Laura Niedernhofer, MD, PhD

Professor, Biochemistry, Molecular Biology, and Biophysics

Laura Niedernhofer

Contact Info

Office Phone 612-626-2549

Office Address:
4-110 Nils Hasselmo Hall

Lab Address:
4-280 Nils Hasselmo Hall

Administrative Assistant Name
Kelly Holmes-Tomei

Administrative Email

MD, Vanderbilt University School of Medicine

PhD, Biochemistry, Vanderbilt University School of Medicine

MS, Physiology, Georgetown University School of Medicine

BS, Chemistry, Duke University

Medicine, University of Alabama, Birmingham

Post-doc, Genetics, Erasmus Medical Centre, Rotterdam, the Netherlands



Aging and age-related diseases, DNA damage, transgenic mouse models, rare genome instability disorders, senescence


Research Summary/Interests

My research career has been dedicated to investigating the impact of DNA damage on the structure of DNA, cell function and organism health. The DNA in each of our cells is damaged thousands of times per day by exposure to environmental factors, dietary components, chemotherapeutic agents and even endogenous by-products of normal metabolism. Studying patients with rare diseases caused by inherited defects in DNA repair provides important insight into the consequences of DNA damage. These patients have a dramatically increased risk of cancer and age prematurely. We engineered mouse models of these genome instability syndromes as a sensitive tool to test hypotheses about how DNA damage promotes cancer and aging.