Jacquetta Blacker, MD, MA

Assistant Professor, Department of Psychiatry and Behavioral Sciences

Jacquetta Blacker

Contact Info

blac0622@umn.edu

Office Phone 612-273-9040

Fax 612-273-9774

Administrative Assistant Name
Molly Jokimaki

Administrative Email
jokim004@umn.edu

BMBCh, Medicine and Surgery, Oxford University, Oxford, UK

Residency, General psychiatry, Mayo School of Graduate Medical Education, Rochester, MN

Fellowship, Child and Adolescent Psychiatry, Mayo School of Graduate Medical Education, Rochester MN

MA, Physiological Sciences, Oxford University, Oxford, UK

BA, Physiological Sciences, Oxford University, Oxford, UK

MRCP Part I, Royal College of Physicians, London, UK

Summary

An award-winning educator, Assistant Professor Jacquetta Blacker, MD, MA, joined the U following several years working for the Mayo Clinic and Mayo Clinic Health System in Rochester and Austin, MN, as an assistant professor in psychiatry and a senior associate consultant. Dr. Blacker is board certified in both adult and child and adolescent psychiatry.

Being at the University enables two goals for Dr. Blacker. “I want to work in clinical care with a population that has a universal shortage of healthcare providers,” she explained. “Part of that is helping to strengthen inpatient services. The other part of my job is research. I want to dig into the huge data sets I have on suicide and use the resources at the U to look at post-traumatic stress disorder [PTSD] and how it intersects with suicide. PTSD is complex – it’s many different sequelae of real and perceived traumatic events.”

Dr. Blacker completed her general psychiatric residency and a Child and Adolescent Psychiatry Fellowship at the Mayo Clinic in Rochester. A native of the United Kingdom, she completed MRCP Part 1 (Membership of the Royal Colleges of Physicians) at the Royal College of Physicians in London. Dr. Blacker earned her BMBCh (the equivalent of an MD) in medicine and surgery, and her Master of Arts and undergraduate degree in physiological sciences at Oxford University.

She brings a wide range of experience to her work. “I have had broad exposure to all kinds of medical settings, from urban to rural, and to all kinds of socioeconomic groups,” she said. “It helps me understand where a lot of people are coming from.” Of the 18 articles that Dr. Blacker has had published in medical journals, she was first or senior author for 10. In addition, she has presented her work during several national and international medical meetings.

When she has some spare time, she enjoys biking along Minneapolis parkways, working on home improvement projects, reading, and cooking.

Awards & Recognition

  • Chief Resident Award, Mayo Clinic, Department of Psychiatry and Psychology, Rochester, MN, 2016
  • Outstanding Resident in Psychiatry, Dr. Henry P. and M. Page Durkee Laughlin Foundation, Mayo Clinic, Department of Psychiatry and Psychology, Rochester, MN, 2016
  • Career Development Institute for Bipolar Disorder, University of Pittsburgh, PA, 2015
  • Resident Teacher of the Year Award, Mayo Clinic Medical School, Rochester, MN, 2014
  • Alexander Lucas Award, (most promising trainee in child and adolescent psychiatry), Mayo Clinic, Rochester, MN, 2013
  • Silver Quality Improvement Course, Mayo Clinic, Rochester, MN, 2013
  • Bronze Quality Improvement Award, Mayo Clinic, Rochester, MN, 2012
  • Mayo Clinic Dictation Award, Mayo Clinic, Rochester, MN, 2012
  • Teacher of the Month, Oxford University Medical School, UK, 2004.

Research

Research Summary/Interests

Dr. Blacker’s research interests include mood and anxiety disorders in medical-surgical populations, and suicide among medical professionals. Being part of a much larger institution that has many disciplines – and the opportunities that creates for doing cross-disciplinary work – is exciting to Blacker. “A lot of what I do is historical, looking at trends over time, how concepts have changed, how treatment has changed,” she said. “Having access to specialists in history and statistics will really help move my research along.” Dr. Blacker was co-investigator for three research grants, one looking at developing biomarkers that would lead to individualized treatments in bipolar patients with and without comorbid addiction; another used EEG to identify potential markers of suicidal behaviors in children between age 13-18; another examined biochemical and genetic differences in mood disorders.

