Jean Regal
,
Credentials
PhD
Credentials
PhD
Department Head, Biomedical Sciences
Professor Pharmacology
Biography
Bio
Dr. Regal was named the Co-Interim Regional Campus Dean of the University of Minnesota Medical School, Duluth Campus. She became active in this role on April 19, 2021 through Summer 2022.
Research Summary
The overall goals of my research program involve understanding basic immune mechanisms of cardiopulmonary disease. I have a long-standing interest in the complement system as a mediator of adverse events in disease states such as anaphylaxis, asthma and most currently pregnancy-induced hypertension. These interests have also involved defining mechanisms of pulmonary immunotoxicity of small molecule workplace allergens such as trimellitic anhydride. My research approach involves experimentation at the molecular, biochemical and physiological levels using animal models of disease. Current research projects include:
Pregnancy-induced Hypertension Preeclampsia and related hypertensive disorders of pregnancy affect ~10% of all pregnancies in the United States, significantly impacting the health of both mother and child. The initiating event of preeclampsia involves impaired blood flow to the placenta and the end result for the mother is high blood pressure and protein in the urine, along with growth restriction in the fetus. During pregnancy, the immune system including the plasma complement system, is tightly regulated to allow fetal survival. In women with preeclampsia the complement system is excessively activated, and our long-term goal is to determine the therapeutic utility of manipulating the complement system to prevent preeclampsia or minimize consequences for the mother and child. We hypothesized that complement system activation and white blood cell recruitment lead to hypertension in the mother and growth restriction in the fetus. Thus, we are manipulating the complement system and white blood cell function in a model of placental ischemia induced high blood pressure to determine the critical mechanisms responsible for the pregnancy complications. Our most recent studies are defining the role of natural antibody and the B lymphocyte in initiating complement activation in vivo, and assessing the importance of endogenous complement regulators in limiting the activation.
Dr. Regal's lab is currently funded through the National Heart Lung and Blood Institute of NIH and the American heart Association.
Professional Associations
- Director, AHC Women's Mentoring Program
- Director, AHC Duluth Research Seminar Series
- Editorial Board, Hypertension
- Editorial Board, Toxicological Sciences
- Associate Editor, Journal of Immunotoxicology
- Fellow, Academy of Toxicological Sciences
Teaching Summary
Chemotherapy of Infection; Anti-inflammatory Drugs; Drugs for Pulmonary Disorders
Mentoring/Advising: undergraduates, graduate & post-doctoral fellows
Education
Summer course in "Physiology: Cell and Molecular Biology",
Marine Biological Laboratories
PhD,
University of Minnesota
Major: Pharmacology
BS,
Summa cum laude,
University of Minnesota
Major: Biochemistry
Fellowships, Residencies, and Visiting Engagements
Research Scientist I and Research Fellow, Fellowship
Kidney Disease Institute
Honors and Recognition
Linda Larson Faculty Woman of the Year Award, University of Minnesota Duluth
2015
The Mullen/Spector/Truax Women’s Leadership Award, University of Minnesota
2012
Basic Science Teacher of the Year, UMD Medical School
1986
Thomas F. Andrews Prize, Society of the Sigma Xi
1973
Minnesota Heart Association Summer Fellowship
1969
Society of the Sigma Xi, Thomas F. Andrews Prize
Fellow, Academy of Toxicological Sciences-elected
Medical School Carole J. Bland Outstanding Faculty Mentor Award, • Medical School Carole J. Bland
Professional Memberships
American Heart Association
American Society of Pharmacology & Experimental Therapeutics
Society of Toxicology
American Association of Immunologists
Selected Presentations
Selected Presentations
Laule, C. F., Odean, E. J., Wing, C. R., Gilbert, J. S., Fleming, S. D., Regal, J. F.
"Depletion of B1 and B2 lymphocytes in placental ischemia-induced hypertension in the rat",
January 01, 2018.
Regal, J. F., Root, K., Gilbert, J. S., Fleming, S. D.
"Endothelin modulation of complement activation in pregnancy",
January 01, 2018.
