Oyedele Adeyi, MD

Professor, Department of Laboratory Medicine and Pathology

Oyedele Adeyi

Contact Info

adeyio@umn.edu

Office Phone 612-626-1005

Mailing Address:
MMC 76 Mayo
420 Delaware St. SE
Minneapolis, MN 55455

MD, College of Medicine, University of Ibadan Ibadan Nigeria, 1987

Residency in Anatomic and Clinical Pathology, Dartmouth-Hitchcock Medical Center / Dartmouth Medical School, 2005

Residency in Pathology, Lagos University, Teaching Hospital, Lagos, Nigeria, 1996

Liver & Transplantation Pathology Clinical Fellowship, University of Pittsburgh Medical Center, 2006

Research Fellowship in Renal Pathology, Brigham & Women's Hospital / Harvard Medical School, Boston, 2000

Pre-med degree, The Ibadan Polytechnic, Ibadan, Nigeria, 1982

Summary

Dr. Adeyi is an anatomic pathologist with expertise in liver and transplantation pathology. His clinical practice covers medical, transplant and oncologic diseases of the liver, with more than 15 years' experience as a hepatobiliary pathology sub-specialist. His primary research interest is in transplant and tumor immunology. During his career he has combined an active clinical service with research and teaching as well as participating locally, nationally, and internationally as a key resource in medical, transplantation and oncologic liver diseases.

Adeyi's research has focused on the interplay between the immune system on the one hand and allogeneic, tumor and viral antigens on the other. In collaboration he has used murine and pig models to study varying aspects of alloimmunity, infections, and tumorigenesis in modified immunologic backgrounds, with a view to understanding how best to utilize the innate and specific immune systems in achieving better outcomes in solid organ transplantation and malignancies, as well as viral infections and organ preservation injury.

Expertise

Liver disease, hepatobiliary pathology, liver transplantation, liver cancer, tumor immunology, renal disease

Awards & Recognition

2019 CAP-ACP Leadership in Education Award

2016 Certificate of Appreciation, Hans Popper Hepatopathology Society, United States of America - for serving as the education committee chairperson for a maximum allowable period of 3 years (2013-2016)

2008 - 2010 Dean’s Commendation, University of Toronto. (Distinction)
For 3 consecutive years by the Faculty of Medicine for serving as a Mentor to Inner City High School students during the 2008, 2009, and 2010 summer mentorship program.

2009 Certificate of Appreciation, College of American Pathologists, Chicago, Illinois. (Distinction) For participating in the College’s Pilot Program that subsequently led to the development of a formal Mentorship Program by the College.

2009 Letter of Appreciation, McMaster University, Hamilton, Ontario. (Distinction) - or serving as Guest Lecturer as well as organizing a half-day slide seminar for pathology residents.

2009 Letter of Appreciation, Ontario Association of Pathologists, Collingwood, Canada. (Distinction) - for serving as a faculty lecturer at the 2009 Annual General meeting of the Association.

2008 Certificate of Appreciation, College of American Pathologists, Chicago, Illinois. (Distinction) - as a participant in the College’s Member Research Panel.

2008 Certificate of Appreciation, College of American Pathologists, Chicago, Illinois. (Distinction) - as a member of the College’s Spokespersons Network.

2008 Certificate of Appreciation, Center for the Evaluation of Health Professionals Educated Abroad, Toronto, Canada. (Distinction)

Professional Associations

2009 Jul - present Member, Banff International Conference on Allograft Pathology
2009 Jan 1 - present Member, American Association for the Study of Liver Diseases (AASLD)
2008 Jan 1 - present Member, International Liver Transplantation Society (ILTS)
2007 Mar 1 - present Member, Hans Popper Hepatopathology Society
2007 Jan 1 - present Member, Canadian Association of Pathologists
2007 Jan 1 - present Member, Ontario Association of Pathologists
2006 Mar 1 - present Member, Canadian Association for the Study of the Liver
2006 Feb 1 - present Member, Canadian Medical Protective Association. 20056841
2006 Jan 17 - present Member, American Society of Transplantation
2006 Jan 18 - present Member, Ontario Medical Association, 0969719
2005 Jan 17 - present Member, College of American Pathologists, 1044454
2001 Feb 1 - present Member, United States and Canadian Academy of Pathology, 13582