Research Funding Grants

  1. Department of Psychiatry and Psychology Small Grant, Co-Investigator. Examination of the correlation of histone acetylation with the expression of metabotropic glutamate receptors (mGluR2 and mGluR3) in patients with bipolar disorder with and without co-morbid addiction (nicotine, alcohol, food). Goals: develop epigenetically based biomarkers that would lead to individualized treatments in bipolar patients with and without comorbid addiction, April 2014
  2. Department of Psychiatry and Psychology Small Grant, Mayo Clinic Health System Co-Investigator. Quantitative EEG correlates of suicidality in adolescents. Goal: investigate potential quantitative EEG markers of suicidal behaviors in children between age 13-18 who are admitted to psychiatric hospital as compared to healthy controls. June 2018.
  3. Department of Psychiatry and Psychology Small Grant, Mayo Clinic Health System Co-Investigator. CD44-Hyaluronan Pathway Regulation in Mood Disorders. Goal: Validate the association of SLC1A2 rs3829280 and CD44 gene expression levels in human prefrontal cortex and temporal pole cortex; examine the differences in CD44 gene and protein expression levels in human prefrontal cortex and temporal pole cortex associated with bipolar disorder and major depressive disorder; investigate hyaluronan level in human prefrontal cortex and temporal pole cortex associated with bipolar disorder and major depressive disorder. June 2019.

Publications

Publications

  1. Lewis CP, Port JD, Blacker CJ, Sonmez AI, Seewoo B, Leffler J, Frye MA, Croarkin, PE. (2020). Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation. Translational Psychiatry 10: 119. https://doi.org/10.1038/s41398-020-0792-z
  2. Manuel Gardea-Resendez, Mehmet Utku Kucuker, Caren J. Blacker, Ada M.C. Ho, Paul E. Croarkin, Mark A. Frye, Marin Veldic.Dissecting the Epigenetic Changes Induced by Non-antipsychotic Mood Stabilizers on Schizophrenia and Affective Disorders: A Systematic Review. Frontiers in Pharmacology . Published online: 22 April 2020. https://doi.org/10.3389/fphar.2020.00467
  3. Lauren M. Webb, Kathryn E. Phillips, Man Choi Ho, Marin Veldic, Caren J. Blacker. The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review. Int. J. Mol. Sci. 2020, 21(3), 826. https://doi.org/10.3390/ijms21030826
  4. Julia Shekunov, Caren J. Blacker, Jennifer L. Vande Voort, Jan-Mendelt Tillema, Paul Croarkin, Magdalena Romanowicz.Immune Mediated Pediatric Encephalitis – Need for Comprehensive Evaluation and Consensus Guidelines.BMC Neurology.20, Article: 44 (2020).https://doi.org/10.1186/s12883-020-1605-y
  5. Blacker CJ.Clinical issues to consider in clozapine patients who vape: a case illustration.Focus, The Journal of Lifelong Learning.Published online: 24 Jan 2020.https://doi.org/10.1176/appi.focus.20190025
  6. Caren J. Blacker, Vincent Millischer, Lauren M. Webb, Ada MC. Ho, Martin Schalling, Mark A. Frye, Marin Veldic. EAAT2 as a research target in bipolar disorder and unipolar depression: a systematic review. Molecular Neuropsychiatry. https://doi.org/10.1159/000501885
  7. Ada M.-C. Ho, Stacey J. Winham, Sebastian M. Armasu, Caren J. Blacker, Vincent Millischer, Catharina Lavebratt, James C. Overholser, George J. Jurjus, Lesa Dieter, Gouri Mahajan, Grazyna Rajkowska, Eric Vallender, Craig A. Stockmeier, Keith D. Robertson, Mark A. Frye, Doo-Sup Choi, Marin Veldic. Genome-wide DNA methylomic differences between dorsolateralprefrontal and temporal pole cortices of bipolar disorder. Journal of Psychiatric Research. October 2019. 117:45-54. https://doi.org/10.1016/j.jpsychires.2019.05.030
  8. Blacker CJ, Mbughuni M, Olsen MW. A suicide attempt, or something else? Current Psychiatry. March 2019;18(3):44-48.https://www.mdedge.com/psychiatry/article/195233/pediatrics/suicide-attempt-or-something-else
  9. Caren J. Blacker, Mark A. Frye, Tamas Kozicz, Eva Morava-Kozicz, Marin Veldic. A review of epigenetics of PTSD in comorbid psychiatric conditions. Genes. 2019, 10(2),140. https://doi.org/10.3390/genes10020140
  10. Marin Veldic, Ahmed T. Ahmed, Caren Jacquetta Blacker, Jennifer R. Geske, Joanna M. Biernacka, Kristin L. Borreggine, Katherine M. Moore, Miguel L. Prieto Cancino, Jennifer L Vande Voort, Paul E. Croarkin, Astrid A. Hoberg, Simon Kung, Renato D. Alarcon, Nicola Keeth, Balwinder Singh, William Victor Bobo, Mark A Frye. Differential Prevalence Rate of Cytochrome P450 2C19 Poor Metabolizer Phenotype and SLC6A4 S allele between Bipolar Disorder and Major Depressive Disorder. Frontiers in Pharmacology. 19 February 2019. https://doi.org/10.3389/fphar.2019.00083
  11. Lee JC, Kenney-Jung DL, Blacker CJ, Doruk Camsari D, Lewis CP. Transcranial Direct Current Stimulation in Child and Adolescent Psychiatric Disorders. Child and Adolescent Psychiatric Clinics of North America. January 2019; 28(1):61-78. https://doi.org/10.1016/j.chc.2018.07.009
  12. Kenney-Jung DL, Blacker CJ, Doruk Camsari D, Lee JC, Lewis CP. Transcranial Direct Current Stimulation: Mechanisms and Psychiatric Applications. Child and Adolescent Psychiatric Clinics of North America. January 2019; 28(1):53-60. https://doi.org/10.1016/j.chc.2018.07.008
  13. Blacker CJ, Lewis CP, Swintak CC, Bostwick JM, Rackley SJ. Medical student suicide rates: A systematic, historical review finds inconsistent measurement and reporting. Academic Medicine. 94(2):274-280, February 2019. https://doi.org/0.1097/ACM.0000000000002430
  14. Lewis CP, Nakonezny PA, Blacker CJ, Vande Voort JL, Port JD, Worrell GA, Jo HJ, Daskalakis ZJ, Croarkin PE. Cortical inhibitory markers of lifetime suicidal behavior in depressed adolescents. Neuropsychopharmacology. 2018; 43: 1822-1831. https://doi.org/10.1038/s41386-018-0040-x
  15. Blacker CJ, Morgan RJ. Research Tracks During Psychiatry Residency Training. Academic Psychiatry. October 2018; 42(5): 698–704. https://doi.org/10.1007/s40596-018-0897-3
  16. Caren J. Blacker, Charles P. Lewis, Mark A. Frye, Marin Veldic. Metabotropic Glutamate Receptors in Bipolar Disorder: A Systematic Review. Psychiatry Research. 2017; 257:327-37. https://doi.org/10.1016/j.psychres.2017.07.059
  17. Blacker CJ. I Hear You. Am J Psychiatry. 2017 May 1;174(5):419-420. https://doi.org/10.1176/appi.ajp.2017.17020153
  18. Gonzalez SD, Williams AJ, Blacker CJ, et al. Putative biological predictors of treatment response in bipolar disorders. Personalized Medicine in Psychiatry. 1-2 (2017) 39-58. https://doi.org/10.1016/j.pmip.2016.11.003.

