Yi-Mei (Amy) Yang, PhD
Address
Department of Biomedical Sciences
SMED 337
1035 University Drive
Duluth, MN 55812
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Education
PhD, Huazhong University of Science and Technology, Tongji Medical School
Major: Pharmacology
BS, Hebei Medical University
Major: Pharmacy
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Publications
Yang, Y.-M., Fekete, A., Arsenault, J., Sengar, A.S., Aitoubah, J., Grande, G., Li, A., Salter, E.W., Wang, A., Mark, M.D., Herlitze, S., Egan, S.E., Salter, M.W. and Wang, L.-Y. (2024), Intersectin-1 enhances calcium-dependent replenishment of the readily releasable pool of synaptic vesicles during development. J Physiol.
https://doi.org/10.1113/JP286462
Rudolph S., Badura A., Lutzu S., Pathak S. S., Thieme A., Verpeut J. L., Wagner M. J., Yang Y. M., Fioravante D., 2023. Cognitive-affective functions of the cerebellum. The Journal of Neuroscience,. 43 (45): 7554-7564.
doi: https://www.jneurosci.org/content/43/45/7554
PubMed ID: 37940582
Chao, O. Y. , Pathak, S. S., Zhang, H., Augustine, G. J., Christie, J. M, Kikuchi, C., Taniguchi, H., Yang, Y. M. , 2023. Social memory deficit caused by dysregulation of the cerebellar vermis. Nature Communications, 14 (6007): 1-19.
doi: https://doi.org/10.1038/s41467-023-41744-2
PubMed ID: 37752149
Levings, D. C., Pathak, S. S., Yang Y. M., Slattery M., 2023. Limited expression of Nrf2 in neurons across the central nervous system. Redox Biology, 65 (102830): 1-8.
doi: https://doi.org/10.1016/j.redox.2023.102830
PubMed ID: 37544245
Chao, O. Y, Nikolaus, S., Yang, Y. M, Huston, J. P., 2022. Neuronal circuitry for recognition memory of object and place in rodent models. Neuroscience & Biobehavioral Reviews, 141 (104855): 1-30.
doi: https://doi.org/10.1016/j.neubiorev.2022.104855
PubMed ID: 36089106
Fang, K., Liu, D., Pathak, S. S., Yang, B., Li, J., Karthikeyan, R., Chao, O. Y., Yang, Y. M., Jin, V. X., Cao, R., 2021. Cells, 10 (12): 3314.
doi: https://doi.org/10.3390/cells10123314
PubMed ID: 34943821
Gurma, M., Yang, Y. M., Wang, L. Y., 2021. Developmental plasticity of NMDA receptors at the calyx of Held synapse. Neuropharmacology, 196: 1-10.
doi: https://doi.org/10.1016/j.neuropharm.2021.108697
PubMed ID: 34242682
Li, J. S., Yang, S. S., Huston, J. P., Chao, O. Y., Yang, Y. M., Mattern, C., 2021. Acute intranasal dopamine application counteracts the reversal learning deficit of spontaneously hypertensive rats in an attentional set-shifting task. Psychopharmacology, 238 (9): 2419-2428.
doi: https://doi.org/10.1007/s00213-021-05863-2
PubMed ID: 33982142
Chao, O. Y., Zhang, H., Pathak, S. S., Huston, J. P., Yang, Y. M., 2021. Functional convergence of motor and social processes in lobule IV/V of the mouse cerebellum.. Cerebellum, 20: 836–852.
doi: https://doi.org/10.1007/s12311-021-01246-7
PubMed ID: 33661502
Yang, Y. M., Arsenault, J., Bah, A., Krzeminski, M., Fekete, A., Chao, O. Y., Pacey, L. K., Wang, A., Forman-Kay, J., Hampson, D. R., Wang, L. Y., 2020. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.. Molecular Psychiatry, 25 (9): 2017-2035.
