Myron Gross

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Credentials

PhD

Bio

Dr. Gross directs the Molecular Epidemiology and Biomarker Research Laboratory (MEBRL) and is a faculty investigator in the Advanced Research and Diagnostic Laboratory (ARDL). MEBRL acts as the central laboratory for several studies wherein he applies biochemical, immunologic and genetic mass spectrometry (MS) and other techniques to the discovery, development, and application of biomarkers in cardiovascular disease, diabetes, and cancer. Special emphasis is placed on mass spectrometry that allows for a highly precise characterization of biomarkers.Dr. Gross and his research team specialize in conducting analyses for large epidemiologic studies with the goal of defining new risk factors and understanding the pathophysiology of the conditions. One of his areas of interest is the interplay of diet and chronic disease, in particular, the role of oxidative cellular damage and antioxidant micronutrients in cardiovascular disease risk and prevention. He has also explored the association between oxidative stress biomarkers and insulin resistance syndrome, a risk factor for developing diabetes and heart disease. Another research focus in Gross's laboratory is the role of gene expression and genetic susceptibility in populations at risk for type-2 diabetes. Despite low rates of obesity, Southeast Asians have high rates of type-2 diabetes, placing a high public health and economic burden upon governments in that part of the world. Gross's research team is participating in major NIH-funded studies of genetic and environmental factors of people with type-2 diabetes in India and Singapore using genetic sequencing, genotyping, and analysis of biochemical receptors. One of the goals is to identify early onset type-2 diabetes in people ages 10 to 30 in order to initiate treatment and prevent or delay the development of cardiovascular complications. Dr. Gross also participates in a program funded by the NIH's Fogarty International Center to strengthen India's clinical research and training capacity. A third area of focus is dietary flavonoids and their biological activities. Dr. Gross is the President of PhenHRIG, a small society devoted to understanding the health effects and activities of flavonoids.

Research Summary

Publications

Kristin M. Hirahatake, Andrew O. Odegaard, Myron D. Gross, Carmen Peralta, Kirsten Bibbins-Domingo, Michael Shlipak, Holly Mattix-Kramer, David R. Jacobs. “Objective Dietary Biomarkers of Vegetable and Fruit Intake Inversely Associate with Rapid Kidney Function Decline: The CARDIA Study.” American Heart Association, Epi Lifestyle 2016. Phoenix, Arizona. Mar 1-4, 2016.

Myron D. Gross, Otto Sanchez, David R. Jacobs. “RELATIONSHIPS AMONG INDICATORS OF OXIDATIVE STRESS AND ANTIOXIDANTS: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.” American Heart Association, Epi Lifestyle 2016. Phoenix, Arizona. Mar 1-4, 2016.

Bharat Thyagajaran, Weihua Guan, Veronika Fedirko, Helene Barcelo, Myron D. Gross, Michael Goodman, Roberd M. Bostick. “Mitochondrial D-Loop Polymorphisms Are Associated With Colorectal Adenoma Risk.” AACR 2016.

Bharat Thyagajaran, Renwei Wang, Woon-Puay Koh, Helene Barcelo, Jennifer Adams-Haduch, Weihua Guan, Roberd M. Bostick, Jian-Min Yuan, Myron D. Gross. “Mitochondrial DNA Copy Number, Urinary Isoprostanes and Colorectal Cancer Risk.” AACR 2016.

April P. Carson, Paul Muntner, Elizabeth Selvin, Mercedes R. Carnethon, Christina M. Shay, David R. Jacobs, Myron D. Gross, Timothy Garvey, Cora E. Lewis. “Total Fat Mass and BMI Exhibit Varying Associations with Glycemic Markers.” ADA June 2016.