Book Chapters

  1. Mbughuni M, Seegmiller JC, Blacker CJ, Karger A. Antidepressants and Antipsychotics (Section II). In: Ketha H, Garg U, editors. Toxicology Cases For The Clinical And Forensic Laboratory. With editors.

Abstracts

  1. Lewis CP, Port JD, Blacker CJ, Vande Voort JL, Romanowicz M, Frye MA, Croarkin PE. Altered anterior cingulate glutamate in depressed adolescents with and without lifetime suicidal behavior: a proton magnetic resonance spectroscopy study. Journal of the American Academy of Child and Adolescent Psychiatry, 56: S225; doi:10.1016/j.jaac.2017.09.210. American Academy of Child and Adolescent Psychiatry, 64th Annual Meeting, Washington, DC, October 2017
  2. Marin Veldic, Ahmed T. Ahmed, Jennifer R. Geske, Joanna M. Biernacka, Caren J. Blacker, Kristin L. Borreggine, Katherine M. Moore, Miguel Prieto, Jennifer L. Vande Voort, Paul E. Croarkin, Mary Jo Moore, Astrid A. Hoberg, Simon Kung, Renato D. Alarcon, Nicola Keeth, William V. Bobo, Mark A. Frye. Clinical Value of Pharmacogenomics Testing [Cytochrome P450 2D6/2C19, Serotonin Transporter (SLC6A4)] for Treatment Resistant Unipolar and Bipolar Depression. The International College of Neuropsychopharmacology (CINP) Thematic Meeting on Treatment Resistant Depression, Prague, Czechia, July 20-22, 2017
  3. Lewis CP, Kohli J, Blacker CJ, Doruk D, Vande Voort JL, Frye MA, Daskalakis ZJ, Croarkin PE. Cortical inhibitory markers of suicidality in depressed adolescents. Brain Stimulation, 10: 494-495; doi:10.1016/j.brs.2017.01.447. 2nd International Brain Stimulation Conference, Barcelona, Spain, March 2017
  4. Veldic M, Choi YB, Ayers-Ringler J, Jia YF, Geske J, Biernacka J, McElroy S, Blacker C, Carneiro N, Frye M, Choi DS. Epigenetic SLC1A2 promoter hypomethylation in bipolar disorder with comorbid addiction. Neuropsychopharmacology. 2015 Dec; 40: S312
  5. Blacker CJ, Lewis CP, Frye MA, Veldic M. Roles of metabotropic glutamate receptors (mGluRs) in bipolar disorder; a systematic review. Bipolar Disorders. 2015 Jun; 17 (Suppl 1): 124-5
  6. Veldic M, Choi YB, Wang HH, Ayers-Ringler J, Biernacka J, McElroy S, Blacker CJ, Seymour L, Frye M, Choi DS. SLC1A2 and GRM5 promoter methylation differentially expressed in bipolar disorder with and without comorbid addiction. Neuropsychopharmacology. 2014 Dec; 39: S431.

