Kendall Wallace
,
Credentials
PhD

Professor
Biography

Research Summary

Toxicology; mechanisms by which foreign chemicals, including drugs, industrial, environmental and agrochemical compounds cause adverse human health effects. My primary focus is on the mitochondrion as a primary target or a critical factor in the pathogenesis of various chemical exposures. Current projects focus on modulating cancer causation or chemical toxicity by manipulating mitochondrial homeostasis and the role of mitochondrial epigenetics in the reprogramming of metabolic homeostasis as a compensatory survival response to mitochondrial toxicity.Dr. Wallace is past president of the Society of Toxicology, the American Board of Toxicology, the Academy of Toxicological Sciences, the Mitochondrial Research Society and the ILSI Health and Environmental Sciences Institute and has served on various scientific panels for the National Institutes of Health, the U.S. Food and Drug Administration, and the U.S. Environmental Protection Agency 

Education

PhD, Michigan State University
Major: Physiology
MS, Michigan State University
Major: Physiology
BS, Michigan State University
Major: Biochemistry
AS, Alpena Community College
Major: Natural Science

Fellowships, Residencies, and Visiting Engagements

Postdoctoral Fellow, Fellowship
University of Iowa

Licensures and Certifications

Diplomate, American Board of Toxicology

Honors and Recognition

Honorable Mention, Basic Science Teacher of the Year, University of Minnesota School of Medicine
2005
First Place, Northland Regional Chapter of SOT Graduate Student Award
2004
Third Place, Northland Regional Chapter of SOT Graduate Student Award
2002
First Place, Northland Regional Chapter, Society of Environmental Toxicology and Chemistry
2002
First Place, Sigma Xi, Graduate Student Award
2002
3M Science & Technology Graduate Fellowship
2002
Honorable Mention, Society of Toxicology, Mechanisms Specialty Section, Meritorious Graduate Student Research
2000
First Place, American Chinese Toxicology Society Graduate Student Award
2000
Toxicology Scholar, University of Connecticut Center for Biochemical Toxicology
2000
First Place, Northland Regional Chapter of SOT Graduate Student Award
1999
Basic Science Teacher of the Year, University of Minnesota School of Medicine
1998
3rd Place, Society of Toxicology, Mechanisms Specialty Section, Meritorious Graduate Student Research
1994
Honorable Mention, Society of Toxicology, Mechanisms Specialty Section, Meritorious Graduate Student Research
1993
Honorable Mention, Society of Toxicology, Mechanisms Specialty Section, Meritorious Graduate Student Research
1993
Honorable Mention, Society of Toxicology, Mechanisms Specialty Section, Meritorious Graduate Student Research
1993
3rd Place, Society of Toxicology, Mechanisms Specialty Section, Meritorious Graduate Student Research
1992
Basic Science Teacher of the Year, University of Minnesota School of Medicine
1991
Basic Science Teacher of the Year, University of Minnesota School of Medicine
1990
Basic Science Teacher of the Year, University of Minnesota School of Medicine
1988

Professional Memberships

American Society for Pharmacology and Experimental Therapeutics
Selected Presentations

