro effects of Escherichia coli lipopolysaccharide on the function and gene expression of neutrophils from the blood of dairy cows. J. Dairy Sci. 2012 95(5): 2422-41.

Revelo X.S. and M.R. Waldron. In-vitro effects of insulin and 2,4-thiazolidinedione on neutrophil function in dairy cows. J. Dairy Sci. 2010. 93(9): 3990-4005.