Poster presentations

  1. Suicides in the Coroners Rolls of London, 1300-1378, Charles P. Lewis, MD, Alastair J. McKean, MD, J. Michael Bostwick, MD, Caren J. Blacker, BMBCh. Aeschi 10: Affirming the Relevance of Narrative in Contemporary Suicide Assessment and Treatment, Vail, CO, May 2019
  2. Research Tracks in Psychiatry Residency Training. Blacker CJ, Gandhi KD, Swintak C, Morgan RJ. American Association of Directors of Psychiatric Residency Training, 47th Annual Meeting, New Orleans, LA.March 2018
  3. Altered anterior cingulate glutamate in depressed adolescents with and without lifetime suicidal behavior: a proton magnetic resonance spectroscopy study. Lewis CP, Port JD, Blacker CJ, Vande Voort JL, Romanowicz M, Frye MA, Croarkin PE. American Academy of Child and Adolescent Psychiatry, 64th Annual Meeting, Washington, DC, Oct 2017
  4. Metabotropic Glutamate Receptors as Research Targets in Bipolar Disorder, C.J. Blacker, C.P. Lewis, M.A. Frye, M. Veldic. 9th International Meeting on Metabotropic Glutamate Receptors, Taormina, Sicily, Italy, Oct 2017
  5. Risk Factors for Suicidality in Medical Students: The Current State of International Knowledge, Charles P. Lewis, Caren J. Blacker, Michael E. Warden, J. Michael Bostwick, Sandra J. Rackley, Cosima C. Swintak. Aeschi 9: Suicide Across the Lifespan: Relational Models of Treatment 2017, Vail, CO, June 2017
  6. Suicide Rates in Medical Students: A Review of Literature to Date, Caren J. Blacker BMBCh, Charles P. Lewis MD, Cosima C. Swintak MD, John M. Bostwick MD, Sandra J. Rackley MD. Aeschi 9: Suicide Across the Lifespan: Relational Models of Treatment 2017, Vail, CO, Jun 2017
  7. Cortical inhibitory markers of suicidality in depressed adolescents, Lewis CP, Kohli J, Blacker CJ, Doruk D, Vande Voort JL, Frye MA, Daskalakis ZJ, Croarkin PE. 2nd International Brain Stimulation Conference, Barcelona, Spain, Mar 2017
  8. Epigenetic SLC1A2 Promoter Hypomethylation in Bipolar Disorder With Comorbid Addiction, Veldic M, Choi Y, Ayers-Ringler J, Jia Y, Geske J, Biernacka J, McElroy S, Blacker C, Carneiro N, Frye M, Choi D. American College of Neuropsychopharmacology 54th Annual Meeting, Hollywood, FL, Dec 2015
  9. Epigenetic regulation of metabotropic glutamate receptors (mGluRs) in bipolar disorder, Caren J. Blacker, Charles P. Lewis, Mark A. Frye, Marin Veldic. 17th Annual Conference of The International Society of Bipolar Disorders, Toronto, Canada, July 2015
  10. Improving safety and patient care during year-end transfer of patients between psychiatric residents. Hendricks, JM, M.D., Morgan, RJ, M.D., Ph.D., Blacker, CJ, BMBCh, Palmer, BA, M.D. 2015 Mayo Clinic Quality Conference, Perspectives on Quality in the Care of Specific Patient Populations, Mayo Clinic, Rochester, MN, March 2015
  11. Epigenetic regulation of metabotropic glutamate receptors (mGluRs) in bipolar disorder. Caren J. Blacker, Charles P. Lewis, Mark A. Frye, Marin Veldic. Annual Departmental Research Summit, Department of Psychiatry and Psychology, poster presentation, Mayo Clinic, Rochester, MN. March 2015
  12. SLC1A2 and GRM5 Promoter Methylation Differentially Expressed in Bipolar Disorder with and without Comorbid Addiction, Marin Veldic, YuBin Choi, Hohui E Wang, Jennifer R Ayers-Ringler, Joanna M Biernacka, Susan L McElroy, Jacquetta Blacker, Lisa R Seymour, Mark A Frye, Doo-Sup Choi. American College of Neuropsychopharmacology 53rd Annual Meeting, Phoenix, AZ, Dec. 2014
  13. Post-Traumatic Stress Disorder in Children following Surgery,Caren J. Blacker. Paediatric Surgical Department, Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK. Oct. 2003.