Akhaphong, B., Jo, S., Wilcox, J., Regal, J. F., Alejandro, E.
"Developmental programming of pancreatic beta-cell mass in the offspring of hypertensive rat dams",
Midwest Islet Club 10th Annual Meeting,
Madison,
Wisconsin,
May 01, 2017.
Regal, J. F., Odean, E. J., Wing, C. R., Wilcox, J. A., Gilbert, J. S., Fleming, S. D.
"Chronic placental ischemia increases innate-like peritoneal B-1 B cells in the rat",
January 01, 2017.
Regal, J. F., Wing, C. R., McCutcheon, L., Gilbert, J. S., Fleming, S. D.
"Endothelin modulates local complement activation in placental ischemia-induced hypertension",
January 01, 2017.
Regal, J. F.
"Preeclampsia and innate immunity: Emerging roles for complement and neutrophils",
Kidney Week 2016,
American Society of Nephrology,
Chicago,
Illinois,
November 20, 2016.
Regal, J. F., Wing, C. R., Nieto, N. F., Gilbert, J. S., Fleming, S. D.
"Mechanisms of increased complement activation in placental ischemia-induced hypertension in rat",
APS Meeting on Inflammation, Immunity and Cardiovascular Disease,
August 01, 2016.
Nieto, N. F., Regal, J. F., Fleming, S. D.
"Regulators of complement system activation increase with placental ischemia-induced hypertension in rat",
6th Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE) meeting ,
Washington,
District of Columbia,
June 01, 2016.
Regal, J. F.
"The complement system and hypertension in pregnancy",
Department of Integrative Biology and Physiology Seminar series,
University of Minnesota,
Minneapolis,
Minnesota,
January 21, 2016.
Strehlke, M. E., Elmquist, B. J., Bemis, L. T., Gilbert, J. S., Regal, J. F.
"Regulators of complement system activation increase with placental ischemia-induced hypertension in rat",
January 01, 2016.
Regal, J. F.
"The innate immune system and pregnancy-induced hypertension",
Pathways to Advanced Degrees in Life Sciences seminar series,
University of Minnesota Medical School Duluth,
Duluth,
Minnesota,
June 16, 2015.
Regal, J. F., Parker, J. E., Opacich, J. W., Strehlke, M. E., Elmquist, B. J., Gilbert, J. S.
"Complement C3 and IgM deposition in placental ischemia-induced hypertension in rat",
January 01, 2015.
Regal, J. F., Strehlke, M. E., Elmquist, B. J., Gilbert, J. S.
"Complement activation in placental ischemia-induced hypertension is not dependent on endothelin A receptor activation",
January 01, 2015.
Regal, J. F., Parker, J. E., Gilbert, J. S., Fleming, S. D.
"IgM and β2-glycoprotein I deposition increases in rat placenta following chronic placental ischemia in late pregnancy and associates with complement activation, hypertension and fetal growth restriction",
January 01, 2015.
Gilham, H. E., Banek, C. T., Needham, K. W., Regal, J. F., Gilbert, J. S.
"Complement components C3a and C5a alter angiogenic balance in placental and endothelial cells",
January 01, 2014.
Peterson, J. M., Lillegard, K. E., Elmquist, B. E., Gilbert, J. S., Regal, J. F.
"Complement C5a receptor antagonist attenuates placental ischemia-induced hypertension in rat",
January 01, 2014.
Regal, J. F., Rear, A. A., Needham, K. W., Lovering, A. T., Gilbert, J. S.
"Reduced uterine perfusion pressure (RUPP) alters angiogenic balance in the amniotic fluid and fetal lung of the rat",
January 01, 2014.
Regal, J. F., Opacich, J. W., Johnson, A. C., Bauer, A. J., Gilbert, J. S.
"Antagonism of complement C5a receptor but not C3a receptor attenuates placental-ischemia induced endothelial dysfunction in rat",
January 01, 2014.
Regal, J. F., Elmquist, B. J., Peterson, J. M., Gilbert, J. S.
"Complement activation in placental ischemia-induced hypertension is not dependent on Angiotensin II Type 1 Receptor",
January 01, 2014.
