Nicole Zantek, MD, PhD

Associate Professor, Department of Laboratory Medicine and Pathology

Nicole Zantek

Contact Info

Office Phone 612-626-3768

Mailing Address:
MMC 609 Mayo
420 Delaware
Minneapolis, MN 55455

Associate Professor, Department of Laboratory Medicine and Pathology


Georgetown University School of Medicine. 2001

Georgetown University Hospital (Anatomic and Clinical Pathology), 2005

University of Minnesota (Blood Banking and Transfusion), 2006

PhD, Purdue University, 1999

Concordia College, Moorhead, MN (Biology), 1992


Dr. Zantek is the medical director of the Special Coagulation Laboratory and conducts research in the areas of hemostasis, transfusion medicine, and blood utilization. She is interested in general issues surrounding hemostasis test performance, utilization, and interpretation. In particular, she is exploring how medical circuits, such as ventricular assist devices and apheresis cell separators, influence hemostasis in adult and pediatric patients. These patients typically are medicated to achieve an appropriate balance between bleeding and clotting, which requires testing. How hemostasis test results are best interpreted is the subject of ongoing research. Under Zantek’s direction, the Special Coagulation Laboratory is the beta test site for a number of new coagulation testing technologies. In addition, standard testing protocols can be modified and assays can be validated using its analyzers for research purposes.

Zantek is also interested in advancing transfusion medicine and blood utilization practices. Using evidence-based hospital guidelines, she is part of a team that has developed an interactive patient blood management system designed to ensure that each transfusion is as safe as possible and limited to transfusing the right blood component to the right patient at the right time. The new system has the potential to conserve transfusion resources and lower costs.



  • Zantek ND, Hsu P, Meijer P, Smock KJ, Plumhoff EA, Refaai MA, Van Cott EMl. Quality of factor XI activity testing in North American Specialized Coagulation Laboratories. International Journal of Laboratory Hematology. 2015;37 Suppl 1:99-107.
  • Adatya S, Uriel N, Yarmohammadi H, Holley CT, Feng A, Roy SS, Reding MT, Eckman JR, Zantek ND. Anti-factor Xa and activated partial thromboplastin time measurements for heparin monitoring in mechanical circulatory support. JACC: Heart Fail. 2015;3(4):314-322.
  • Hummon D, Zantek ND, Sumstad D, Miller JS, McKenna DH. Transfusion-associated graft-versus-host disease: a perspective from a cell therapy laboratory. Transfusion 49:1018-19, 2009.
  • Cohn, Claudia S.; Welbig, Julie; Bowman, Robert J.; Kammann, Susan; Frey, Katherine; Zantek, Nicole Dodge. A data-driven approach to patient blood management. Transfusion. 54(2): 316-322.
  • Zantek N.D., Hsu P., Refaai M.A., Ledford-Kraemer P., Meijer M., Van Cott E.M. Factor VII assay performance: An analysis of the North American Specialized Coagulation Laboratory Association Proficiency Testing Results. International Journal of Laboratory Hematology 25:314-21, 2013
  • Zantek, Nicole Dodge, Koepsell, Scott A., Tharp, Daryl R., Cohn, Claudia S. The direct antiglobulin test: A critical step in the evaluation of hemolysis. American Journal of Hematology. 87(7):707-709, 2012
  • Morgan, Shanna M.; Zantek, Nicole Dodge. Therapeutic plasma exchange for fulminant hepatic failure secondary to Wilson's disease. Journal of Clinical Apheresis. 27(5): 282-286, 2012


Board Certifications

Anatomic Pathology, Clinical Pathology, Transfusion Medicine / Blood Banking