Research

Research Summary/Interests

Transplant and tumor immunology

Publications

  • Sheka AC, Adeyi O, Thompson J, Hameed B, Crawford PA, Ikramuddin S. Nonalcoholic steatohepatitis: A review. JAMA. 2020;323(12):1175-1183.
  • Kei S, Adeyi OA.Practical Application of Lineage-Specific Immunohistochemistry Markers: Transcription Factors (Sometimes) Behaving Badly. Arch Pathol Lab Med. 2020 May;144(5):626-643.
  • Pai RK, Kleiner DE, Hart J, Adeyi OA, Clouston AD, Behling CA, Jain D, Kakar S, Brahmania M, Burgart L, Batts KP, Valasek MA, Torbenson MS, Guindi M, Wang HL, Ajmera V, Adams LA, Parker CE, Feagan BG, Loomba R, Jairath V. Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials. Aliment Pharmacol Ther. 2019 Nov;50(10):1100-1111
  • Galante A, Adeyi O, Lau L, Humar A, Galvin Z, Selzner N, Lilly L, Sapisochin G, Bhat M. Liver Transplantation for Acute Liver Failure Due to Dengue Fever. Hepatology. 2019 Nov;70(5):1863-1865.
  • Linares-Cervantes I, Echeverri J, Cleland S, Kaths JM, Rosales R, Goto T, Kollmann D, Hamar M, Urbanellis P, Mazilescu L, Ganesh S,, Adey iOA, Yip P, Gory?ska P, Bojko B, Gory?ski K, Grant DR, Selzner N, W?sowicz M, Selzner M. Predictor parameters of liver viability during porcine normothermic ex situ liver perfusion in a model of liver transplantation with marginal grafts. Am J Transplant. 2019 Nov;19(11):2991-3005
  • Klingberg O, Khattar R, Farrokhi K, Ferri D, Yavorska N, Zhang J, Sadozai H, Adeyi O, Chruscinski A, Levy GA, Selzner N. Inhibition of the FGL2:Fc?RIIB/RIII Immunosuppressive Pathway Enhances Antiviral T cell and B Cell Responses Leading to Clearance of LCMV cl-13. Immunology. 2018 Jan 17 [Epub ahead of print]
  • Echeverri J, Goldaracena N, Kaths JM, Linares I, Roizales R, Kollmann D, Hamar M, Urbanellis P, Ganesh S, Adeyi OA, Tazari M, Selzner M, Selzner N. Comparison of BQ123, Epoprostenol, and Verapamil as Vasodilators During Normothermic Ex Vivo Liver Machine Perfusion. Transplantation. 2017 Nov 20. [Epub ahead of print]
  • Adeyi OA. Pathology primer: Common liver biopsy findings in patients who have recently undergone liver transplant or resection. Clinical Liver Disease. 2017 August 30; 10:42–48.
  • Bartczak A, Zhang J, Adeyi O, Amir A, Grant D, Gorczynski R, Selzner N, Chruscinski A, Levy GA. Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis. World J Gastroenterol. 2017 Apr 21;23(15):2673-
    2684.
  • Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Chng MHY, Shen L, D'Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer DA. Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome. Sci Immunol. 2017 Apr 21;2(10).
  • Goldaracena N, Echeverri J, Spetzler VN, Kaths JM, Barbas AS, Louis KS, Adeyi OA, Grant DR, Selzner N, Selzner M. Anti-inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation. Liver Transpl. 2016 Nov;22(11):1573-1583
  • Tsoi KM, MacParland SA, Ma XZ, Spetzler VN, Echeverri J, Ouyang B, Fadel SM, Sykes EA, Goldaracena N, Kaths JM, Conneely JB, Alman BA, Selzner M, Ostrowski MA, Adeyi OA, Zilman A, McGilvray ID, Chan WC. Mechanism of hard-nanomaterial clearance by the liver. Nat Mater. 2016 Nov;15(11):1212-1221.
  • Demetris AJ, Bellamy C, Hu?bscher SG, O'Leary J, Randhawa PS, Feng S, Neil D, Colvin RB, McCaughan G, Fung JJ, Del Bello A, Reinholt FP, Haga H, Adeyi O, Czaja AJ, Schiano T, Fiel MI, Smith ML, Sebagh M, Tanigawa RY, Yilmaz F, Alexander G, Baiocchi L, Balasubramanian M, Batal I, Bhan AK, Bucuvalas J, Cerski CTS, Charlotte F, de Vera ME, ElMonayeri M, Fontes P, Furth EE, Gouw ASH, Hafezi-Bakhtiari S, Hart J, Honsova E, Ismail W, Itoh T, Jhala NC, Khettry U, Klintmalm GB, Knechtle S, Koshiba T, Kozlowski T, Lassman CR, Lerut J, Levitsky J, Licini L, Liotta R, Mazariegos G, Minervini MI, Misdraji J, Mohanakumar T, Mölne J, Nasser I, Neuberger J, O'Neil M, Pappo O, Petrovic L, Ruiz P, Sa?ol Ö, Sanchez Fueyo A, Sasatomi E, Shaked A, Shiller M, Shimizu T, Sis B, Sonzogni A, Stevenson HL, Thung SN, Tisone G, Tsamandas AC, Wernerson A, Wu T, Zeevi A, Zen Y. 2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection. Am J Transplant. 2016 Oct;16(10): 2816-2835.