doi: https://doi.org/10.1038/s41380-018-0240-0
PubMed ID: 30224722
Chao, O. Y., Pathak, S. S., Zhang, H., Dunaway, N., Li , J. S., Mattern, C., Nikolaus, S., Huston, J. P., Yang, Y. M., 2020. Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism.. Molecular Brain, 13: 1-16.
doi: https://doi.org/10.1186/s13041-020-00649-7
PubMed ID: 32778145
Chao, O. Y., de Souza Silva, M. A., Yang, Y. M., Huston, J. P., 2020. The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties.. Neuroscience and biobehavioral reviews, 113: 373-407.
doi: https://doi.org/10.1016/j.neubiorev.2020.04.007
PubMed ID: 32298711
Chao, O. Y., de Marron Fernandez Velasco, E., Pathak, S. S., Maitra, S., Zhang, H., Duvick, L., Wickman, K., Orr, H. T., Hirai, H., Yang, Y. M., 2020. Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45 (7): 1159-1170.
doi: https://doi.org/10.1038/s41386-020-0656-5
PubMed ID: 32179875
Lesperance, L. S., Yang, Y. M., Wang, L. Y., 2020. Delayed expression of activity-dependent gating switch in synaptic AMPARs at a central synapse.. Molecular Brain, 13: 1-18.
doi: https://doi.org/10.1186/s13041-019-0536-2
PubMed ID: 31941524
Chao, O. Y., Yang, Y. M., 2019. Timing constraints of action potential evoked Ca2+ current and transmitter release at a central nerve terminal.. Scientific Reports, 9: 1-14.
doi: https://doi.org/10.1038/s41598-019-41120-5
PubMed ID: 30872753
Fekete, A., Nakamura, Y., Yang, Y. M., Herlitze, S., Mark, M. D., DiGregorio, D. A., Wang, L. Y., 2019. Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules.. Nature Communications, 10 (1): 826-842.
doi: https://doi.org/10.1038/s41467-019-08452-2
PubMed ID: 30778063
Wang, A. L., Chao, O. Y., Yang, Y. M., Trossbach, S. V., Müller, C. P., Korth, C., Huston, J. P., de Souza Silva, M. A., 2019. Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene.. Pharmacology, Biochemistry, and Behavior, 179: 73-79.
doi: https://doi.org/10.1016/j.pbb.2019.02.005
PubMed ID: 30779934
Chao, O. Y., Yunger, R., Yang, Y. M., 2018. Behavioral assessments of BTBR T+Itpr3tf/J mice by tests of object attention and elevated open platform: Implications for an animal model of psychiatric comorbidity in autism.. Behavioural Brain Research, 347: 140-147.
doi: https://doi.org/10.1016/j.bbr.2018.03.014
PubMed ID: 29545145
Yang, Y. M., Wang, L. Y., 2017. Ageing brains attend a symphony with asynchronous transmitter release.. The Journal of Physiology, 595 (3): 613-614.
doi: https://doi.org/10.1113/JP273421
PubMed ID: 28145009
Yang, Y. M., Wang, W., Fedchyshyn, M. J., Zhou, Z., Ding, J., Wang, L. Y., 2014. Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic potassium currents.. Nature Communications, 5: 1-13.
doi: https://doi.org/10.1038/ncomms5564
PubMed ID: 25078759
Wang, W., Luo, J., Hou, P., Yang, Y. M., Xiao, F., Yuchi, M., Qu, A., Wang, L. Y., Ding, J., 2013. Native gating behavior of ion channels in neurons with null-deviation modeling.. PloS One, 8 (10): 1-10.
doi: https://doi.org/10.1371/journal.pone.0077105
Yang, Y. M., Aitoubah, J., Lauer, A. M., Nuriya, M., Takamiya, K., Jia, Z., May, B. J., Huganir, R. L., Wang, L. Y., 2011. GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse.. The Journal of Physiology, 589 (17): 4209-4227.