Selected Presentations

Wallace, K. "Mitochondrial drug toxicity and stress response", United Mitochondrial Disease Foundation, Nashville, Tennessee, June 30, 2018.
Wallace, K. "Mitochondrial disease of non-genetic origin", United Mitochondrial Disease Foundation, Nashville, Tennessee, June 29, 2018.
Wallace, K. "Doxorubicin redox-cycling by mitochondria and activation of the Keap1/NRF antioxidant response pathway", U.S. Food & Drug Administration, National Center for Toxicology Research, Little Rock, Arkansas, April 28, 2017.
Wallace, K. "Compensatory metabolic remodeling in response to mitochondrial toxicity", University of Arkansas Medical Sciences, Little Rock, Arkansas, April 27, 2017.
Wallace, K. "A primer on genotoxicity and oxidative stress", U.S. District Court, Southern District of California, San Francisco, California, February 22, 2017.
Wallace, K. "Mitochondrial targets and petite toxicities", Alnylam Pharmaceuticals, Cambridge, Massachusetts, January 31, 2017.
Wallace, K. "Exposure-related mitochondrial disease", United Mitochondrial Disease Foundation, Seattle, Washington, June 18, 2016.
Wallace, K. "Contributions of mitophagy in cumulative doxorubicin-induced cardiomyopathy", Society of Toxicology Workshop, New Orleans, Louisiana, March 16, 2016.
Wallace, K. "Doxorubicin-induced mitochondrial cardiomyopathy", Society of Toxicology, Continuing Education Course, New Orleans, Louisiana, March 13, 2016.
Wallace, K. "Mitochondrial toxicity", Mito Action, October 02, 2015.
Wallace, K. "Alternative approaches to acute systemic animal toxicity testing", PETA, Physicians Committee for Responsible Medicine, NICETAM and the NIEHS, Bethesda, Maryland, September 24, 2015.
Wallace, K. "Safety assessment and risk perception of high intensity sweeteners", Ingestive Behavior Research Center, Purdue University, West Lafayette, Indiana, September 22, 2015.
Wallace, K. "Broadening the scope of mitochondrial targets", Targeting Mitochondrial Dysfunction and Toxicity, Cambridge Healthtech Institute, Cambridge, Massachusetts, March 19, 2015.
Wallace, K. "Occupational, environmental and therapeutically acquired mitochondrial disorders", Neurobiology of Disease in Children, Austin, Texas, October 30, 2013.
Wallace, K. "The many faces of mitochondrial disease", European Society for Clinical Investigation, Algarve, Portugal. April 17, 2013.
Wallace, K. "Weight of evidence workshop", International Life Sciences Institute, Food Safety Technical Committee, Miami, Florida, January 23, 2013.
Wallace, K. "Pre-clinical alerts for mitochondrial toxicities", Continuing Education Course for Reviewers, U.S. Food & Drug Administration, Washington, District of Columbia, November 29, 2012.
Wallace, K. "Adverse outcome pathways for mitochondrial toxicity", European Commission Joint Research Centre, Ispra, Italy. October 24, 2012.
Wallace, K. "Differential diagnosis of mitochondrial disease", U.S. DHHS Health Resources and Services Administration and the U.S. Department of Justice, May 25, 2012.
Wallace, K. "Molecular remodeling with doxorubicin-induced cardiomyopathy: Adverse v/ adaptive response", St. John’s University, Jamaica, New York, April 23, 2012.
Wallace, K. "Harnessing the chemistry of life: Revolutionizing toxicology", Workshop to Develop a Research Prospectus, European Partnership for Alternative Approaches to Animal Testing, Brussels, Belgium. April 03, 2012.
Wallace, K. "Drug-induced cardiomyopathies of mitochondrial origin", European Society for Clinical Investigation, Budapest, Hungary. March 22, 2012.
Wallace, K. "QSAR approach to perfluoroalkyl acid toxicity", University of Coimbra, Coimbra, Portugal. March 19, 2012.
Wallace, K. "Translating in vitro mitochondrial toxicity to predict cardiovascular safety", Safety Pharmaceutical Society, Insbrook, Austria. September 11, 2011.
Wallace, K. "The metabolic phenotype of environmentally-induced mitochondrial disease", United Mitochondrial Disease Foundation, Chicago, Illinois, June 17, 2011.
Wallace, K. "Enhancing FDA’s evaluation of science to ensure chemicals added to food are safe", Nature, Institute of Food Technology, and PEW Health Group sponsored workshop, Washington, District of Columbia, April 05, 2011.
Wallace, K. "Mitochondrial metabonomics", University of Coimbra, Coimbra, Portugal. September 30, 2010.
Wallace, K. "Molecular determinants of mitochondrial disease", Society of Toxicology, Salt Lake City, Utah, March 12, 2010.
Wallace, K. "Metabolic basis of pefluoroalkyl acid toxicity", Rutgers University, Division of Environmental and Occupational Health, Piscataway, New Jersey, October 01, 2009.