  • Doyle A, Adeyi O, Khalili K, Fischer S, Dib M, Goldaracena N, Dillon J, Grant D, Cattral M, McGilvray I, Greig P, Ghanekar A, Lilly L, Renner E, Levy G, Selzner N. Treatment with Optifast reduces hepatic steatosis and increases candidacy rates for living donor liver transplantation. Liver Transpl. 2016 Sep;22(9):1295-300.
  • Bartczak A, Chruscinski A, Mendicino M, Liu H, Zhang J, He W, Amir AZ, Nguyen A, Khattar R, Sadozai H, Lobe CG, Adeyi O, Phillips MJ, Zhang L, Gorczynski RM, Grant D, Levy GA. Overexpression of Fibrinogen-Like Protein 2 Promotes Tolerance in a Fully Mismatched Murine Model of Heart Transplantation. Am J Transplant. 2016 Jun;16(6):1739-50.
  • Toba H, Tomankova T, Wang Y, Bai X, Cho HR, Guan Z, Adeyi OA, Tian F, Keshavjee S, Liu M. XB130 deficiency enhances lipopolysaccharide-induced septic response and acute lung injury. Oncotarget. 2016 May 3;7(18):25420-
    31.
  • Duarte-Rojo A, Fischer SE, Adeyi O, Zita D, Deneke MG, Selzner N, Chen L, Malespin M, Cotler SJ, McGilvray ID, Feld JJ. Protease inhibitors partially overcome the interferon nonresponse phenotype in patients with chronic
    hepatitis C. J Viral Hepat. 2016 May;23(5):340-347.
  • Spetzler VN, Goldaracena N, Echiverri J, Kaths JM, Louis KS, Adeyi OA, Yip PM, Grant DR, Selzner N, Selzner M. Subnormothermic ex vivo liver perfusion is a safe alternative to cold static storage for preserving standard criteria grafts. Liver Transpl. 2016 Jan;22(1):111-119.
  • Siddiqui I, Selzner N, Hafezi-Bakhtiari S, Marquez MA, Adeyi OA. Infiltrative (sinusoidal) and hepatitic patterns of injury in acute cellular rejection in liver allograft with clinical implications. Mod Pathol. 2015 Sep;28(9):1275-
    1281.
  • Urbanellis P, Shyu W, Khattar R, Wang J, Zakharova A, He W, Sadozai H, Amir AZ, Shalev I, Phillips MJ, Adeyi O, Ross H, Grant D, Levy GA, Chruscinski A. The regulatory T cell effector molecule fibrinogen-like protein 2 isnecessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts. Immunology. 2015 Jan;144(1):91-106. 16. Mason M, Adeyi O, Fung S, Millar BA. Vanishing bile duct syndrome in the context of concurrent temozolomide for glioblastoma. BMJ Case Rep. 2014 Nov 28;2014.
  • Knaak JM, Spetzler VN, Goldaracena N, Boehnert MU, Bazerbachi F, Louis KS, Adeyi OA, Minkovich L, Yip PM,Keshavjee S, Levy GA, Grant DR, Selzner N, Selzner M. Subnormothermic ex vivo liver perfusion reduces endothelial
    cell and bile duct injury after donation after cardiac death pig liver transplantation. Liver Transpl. 2014 Nov;20(11):1296-1305.
  • Terrault NA, Stravitz RT, Lok AS, Everson GT, Brown RS Jr, Kulik LM, Olthoff KM, Saab S, Adeyi O, Argo CK, Everhart JE, Rodrigo del R; A2ALL Study Group.. Hepatitis C disease severity in living versus deceased donor liver
    transplant recipients: an extended observation study. Hepatology. 2014 Apr;59(4):1311-1319.
  • Klein J, Dawson LA, Tran TH, Adeyi O, Purdie T, Sherman M, Brade A. Metabolic syndrome-related hepatocellular carcinoma treated by volumetric modulated arc therapy. Curr Oncol. 2014 Apr;21(2):e340-4.
  • Hafezi-Bakhtiari S, Adeyi OA. Metabolic disorders of the liver. Diagnostic Histopathology. 2014 March; 20(3):125-133.
  • Mitrovic B, Danielson B, Adeyi OA. Hepatitis or not hepatitis: it all depends on the liver biopsy… or does it?. Diagnostic Histopathology. 2013 November; 19(11):426-428.
  • Ghanekar A, Ahmed S, Chen K, Adeyi O. Endothelial cells do not arise from tumor-initiating cells in human hepatocellular carcinoma. BMC Cancer. 2013 Oct 20;13:485.

