Mark Luquette

Assistant Professor, Department of Laboratory Medicine and Pathology

Mark Luquette

Contact Info

Office Phone 612-273-5102

MD, Louisiana State University School of Medicine, 1985

Residency in Pathology, BarnesJewish Hospital, Washington University School of Medcine, 1989

Fellowship in Pathology, University of Alabama in Birmingham School of Medicine, 1983

Fellowship in Pediatric Pathology, Children's Hospital of Pittsburgh, 1991



Research Summary/Interests

Dr. Luquette is a pediatric-perinatal pathologist with a background in basic science and information technology (including programing and systems development). He has also served in administrative roles with an emphasis on development of infrastructure and deployment of cutting edge services. His current research interests include diagnostic techniques and have focused on molar gestation, Hirschsprung’s disease and inflammatory bowel disease.

Current studies of molar pregnancies include analysis of p53 as a marker to separate partial hydatidiform moles from nonmolar gestations using morphometric techniques. The benefit would be improved identification of cases that require ploidy studies, a more costly test that requires a greater amount of time for a result.

Since joining the department, Dr. Luquette has validated the Acetylcholinesterase enzyme histochemical stain for use in rectal biopsies and added some refinements to expand the ability of practitioners to obtain, store and ship specimens in a stable transport medium. This allows specimens to be harvested at any hour, be stable for days prior to processing, and to be shipped long distances for consultation.

Studies planned for inflammatory bowel disease include the development of methods using flow cytometry to immunophenotype the inflammatory cells in intestinal biopsies in an effort to distinguish ulcerative colitis from Crohn’s disease.


Naumchik B, Weigel BJ, Murati MA, Rudzinski E, Paulson V, Lockwood CM, Dolan M, Flanagan S, Luquette M. Congenital infantile fibrosarcoma involving pelvic wall and thigh soft tissues and placenta, presenting with coagulopathy. Pediatr Dev Pathol. 2022 Jul 14:10935266221114017. doi: 10.1177/10935266221114017.

Oltvai ZN, Smith EA, Wiens K, Nogee LM, Luquette M, Nelson AC, and Wikenheiser-Brokamp KA. Neonatal respiratory failure due to novel compound heterozygous mutations in the ABCA3 lipid transporter. Cold Spring Harb Mol Case Stud. 2020;6(3):a005074. 2020 Jun 12. doi:10.1101/mcs.a005074

Aqsa Nasir, MD; Mark Luquette, MD; Paari Murugan, MD., "Retroperitoneal Ganglioneuroblastoma and Plexiform Neurofibroma in an Adult: A Rare Presentation", in press, published as a web-only supplement to the September 2016 issue of theArchives of Pathology & Laboratory Medicine.

Mark Luquette, M.D.,Use of Tissue Fixatives on Rectal Biopsies for Subsequent Staining for Acetylcholinesterase in the Diagnosis of Hirschsprung's Disease.” , submitted Society for Pediatric Pathology, Fall 2016 meeting.

Daniel Beisang, MD, PhD; Gregory P. Forlenza, MD; Mark Luquette, MD; Kyriakie Sarafoglou, MD, “Sporadic Insulinoma Presenting as Early Morning Night Terrors”, submitted to Pediatrics.

M. Van Den Berg, C. Di Lorenzo, H. Mousa, M. Benninga, G. Boeckxstaens, M. Luquette: “Morphological changes of the enteric nervous system, interstitial cells of Cajal, and smooth muscle in children with colonic motility disorders.” Journal Pediatr Gastroenterol Nutr. 2009 Jan;48(1):22-9.

M. Luquette, M. Van Den Berg, H. Mousa, M. Uddin: Absence of Calretinin in a Suction Rectal Biopsy Appears Diagnostic of Hirschsprung’s Disease. (platform presentation at Society for Pediatric Pathology Interim Meeting, Columbus, Ohio, October 5–8, 2006). Pediatric and Developmental Pathology, Volume 10, Issue 1 (January-February 2007) pp. 76–77


Board Certifications

Anatomic Pathology, American Board of Pathology

Pediatric Pathology, American Board of Pathology