Alik Widge, MD, PhD
Assistant Professor, Department of Psychiatry
Assistant Professor, Department of Psychiatry
Preceptor, Medical Scientist Training Program (Combined MD/PhD Training Program)
Faculty, Graduate Program in Neuroscience
MD, University of Pittsburgh
Residency in Psychiatry, University of Washington
Research Fellow, Interventional Psychiatry, Massachusetts General Hospital
Research Fellow, Picower Institute for Learning & Memory, Massachusetts Institute of Technology
PhD, Robotics, Carnegie Mellon University
BA, Computer Science & Cognitive Science, Dartmouth College
Postdoctoral Researcher, Biophysics, Neurophysiology, Rehabilitation Medicine, University of Washington
Summary
I am a psychiatrist and biomedical engineer. Clinically, I provide brain stimulation treatments for mood, anxiety, and substance disorders. These include deep brain stimulation, cortical stimulation, and transcranial magnetic stimulation. My research focuses on developing these treatments further, particularly the creation of new "closed loop" devices. These devices sense brain signals in real-time and deliver energy in a planned and rational fashion, compensating for each patient's specific brain network abnormalities. My laboratory (TNE Lab) prototypes new stimulation paradigms and targets in rodent models, conducts clinical trials of these new technologies, and searches for biomarkers of illness and recovery to guide next-generation therapies. To inquire about being part of our neurostimulation trials or about existing clinical treatments, please contact my clinical office at 952-525-4500.
Expertise
- Humans: DBS, TMS, VNS, cortical stimulation, EEG, intracranial LFP, cognitive neuroscience.
- Animals: single-unit and LFP electrophysiology, optogenetics, real-time/closed-loop brain stimulation, real-time video analysis, computational modeling.
Awards & Recognition
Professional Associations
Research
Research Summary/Interests
Our laboratory develops new ways of modifying brain circuits to treat mental illness. We take a "dimensional" approach, breaking mental disorders into their core components that cut across diagnoses. We use a variety of tools, including electrical, magnetic, and optical stimulation, to change those circuits in a way we hope will translate to humans.
Research Funding Grants
6/1/2014 – 5/30/2019, W911NF-14-2-0045 (Dougherty/Eskandar)
Defense Advanced Research Projects Agency $7,584,647
Transdiagnostic Restoration of Affective Networks by Systematic, Function-Oriented, Real-time Modeling and Deep Brain Stimulation (TRANSFORM DBS)
8/1/2016 – 7/31/2019 (NCE), R21 MH109722-01A1 (Widge)
NIH/NIMH $150,000
Synchronizing a Fear Regulation Circuit by Temporally Patterned Closed-Loop Neurostimulation
9/1/2016 – 8/30/2021, UH3 NS100548-01 (Dougherty/Widge)
NIH/NINDS $364,456
Combined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
9/1/2016 – 8/30/2020, R01 MH111872 (Anikeeva)
NIH/NIMH $91,972
Multi-Site Non-Invasive Magnetothermal Excitation and Inhibition of Deep Brain Structures
5/1/2017 – 4/30/2020, R01 MH111917-01A1 (Dougherty/Makris)
NIH/NIMH $474,649
Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCD (PERFECT DBS)
9/1/2017 – 8/31/2019, R21 MH113103-01A1 (Widge)
NIH/NIMH $150,000
Engineering Plasticity and Connectivity in a Fear Regulation Circuit
Clinical
Board Certifications
General Psychiatry