BOOK CHAPTERS

Adeyi O. Liver Transplant Pathology. Consultant Pathology Series: Liver Pathology [Eds. Ferrell LD & Kakar S].  Chapter 22; (pp 307-342); New York City; DemosMedical, 2011. ISBN 978-1-933864-93-8. Principal Author.

Dawson LA, Adeyi O, Guha C. The Liver. Volume 2: Specific Normal Tissue Sites. In ALERT – Adverse Late Effects of Cancer Treatment. Medical Radiology - Radiation Oncology Edited by P. Rubin, L.S. Constine, L.B. Marks, L.A. Dawson. Springer 2009 (PA). ISBN 978-3-540-75862-4. Coauthor or Collaborator.

Adeyi O. Integrated molecular and cytogenetic pathology. In Abudu A (Ed.,): Annual Symposium: Advances in medical care (pp 124-129). Ibadan, Nigeria: Dokun Publishing House 2008. ISBN 978-37962-7-5. Principal Author.

COMMENTARIES

Adeyi O.A. Transplantation pathology.  Phillip Ruiz. Published by Cambridge University Press, 2009, 408 pp. Hardcover. ISBN-13: 978-0521879958. Journal of Clinical Pathology. 2015 Oct;68(10):858. Principal Author.

MONOGRAPHS

Adeyi OA (editor). Mini-Symposium: Transplant Pathology. Diagnostic Histopathology. 2012; 18(7): 269-312. Editor.

SNAPSHOTS IN SURGERY

Gunn V, Adeyi O, Jhaveri K, Wei AC. Snapshots in Surgery: Type I Choledochal Cyst. British Journal of Surgery. 2010; 97:117. Coauthor or Collaborator.

PRESENTATIONS AND LECTURES

INTERNATIONAL

2019 Oct. 3-5  (CME Course Faculty) Seth GS Medical College & KEM Hospital, International Update Course in Liver Pathology, Mumbai, India

Lecture topics:

  • Medical Liver Biopsy Interpretation: An Approach
  • Liver Transplantation Pathology: Old & New Entities and an Approach
  • Histopathological Application of Staging and Grading Parameters in Medical Liver Diseases

2018 April 5 Visiting professor. McMaster University Department of Pathology and Molecular Medicine, Hamilton,ON, Canada Presenter(s): Adeyi OA. Residents Academic Half Day program.

2018 March 23 Invited Speaker. If it Doesn't Make Sense...It's Because It Doesn't: "Specific" Immunostains Fail Out of Context. United States and Canadian Academy of Pathology. San Diego, California, United States. Presenter(s): Adeyi OA. Specialty conference: I was invited as one of five-member specialty conference panel at the world's largest annual conference of pathologists.

2017 Aug 4 Invited Guest Lecturer, Public Workshop of Brain Drain in Nigeria: Nigeria’s Next Big Danger: The New Wave Of Brain Drain. College of Medicine, University of Ibadan, Nigeria

2017 Aug 1 Visiting Professor & Moderator Public Symposium on Cancer in Nigeria. Role of Tissue in Personalized Cancer Care & Treatment Outcomes. Lagos University Teaching Hospital/Nigeria's Federal Ministry of Health, Lagos, Nigeria

2016 Nov 27 Visiting Professor. Liver Pathology: Intraoperative Consultations for Frozen Section Diagnosis. Hamad Medical Center, Qatar. Doha, Qatar. Presenter(s): Oyedele A. Adeyi. (Continuing Education).

2016 Nov 28 Visiting Professor. Liver Allograft Pathology. Hamad Medical Center, Qatar. Doha, Qatar. Presenter(s): Oyedele A. Adeyi. (Continuing Education).