Beasley, K., Needham, K., Regal, J. F., Lovering, A., Gilbert, J.
"Chronic placental ischemia alters expression of placental and fetal insulin-like growth factor (IGF) proteins in the rat",
January 01, 2014.
Regal, J. F.
"Women inspiring innovation through imagination: Celebrating women in science, technology, engineering and mathematics",
University of Minnesota Duluth, Women’s History Month,
Duluth,
Minnesota,
March 28, 2013.
Regal, J. F.
"The innate immune system and pregnancy-induced hypertension",
Duluth Medical Research Institute,
Duluth,
Minnesota,
January 14, 2013.
Midttveit, E., Needham, K., Banek, C. T., Rear, A. A., Regal, J. F., Gilbert, J. S.
"Complement factors C3a and C5a contribute to angiogenic imbalance in preeclampsia",
January 01, 2013.
Lillegard, K. E., Bauer, A. J., Johnson, A. C., Lojovich, S. J., Gilbert, J. S., Regal, J. F.
"Neutrophil depletion attenuates placental ischemia induced hypertension in rat",
January 01, 2013.
Bauer, A. J., Banek, C. T., Regal, J. F., Gilbert, J. S.
"Alterations in placental TGF-beta signaling pathways in rats with placental ischemia-induced hypertension",
January 01, 2013.
Regal, J. F., Lillegard, K. E., Elmquist, B. J., Bauer, A. J., Johnson, A. C., Opacich, J. W., Peterson, J. M., Gilbert, J. S.
"Complement C3a receptor antagonist attenuates placental ischemia-induced hypertension in rat",
January 01, 2013.
Regal, J. F.
"The innate immune system and pregnancy-induced hypertension",
University of Minnesota Duluth, Department of Biology,
Duluth,
Minnesota,
November 16, 2012.
Regal, J. F.
"Complement activation in pregnancy and hypertension",
University of Oregon, Department of Human Physiology,
Eugene,
Oregon,
November 01, 2012.
Lillegard, K. E., Johnson, A. C., Lojovich, S. J., Bauer, A. J., Marsh, H., Gilbert, J. S., Regal, J. F.
"Inhibitor of complement activation attenuates placental ischemia-induced hypertension in rat",
January 01, 2012.
Regal, J. F., Lawrence, B. P., Johnson, A. C., Lojovich, S. J., O’Reilly, M. A.
"Neonatal oxygen exposure alters airway hyperresponsiveness in adult mice but does not exacerbate allergen-induced inflammation",
January 01, 2012.
Regal, J. F., Lillegard, K. E., Bauer, A. J., Johnson, A. C., Lojovich, S. J., Marsh, H., Gilbert, J. S.
"Complement activation mediates placental ischemia-induced hypertension in the rat independent of vascular endothelial growth factor",
January 01, 2012.
Bauer, A. J., Banek, C. T., Lillegard, K. E., Regal, J. F., Gilbert, J. S.
"Pravastatin attenuates hypertension and angiogenic imbalance in placental ischemia induced hypertension in the rat",
January 01, 2012.
Regal, J. F., Johnson, A. C., Eskuri, R. S., Gilbert, J. S.
"Pulmonary inflammation and airway hyperresponsiveness associated with placental ischemia induced hypertension in rat dams and offspring",
January 01, 2012.
Regal, J. F.
"Insults to the developing lung: Allergens, etc.",
University of Rochester, School of Medicine and Dentistry, Lung Biology and Disease Program,
Rochester,
New York,
March 01, 2011.
Regal, J. F., Regal, R. R., Mohrman, M. E.
"Age and sex influence primary and secondary prevention strategies for controlling asthma as modeled in the mouse",
January 01, 2010.
Regal, J. F., Regal, R. R., Mohrman, M. E.
"Primary and secondary prevention strategies in a mouse model of asthma: Age and sex considerations",
Keystone Symposium on Allergy and Asthma,
Keystone,
Colorado,
January 01, 2009.
Regal, J. F., Tuthill, C., Mohrman, M. E.