Wallace, K. "Mitochondrial toxicity of perfluoroalkyl acids: A structure-activity analysis", National Toxicology Program, NIEHS, Research Triangle Park, North Carolina, July 13, 2009.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy", EUROTOX, European Society of Toxicology, Rhodes, Greece. October 07, 2008.
Wallace, K. "Metabolic profiles of mitochondrial toxicities", United Mitochondrial Disease Foundation, Indianapolis, Indiana, June 28, 2008.
Wallace, K. "Transcriptional signature of mitochondrial toxicities", Society of Toxicology, Seattle, Washington, March 19, 2008.
Wallace, K. "Stratifying risks of complex exposures", American College of Occupational and Environmental Medicine, Vancouver, Canada. October 28, 2007.
Wallace, K. "An editorial perspective of effective scientific writing", International Society of Exposure Analysis, Durham, North Carolina, October 16, 2007.
Wallace, K. "Metabolic correlates of the transcriptional signature of doxorubicin-induced cardiomyopathy", Gordon Research Conference, Toxicogenomics, New London, New Hampshire, June 26, 2007.
Wallace, K. "Mitochondrial toxicity related cardiac and muscle injury", Gordon Research Conference, Adverse Drug Reactions, Waterville, Maine, June 11, 2007.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy and the compensated metabolic state", 2006 Sitlington Lecturer in Toxicology, Oklahoma State University, Stillwater, Oklahoma, November 30, 2006.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy and the compensated metabolic state", University of Iowa College of Pharmacy, Division of Medicinal and Natural Products Chemistry, Iowa City, Iowa, November 07, 2006.
Wallace, K. "Adriamycin mitochondrionopathy", Anthracycline Cardiotoxicity: Molecular Mechanisms and Clinical Correlates, Como, Italy. October 20, 2006.
Wallace, K. "Dose-dependent transitions in mechanisms of toxicity", EUROTOX 2006/6th Croatian Toxicological Society, Dubrovnik, Croatia. September 22, 2006.
Wallace, K. "Evolving identity of toxicology", EUROTOX 2006/6th Croatian Toxicological Society, Dubrovnik, Croatia. September 21, 2006.
Wallace, K. "Transcriptional control of the metabolic compensatory response to doxorubicin-induced cardiac failure", ILSI Health and Environmental Sciences Institute, Genomics in Mechanism Based Risk Assessment, Washington, District of Columbia, September 11, 2006.
Wallace, K. "Cardiomyopathies induced by mitochondrial damage", Society for Heart and Vascular Metabolism, Semiahmoo, California, September 06, 2006.
Wallace, K. "A small dose of toxicology", Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas de Ribeiro Preto, Ribeiro Preto, Brazil. August 29, 2006.
Wallace, K. "Mitochondrial cardiomyopathy and the compensated metabolic state", Keystone Symposium, Victoria, Canada. May 09, 2006.
Wallace, K. "QSAR inhalation toxicity database", 2nd Knoxville Reactivity Workshop, Knoxville, Tennessee, April 02, 2006.
Wallace, K. "Chemical-induced mitochondrial cardiomyopathies", University of Cincinnati, Department of Environmental Health, Cincinnati, Ohio, June 07, 2005.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy: A molecular basis for persistent metabolic adaptations", Penn State University, Center for Molecular Toxicology, State College, Pennsylvania, April 29, 2005.
Wallace, K. "Reverse transcriptase inhibitor-induced mitochondrial depletion", University of Coimbra, Center of Neuroscience and Cell Biology, Coimbra, Portugal. December 09, 2004.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy", University of Coimbra, Center of Neuroscience and Cell Biology, Coimbra, Portugal. December 08, 2004.
Wallace, K. "Multiplicity of mitochondrial toxicities", University of Coimbra, Center of Neuroscience and Cell Biology, Coimbra, Portugal. December 08, 2004.
Wallace, K. "Adriamycin-induced cardiomyopathy: A radical mechanism of toxicity", Mid-Atlantic Regional Chapter, Society of Toxicology, Research Triangle Park, North Carolina, October 21, 2004.
Wallace, K. "Multiple mechanisms of chemical-induced mitochondrionopathies", South Central Regional Chapter, Society of Toxicology, Starkville, Mississippi, October 15, 2004.
Wallace, K. "NRTI-induced mitochondrial cardiomyopathy", NHLBI Working Group on Cardiovascular Complications of HIV Infection and AIDS, Bethesda, Maryland, October 13, 2004.
Wallace, K. "Early preclinical signals for drug-induced mitochondrial toxicities", U.S. Food and Drug Administration, Rockvillle Pike, Maryland, September 14, 2004.
