Paul Orchard, MD

Professor, Department of Pediatrics

Paul Orchard

Contact Info

Office Phone 612-626-2313

Fax 612-626-4074

Office Address:
Pediatric BMT
660B Masonic Cancer Research Building
425 East River Parkway
Minneapolis, MN 55455

Mailing Address:
Pediatrics BMT
MMC 366 Mayo
8366A (Campus Delivery Code)
420 Delaware St SE
Minneapolis, MN 55455

MD, Brown University Hospital, Providence RI

Residency in Pediatrics, University of Wisconsin Hospital, Madison, WI

Fellowship in Hematology-Oncology and Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN


Dr. Paul Orchard is the Medical Director of the Inherited Metabolic and Storage Disease Program and a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy. Dr. Orchard's focus is in the use of hematopoietic stem cell transplantation and other cell therapies for inherited metabolic disorders, with a special interest in the inherited leukodystrophies, the mucopolysaccharidoses and osteopetrosis. His clinical research is in evolving new and combination therapies to decrease toxicity and improve outcomes, with a particular interest in the use of gene therapy approaches.

Awards & Recognition

  • Minneapolis/St. Paul Magazine 2022 Health Care Hero (2022)
  • UMMC Clinical Research and Innovation Award (2022)
  • Team Science Award, Department of Pediatrics, University of Minnesota (2019)
  • Minneapolis - St. Paul Magazine “Top Doctors” (2012-2018, 2020-2022)
  • Best Doctors in America® (2011-2012, 2013)
  • Recipient, Jundt Research Award (1998-2000)
  • Recipient, Amy Strelzer-Manasevit Scholar's Award (1 of 2 National Awards)
  • Amy Strelzer-Manasevit Scholar’s award (1998-2000)
  • Recipient, American Cancer Society Career Development Award (1994-1996)


Research Summary/Interests

  • Hematopoietic Cell Transplantation of Genetic Disorders Transplant related toxicity and graft failure Use of reduced intensity preparative regimens Risk factors affecting outcomes following transplantation
  • Osteopetrosis Biology and genetics of osteopetrosis Correlations of clinical and genetic parameters to outcome and prognosis Hematopoietic transplantation and other therapies
  • Gene Therapy T cell engineering with "suicide genes" for transplantation Infusions of mismatched T cells with following genetic manipulation Treatment of genetic and metabolic diseases with gene therapy
  • Development of Alternative Cellular Therapy Use of mesenchymal stem cells for genetic diseases Infusions of immunologically active cell populations



  • Pediatric Blood and Bone Marrow Transplant
  • Pediatrics


Journey Clinic - Center for Pediatric Blood and Marrow Transplantation

Board Certifications

American Board of Pediatrics; American Board of Hematology/Oncology

Clinical Interests

Bone marrow transplants to treat genetic diseases; Osteopetrosis; Inherited conditions

Hospital Privileges

M Health Fairview Masonic Children's Hospital; University of Minnesota Medical Center