"Effect of the immunostimulant gamma -D-glutamyl-L-tryptophan on the effector phase of asthma in a guinea pig model",
January 01, 2009.
Regal, J. F.
"How to publish",
Networking group for women in higher education, Regional spring conference,
Minnesota ACE Network,
Duluth,
Minnesota,
April 18, 2008.
Regal, J. F.
"Progress in the development of new approaches to the identification of respiratory allergens",
ECVAM Expert Meeting,
Ispra,
Italy.
April 01, 2008.
Regal, J. F.
"Asthma: Aspects of concern for dentists",
Duluth Dental Forum,
Duluth,
Minnesota,
March 06, 2008.
Regal, J. F., Greene, A. L., Rutherford, M. S., Regal, R. R., Duan, M., Haynes, V., Mohrman, M.
"Limiting allergen exposure during development: Differential effect on asthma symptoms in a mouse model",
January 01, 2008.
Regal, J. F.
"Creating successful mentoring relationships",
University of Minnesota AHC Fall Faculty Forum,
Minneapolis,
Minnesota,
November 02, 2007.
Regal, J. F.
"Allergy of the respiratory tract",
Society of Toxicology,
Charlotte,
North Carolina,
March 25, 2007.
Regal, J. F., Greene, A., Rutherford, M. S., Regal, R. R., Duan, M., Haynes, V. L., Mohrman, M. E.
"Age and sex influence the effectiveness of primary prevention of asthma in a mouse model",
January 01, 2007.
Regal, J. F., ne, A., Rutherford, M., Regal, R., Duan, M., Haynes, V., Meehan, J., Mohrman, M.
"Age and sex contribute to asthma heterogeneity in animal models",
January 01, 2007.
Regal, J. F.
"Models and mechanisms of chemical respiratory allergy: Not all allergens are equal",
13th Annual Meeting, Japanese Society of Immunotoxicology,
Kurashiki,
Japan.
September 15, 2006.
Regal, J. F.
"Mechanisms of chemical allergy",
Shionogi & Co., Ltd,
Osaka,
Japan.
September 13, 2006.
Regal, J. F.
"Primary prevention of asthma: Sensitivity to Allergen differs for young and adult, male and female mice",
2006 Peer Reviewed Medical Research Program Military Health Research Forum,
San Juan,
Puerto Rico,
May 01, 2006.
Regal, J. F., Greene, A., Rutherford, M. S., Regal, R. R., Flickinger, G. H., Hendrickson, J. A., Mohrman, M. E.
"Chemokine expression differs with allergen in the effector phase of ovalbumin- vs trimellitic anhydride-induced asthma",
Keystone Symposium on Allergy, Allergic Inflammation and Asthma,
Breckenridge,
Colorado,
April 01, 2006.
Regal, J. F.
"Differential gene expression and effector mechanisms in murine models of trimellitic anhydride and ovalbumin induced asthma",
Society of Toxicology,
San Diego,
California,
March 01, 2006.
Regal, J. F.
"Exploring careers in the life sciences",
College of Biological Sciences Alumni Speakers Bureau, University of Minnesota,
February 01, 2006.
Regal, J. F., Greene, A., Rutherford, M., Regal, R. R., Giulivi, C., Mohrman, M., Flickinger, G., Hendrickson, J.
"Differential gene expression and effector mechanisms in murine models of trimellitic anhydride and ovalbumin- induced asthma",
January 01, 2006.
Regal, J. F.
"Stomach bugging you?",
DocTalks series for the general public,
University of Minnesota Medical School Duluth,
Duluth,
Minnesota,
December 15, 2005.
Regal, J. F.
"Gene expression patterns in respiratory hypersensitivity",
Immunotoxicogenomics Workshop,
U.S. Environmental Protection Agency,
Research Triangle Park,
North Carolina,
September 28, 2005.
Regal, J. F.
"Alternative funding to NIH: Being creative",
Grantsmanship Forum,
Society of Toxicology,
March 08, 2005.
Regal, J. F., Regal, R. R., Duan, M., Meehan, J. L., Mohrman, M. E.
"Elicitation of asthma in guinea pigs: Differential antigen sensitivity with age and gender",
January 01, 2005.