doi: https://doi.org/10.1113/jphysiol.2011.208066
PubMed ID: 21690196
Zhang, B., Sun, L., Yang, Y. M., Huang, H. P., Zhu, F. P., Wang, L., Zhang, X. Y., Guo, S., Zuo, P. L., Zhang, C. X., Ding, J. P., Wang, L. Y., Zhou, Z., 2011. Action potential bursts enhance transmitter release at a giant central synapse.. The Journal of Physiology, 589 (9): 2213-2227.
doi: https://doi.org/10.1113/jphysiol.2010.200154
PubMed ID: 21486773
Yang, Y. M., Fedchyshyn, M. J., Grande, G., Aitoubah, J., Tsang, C. W., Xie, H., Ackerley, C. A., Trimble, W. S., Wang, L. Y., 2010. Septins regulate developmental switching from microdomain to nanodomain coupling of Ca(2+) influx to neurotransmitter release at a central synapse.. Neuron, 67 (1): 100-115.
doi: https://doi.org/10.1016/j.neuron.2010.06.003
PubMed ID: 20624595
Wang, L. Y., Fedchyshyn, M. J., Yang, Y. M., 2009. Action potential evoked transmitter release in central synapses: Insights from the developing calyx of Held.. Molecular Brain, 2: 1-11.
doi: https://doi.org/10.1186/1756-6606-2-36
PubMed ID: 19939269
Joshi, I., Yang, Y. M., Wang, L. Y., 2007. Coincident activation of metabotropic glutamate receptors and NMDA receptors (NMDARs) downregulates perisynaptic/extrasynaptic NMDARs and enhances high-fidelity neurotransmission at the developing calyx of Held synapse.. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 27 (37): 9989-9999.
doi: https://doi.org/10.1523/JNEUROSCI.2506-07.2007
PubMed ID: 17855613
Yang, Y. M., Wang, L. Y., 2006. Amplitude and kinetics of action potential-evoked Ca2+ current and its efficacy in triggering transmitter release at the developing calyx of Held synapse.. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 26 (21): 5698-5708.
doi: https://doi.org/10.1523/JNEUROSCI.4889-05.2006
PubMed ID: 16723526
Chen, S., Yang, Y., Zhang, L., Pang, X., Dai, Z., Zeng, F., 2000. A sensitive HPLC technique for the quantitation of dauricine. Journal of Tongji Medical University, 20: 39-42.
doi: https://doi.org/10.1007/bf02887672
PubMed ID: 12845753
Chen, S., Liu, L., Yang, Y., Dai, Z., Zeng, F., 2000. Metabolism of dauricine and identification of its main metabolites. Journal of Tongji Medical University, 20 (3): 253-256.
doi: https://doi.org/10.1007/bf02887006
PubMed ID: 11215064
Chao, O. Y., Pathak, S. S., Zhang, H., Augustine, G. J., Christie, J. M., Kikuchi, C., Taniguchi, H., Yang, Y. M., Social memory deficit gated by dysregulation of the cerebellar vermis. Nature Communications,
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Research
Synapses are the fundamental units of neural communication in the brain. Using multidisciplinary approaches, we study how synaptic structure and function are precisely shaped during development and how their dysfunctions lead to neurological disorders. By understanding the physio-pathological roles of critical synaptic proteins and ion channels at the cellular, circuitry and system levels, we aim to identify novel targets and further develop pharmacological and genetic therapies for neurodevelopmental disorders, such as autism spectrum disorder (ASD). ASD is characterized by defective social interactions, impaired communication and restricted patterns of repetitive behaviors. Although ASD involves many brain areas, emerging evidence suggests that aberrant activity of the cerebellum in the early developmental stage can lead to ASD. Employing various autistic mouse models to simulate the complex etiology of ASD, we investigate the cellular and molecular mechanisms underlying the cerebellum pathology. By selectively manipulating the excitability of cerebellar neurons, we ask how dysfunction of the cerebellum affects the brain circuitry and generates the autistic phenotypes over development.
