Research in the Lipscomb Lab employs both basic and translational approaches to delineate the immunoregulatory networks that govern antigen presenting myeloid cell development and function. Investigations focus on defining the roles of novel genes that regulate dendritic cells (DC), monocyte and macrophage intracellular signaling events that include modulation of Ca2+ and cyclic nucleotides levels, activation/inactivation of protein kinases and post-translational modifications that alter downstream functional responses. In a related series of studies, the lab investigates how antigen presenting myeloid cells contribute to autoimmune disorders. Inflammatory regulating genes present in the MHC class III locus within the myeloid groups are studied to determine their collective contribution to initiating, sustaining and directing autoimmune pathologies. Lastly, the Lipscomb laboratory employs biomaterial compounds seeded with immune cells to generate new organoid structures as an innovative means of tissue restoration for alleviating immunodeficiency disorders.
