Xavier Revelo, PhD

Dr. Revelo is an Assistant Professor in the Department of Integrative Biology & Physiology with expertise in inflammation and cardio-metabolic disease. His research explores the molecular and integrative biology of inflammation and metabolism with emphasis on the immune mechanisms that drive obesity, insulin resistance, fatty liver disease and cardiac dysfunction.

• 2022 McKnight Land-Grant Professor, University of Minnesota
• 2021 Keystone Symposia Fellow
• 2020    American Association of Immunologists Careers in Immunology Fellowship
• 2018    Maurice Visscher Biomedical Scholar, University of Minnesota
• 2015    Canadian Diabetes Association Postdoctoral Fellowship
• 2013    Banting and Best Diabetes Centre Postdoctoral Fellowship, University of Toronto
• 2011    Graduate Student Award, Experimental Biology Meeting
• 2011    Graduate Student Award, American Association Veterinary Immunologists
• 2011    Douglas Randall Young Scientists Development Scholarship, University of Missouri
• 2010   Turner Graduate Scholarship, University of Missouri

Our NIH-funded laboratory investigates the role of the immune system and inflammation in the pathophysiology of cardio-metabolic diseases such as diabetes, non-alcoholic fatty liver disease, and heart failure. As the outcome of inflammation largely depends on the balance between the pro- and anti-inflammatory functions, strategies that modulate these pathways will provide avenues to manage these diseases.

Our research program focuses on the following areas:

1. Mechanisms of hepatic and intestinal inflammation in non-alcoholic fatty liver disease, steatohepatitis, and liver cancer
2. Immune mechanisms of cardiac remodeling
3. Mechanisms of obesity-related inflammation and food allergy
4. Anti-inflammatory mechanisms of exercise training

1. R01DK122056 (NIH NIDDK). PI. Mechanisms of B Cell Pathogenicity in Non-Alcoholic Fatty Liver Disease. 2019-2024
2. R01HL155993 (NIH NHLBI). MPI. Immune Mechanisms Regulating Cardiac Remodeling . 2020-2024

Selected Publications

• Revelo XS*, Parthiban P, Barrow F, Fredrickson G, Wang H, Yücel D, Chen C, and van Berlo JH*. Cardiac macrophages prevent fibrosis and stimulate angiogenesis. Circulation Research 2021. 129:1086 (Issue cover). PMID 34645281. *Corresponding senior authors. Commented in “Resident macrophages in the heart: cardioprotective under pressure” Circulation Research 2021. 129:1102.

• Barrow F, Khan S, Fredrickson G, Wang H, Dietsche K, Parthiban P, Robert S, Kaiser T, Winer S, Herman A, Adeyi O, Mouzaki M, Khoruts A, Staley C, Hogquist KA, Winer DA, and Revelo XS.Microbiota-Driven Activation of Intrahepatic B Cells Aggravates Nonalcoholic Steatohepatitis through Innate and Adaptive Signaling. Hepatology 2021; 74(2):704 (Issue cover). PMID 33609303.

• Fredrickson G., Barrow F., Dietsche K., Parthiban P., Khan S., Robert S., Demirchian M., Wang H., and Revelo XS. Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH. Molecular Metabolism 2021; 53:101270. PMID 34118476.

• Ghazarian M *, Revelo XS*, Nøhr MK,Luck H, Kim H, Zeng K, Tsai S, Lei H, Ohashi P, Hirano N, Adeyi O, Jin T, Winer, S and Winer DA. Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome. Science Immunology 2017; 2 eaai7616. PMID 28567448,*Equally contributed.

• Revelo XS*, Ghazarian M, Chng M, Luck H, Kim J, Zeng K, Shi SY, Tsai S, Lei H, Kenkel J, Liu CL, Tangsombatvisit S, Tsui H, Sima C, Xiao C, Shen L, Li X, Jin T, Lewis GF, Woo M, Utz PJ, Glogauer M, Winer S and Winer DA*. Nucleic acid targeting pathways promote inflammation in obesity-related insulin resistance. Cell Reports 2016;16(3):717-730. PMID 27373163, *Corresponding authors.

• Revelo XS, Tsai S, Lei H, Luck H, Tsui H, Schroer S, Luck C, Woo M, Winer S, and Winer DA. Perforin is a Novel Immune Regulator of Obesity-Related Insulin Resistance. Diabetes 2015; 64(1):90-103. PMID 25048196.