Selected Publications
Chao, O. Y., Pathak, S. S., Zhang, H., Augustine, G. J., Christie, J. M., Kikuchi, C., Taniguchi, H., Yang, Y. M. (2023). Social memory deficit caused by dysregulation of the cerebellar vermis. Nature Communications, 14 6007: 1-19. PMID: 37752149. doi: https://doi.org/10.1038/s41467-023-41744-2
Levings, D. C., Pathak, S. S., Yang Y. M., Slattery M. (2023). Limited expression of Nrf2 in neurons across the central nervous system. Redox Biology, 65 102830: 1-8. PubMed ID: 37544245. doi: https://doi.org/10.1016/j.redox.2023.102830
Rudolph S., Badura A., Lutzu S., Pathak S. S., Thieme A., Verpeut J. L., Wagner M. J., Yang Y. M., Fioravante D. (2023). Cognitive-affective functions of the cerebellum. The Journal of Neuroscience, 43 (45): 7554-7564. PMID: 37940582. doi: https://www.jneurosci.org/content/43/45/7554
Chao, O. Y., Nikolaus, S., Yang, Y. M.*, Huston, J. P. (2022). Neuronal circuitry for recognition memory of object and place in rodent models. Neuroscience & Biobehavioral Reviews, 141 (104855): 1-30. PMID: 36089106. doi: https://doi.org/10.1016/j.neubiorev.2022.104855 (*Co-corresponding author)
Fang, K., Liu, D., Pathak, S. S., Yang, B., Li, J., Karthikeyan, R., Chao, O. Y., Yang, Y. M.*, Jin, V. X., Cao, R. (2021). Disruption of circadian rhythms by ambient light during neurodevelopment leads to autistic-like molecular and behavioral alterations in adult mice. Cells, 10 (12), 3314-3333. PMID: 34943821. doi: https://doi.org/10.3390/cells10123314 (*Co-corresponding author)
Chao, O. Y., Zhang, H., Pathak, S. S., Huston, J. P., Yang, Y. M. (2021). Functional convergence of motor and social processes in lobule IV/V of the mouse cerebellum. Cerebellum, 20: 836–852. PMID: 33661502. doi: https://doi.org/10.1007/s12311-021-01246-7
Chao, O. Y., Pathak, S. S., Zhang, H., Dunaway, N., Li, J. S., Mattern, C., Nikolaus, S., Huston, J. P., Yang, Y. M. (2020). Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism. Molecular Brain, 13: 1-16. PMID: 32778145. doi: https://doi.org/10.1186/s13041-020-00649-7
Chao, O. Y., de Souza Silva, M. A., Yang, Y. M.*, Huston, J. P. (2020). The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties. Neuroscience and Biobehavioral Reviews, 113: 373-407. PMID: 32298711. doi: https://doi.org/10.1016/j.neubiorev.2020.04.007 (*Co-corresponding author)
Chao, O. Y., de Marron Fernandez Velasco, E., Pathak, S. S., Maitra, S., Zhang, H., Duvick, L., Wickman, K., Orr, H. T., Hirai, H., Yang, Y. M. (2020). Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism. Neuropsychopharmacology, 45 (7): 1159-1170. PMID: 32179875. doi: https://doi.org/10.1038/s41386-020-0656-5
Lesperance, L. S., Yang, Y. M., Wang, L. Y. (2020). Delayed expression of activity-dependent gating switch in synaptic AMPARs at a central synapse. Molecular Brain, 13: 1-18. PMID: 31941524. doi: https://doi.org/10.1186/s13041-019-0536-2
Chao, O. Y., Yang, Y. M. (2019). Timing constraints of action potential evoked Ca2+ current and transmitter release at a central nerve terminal. Scientific Reports, 9: 1-14. PMID: 30872753. doi: https://doi.org/10.1038/s41598-019-41120-5
Fekete, A., Nakamura, Y., Yang, Y. M., Herlitze, S., Mark, M. D., DiGregorio, D. A., Wang, L. Y. (2019). Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules. Nature Communications, 10 (1): 826-842. PMID: 30778063. doi: https://doi.org/10.1038/s41467-019-08452-2
