Khalid Amin, MD

Associate Professor, Department of Laboratory Medicine and Pathology

Khalid Amin

Contact Info

kamin@umn.edu

Office Phone 612-273-5684

Mailing Address:
MMC 76 Mayo
8076A (Campus Delivery Code)
420 Delaware St. SE
Minneapolis, MN 55455

MBBS (MD) Rawalpindi Medical College, Rawalpindi, Pakistan, 1994

University of Kansas Medical Center, Kansas City, Kansas (Residency in Anatomical and Clinical Pathology), 2007-2011

Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan, (Residency in Anatomical Pathology), 1996-1999

University of Kansas Medical Center, Kansas City, Kansas (Fellowship in Cytopathology), 2011-2012

Summary

Dr. Amin is an anatomic and clinical pathologist who has conducted research in the areas of angiogenesis, carcinogenesis and radiation-induced lung disease. He has also pursued studies of various human diseases in animal models, in vivo toxicology assays, and preclinical drug development of anti-cancer drugs in collaboration with the biotechnology industry. Amin was part of a collaborative research group that discovered a link between the clinical use of synthetic erythropoietin (EPO) and risk of tumorigenesis. He and his colleagues showed that tumor cells have cell-surface receptors for EPO, which can stimulate tumor cells to proliferate and enhances the formation of new blood vessels in tumors.

Recently, Amin has collaborated with clinical colleagues in studies of cyroprobe lung biopsy, a new tool in diagnosing lung diseases; endoscopic ultrasound-guided fine needle aspiration as a diagnostic and staging tool for rectal and perirectal lesions; and the value of ex vivo dermoscopy of cutaneous biopsies in the histopathologic diagnosis of melanoma. He also collaborated in studies showing that the metal-responsive transcription factor-1 (MTF-1) zinc finger protein is elevated in human tumors, suggesting a role for MTF-1 in human carcinogenesis. As a cytopathologist he has a special interest in defining the role of molecular testing in diagnosis of thyroid cancer on cytology specimens. Although Amin is currently engaged mostly in clinical work, he has an interest in pursuing translational research in collaboration with clinicians and basic scientists.

Research

Publications

    • Goswami A, Zhang AJ, Vahidi S, Mettler T, Stewart 3rd J, and Amin K. Oncocytic features in salivary duct carcinoma, a potential pitfall for misdiagnosis as Warthin tumor in fine needle aspiration specimens: A cytomorphologic analysis of 14 cases. Diagnostic Cytopathology, April 9, 2020. https://doi.org/10.1002/dc.24426
    • Moisini I, Amin K, Mallery S, Stewart J 3rd, Mettler T. Efficacy of endoscopic-guided fine-needle aspiration in the diagnosis of gastrointestinal spindle cell tumors. Diagn Cytopathol. 2018 Aug;46(8):663-669. doi: 10.1002/dc.23976.
    • Hupp M, Najmuddin M, Dincer HE, Mallery JS, Amin K, Stewart J 3rd, Cytomorphologic features of malignant or high risk solitary fibrous tumors of the mediastinum sampled by endoscopic and endobronchial ultrasound-guided fine needle aspiration: a comparison of two case reports, In Early View Diagnostic Cytopathology in April 2019.doi: 10.1002/dc.24192
    • Nasir A, Amateau SK, Khan S, Simpson RW, Snover DC, Amin K. The Many Faces of Intestinal Tract Gastric Heterotopia; A Series of Four Cases Highlighting Clinical and Pathological Heterogeneity. Hum Pathol. 2018 Jan 7. pii: S0046-8177(18)30004-2. doi: 10.1016/j.humpath.2018.01.003. [Epub ahead of print] PubMed PMID: 29320750. http://www.humanpathol.com/article/S0046-8177(18)30004-2/fulltext
    • Amin K, El-Rayess D, Snover D, Mettler T, Vogel RI, Khalifa MA. Patterns of Immunohistochemistry Utilization in Metastases to the Liver. Appl Immunohistochem Mol Morphol. 2018 Sep 5. [Epub ahead of print]
      Vahidi S, Stewart J, Amin K, Racila E, Li F. Metastatic medullary thyroid carcinoma or calcitonin-secreting carcinoid tumor of lung? A diagnostic dilemma in a patient with lung mass and thyroid nodule. Diagnostic Cytopathology. 10 Nov 2017, DOI: 10.1002/dc 23852 http://onlinelibrary.wiley.com/doi/10.1002/dc.23852/full
    • Sekulic M, Gilles S, Amin K, Stewart Jimmie III. Undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: a series of 5 cases with clinicopathologic correlation and cytomorphologic characterization. J Amer Soc Cytopath 2016. DOI: http://dx.doi.org/10.1016/j.jasc.2016.04.00
    • Fitzpatrick M, Pulver T, Klein M, Murugan P, Khalifa M, Amin K. Perivascular Epithelioid Cell Tumor of the Uterus with Ovarian Involvement: A Case Report and Review of the Literature. Am J Case Rep. 2016 May 6;17:309-14.
    • Amin K, Fraga GR. Ex Vivo Dermoscopy of Cutaneous Biopsies For Melanocytic Neoplasms: A Retrospective Review of 517 Cases With Histopathologic Correlation. Am J Dermatopathol. 2012 Mar 14. [Epub ahead of print].
    • Amin K, O'Neil MF, Fan F, McGregor DH. Epidermal Growth Factor Receptor Positivity In Angiomyolipoma Contiguous To Renal Cell Carcinoma: Report Of Two Cases With Immunohistochemical Analysis. Ann Clin Lab Sci. 2011 Fall;41(1):56-60.
    • Chao WR,Amin K, Shi Y, Hobbs P, Tanabe M, Tanga M, Jong L, Collins N, Peters R, Laderoute K, Dinh D, Yean D, Hou C, Sato B, Alt C, Sambucetti L. SR16388: A Steroidal Antiangiogenic Agent With Potent Inhibitory Effect On Tumor Growth In vivo. Angiogenesis. 2011 Mar;14(1):1-16.
      Pan CP, Shi Y,Amin K, Greenberg CS, Haroon Z, and Faris GW. Wound Healing Monitoring Using Near Infrared Fluorescent Fibrinogen. Biomed Opt Express. 2010 Jul 27;1(1):285-294.

    Clinical

    Board Certifications

    • Anatomical and Clinical Pathology, American Board of Pathology
    • Cytopathology, American Board of Pathology