Regal, J. F., Greene, A. L., Regal, R. R., Rutherford, M., Giulivi, C., Flickinger, G., Hendrickson, J., Mohrman, M.
"Differential expression of arginase in ovalbumin (OA) and trimellitic anhydride (TMA) induced asthma",
January 01, 2005.
Regal, J. F.
"Differential allergen sensitivity in the induction phase of asthma in young and adult, male and female guinea pigs",
Women’s Health Research Conference 2004,
University of Minnesota, National Center of Excellence in Women’s Health,
September 13, 2004.
Regal, J. F.
"Asthma attack! Why can’t I breathe?",
DocTalks series for the general public,
University of Minnesota Duluth School of Medic,
Duluth,
Minnesota,
April 13, 2004.
Regal, J. F., Regal, R. R., Meehan, J. L., Mohrman, M. E.
"Allergen sensitivity in induction of asthma differs in young and adult male and female guinea pigs",
2004 Peer Reviewed Medical Research Program Military Health Research Forum,
San Juan,
Puerto Rico,
April 01, 2004.
Regal, J. F.
"Women scientists and engineers talk about career choices and issues",
UMD Career Services and Association for Women in Science, Lake Superior Chapter,
Duluth,
Minnesota,
February 10, 2004.
Regal, J. F., Greene, A. L., Regal, R. R., Rutherford, M. S., Flickinger, G. H., Hendrickson, J. A., Mohrman, M. E.
"Differential gene expression in occupational asthma",
January 01, 2004.
Regal, J. F., Regal, R. R., Meehan, J. L., Mohrman, M. E.
"Differential allergen sensitivity in the induction phase of asthma in young and adult male and female guinea pigs",
January 01, 2004.
Regal, J. F.
"Recent advances in the basic science of asthma",
Continuing Medical Education Seminar,
Duluth,
Minnesota,
July 21, 2003.
Regal, J. F.
"Exploring careers in the life sciences",
College of Biological Sciences Alumni Speakers Bureau, University of Minnesota,
Minneapolis,
Minnesota,
February 05, 2003.
Regal, J. F., Regal, R. R., Meehan, J. L., Mohrman, M. E.
"Similar relationship of the sensitizing dose of antigen to the asthmatic response in both young and adult female guinea pigs",
January 01, 2003.
Regal, J. F., Mohrman, M. E.
"Trimellitic anhydride (TMA)-induced cell infiltration in a mouse model of occupational asthma is not complement dependent",
January 01, 2003.
Larsen, C. P., Regal, J. F.
"Trimellitic anhydride dust induces airway obstruction and eosinophilia in non-sensitized guinea pigs",
Northland SOT Meeting,
Duluth,
Minnesota,
April 09, 2002.
Regal, J. F., Mohrman, M. E.
"Changes in the complement system in trimellitic anhydride-induced occupational asthma in the mouse",
January 01, 2002.
Regal, J. F.
"Occupational asthma",
Department of Chemistry, University of Minnesota Duluth,
Duluth,
Minnesota,
November 16, 2001.
Regal, J. F.
"Respiratory and contact sensitizers",
Annual Meeting,
Northland Chapter of Society of Toxicology,
May 30, 2001.
Regal, J. F.
"Anaphylatoxins as mediators of asthma",
Immunotoxicology Branch, US EPA,
Research Triangle Park,
North Carolina,
April 01, 2001.
Regal, J. F.
"Anaphylatoxins as mediators of asthma",
Immunotoxicology Branch, US EPA,
Research Triangle Park,
North Carolina,
April 01, 2001.
Regal, J. F., Larsen, C. P.
"Intratracheally instilled trimellitic anhydride dust causes both sensitization dependent and independent bronchoconstriction",
January 01, 2001.
Regal, J. F., Mohrman, M. E., Boykin, E., Sailstad, D.
"Trimellitic anhydride-induced eosinophilia in a murine model of occupational asthma",
January 01, 2001.
Larsen, C. P., Regal, J. F.