Wallace, K. "Case-studies of dose-dependent transitions in toxicology", Schering AG, Berlin, Germany. September 02, 2004.
Wallace, K. "Troponin biomarkers of cardiac injury", Schering AG, Berlin, Germany. September 02, 2004.
Wallace, K. "Conclusions of the FDA expert working group on biomarkers of drug-induced cardiac toxicity", AACC/Division of Animal Clinical Chemistry, Nutley, New Jersey, April 23, 2004.
Wallace, K. "Multiple mechanisms of chemical-induced mitochondrionopathies", South Central Regional Chapter, Society of Toxicology, Shreveport, Louisiana, October 10, 2003.
Wallace, K. "Free-radical-mediated mitochondrionopathies", Mitochondrial Medicine/Research Society, San Diego, California, June 12, 2003.
Wallace, K. "Biomarkers of drug-induced cardiac toxicity", Hoffman-Roche Pharmaceuticals, Nutley, New Jersey, May 06, 2003.
Wallace, K. "Perfluoroalkane-induced mitochondrionopathies", National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, April 10, 2003.
Wallace, K. "Multiple mechanisms of drug-induced mitochondrionopathy", Merck & Co., Inc., West Point, Pennsylvania, December 19, 2002.
Wallace, K. "Molecular mechanisms of chemical-induced cardiac injury", University of Louisville, Louisville, Kentucky, November 08, 2002.
Wallace, K. "Molecular mechanisms of perfluorooctane toxicity", Society of Toxicology, Nashville, Tennessee, March 01, 2002.
Wallace, K. "Genomic technologies", International Life Sciences Institute, Cancun, Mexico. January 22, 2002.
Wallace, K. "Mechanisms of mitochondrial injury", ILSI Seminars on Advanced Pathologic Techniques: Mechanisms of Mitochondrial Pathobiology, American College of Veterinary Pathobiology, Salt Lake City, Utah, December 01, 2001.
Wallace, K. "Mitochondrial pathobiology", International Life Sciences Institute, Salt Lake City, Utah, December 01, 2001.
Wallace, K. "Cardiac troponins as biomarkers of drug-induced myocardial injury", American College of Toxicology, Rockville, Maryland, November 05, 2001.
Wallace, K. "Adriamycin-induced irreversible mitochondrial cardiomyopathy", University of Coimbra, Center of Neuroscience and Cell Biology, Coimbra, Portugal. May 23, 2001.
Wallace, K. "Calcium-loading and induction of the mitochondrial permeability transition", University of Coimbra, Center of Neuroscience and Cell Biology, Coimbra, Portugal. May 21, 2001.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy", Washington State University, Department of Pharmaceutical Sciences, Pullman, Washington, April 27, 2001.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy: A pore way to die", Toxicology Scholars Colloquium, University of Connecticut, Storrs, Connecticut, April 07, 2000.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy", Pfizer Pharmaceuticals, Inc., Groton, Connecticut, April 06, 2000.
Wallace, K. "Cardiotoxicity: critical events and emerging issues", Society of Toxicology , Philadelphia, Pennsylvania, March 01, 2000.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy: A pore way to die", Michigan State University, Department of Pharmacology & Toxicology, East Lansing, Michigan, February 22, 2000.
Wallace, K. "Adriamycin-induced Mitochondrial Cardiomyopathy", University of Minnesota, Department of Medicinal Chemistry, Minneapolis, Minnesota, February 08, 2000.
Wallace, K. "Adriamycin-induced mitochondrial pathogenesis in vivo", Keystone Symposia on Molecular and Cellular Biology, Santa Fe, New Mexico, January 01, 2000.
Wallace, K. "The mitochondrial permeability transition: A pore way to signal cell death", Parke-Davis Pharmaceuticals, Experimental Pathology & Toxicology Division, Ann Arbor, Michigan, June 10, 1999.
Wallace, K. "The mitochondrial permeability transition: A pore way to regulate cell function and fate", Pharmacia & Upjohn, Investigative Toxicology Division, Kalamazoo, Michigan, June 04, 1999.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy: A pore way to signal cell death", University of Coimbra, Center of Neuroscience and Cell Biology, Coimbra, Portugal. May 15, 1999.
Wallace, K. "Mitochondrial permeability transition: A redox sensor for chemical toxicity", University of Coimbra, Center of Neuroscience and Cell Biology, Coimbra, Portugal. May 14, 1999.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy", Indiana University, Department of Pharmacology & Toxicology, Indianapolis, Indiana, April 16, 1999.
Wallace, K. "Mitochondrial-mediated apoptosis", Society of Toxicology Annual Meeting, New Orleans, Louisiana, March 17, 1999.