Chao, O. Y., Yunger, R., Yang, Y. M. (2018). Behavioral assessments of BTBR T+Itpr3tf/J mice by tests of object attention and elevated open platform: Implications for an animal model of psychiatric comorbidity in autism. Behavioural Brain Research, 347: 140-147. PMID: 29545145. doi: https://doi.org/10.1016/j.bbr.2018.03.014
Yang, Y. M.*, Arsenault, J., Bah, A., Krzeminski, M., Fekete, A., Chao, O. Y., Pacey, L. K., Wang, A., Forman-Kay, J., Hampson, D. R., Wang, L. Y. (2020). (Epub 2018) Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain. Molecular Psychiatry, 25 (9): 2017-2035. PMID: 30224722. doi: https://doi.org/10.1038/s41380-018-0240-0 (*Co-corresponding author)
Yang, Y. M., Wang, W., Fedchyshyn, M. J., Zhou, Z., Ding, J., Wang, L. Y. (2014). Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic potassium currents. Nature Communications, 5: 1-13. PMID: 25078759. doi: https://doi.org/10.1038/ncomms5564 .
Yang, Y. M., Aitoubah, J., Lauer, A. M., Nuriya, M., Takamiya, K., Jia, Z., May, B. J., Huganir, R. L., Wang, L. Y. (2011). GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse. The Journal of Physiology, 589 (17): 4209-4227. PMID: 21690196. doi: https://doi.org/10.1113/jphysiol.2011.208066
Zhang, B., Sun, L., Yang, Y. M., Huang, H. P., Zhu, F. P., Wang, L., Zhang, X. Y., Guo, S., Zuo, P. L., Zhang, C. X., Ding, J. P., Wang, L. Y., Zhou, Z. (2011). Action potential bursts enhance transmitter release at a giant central synapse. The Journal of Physiology, 589 (9): 2213-2227. PMID: 21486773. doi: https://doi.org/10.1113/jphysiol.2010.200154
Yang, Y. M., Fedchyshyn, M. J., Grande, G., Aitoubah, J., Tsang, C. W., Xie, H., Ackerley, C. A., Trimble, W. S., Wang, L. Y. (2010). Septins regulate developmental switching from microdomain to nanodomain coupling of Ca2+ influx to neurotransmitter release at a central synapse. Neuron, 67 (1): 100-115. PMID: 20624595. doi: https://doi.org/10.1016/j.neuron.2010.06.003
Wang, L. Y., Fedchyshyn, M. J., Yang, Y. M. (2009). Action potential evoked transmitter release in central synapses: Insights from the developing calyx of Held. Molecular Brain, 2: 1-11. PMID: 19939269. doi: https://doi.org/10.1186/1756-6606-2-36
Joshi, I., Yang, Y. M.*, Wang, L. Y. (2007). Coincident activation of metabotropic glutamate receptors and NMDA receptors (NMDARs) downregulates perisynaptic/extrasynaptic NMDARs and enhances high-fidelity neurotransmission at the developing calyx of Held synapse. The Journal of Neuroscience, 27 (37): 9989-9999. PMID: 17855613. doi: https://doi.org/10.1523/JNEUROSCI.2506-07.2007 (*Co-first author)
Yang, Y. M., Wang, L. Y. (2006). Amplitude and kinetics of action potential-evoked Ca2+ current and its efficacy in triggering transmitter release at the developing calyx of Held synapse. The Journal of Neuroscience, 26 (21): 5698-5708. PMID: 16723526. doi: https://doi.org/10.1523/JNEUROSCI.4889-05.2006
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Awards, Honors and Recognitions
Assistant Professor Award, University of Minnesota Foundation, 2017
Trainee Travel Award, SickKids Research Institute, 2011
Brain Star Award, Canadian Institutes of Health Research, 2010