Khalid Amin

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Credentials

MD

Bio

Dr. Amin is an anatomic and clinical pathologist who has conducted research in the areas of angiogenesis, carcinogenesis and radiation-induced lung disease. He has also pursued studies of various human diseases in animal models, in vivo toxicology assays, and preclinical drug development of anti-cancer drugs in collaboration with the biotechnology industry. Amin was part of a collaborative research group that discovered a link between the clinical use of synthetic erythropoietin (EPO) and risk of tumorigenesis. He and his colleagues showed that tumor cells have cell-surface receptors for EPO, which can stimulate tumor cells to proliferate and enhances the formation of new blood vessels in tumors. Recently, Amin has collaborated with clinical colleagues in studies of cyroprobe lung biopsy, a new tool in diagnosing lung diseases; endoscopic ultrasound-guided fine needle aspiration as a diagnostic and staging tool for rectal and perirectal lesions; and the value of ex vivo dermoscopy of cutaneous biopsies in the histopathologic diagnosis of melanoma. He also collaborated in studies showing that the metal-responsive transcription factor-1 (MTF-1) zinc finger protein is elevated in human tumors, suggesting a role for MTF-1 in human carcinogenesis. As a cytopathologist he has a special interest in defining the role of molecular testing in diagnosis of thyroid cancer on cytology specimens. Although Amin is currently engaged mostly in clinical work, he has an interest in pursuing translational research in collaboration with clinicians and basic scientists.

Research Summary

Publications

• Khalifa MA, Gagner B, Chen L, Murugan P, Klein ME, Racila E, Amin K, Miller F, Stewart J, Ding Y, Farooqui M, Dasaraju S, and Adeyi OA.  Immunohistochemistry and immunofluorescence utilization audit by subspecialty in an academic setting: A step toward stewardship.  Annals of Diagnostic Pathology, Volume 67, 2023, 152214, https://doi.org/10.1016/j.anndiagpath.2023.152214.
• Rothrock AT, Stewart lll J, Li F, Racila E and Amin K. Exploration of INSM1 and hASH1 as additional markers in lung cytology samples of high-grade neuroendocrine carcinoma with indeterminate neuroendocrine differentiation. Diagnostic Cytopathology, 11 February 2022. https://doi.org/10.1002/dc.24938
• Goswami A, Zhang AJ, Vahidi S, Mettler T, Stewart 3^rd J, and Amin K. Oncocytic features in salivary duct carcinoma, a potential pitfall for misdiagnosis as Warthin tumor in fine needle aspiration specimens: A cytomorphologic analysis of 14 cases. Diagnostic Cytopathology, April 9, 2020. https://doi.org/10.1002/dc.24426
• Moisini I, Amin K, Mallery S, Stewart J 3rd, Mettler T. Efficacy of endoscopic-guided fine-needle aspiration in the diagnosis of gastrointestinal spindle cell tumors. Diagn Cytopathol. 2018 Aug;46(8):663-669. doi: 10.1002/dc.23976.
• Hupp M, Najmuddin M, Dincer HE, Mallery JS, Amin K, Stewart J 3rd, Cytomorphologic features of malignant or high risk solitary fibrous tumors of the mediastinum sampled by endoscopic and endobronchial ultrasound-guided fine needle aspiration: a comparison of two case reports, In Early View Diagnostic Cytopathology in April 2019.doi: 10.1002/dc.24192
• Nasir A, Amateau SK, Khan S, Simpson RW, Snover DC, Amin K. The Many Faces of Intestinal Tract Gastric Heterotopia; A Series of Four Cases Highlighting Clinical and Pathological Heterogeneity. Hum Pathol. 2018 Jan 7. pii: S0046-8177(18)30004-2. doi: 10.1016/j.humpath.2018.01.003. [Epub ahead of print] PubMed PMID: 29320750. http://www.humanpathol.com/article/S0046-8177(18)30004-2/fulltext