The Center for Genome Engineering shaping the future of medicine

The Center for Genome Engineering (CGE) develops and deploys genetically modified cells while training the next generation of genetic engineers. With a strong focus on collaboration with academic institutions, the CGE is dedicated to advancing innovative regenerative therapies for genetic diseases.

“The CGE offers the potential to cure patients without the need for harsh chemotherapy or radiation. Not only that, therapies like these could one day prevent cancer, especially for people who we know are prone to it. I also believe that the research we’re conducting could influence policy. New regulations may be required to make these therapies widely accessible, even to people who don't live near cutting-edge, tertiary care hospitals,” says David Largaespada, PhD, professor in the Departments of Pediatrics and Genetics, Cell Biology, and Development, and associate director for Basic Research at the Masonic Cancer Center, University of Minnesota Medical School.

Among its groundbreaking achievements are the invention of Sleeping Beauty, a gene transfer platform that reprograms the human immune system to detect and attack cancer cells, and TALENs, a method of precise genome editing in plants.

Looking ahead, the CGE has welcomed Minnesota state representatives to share their support for their groundbreaking work. “I’m excited about this facility, which is forward-thinking, pushing boundaries, and keeping the people it serves at the forefront,” says Minnesota Representative Liz Reyer.