Laura Niedernhofer, PhD

Professor, Biochemistry, Molecular Biology, and Biophysics

Laura Niedernhofer

Contact Info

lniedern@umn.edu

Office Phone 612-626-2549

Office Address:
4-110 Nils Hasselmo Hall
321 CHURCH ST. SE
MINNEAPOLIS, MN 55455

Lab Address:
4-280 Nils Hasselmo Hall

Summary

Expertise

Aging and age-related diseases, DNA damage, transgenic mouse models, rare genome instability disorders, senescence

Research

Research Summary/Interests

My research career has been dedicated to investigating the impact of DNA damage on the structure of DNA, cell function and organism health. The DNA in each of our cells is damaged thousands of times per day by exposure to environmental factors, dietary components, chemotherapeutic agents and even endogenous by-products of normal metabolism. Studying patients with rare diseases caused by inherited defects in DNA repair provides important insight into the consequences of DNA damage. These patients have a dramatically increased risk of cancer and age prematurely. We engineered mouse models of these genome instability syndromes as a sensitive tool to test hypotheses about how DNA damage promotes cancer and aging.