Wallace, K. "Generation of reactive oxygen by mitochondria", Society of Toxicology Annual Meeting, New Orleans, Louisiana, March 14, 1999.
Wallace, K. "The biological basis of anti-arrhythmic drug therapy", CE Cardiac Update, St. Luke’s Hospital, Duluth, Minnesota, February 18, 1999.
Wallace, K. "Multiple modes of mitochondrial myopathies", West Virginia University, Department of Pharmacology & Toxicology, Morgantown, West Virginia, November 16, 1998.
Wallace, K. "Oxidative stress", International Congress of Toxicology, Paris, France. July 04, 1998.
Wallace, K. "Free radical-mediated mitochondrial myopathies", University of Minnesota-Twin Cities, Department of Biochemistry & Molecular Biology, Minneapolis, Minnesota, June 15, 1998.
Wallace, K. "Mitochondrial permeability transition in oxidant-induced cardiomyopathy", Society of Toxicology Annual Meeting, Seattle, Washington, March 01, 1998.
Wallace, K. "Radical differences in the mechanisms of chemical-induced mitochondrial toxicity", University of Minnesota-Duluth, Chemistry Department, Duluth, Minnesota, October 10, 1997.
Wallace, K. "Molecular mechanisms of mitochondrial myopathies", International Series in Biomedical Science – Molecular Mechanisms of Cardiovascular Disease, Center for Neuroscience of Coimbra, Coimbra, Portugal. November 22, 1996.
Wallace, K. "Differential mechanisms of induction of the mitochondrial permeability transition by naphthoquinones", Department of Pharmacology and Toxicology – University of Kansas Medical Center, Kansas City, Kansas, October 08, 1996.
Wallace, K. "Regulation of the mitochondrial permeability pore by naphthoquinones: Chemical reactivity-dependent mechanisms", Frontiers of Mitochondrial Research, Rensselaerville Conference Center, New York, September 19, 1996.
Wallace, K. "Adriamycin-induced mitochondrial cardiomyopathy", 9th Annual European Bioenergetics Conference, Louvain-la-Neuve, Belgium. August 17, 1996.
Wallace, K. "Molecular mechanisms of toxic tissue injury", University of Coimbra, Departments of Biochemistry and Toxicology, Coimbra, Portugal. April 17, 1996.
Wallace, K. "Mechanisms mitochondrial toxicity: An advanced investigative laboratory course", University of Coimbra, Departments of Biochemistry and Toxicology, Coimbra, Portugal. April 08, 1996.
Wallace, K. "Mitochondrial-mediated cell injury", Society of Toxicology Annual Meeting, Anaheim, California, March 13, 1996.
Wallace, K. "Quinone-induced interference with mitochondrial calcium regulation", Society of Toxicology Annual Meeting, Anaheim, California, March 13, 1996.
Wallace, K. "Mitochondrial injury in toxicology", Society of Toxicology Annual Meeting, Anaheim, California, March 10, 1996.
Wallace, K. "Mitochondrial calcium cycling and activation of the permeability transition pore", Society of Toxicology Annual Meeting, Anaheim, California, March 10, 1996.
Wallace, K. "Mitochondrial mutagens: Drug accelerants of cardiomyopathy", National Heart, Lung, and Blood Institute – NIH, Bethesda, Maryland, May 15, 1995.
Wallace, K. "Mechanisms of adriamycin-induced mitochondrial cardiomyopathy", Medical College of Wisconsin, Department of Pharmacology & Toxicology, Milwaukee, Wisconsin, February 16, 1995.
Wallace, K. "Mitochondrial-mediated toxicity", Mississippi State University, Toxicology Graduate Program, Starkville, Mississippi, April 18, 1994.
Wallace, K. "Mitochondrial toxicity of adriamycin", Society of Toxicology, Michigan Chapter, Ann Arbor, Michigan, October 08, 1993.
Wallace, K. "Oxygen free radical-independent generation of microsomal lipid aldehydes and consumption of glutathione by adriamycin", Fifth Biennial Meeting, International Society for Free Radical Research, Pasadena, California, November 14, 1990.
Wallace, K. "Species-related differences in the catalytic site of brain acetylcholinesterase", 199th National Meeting, American Chemical Society, Agrochemicals Division, Boston, Massachusetts, April 22, 1990.
Wallace, K. "Enzymological basis of species-selective anticholinesterase toxicity", Iowa State University, Toxicology Program, Ames, Iowa, April 04, 1989.
Wallace, K. "Enzymological basis of species-selective anticholinesterase toxicity", Midwest Regional Chapter Annual Symposium, Society of Toxicology, Chicago, Illinois, November 04, 1988.
Wallace, K. "Species-selective targeting of anticholinesterase insecticides", University of Minnesota Graduate School Research Symposium: Academia in Review, Minneapolis, Minnesota, October 06, 1988.
Grants and Patents

Grants and Patents

Patents

Cyclodextrin Compositions and Methods of Treating Viral Infections. Issued: 2002