"Trimellitic anhydride (TMA) induced respiratory hypersensitivity in the guinea pig does not differ in sexually immature or mature animals of either gender",
January 01, 2000.
Regal, J. F., Larsen, C. P., Kane, T. M.
"Activation of guinea pig complement by trimellitic anhydride conjugated to guinea pig serum albumin",
January 01, 2000.
Regal, J. F., Larsen, C. P., Kane, T. M.
"Complement activation by the occupational allergen trimellitic anhydride (TMA)",
January 01, 2000.
Regal, J. F., Larsen, C. P.
"Trimellitic anhydride induced complement activation contributes to respiratory hypersensitivity in the guinea pig",
January 01, 2000.
Regal, J. F., Klos, A.
"Minor role of the complement activation product C3a in systemic anaphylaxis in the guinea pig",
January 01, 1999.
Larsen, C. P., Regal, J. F.
"Complement activation in trimellitic anhydride (TMA)-induced pulmonary hypersensitivity in the guinea pig",
January 01, 1999.
Regal, J. F., Fraser, D. G., Regal, R. R., Larsen, C. P.
"IgG subclasses as predictors of trimellitic anhydride-induced asthma in the guinea pig",
IOSH Conference on 'Occupational Asthma: In and out of the workplace',
Morgantown,
West Virginia,
May 01, 1998.
Regal, J. F., Mohrman, M. E.
"Role of the complement activation product, C3a, in systemic anaphylaxis in the guinea pig",
Sigma Xi, University of Minnesota Duluth,
Duluth,
Minnesota,
February 01, 1998.
Larsen, C. P., Fraser, D. G., Regal, J. F.
"IgG Subclasses and trimellitic anhydride (TMA)-induced pulmonary hypersensitivity in the guinea pig",
January 01, 1998.
Regal, J. F., Fraser, D. G.
"IgG Subclasses in trimellitic anhydride (TMA)-induced pulmonary hypersensitivity in the guinea pig",
Inflammation '97 Tokyo: Third World Congress on Inflammation,
Tokyo,
Japan.
November 01, 1997.
Regal, J. F.
"Biologically active products of the complement system",
ASPET 97 Symposium ,
San Diego,
California,
March 01, 1997.
Regal, J. F., Xu, C.
"Role of histamine and kinins in C3a-peptide induced bronchoconstriction and changes in blood pressure",
January 01, 1997.
Regal, J. F.
"Mechanisms of Pulmonary Hypersensitivity induced by Trimellitic Anhydride",
Institute of Environmental Medicine, New York University Medical Center,
June 01, 1996.
Regal, J. F.
"Medical panel",
Women in Engineering and Science, College of Science and Engineering, University of Minnesota Duluth,
Duluth,
Minnesota,
January 01, 1996.
Fraser, D. G., Graziano, F. M., Regal, J. F.
"Role of IgG2 in trimellitic anhydride (TMA)-induced pulmonary hypersensitivity in the guinea pig",
January 01, 1996.
Xu, C., Fraser, D. G., Regal, J. F.
"Mediators of C3a-peptide induced bronchoconstriction and changes in blood pressure",
January 01, 1996.
Arndt, M. L., Fraser, D. G., Toth, C. A., Regal, J. F.
"Soluble Complement Receptor 1 (sCR1) prevents the increase in C3a during systemic anaphylaxis in the guinea pig",
January 01, 1995.
Fraser, D. G., Regal, J. F.
"Trimellitic anhydride (TMA)-induced decrease in platelets does not alter lung inflammation",
January 01, 1995.
Regal, J. F.
"Role of the complement system in anaphylaxis and asthma",
Department of Pharmacology, University of Minnesota,
December 01, 1994.
Regal, J. F.
"Medical panel",
Women in Engineering and Science, College of Science and Engineering, University of Minnesota Duluth,
Duluth,
Minnesota,
September 01, 1994.
Regal, J. F.
"Role of the complement system in anaphylactic shock",
Duluth Division of the Minnesota Heart Association,
Duluth,
Minnesota,
May 01, 1994.
Regal, J. F.
"Role of the complement system in antigen-induced events",
Riker Labs, 3M,
St. Paul,
Minnesota,
April 01, 1994.
