Nicole Zantek

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Credentials

MD, PhD

Bio

Dr. Zantek is the medical director of the Special Coagulation Laboratory and conducts research in the areas of hemostasis, transfusion medicine, and blood utilization. She is interested in general issues surrounding hemostasis test performance, utilization, and interpretation. In particular, she is exploring how medical circuits, such as ventricular assist devices and apheresis cell separators, influence hemostasis in adult and pediatric patients. These patients typically are medicated to achieve an appropriate balance between bleeding and clotting, which requires testing. How hemostasis test results are best interpreted is the subject of ongoing research. Under Zantek's direction, the Special Coagulation Laboratory is the beta test site for a number of new coagulation testing technologies. In addition, standard testing protocols can be modified and assays can be validated using its analyzers for research purposes.Zantek is also interested in advancing transfusion medicine and blood utilization practices. Using evidence-based hospital guidelines, she is part of a team that has developed an interactive patient blood management system designed to ensure that each transfusion is as safe as possible and limited to transfusing the right blood component to the right patient at the right time. The new system has the potential to conserve transfusion resources and lower costs.

Research Summary

Publications

• Zantek ND, Hsu P, Meijer P, Smock KJ, Plumhoff EA, Refaai MA, Van Cott EMl. Quality of factor XI activity testing in North American Specialized Coagulation Laboratories. International Journal of Laboratory Hematology. 2015;37 Suppl 1:99-107.
• Adatya S, Uriel N, Yarmohammadi H, Holley CT, Feng A, Roy SS, Reding MT, Eckman JR, Zantek ND. Anti-factor Xa and activated partial thromboplastin time measurements for heparin monitoring in mechanical circulatory support. JACC: Heart Fail. 2015;3(4):314-322.
• Hummon D, Zantek ND, Sumstad D, Miller JS, McKenna DH. Transfusion-associated graft-versus-host disease: a perspective from a cell therapy laboratory. Transfusion 49:1018-19, 2009.
• Cohn, Claudia S.; Welbig, Julie; Bowman, Robert J.; Kammann, Susan; Frey, Katherine; Zantek, Nicole Dodge. A data-driven approach to patient blood management. Transfusion. 54(2): 316-322.