Samir Khariwala

Department Chair


I am committed to treating my patients with a combination of well-established therapies and new technology to optimize cure of the disease and quality of life. My goal is to establish a foundation of trust and understanding such that my patients fully understand the nature of their disease, the treatment options available, and expected outcomes. 


Head and Neck Oncologic Surgery and Microvascular Reconstruction


Undergrad: University of Michigan
Medical school: University of Pennsylvania School of Medicine
Residency: Cleveland Clinic Foundation
Fellowship: University of Michigan

Board Certifications

American Board of Otolaryngology

Awards and Recognitions

  • "Top Doctor," Minnesota Monthly 
  • “Top Doctor” Mpls-St Paul Magazine

Professional Associations

  • American Head and Neck Society
  • Triological Society
  • American Academy of Otolaryngology-Head and Neck Surgery
  • American College of Surgeons

Research Summary

I spend my clinical time treating patients with benign and malignant disease of the head neck. Given that this disease is strongly associated with tobacco use, I have become interested in the tobacco-related carcinogenesis and the risk of oral cancer. Specifically, I am driven to produce new and clinically applicable knowledge about the carcinogenic events that lead to oral carcinoma. Many of our patients have a history of smoking, but the factors that cause some smokers to develop carcinoma while others do not are poorly studied. This gap in knowledge led me to study tobacco related carcinogenesis in oral/head and neck cancer. We seek to better understand the specific carcinogens most important in the genesis of oral cancer. This research is expected to not only significantly increase understanding of tobacco-related carcinogenesis, but also aid in risk assessment for oral cancer as well as tobacco regulation efforts.


  • Khariwala SSMoving forward after gaining hard-won experience through the Covid-19 pandemic. JAMA Otolaryngol Head Neck Surg. 2022 doi: 10.1001/jamaoto.2022.273
  • Van Heest T, Rubin N, Khariwala SS. Persistent tobacco use following treatment for head and neck cancer.  JAMA Otolaryngol Head Neck Surg.  2022 JAMA Otolaryngol Head Neck Surg. 2022;148(7):597-603. doi: 10.1001/ jamaoto.2022.0810.
  • Osazuwa-Peters N, Graboyes E, Khariwala SSExpanding indications for the human papillomavirus vaccine: One small step for the prevention of head and neck cancer but one giant leap remains.  JAMA Otolaryngol Head Neck Surg. 2020 doi:10.1001/jamaoto.2020.4068





Philips Wangensteen Building
420 Delaware St MMC-396
Minneapolis, MN 55455

Administrative Contact

Nicole Rueger