Regal, J. F., Fraser, D. G.
"Enhanced antigen-induced cellular infiltration into the lung after depletion of the complement system with cobra venom factor (CVF)",
January 01, 1994.
Fraser, D. G., Regal, J. F., Nandiwada, L. S.
"Effect of complement system depletion on trimellitic anhydride (TMA)-induced cell changes",
January 01, 1994.
Regal, J. F.
"Invited presentation",
St. Mary’s College of Minnesota, Department of Biology,
Winona,
Minnesota,
October 01, 1993.
Regal, J. F.
"Invited presentation",
Augsburg College, Department of Biology,
Minneapolis,
Minnesota,
April 01, 1993.
Regal, J. F., Fraser, D. G., Shaw, D., Toth, C. A.
"Soluble complement receptor 1 (sCR1) inhibits antigen-induced bronchoconstriction and changes in blood pressure in the guinea pig",
January 01, 1993.
Fraser, D. G., Regal, J. F.
"C5a-induced thromboxane release from granulocytes and platelets: Effect of antioxidants",
January 01, 1993.
Regal, J. F.
"Adverse immune responses in the respiratory system",
Toxicology Discussion Group, University of Minnesota, Twin Cities ,
Minneapolis,
Minnesota,
April 15, 1992.
Fraser, D. G., Regal, J. F.
"Oxygen radical scavengers inhibit recombinant human C5a (rHuC5a)-induced bronchoconstriction in guinea pigs",
January 01, 1992.
Hammerbeck, D. M., McGurran, S. M., Nandiwada, L. S., Regal, J. F., Swingle, K. F.
"Reversal of late phase anaphylactic responses (LPAR) following ovalbumin aerosolization in sensitized guinea pigs",
January 01, 1992.
Regal, J. F.
"Invited presentation",
Riker Labs, 3M,
St. Paul,
Minnesota,
March 01, 1991.
Regal, J. F.
"Invited presentation",
Pulmonology Conference,
Duluth,
Minnesota,
March 01, 1991.
Heller, L. J., Regal, J. F., Mohrman, D. E.
"Coronary endothelial adenosine handling in isolated guinea pig hearts is altered during cardiac anaphylaxis",
January 01, 1991.
Regal, J. F., Fraser, D. G.
"Role of circulating white blood cells (WBC) in the enhancement of antigen-induced bronchoconstriction after intravascular complement activation with cobra venom factor (CVF)",
New York Academy of Science Conference on the 'Advances in the Understanding and Treatment of Asthma',
Royal College of Surgeons,
London,
England.
January 01, 1991.
Regal, J. F., Fraser, D. G.
"Platelet depletion inhibits antigen-induced bronchoconstriction in a passively sensitized guinea pig",
January 01, 1991.
Regal, J. F., Fraser, D. G., Solem, L.
"Cobra Venom Factor-induced enhancement of antigen-induced bronchoconstriction in the guinea pig: Sequestration of neutrophils with no change in vascular permeability",
January 01, 1991.
Regal, J. F.
"Role of complement in antigen-induced bronchoconstriction",
Minisymposium on mediators of allergic airway disease,
Riker Labs, 3M,
St. Paul,
Minnesota,
August 01, 1990.
Fraser, D. G., Regal, J. F.
"Recombinant human C5a-induced bronchoconstriction in the guinea pig: Role of circulating cells",
January 01, 1990.
Regal, J. F., Fraser, D. G.
"Enhancement of antigen-induced bronchoconstriction in the guinea pig after intravascular complement activation with cobra venom factor (CVF): Role of histamine",
January 01, 1990.
Grund, V. R., Regal, J. F.
"Endogenous histamine release associated with H2-receptor mediated insulin secretion and free fatty acid mobilization",
January 01, 1989.
Regal, J. F., Fraser, D. G.
"Recombinant human C5a-induced bronchoconstriction in the guinea pig: Mediators",
January 01, 1989.
Regal, J. F., Fraser, D.
"Cobra venom factor (CVF) treatment enhances antigen- and PGD2-induced bronchoconstriction",
January 01, 1988.