2016 Nov 28 Visiting Professor. Medical Liver Biopsies: Hepatitis Staging & Grading. Hamad Medical Center, Qatar. Doha, Qatar. Presenter(s): Oyedele A. Adeyi. Residents Teaching

2016 Nov 28 Visiting Professor. Traditions in Liver Biopsy and The Demands of A New Era. Hamad Medical Center, Qatar. Doha, Qatar. Presenter(s): Oyedele A. Adeyi. Continuing Education

2016 Nov 29 Visiting Professor. Pathologic-Radiologic Correlations in Clinical & Surgical Hepatology. Hamad Medical Center, Qatar. Doha, Qatar. Presenter(s): Oyedele A. Adeyi. Radiology Fellows, Faculty and Residents Teaching

2016 May 20 Visiting Professor.Thinking Long-Term with Liver Allografts: Attention-shift to the Sinusoids. Johns Hopkins University, Department of Pathology, GI/Liver Division. Presenter(s): Oyedele A. Adeyi. Invited Special Lecture

2016 Mar 22 Visiting Professor. Drug-induced liver injury. Hamad Medical Center, Qatar. Doha, Qatar. Presenter(s): Oyedele A. Adeyi. (Continuing Education).

2016 Mar 20 Visiting Professor. Hepatocellular carcinoma: risks and role of the pathologist. Hamad Medical Center, Qatar. Doha, Qatar. Presenter(s): Oyedele A. Adeyi. (Continuing Education).

2016 Mar 20 Visiting Professor. Introduction to Liver Pathology. Hamad Medical Center, Qatar. Doha, Qatar. Presenter(s): Oyedele A. Adeyi. Residents Teaching

2016 Mar 17 Invited Speaker. Twists in Liver Pathology: Unsuspected Findings that Changed “Everything”. United States and Canadian Academy of Pathology. Seattle, Washington, United States. Presenter(s): Adeyi OA. Interactive Microscopy Session/Continuing Education at International Conference.

2015 Aug 28 Invited Speaker. Interactive session depicting multidisciplinary approach to cancer care. West African Division of the International Academy of Pathology (WADIAP). Ibadan, Nigeria. Presenter(s): Adeyi OA, Abudu TA.  Major international annual pathology conference. Invited as a key resource person and delivered three lectures.

2015 Aug 25 Invited Speaker. Hepatocellular carcinoma: The disease, its sponsors and victims with emphasis on “new players”. West African Division of the International Academy of Pathology (WADIAP). Ibadan, Nigeria.

Presenter(s): Adeyi OA. Major international annual pathology conference. Invited as a key resource person and delivered three lectures.

2015 Aug 24 Invited Speaker. Problematic vascular neoplasms of the liver and Recent Updates. West African Division of the International Academy of Pathology (WADIAP). Ibadan, Nigeria. Presenter(s): Adeyi OA. Major international annual pathology conference. Invited as a key resource person and delivered three lectures.

PROVINCIAL/REGIONAL

Feb. 27, 2020: Cedar Sinai Medical Center, Department of Pathology and Laboratory Medicine, Los Angeles: Visiting Professor: Lecture: Topic: The Tyranny of the Obvious & The Lessons Beneath

March 1, 2020: USCAP, Los Angeles: Speaker Hans Popper Hepatopathology Society Companion Meeting: Topic: Metastatic Tumors Frequently Mistaken for Hepatocellular Carcinoma: How to Avoid Traps in Diagnosis

December 2019: University of Minnesota Medical School, Surgery Department: Speaker Transplant Conference: . Topic: "Bedside-to-Bench-to-Bedside: A Full-circle Approach to Solid Organ Transplantation"2015 Mar 5 Invited Speaker. Drug-Induced Liver injury: The idiosyncrasy of an idiosyncratic process. Trillium Mississauga Hospital - gastroenterology Weekly CME Rounds. Mississauga, Ontario, Canada. Presenter(s):

Oyedele Adeyi. The Gastroenterology group at a major hospital in The GTA - Trillium invited me to give a presentation as part of their weekly teaching rounds. This is in recognition of having served as a consultant to their local pathologists for several years.

2013 Nov 9 Lecturer. Current Topics in Liver pathology: Hepatic Adenomas - The New Classification. University of Toronto Annual Pathology Update Conference. Toronto, Ontario, Canada. Presenter(s): Adeyi OA. (Continuing Education).

Clinical

Board Certifications

Board Certified in Anatomic Pathology & Clinical Pathology