Jop van Berlo

Associate Professor of Medicine, Cardiovascular Division
Director of Graduate Studies, PhD Program in Integrative Biology and Physiology
Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)
Faculty, PhD Program in Integrative Biology and Physiology
Faculty, PhD Program in Molecular, Cellular, Developmental Biology and Genetics
Faculty, Masters Program in Stem Cell Biology


Administrator Info
Name: Mayna Xiong
Mail: Lillehei Heart Institute
2231 6th Street SE
1st-floor Mailroom CCRB
Minneapolis, Minnesota 55455

After obtaining his M.D. and Ph.D. degrees from the University of Maastricht, the Netherlands, Dr. Jop van Berlo performed postdoctoral research with Dr.Jeffery Molkentin at the Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center. Upon joining the University of Minnesota he has built a research program focused on the cellular and molecular mechanisms of cardiac remodeling and regeneration. An active area of research is on the role of the immune system in orchestrating cardiac remodeling. Separately, the laboratory is interested in discovering regulators of cardiomyocyte proliferation.

Research Summary

My laboratory studies the cellular and molecular mechanisms of cardiac remodeling and regeneration. The goal of this research is to develop innovative strategies to enhance the limited ability of the heart to regenerate and stimulate reverse remodeling. To identify these strategies, we study the underlying mechanisms of endogenous remodeling and regeneration in mice. We are currently interested in discovering novel regulators of cardiomyocyte proliferation. We have candidate regulators that we are verifying in cell culture and in genetic mouse models. Furthermore, we are interested in the role of the immune system in orchestrating remodeling and regeneration.


University Hospital Maastricht
MD, University of Maastricht

Honors and Recognition

Dr. Marvin and Hadassah Bacaner Research Award
The Hartwell Foundation Biomedical Research Award
Richard and Lois King Professorhip, University of Minnesota, Department of Medicine
Finalist Melvin L. Marcus Young Investigator Award
National Heart Lung and Blood Institute

Media Appearances

Causal Role of Oxidized Lipids in Pulmonary Hypertension Development
BCVS17: Early Career "Next Best Thing" Session
Live Cell Imaging Reveals 2 Microdomains of Beta1 adrenoreceptor Signaling
Identification of novel regulators of heart regeneration

Professional Memberships

International Society for Heart Research
American Physiological Society
American Heart Association
Selected Publications

Selected Publications

Van Berlo JH and Molkentin JD. An Emerging Consensus on Cardiac Regeneration. Nat Med. 2014 Dec;20(12):1386-93,
Chen Z, Zhu W, Bender I, Yellamilli A, Hodges TJ, Zhang J, Garry DJ, van Berlo JH. Pathologic stimulus determines lineage commitment of c-kit+ cardiac progenitor cells. Circulation. 2017 Dec 12;136(24):2359-72,
Dorn LE, Lasman L, Chen J, Xu X, Hund TJ, Medvedovic M, Hanna JH, van Berlo JH, Accornero F. Circulation 2019 Jan 22;139(4):533-45,
Neidig LE, Weinberger F, Palpant NJ, Mignone J, Sorensen D, Martinson AM, Bender I, Nemoto N, Reinicke H, Pabon L, Molkentin JD, Murry CE, van Berlo JH. Evidence for minimal cardiogenic potential of Sca-1 positive cells in the adult mouse heart. Circulation 2018 Dec 18;138(25):2960-2,
Yellamilli A, Ren Y, McElmurry RT, Lambert JP, Gross P, Mohsin S, Houser SR, Elrod JW, Tolar J, Garry DJ, van Berlo JH. Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion. FASEB j. 2020 Apr;34(4):5642-57,