Paul Orchard, MD

Professor, Department of Pediatrics

Paul Orchard

Contact Info

orcha001@umn.edu

Office Phone 612-626-2313

Fax 612-626-4074

Office Address:
Pediatric BMT
660B Masonic Cancer Research Building
425 East River Parkway
Minneapolis, MN 55455

Mailing Address:
Pediatrics BMT
MMC 366 Mayo
8366A (Campus Delivery Code)
420 Delaware St SE
Minneapolis, MN 55455

Administrative Assistant Name
Matthew Stoffel

Administrative Phone
612-626-5768

Administrative Email
stof0040@umn.edu

MD, Brown University Hospital, Providence RI

Residency in Pediatrics, University of Wisconsin Hospital, Madison, WI

Fellowship in Hematology-Oncology and Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN

Summary

Dr. Paul Orchard is the Medical Director of the Inherited Metabolic and Storage Disease Program and a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy. Dr. Orchard's focus is in the use of hematopoietic stem cell transplantation and other cell therapies for inherited metabolic disorders, with a special interest in the inherited leukodystrophies, the mucopolysaccharidoses and osteopetrosis. His clinical research is in evolving new and combination therapies to decrease toxicity and improve outcomes, with a particular interest in the use of gene therapy approaches.

Awards & Recognition

  • Team Science Award, Department of Pediatrics, University of Minnesota (2019)
  • Minneapolis - St. Paul Magazine “Top Doctors” (2012-2018, 2020)
  • Best Doctors in America® (2011-2012, 2013)
  • Recipient, Jundt Research Award (1998-2000)
  • Recipient, Amy Strelzer-Manasevit Scholar's Award (1 of 2 National Awards)
  • Amy Strelzer-Manasevit Scholar’s award (1998-2000)
  • Recipient, American Cancer Society Career Development Award (1994-1996)

Research

Research Summary/Interests

  • Hematopoietic Cell Transplantation of Genetic Disorders Transplant related toxicity and graft failure Use of reduced intensity preparative regimens Risk factors affecting outcomes following transplantation
  • Osteopetrosis Biology and genetics of osteopetrosis Correlations of clinical and genetic parameters to outcome and prognosis Hematopoietic transplantation and other therapies
  • Gene Therapy T cell engineering with "suicide genes" for transplantation Infusions of mismatched T cells with following genetic manipulation Treatment of genetic and metabolic diseases with gene therapy
  • Development of Alternative Cellular Therapy Use of mesenchymal stem cells for genetic diseases Infusions of immunologically active cell populations

Clinical

Specialties

  • Pediatric Blood and Bone Marrow Transplant
  • Pediatrics

Clinics

Journey Clinic - Center for Pediatric Blood and Marrow Transplantation

Board Certifications

American Board of Pediatrics; American Board of Hematology/Oncology

Clinical Interests

Bone marrow transplants to treat genetic diseases; Osteopetrosis; Inherited conditions

Hospital Privileges

University of Minnesota Masonic Children's Hospital; University of Minnesota Medical Center

Media