Regal, J. F.
"Role of C5a in hypersensitivity reactions in the lung",
FASEB 88 theme on Immunopharmacology - "Mediators of Hypersensitivity Reactions in the Lung",
Las Vegas,
Nevada,
January 01, 1988.
Heller, L. J., Nelson, R. A., Regal, J. F.
"Role of adenosine in arrhythmia generation during cardiac anaphylaxis",
January 01, 1987.
Regal, J. F., Sheedy, B. R.
"Enhancement of antigen-induced bronchoconstriction after intravascular complement activation with cobra venom factor (CVF)",
January 01, 1987.
Regal, J. F.
"Mediators of C5a-induced bronchoconstriction",
January 01, 1987.
Regal, J. F.
"Invited presentation",
Department of Chemistry, Bemidji State University,
Bemidji,
Minnesota,
November 01, 1986.
Regal, J. F., Sheedy, B. R.
"Cobra venom factor-induced bronchoconstriction",
Sixth International Congress of Immunology,
July 01, 1986.
Regal, J. F.
"C5a induced bronchoconstriction",
Riker Labs, 3M,
St. Paul,
Minnesota,
May 01, 1986.
Regal, J. F.
"Invited presentation",
Department of Biology, St. Cloud State,
St. Cloud,
Minnesota,
March 01, 1986.
Regal, J. F., Sheedy, B. R., Nelson, R. A.
"Inhibition of C5a-induced bronchoconstriction in the guinea pig",
January 01, 1986.
Heller, L. J., Nelson, R. A., Regal, J. F.
"Adenosine increases antigen-induced histamine release from isolated guinea pig hearts",
January 01, 1986.
Regal, J. F.
"Invited presentation",
Department of Chemistry, Moorhead State University,
Moorhead,
Minnesota,
December 01, 1985.
Regal, J. F., Heller, L. J., Sunnarborg, L. J., Nelson, R.
"Anaphylaxis in the isolated heart perfused at constant high flow",
January 01, 1985.
Regal, J. F.
"Mediators of antigen-induced guinea pig airway contraction",
January 01, 1984.
Regal, J. F.
"C5a and antigen-induced contraction of isolated tracheal smooth muscle",
Travenol Labs,
Morton Grove,
Illinois,
November 01, 1983.
Regal, J. F.
"Differential antagonism of IgG and IgE-mediated tracheal contraction",
January 01, 1983.
Regal, J. F., Hardy, T. M., Casey, F. B., Chakrin, L. W.
"Effects of C5a on lung parenchyma: Contraction and histamine release",
January 01, 1982.
Regal, J. F., Pickering, R. J.
"C5a and antigen-induced tracheal contraction: Effect of cyclo-oxygenase inhibitors and an antihistamine",
January 01, 1981.
Regal, J. F., Pickering, R. J.
"Inhibition of C5a induced tracheal contraction",
January 01, 1980.
Regal, J. F., Pickering, R. J.
"The effect of C5a on isolated guinea pig aorta",
January 01, 1980.
Regal, J. F., Pickering, R. J.
"The effect of C5a on isolated guinea pig trachea",
January 01, 1979.
Regal, J. F., Danielson, T., Shideman, F. E.
"The effect of phospholipase C on the responsiveness of cardiac receptors",
January 01, 1977.
Regal, J. F., Danielson, T., Shideman, F. E.
"Alteration of cardiac autonomic receptors by phospholipases",
January 01, 1975.
Regal, J. F., Danielson, T., Shideman, F. E.
"Enzymic alteration of cardiac autonomic receptors",
January 01, 1974.
Regal, J. F., Fong, J. S.
"Simple methods for rabbit hemolytic complement component assays",
January 01, 1972.
Grants and Patents
Grants and Patents
Patents
Pulmonary administration of soluble complement receptor-1 (sCR1) and its derivatives.
Issued: 2001
Pulmonary administration of sCR1 and other complement inhibitory proteins.
Issued: 2000
Contact
Contact
Address
313 SMed1035 University Drive
Duluth, MN 55812